1,222 research outputs found
An Active helideck testbed for floating structures based on a Stewart-Gough platform
No full textA parallel robot testbed based on Stewart-Gough platform called Active-helideck is designed, developed and tested as a helicopter floating helideck. The objective of this testbed is to show the advantages of helicopters that use an active helideck upon landing on and taking off from ships or from offshore structures. Active-helideck compensates simulated movements of a ship at sea. The main goal of this study is to maintain the robot’s end effector (helideck) in a quasi-static position in accordance to an absolute inertial frame. Compensation is carried out through the coordinate action of its six prismatic actuators in function of an inertial measurement unit. Moreover, the simulation of the sea movement is done by a parallel robot called ship platform with three degrees of freedom. The ship platform is built with a vertical oscillation along the z axis, i.e. heave, and rotates on remaining axes, i.e. roll and pitch. Active helideck is able to compensate simulated movements by considering the ship as an inertial frame as observed in the experiment
Transcriptional Control of Metabolism and the Response to Ischemia in Muscle
No full textSkeletal muscle is one of the largest tissues in humans and provides many pivotal functions to support life. Abnormality in skeletal muscle functions can lead to disease. For example, insulin resistance in skeletal muscle leads to type II diabetes. The underlying mechanisms that control energy balance in skeletal muscle remain largely elusive, especially at the genetic level. Here in the second chapter, I showed that MyoD mediated the transcriptional regulation of ACSL5, a mitochondrial protein, in C2C12 myoblasts via two E-box elements. A SNP rs2419621 (T) created a de novo E-box that together with the two pre-existing proximal E-boxes strongly enhances ACSL5 expression in both CV1 and C2C12 cells. In the third chapter, I identified a novel VGLL4-interacting protein IRF2BP2 and verified the interaction with co-immunoprecipitation and mammalian two-hybrid assays. Functionally, overexpression of IRF2BP2 and transcription factor TEAD1 activates mouse VEGF-A promoter in CV1 cells and enhances the biosynthesis of VEGF-A in C2C12 myoblasts. In vivo studies showed that ischemia induced the expression of IRF2BP2 by more than three fold, suggesting that IRF2BP2 could play a pivotal role during tissue ischemia. IRF2BP2 is a nuclear protein in both mouse cardiac myocytes and C2C12 myoblasts as demonstrated by immunohistochemistry and immunocytochemistry, respectively. Therefore, I sought to delineate the mechanism for the nuclear shuttling of IRF2BP2 in the fourth chapter. With various DNA alternations, I mapped the NLS to an evolutionarily conserved sequence 354ARKRKPSP361 in IRF2BP2. Deletion of the positively charged amino acids resulted in the abolishment of the NLS signal. Next, I showed that phosphorylation of serine 360 (S360) mediates the nuclear import of the protein. Whereas an alanine substitution (S360A) at the site resulted in perinuclear accumulation of the protein, an aspartic acid substitution (S360D) forced the nuclear accumulation. Nevertheless, the forced accumulation of the S360D mutant did not enhance the activation of VEGF-A promoter in CV1 cells as did the wild-type protein. My studies revealed two novel mechanisms by which skeletal muscle could harvest energy, thus providing new insight into the energy metabolism in skeletal muscl
Rewarding Innovation: Improving Federal Tax Support for Business R&D in Canada
