191 research outputs found
Hypothalamic alpha adrenergic receptors and the regulation of LHRH release
No full textThe neurotransmitter system regulating the release of luteinizing hormone releasing hormone (LHRH) has been actively investigated since the classic 1947 work of Sawyer. The literature indicates that LHRH release is primarily under the control of the adrenergic system. The adrenergic receptor subtype mediating LHRH release has not been established however. Also, most investigators have used changes in plasma luteinizing hormone to infer changes in hypothalamic LHRH release, rather than directly examining LHRH release. The purpose of this work was to directly examine the release of hypothalamic LHRH and determine if \alpha\sb1 or \alpha\sb2 receptors mediates changes in its release. Initially, this thesis demonstrates that the in vitro pulsatile administration of 10\sp{-5}M of the \alpha\sb1 adrenergic agonist methoxamine (MTX) stimulates LHRH release from superfused female rat mediobasal hypothalami. This is a specific effect, blocked by the \alpha\sb1 antagonist prazosin. This data was the first to demonstrate that the specific activation of hypothalamic \alpha\sb1 adrenoceptors sharply stimulates the release of LHRH. This effect occurred in hypothalami from proestrus and ovariectomized rats with or without estrogen.To establish that \alpha\sb1 stimulation of LHRH release also occurs in vivo, the push-pull cannula (PPC) technique was used. Via the PPC, LHRH release showed moderate pulsatility during the initial baseline period. Immediately following infusion of 10\sp{-4}M MTX there was a robust, significant, increase in LHRH release. This indicates that the activation of rat MBH \alpha\sb1 adrenoceptors stimulates LHRH release in vivo also, and that this stimulatory \alpha\sb1 effect is an underlying physiological mechanism. In a second PPC experiment, infusion of 10\sp{-4}M prazosin decreased LHRH release, indicating that basal LHRH release is also modulated by \alpha\sb1 receptors. The \alpha\sb2 adrenergic agonist -methyl-norepinephrine and antagonist yohimbine had no effect upon in vitro LHRH release. Last, median eminence LHRH terminals from in vitro superfused and in vivo PPC hypothalami were immunocytochemically stained. Superfusion and PPC had no apparent effect upon LHRH terminals.Made available in DSpace on 2011-05-07T12:42:20Z (GMT). No. of bitstreams: 2
license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5)
9021687.pdf: 6131979 bytes, checksum: b8453e855d2e8906febf2eaca6719333 (MD5)
Previous issue date: 1990Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding ([email protected]) on 2011-05-07T14:44:37Z
Item is restricted indefinitely.Restriction data tranferred 2014-07-01T11:19:39-05:00
Original Data
Group with Access UIUC Users [automated]
Release Date: none
Reason: ETDs are only available to UIUC Users without author permissionETDs are only available to UIUC Users without author permissionU of I Onl
Rio Bravo: A bilingual journal of international studies Spring 1992 v.1 no.2
No full textHigher Education and Borderlands Telecommunications in Texas, California, and Arizona / Armando A. Arias, Jr. and Beryl Bellman -- Tamaulipas - la Ausencia de Oposicion Politica y la Persistencia de los Factores Culturales Corporativos - el Caso de Matamoros / Vicente Sanchez-Mungia -- Sindicalismo Tradicional en Maquiladoras - el Caso de Matamoros / Cirila Quintero Ramirez -- Estancia temporal de migrantes indocumentados en Tijuana - Una estimacion sobre su aportacion a la economia de la ciudad / Maria Eugenia Anguiano -- Latin America - Illusions and Reality / Rafael A. Lecuona -- George Baker\u27s \u27Mexican Labor is Not Cheap\u27 - a Rejoinder and Critical Commentary / Ellwyn R. Stoddard -- XV Simposio de Historia y Antropologia de Sonora. Memoria. 3 Vols, Hermosillo, Sonora, Mexico, Instituto de Investigaciones Historicas de la Unison, 1991 -- La Revista Cultura Norte -- Borderlife Project -- Author\u27s Guidelines - Rio Bravo.https://scholarworks.utrgv.edu/riobravojournal/1001/thumbnail.jp
Diagnóstico de los niveles de despilfarro, que afectan la productividad de la empresa Maderas Cimarrón en el municipio de Villavicencio, Meta
No full textLa siguiente investigación fue realizada en el área de producción de la microempresa maderera MADERAS CIMARRÓN DEL LLANO, dedicada a la comercialización, distribución y corte de madera. Dicha investigación permite identificar los diferentes tipos de despilfarro que se presentan en la compañía y que interrumpen el buen desarrollo productivo basado en un estudio cuantitativo de la mano de la Teoría del Despilfarro.
