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    Parallel geodesics and minimal stable length of random groups

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    21 pagesWe show that for any pair of long enough parallel geodesics in a random group G(m, d) with m generators at density d < 1/6, there is a van Kampen diagram having only one layer of faces. Using this result, we give an upper bound, depending only on d, of the number of pairwise parallel geodesics in G(m, d) when d < 1/6. As an application, we show that the minimal stable length of a random group at density d < 1/6 is exactly 1

    Use of PET derived features to predict mutational status in lung adenocarcinomas

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    International audienceObjectives: The treatment of pulmonary adenocarcinomas is nowadays driven by the presence/absence of some genetic abnormalities defining distinct molecular sub-groups of patients with various outcomes. The aim of our study was to determine the ability of a large number of parameters derived from initial pre-treatment 18FDG PET images to predict the mutational status.Methods: 498 patients with pulmonary adenocarcinoma who underwent 18FDG PET/CT before treatment were retrospectively included. All primary tumors (tumor volume larger than 4 cm3) were identified visually on PET images and were automatically segmented with the FLAB algorithm. Derived radiomic parameters were confronted with EGFR, KRAS, BRAF mutational status, and PDL1 expression. ALK translocation and ROS1 fusion were also considered. The performance of each PET derived feature was evaluated using ROC methodology.Results: A total of 120 features were extracted from PET images. Several parameters were efficient in predicting EGFR, PDL1, ROS and BRAF status with an individual AUC reaching 0.86. The best predictive parameters were different depending on the gene studied. None of the evaluated parameters could predict KRAS and ALK status (AUC <0.65). Routinely used SUVmax had no significant predictive value for any of the studied genetic profiles. in addition, textural parameters performed better than any tumor volume related parameters.Conclusions: Our results confirm that PET derived radiomics could be a powerful approach to identify specific molecular subgroups of pulmonary adenocarcinoma and should be considered to guide patient management. A model based on a selection of the best correlating parameters to each genetic profile will be tested and results will be presented

    Radiotherapy after D2 Lymph Node Dissection +/- Omentectomy in Gastric Cancer

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    International audienceThe review aims to address the indications and areas of radiotherapy in gastric cancer. Gastric cancer is the 5th most common cancer worldwide and ranks third in cancer deaths. It is an insidious disease and it is usually asymptomatic until it reaches the advanced stage. Surgical treatment is still standard treatment, although chemotherapy, radiotherapy and immunotherapy have been advancing in recent years. The lymph nodes of the stomach are collected in 16 groups and are classified from N1 to N3 according to their stations. Parallel to this order of lymph nodes, lymph node dissections are separated from D0 to D3. D0 dissection N1 group lymph nodes were not dissected; D1 dissection dissolves the entire N1; D2 dissection N1 and N2 group lymph nodes all dissected; D3 dissection indicates that all of the lymph nodes of N1, N2, N3. It is concluded that gastric cancer has a poor prognosis and aggressive cancer. The standard treatment is surgery. In the surgical treatment, total / subtotal gastrectomy + D1 (+/-) D2 lymph node dissection +/- omentectomy is performed. D2 dissected +/- omentectomy gastric cancer postoperative radiotherapy, the role of RT in the treatment, the target volume of RT, new RT techniques to reduce the potential toxicity and which group of patients is not clear is clear. The results of a prospective randomized study will provide more reliable results

    L'expérience de la fuite, phénoménologie politique de l'ordinaire - "En cours"

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    The PHD tries to explore the lived experience of oppression through the experience of fligth.Cette recherche s'intéresse à l'expérience de l'oppression pensée au prisme de l'expérience de la fuite. Il s'agit de s'intéresser à la fuite tant dans ses dimensions ordinaires d'évitement que dans la dimension plus rare de la prise de fuite réelle

    Archives mauristes conservées à l'abbaye de Melk: (Première partie)

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    On Runs Tests for Directional Data and Their Local and Asymptotic Optimality Properties

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    The interactions between the Syriac, Arabic and Greek traditions

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    This article examines the correlations and mutual influences of the Syriac, Arabic and Greek grammatical traditions, in a historical and chronological approach. The spreading of Greek culture in the Middle East during Late Antiquity provides the context for the assimilation of the Greek grammatical theories, first and more clearly by Syriac scholars and translators and later on, through a less certain path, by Arabic grammarians and philosophers. Evidences of contacts among the three traditions grow during the Abbasid rule of the Middle East, from the 9th to the 13th cent., with the progressive infiltration of Arabic linguistic ideas in the works of Syriac grammarians

    Les formes conventionnelles de la coopération territoriale

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