No full textBusiness innovation is viewed by many as a solution to Canada’s ailing productivity performance. One of the more troubling aspects of Canada’s innovation track record is that businesses spend relatively little on research and development (R&D) despite having access to some of the world’s most generous R&D tax incentives. Canada’s low levels of business R&D have called into question the effectiveness of Canada’s generous R&D tax incentives, particularly the flagship federal Scientific Research and Experimental Development (SR&ED) program. A deeper analysis, however, reveals that tax incentives are effective in stimulating more R&D – that is, Canada would have lower levels of business R&D in the absence of these inducements. Instead, the root cause of Canada’s business R&D deficit appears to stem from structural aspects of the economy and, more importantly, a lack of demand-related pressure to pursue innovation.Fiscal and Tax Competitiveness, Canada, research and development (R&D) incentives, Scientific Research and Experimental Development (SR&ED) program
The R Journal (December 2018) 10(2): Complete Issue
No full textEditorial, John Verzani
Contributed Research Articles
stplanr: A Package for Transport Planning, Robin Lovelace and Richard Ellison
The utiml Package: Multi-label Classification in R, Adriano Rivolli and Andre C. P. L. F. de Carvalho
rcss: R Package for Optimal Convex Stochastic Switching, Juri Hinz and Jeremy Yee
nsROC: An R package for Non-Standard ROC Curve Analysis, Sonia Pérez-Fernández, Pablo Martínez-Camblor, Peter Filzmoser, and Norberto Corral
addhaz: Contribution of Chronic Diseases to the Disability Burden Using R, Renata Tiene de Carvalho Yokota, Caspar WN Looman, Wilma Johanna Nusselder, Herman Van Oyen, and Geert Molenberghs
Snowboot: Bootstrap Methods for Network Inference, Yuzhou Chen, Yulia R. Gel, Vyacheslav Lyubchich, and Kusha Nezafati
revengc: An R package to Reverse Engineer Summarized Data, Samantha Duchscherer, Robert Stewart, and Marie Urban
Basis-Adaptive Selection Algorithm in dr-package, Jae Keun Yoo
SARIMA Analysis and Automated Model Reports with BETS, an R Package, Talitha F. Speranza, Pedro C. Ferreira, and Jonatha A. da Costa
fICA: FastICA Algorithms and Their Improved Variants, Jari Miettinen, Klaus Nordhausen, and Sara Taskinen
Profile Likelihood Estimation of the Correlation Coefficient in the Presence of Left, Right or Interval Censoring and Missing Data, Yanming Li, Brenda W. Gillespie, Kerby Shedden, and John A. Gillespie
Spatial Uncertainty Propagation Analysis with the spup R Package, Kasia Sawicka, Gerard B. M. Heuvelink and Dennis J. J. Walvoort
clustMixType: User-Friendly Clustering of Mixed-Type Data in R, Gero Szepannek
Stilt: Easy Emulation of Time Series AR(1) Computer Model Output in Multidimensional Parameter Space, Roman Olson, Kelsey L. Ruckert, Won Chang, Klaus Keller, Murali Haran, and Soon-Il An
SMM: An R Package for Estimation and Simulation of Discrete-time semi-Markov Models, Vlad Stefan Barbu, Caroline Bérard, Dominique Cellier, Mathilde Sautreuil, and Nicolas Vergne
ggplot2 Compatible Quantile-Quantile Plots in R, Alexandre Almeida, Adam Loy, and Heike Hofmann
Forecast Combinations in R using the ForecastComb Package, Christoph E. Weiss, Eran Raviv, and Gernot Roetzer
testforDEP: An R Package for Modern Distribution-free Tests and Visualization Tools for Independence, Jeffrey C. Miecznikowski, En-shuo Hsu, Yanhua Chen, and Albert Vexler
rFSA: An R Package for Finding Best Subsets and Interactions, Joshua Lambert, Liyu Gong, Corrine F. Elliott, Katherine Thompson, and Arnold Stromberg
Dot-Pipe: An S3 Extensible Pipe for R, John Mount and Nina Zumel
idmTPreg: Regression Model for Progressive Illness Death Data, Leyla Azarang and Manuel Oviedo de la Fuente
lmridge: A Comprehensive R Package for Ridge Regression, Muhammad Imdad Ullah, Muhammad Aslam, and Saima Altaf
Geospatial Point Density, Paul F. Evangelista and David Beskow
Consistency Cubes: A Fast, Efficient Method for Exact Boolean Minimization, Adrian Dusa
sdpt3r: Semidefinite Quadratic Linear Programming in R, Adam Rahman
Explanations of Model Predictions with Live and breakDown Packages, Mateusz Staniak and Przemysław Biecek
Downside Risk Evaluation with the R Package GAS, David Ardia, Kris Boudt, and Leopoldo Catania
NetworkToolbox: Methods and Measures for Brain, Cognitive, and Psychometric Network Analysis in R, Alexander P. Christensen
jsr223: A Java Platform Integration for R with Programming Languages Groovy, JavaScript, JRuby, Jython, and Kotlin, Floid R. Gilbert and David B. Dahl
bnclassify: Learning Bayesian Network Classifiers, Bojan Mihaljević, Concha Bielza, and Pedro Larrañaga
Dynamic Simulation and Testing for Single-Equation Cointegrating and Stationary Autoregressive Distributed Lag Models, Soren Jordan and Andrew Q. Philips
The politeness Package: Detecting Politeness in Natural Language, Michael Yeomans, Alejandro Kantor, and Dustin Tingley
ShinyItemAnalysis for Teaching Psychometrics and to Enforce Routine Analysis of Educational Tests, Patrícia Martinková and Adéla Drabinová
RcppMsgPack: MessagePack Headers and Interface Functions for R, Travers Ching and Dirk Eddelbuettel
BNSP: An R Package for Fitting Bayesian Semiparametric Regression Models and Variable Selection, Georgios Papageorgiou
Measurement Errors in R, Iñaki Ucar, Edzer Pebesma and Arturo Azcorra
Navigating the R Package Universe, Julia Silge, John C. Nash and Spencer Graves
News and Notes
Conference Report: LatinR 2018, Laura Acion, Natalia da Silva and Riva Quiroga
Conference Report: SER III, Ariel Levy, Luciane F. Alcoforado and Orlando Celso Longo
Conference Report: Why R? 2018, Michał Burdukiewicz, Marta Karas, Leon Eyrich Jessen, Marcin Kosiński, Bernd Bischl, and Stefan Rödiger
Conference Report: R / Pharma 2018, Joseph Rickert
Conference Report: R / Medicine Report, Joseph Rickert, Naras Balasubramanian and Michael Kane
R Foundation News, Torsten Hothorn
Changes on CRAN, Kurt Hornik, Uwe Ligges and Achim Zeileis
News from the Bioconductor Project, Bioconductor Core Team
Changes in R, R Core Tea
Edição anotada e estudo das narrativas históricas de Alexandre Herculano situadas entre 1367 a 1433.
No full textThis thesis proposes a annotated edition and a study of the historical narratives of
Alexandre Herculano located between 1367-1433, Arras forum for Spain, The vault,
and Castle of Faria in this period include the reign of Ferdinand and D . John I. Such
narratives were published at the beginning of the Portuguese Romanticism initially in
journals of Portuguese journals then were gathered in volumes with other historical
narratives of the author, and published under the title Legends and Lore. This research
was developed from concern over the lack of this material in our academic context, it is
noteworthy that other works of Herculaneum are much more affordable and therefore
more known and studied, for example, the novels The Fool ( 1843), Eurico the priest
(1844), and the Monk Cistercian (1848). This annotated edition proposal, we intend
school player, college player, even the lay reader in general. Therefore, we intend to put
the scope of this public an issue with notes to assist them while reading these stories, to
have an enriched text with relevant information to clarify and enable a better
understanding of it.
Keywords: Historical Narratives; Annotated Edition; Alexandre Herculano.Esta dissertação apresenta uma proposta de edição anotada e um estudo das narrativas
históricas de Alexandre Herculano situadas entre 1367 a 1433, Arras por Foro de
Espanha, A Abóbada, e O Castelo de Faria. A este período compreendem o reinado de
D. Fernando e D. João I. Tais narrativas foram publicadas no início do Romantismo
português, inicialmente, em periódicos de revistas portuguesas, em seguida, foram
reunidas em volumes com outras narrativas históricas deste autor, e publicadas sob o
título de Lendas e Narrativas. Esta pesquisa desenvolveu-se a partir da inquietação
suscitada pela carência deste material em nosso contexto acadêmico. Vale ressaltar, que
outras obras de Herculano são bem mais acessíveis, e por consequência mais conhecidas
e estudadas, como, por exemplo, os romances O Bobo (1843), Eurico o Presbítero
(1844), e O Monge de Cister (1848). Nesta proposta de edição anotada, temos em vista
o leitor escolar, o leitor universitário, até mesmo, o leitor leigo em geral. Por isso,
pretendemos colocar ao alcance deste público uma edição com anotações que os
auxiliem durante a leitura destas narrativas, ao terem um texto enriquecido com
informações pertinentes que esclareçam e possibilitem sua compreensão.
Palavras Chave: Narrativas históricas; Edição anotada; Alexandre Herculano
The expression of myosin isoenzymes in the muscles of normal and C57 BL/6J DY2J/DY2J mice.
No full textThe expression of myosin isoenzymes in the muscles of normal and C57 BL/6J DY2J/DY2J mice.
No full textSearch for a CP-odd Higgs boson decaying to Zh in pp collisions at root s=8 TeV with the ATLAS detector
No full textSee paper for full list of authors – 13 pages plus author list + cover pages (30 pages total), 5 figures, 2 tables, submitted to Phys. Lett. B, All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HIGG-2013-06/International audienceA search for a heavy, CP-odd Higgs boson, , decaying into a boson and a 125 GeV Higgs boson, , with the ATLAS detector at the LHC is presented. The search uses proton--proton collision data at a centre-of-mass energy of 8 TeV corresponding to an integrated luminosity of 20.3 fb. Decays of CP-even bosons to or pairs with the boson decaying to electron or muon pairs are considered, as well as decays with the boson decaying to neutrinos. No evidence for the production of an boson in these channels is found and the 95% confidence level upper limits derived for \sigma (gg\rightarrow A) \times \mbox{BR}(A \rightarrow Zh) \times \mbox{BR}(h \rightarrow f\bar{f}) are 0.098--0.013 pb for and 0.57--0.014 pb for in a range of 220--1000 GeV. The results are combined and interpreted in the context of two-Higgs doublet models
Masculinidades e comportamentalismo radical : uma proposta interpretativa com base em R. Conell e B. F. Skinner
No full textOrientador: Prof. Dr. Alexandre DittrichDissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Humanas, Programa de Pós-Graduação em Psicologia. Defesa: Curitiba, 13/02/2023Inclui referênciasÁrea de concentração: PsicologiaResumo: A inserção da perspectiva feminista na (re)formulação dos estudos sobre gênero se constituiu como uma etapa substancial no processo de objeção ao caráter naturalizante, essencialista e binário até então atribuído às práticas generificadas e, como efeito, novos fenômenos puderam ser explorados e criticamente analisados nesse domínio dos saberes. A produção de conhecimentos sobre os homens e as masculinidades é exemplo desta vasta gama de possibilidades investigativas no campo dos estudos de gênero, tendo se multiplicado sobretudo após a década de 1970, especialmente impulsionada pelos estudos elaborados pela socióloga australiana R. Connell. Connell foi responsável, por exemplo, por cunhar o termo "masculinidade hegemônica", o que se mostrou bastante pertinente para discussões de temas como educação, saúde física e mental, violência etc. Dada a importância da autora para o exame desta temática, a sua obra foi tomada como base para a formulação da primeira etapa deste estudo. Não obstante, o avanço atrelado ao desenvolvimento de novos estudos sobre os homens e masculinidades demanda uma ampliação do diálogo com outros campos científicos. Nesta perspectiva, construir uma interlocução com a Análise do Comportamento pode ser útil para expandir as interpretações acerca dos fenômenos comportamentais complexos que constituem as masculinidades, uma vez que os pressupostos teóricos e tecnológicos da Análise do Comportamento têm sido cada vez mais utilizados na delimitação e na construção de propostas resolutivas no que concerne a temáticas socialmente relevantes. Tendo isso em vista, esta dissertação objetivou construir uma interpretação comportamentalista radical dos conceitos de masculinidades apresentados por R. Connell. Partindo de uma pesquisa de caráter teórico e interdisciplinar, as masculinidades, aqui entendidas como práticas que se configuram de acordo com a posição dos homens na estrutura das relações de gênero, foram examinadas à luz da teoria skinneriana, procedimento que constituiu a segunda etapa do estudo. Assim, as diferentes configurações de masculinidades descritas por Connell – hegemônica, subordinada, cúmplice e marginalizada – foram descritas de modo coerente com o escopo analítico-comportamental. Uma vez que as diferentes práticas de masculinidades são socialmente construídas, complexas e plurais (i.e., podem variar de acordo com a cultura, o espaço e o tempo), temas como comportamento social e práticas culturais foram empregados na formulação da análise interpretativa nesta etapa do estudo. Ao final, foram exploradas as possibilidades de se fortalecer políticas que visam a transformação das práticas de masculinidades vigentes e que, atualmente, acarretam efeitos nocivos aos homens e à sociedade como um todo. Tópicos como controle ético, contracontrole e controle face a face foram abordados para embasar as discussões traçadas. Em síntese, foi sendo evidenciado ao longo deste trabalho que os homens, à medida em que são partes fundamentais dos problemas oriundos dos modelos nefastos de masculinidade atualmente privilegiados em nossa sociedade, também devem ser parte da solução.Abstract: The insertion of the feminist perspective in the (re)formulation of gender studies constituted a substantial step in the process of objection to the naturalizing, essentialist and binary character by that time attributed to gendered practices and, as an effect, new phenomena could be explored and critically analyzed in this domain of knowledge. The production of knowledge about men and masculinities is an example of this vast range of investigative possibilities in the field of gender studies, having multiplied after the 1970s, especially driven by studies developed by the Australian sociologist R. Connell. Connell was responsible, for example, for coining the term "hegemonic masculinity", which proved to be quite relevant for discussions of topics such as education, physical and mental health, violence, etc. Given the importance of the author for the examination of this theme, her work was taken as the basis for the formulation of the first step of this study. However, the progress linked to the development of new studies on men and masculinities demands an expansion of the dialogue with other scientific fields. In this perspective, building a dialogue with radical behavioral science can be useful to expand interpretations about the complex behavioral phenomena that constitute masculinities, since the theoretical and technological assumptions of Behavior Analysis have been increasingly used in the delimitation and construction of resolutive proposals regarding socially relevant themes. Hence, this dissertation aimed to build a radical behaviorist interpretation of the concepts of masculinity presented by R. Connell. Based on a theoretical and interdisciplinary research, masculinities, understood here as practices that are configured according to the position of men in the structure of gender relations, were examined in the light of Skinner's theory, a procedure that constituted the second step of the study. Thus, the different configurations of masculinities described by Connell – hegemonic, subordinate, complicity and marginalized – were described coherently with the Behavior Analysis’ scope. Since the different masculinity practices are socially constructed, complex and plural (i.e., may vary according to culture, space and time), themes such as social behavior and cultural practices were used to formulate the interpretative analysis at this stage of the study. Finally, the possibilities of strengthening politics aimed at transforming current masculinity practices which currently have harmful effects on men and society were explored. Topics such as ethical control, counter-control and face-to-face control were addressed to support the outlined discussions. In short, it became evident throughout this study that men, as they are fundamental parts of the problems arising from the harmful models of masculinity currently privileged in our society, must also be part of the solution
Masculinidades e comportamentalismo radical : uma proposta interpretativa com base em R. Conell e B. F. Skinner
No full textOrientador: Prof. Dr. Alexandre DittrichDissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências Humanas, Programa de Pós-Graduação em Psicologia. Defesa: Curitiba, 13/02/2023Inclui referênciasÁrea de concentração: PsicologiaResumo: A inserção da perspectiva feminista na (re)formulação dos estudos sobre gênero se constituiu como uma etapa substancial no processo de objeção ao caráter naturalizante, essencialista e binário até então atribuído às práticas generificadas e, como efeito, novos fenômenos puderam ser explorados e criticamente analisados nesse domínio dos saberes. A produção de conhecimentos sobre os homens e as masculinidades é exemplo desta vasta gama de possibilidades investigativas no campo dos estudos de gênero, tendo se multiplicado sobretudo após a década de 1970, especialmente impulsionada pelos estudos elaborados pela socióloga australiana R. Connell. Connell foi responsável, por exemplo, por cunhar o termo "masculinidade hegemônica", o que se mostrou bastante pertinente para discussões de temas como educação, saúde física e mental, violência etc. Dada a importância da autora para o exame desta temática, a sua obra foi tomada como base para a formulação da primeira etapa deste estudo. Não obstante, o avanço atrelado ao desenvolvimento de novos estudos sobre os homens e masculinidades demanda uma ampliação do diálogo com outros campos científicos. Nesta perspectiva, construir uma interlocução com a Análise do Comportamento pode ser útil para expandir as interpretações acerca dos fenômenos comportamentais complexos que constituem as masculinidades, uma vez que os pressupostos teóricos e tecnológicos da Análise do Comportamento têm sido cada vez mais utilizados na delimitação e na construção de propostas resolutivas no que concerne a temáticas socialmente relevantes. Tendo isso em vista, esta dissertação objetivou construir uma interpretação comportamentalista radical dos conceitos de masculinidades apresentados por R. Connell. Partindo de uma pesquisa de caráter teórico e interdisciplinar, as masculinidades, aqui entendidas como práticas que se configuram de acordo com a posição dos homens na estrutura das relações de gênero, foram examinadas à luz da teoria skinneriana, procedimento que constituiu a segunda etapa do estudo. Assim, as diferentes configurações de masculinidades descritas por Connell – hegemônica, subordinada, cúmplice e marginalizada – foram descritas de modo coerente com o escopo analítico-comportamental. Uma vez que as diferentes práticas de masculinidades são socialmente construídas, complexas e plurais (i.e., podem variar de acordo com a cultura, o espaço e o tempo), temas como comportamento social e práticas culturais foram empregados na formulação da análise interpretativa nesta etapa do estudo. Ao final, foram exploradas as possibilidades de se fortalecer políticas que visam a transformação das práticas de masculinidades vigentes e que, atualmente, acarretam efeitos nocivos aos homens e à sociedade como um todo. Tópicos como controle ético, contracontrole e controle face a face foram abordados para embasar as discussões traçadas. Em síntese, foi sendo evidenciado ao longo deste trabalho que os homens, à medida em que são partes fundamentais dos problemas oriundos dos modelos nefastos de masculinidade atualmente privilegiados em nossa sociedade, também devem ser parte da solução.Abstract: The insertion of the feminist perspective in the (re)formulation of gender studies constituted a substantial step in the process of objection to the naturalizing, essentialist and binary character by that time attributed to gendered practices and, as an effect, new phenomena could be explored and critically analyzed in this domain of knowledge. The production of knowledge about men and masculinities is an example of this vast range of investigative possibilities in the field of gender studies, having multiplied after the 1970s, especially driven by studies developed by the Australian sociologist R. Connell. Connell was responsible, for example, for coining the term "hegemonic masculinity", which proved to be quite relevant for discussions of topics such as education, physical and mental health, violence, etc. Given the importance of the author for the examination of this theme, her work was taken as the basis for the formulation of the first step of this study. However, the progress linked to the development of new studies on men and masculinities demands an expansion of the dialogue with other scientific fields. In this perspective, building a dialogue with radical behavioral science can be useful to expand interpretations about the complex behavioral phenomena that constitute masculinities, since the theoretical and technological assumptions of Behavior Analysis have been increasingly used in the delimitation and construction of resolutive proposals regarding socially relevant themes. Hence, this dissertation aimed to build a radical behaviorist interpretation of the concepts of masculinity presented by R. Connell. Based on a theoretical and interdisciplinary research, masculinities, understood here as practices that are configured according to the position of men in the structure of gender relations, were examined in the light of Skinner's theory, a procedure that constituted the second step of the study. Thus, the different configurations of masculinities described by Connell – hegemonic, subordinate, complicity and marginalized – were described coherently with the Behavior Analysis’ scope. Since the different masculinity practices are socially constructed, complex and plural (i.e., may vary according to culture, space and time), themes such as social behavior and cultural practices were used to formulate the interpretative analysis at this stage of the study. Finally, the possibilities of strengthening politics aimed at transforming current masculinity practices which currently have harmful effects on men and society were explored. Topics such as ethical control, counter-control and face-to-face control were addressed to support the outlined discussions. In short, it became evident throughout this study that men, as they are fundamental parts of the problems arising from the harmful models of masculinity currently privileged in our society, must also be part of the solution
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