Igualmente para la investigación fue de vital importancia realizar una medición de tiempos que identificara la situación actual del proceso en materia de duración. El diagnóstico realizado se apoya en herramientas académicas organizacionales como el diagrama de flujo de procesos, estudio de tiempos, coeficientes de despilfarro, diagrama causa-efecto y por último un estudio de distribución de planta que arroja la situación actual de la ubicación de cada una de las áreas de trabajo que intervienen en el proceso productivo y que afectan de manera directa-indirecta la producción.
Finalmente, en cada capítulo se arroja el resultado de la metodología empleada y el análisis correspondiente al diagnóstico realizado junto con recomendaciones de mejora y una redistribución de la planta actual que permita conseguir una disminución en los tiempos del proceso y al aumento de la producción.Glosario 10
Resumen 15
Palabras clave 16
Introducción 17
Capítulo I: Descripción de la empresa . 18
Análisis del sector 18
Situación actual de la empresa 21
Razón Social. 21
Forma jurídica. ................................................................................................................... 21
Reseña Histórica. 22
Ubicación planta de producción. 22
Misión23
Visión 23
Portafolio de productos y servicios. 24
Número de empleados. 24
Maquinaria24
Capítulo II: Generalidades del proyecto. 25
Planteamiento del problema 25
Pregunta de la investigación 25
Objetivos de la investigación . 26
Objetivo general.26
Objetivos específicos. 26
Justificación: 27
Metodología 29
Capitulo III: Marco teórico. . 30
Teoría del despilfarro 30
Control de la productividad. 32
Desglose del despilfarro.33
Despilfarros por improductividades causadas por la mano de obra directa y cálculo de Cact. 34
Despilfarros por fallos de gestión y cálculo del Cg 35
La teoría de la medición del despilfarro como método de diagnóstico36
Estudio de tiempos y movimientos. 38
Técnicas de medida: . 40
Tiempo estándar y ritmo de trabajo. 40
¿Cómo realizar el estudio de métodos y tiempos? 41
Diseño y distribución de planta. 42
Objetivos del diseño y distribución en planta. 42
Capitulo IV: Estudio de tiempos y movimientos en Maderas Cimarrón 47
Modelo de medición del trabajo (Calculo del Tiempo Promedio, Tiempo Básico, Tiempo Tipo y Tiempo Ciclo) en Maderas Cimarrón 49
Capítulo V: Medición de despilfarro en Maderas Cimarrón. 55
Capítulo VI: Distribución de planta en Maderas Cimarrón64
Tipo de distribución 64
Factor edificio. 65
Factores que afectan la distribución de planta 67
Factor material. 67
Factor maquinaria 68
Factor hombre. 70
Factor movimiento.71
Factor espera.71
Plano de distribución actual. 72
Propuesta de nueva distribución de planta 76
Mejora enfocada78
Metodología 5S 78
Usos del aserrín y viruta. 83
Conclusiones 85
Bibliografía 86
ANEXOS 87PregradoIngeniero(a) Industria
Glória póstuma :: almanaque objeto de estudo /
No full textDissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão.Análise da revista Almanaque-cadernos de literatura e ensaio, centrada em seus sete primeiros números, publicados pela Editora Brasiliense e organizados por Walnice Nogueira Galvão e Bento Prado Jr., de 1976 a 1976 a 1978. A partir dos manifestos de crítica literária presentes nessa primeira fase da revista, a dissertação busca respostas para as questões presentes no título: a relação entre discurso acadêmico e indústria cultural, cadernos de literatura e ensaio e almanaques, mapeando as posições defendidas e as alternativas vislumbradas pela crítica literária brasileira no final dos anos 70. A dissertação inclui ainda a indexação completa dos quatorze números do periódico, desenvolvida no banco de dados do projeto "Poéticas contemporâneas: histórias e caminhos", do Núcleo de Estudos Literários e Culturais (NELIC), na UFSC
El síndrome de burnout y su relación con las creencias irracionales en el docente universitario
No full textObjective: To study the prevalence of burnout syndrome in teachers and assessing its relationship with irrational beliefs. Methodology: The sample consisted of 115 teachers. Burnout syndrome was analyzed by Maslach Burnout Inventory (MBI), and to identify irrational beliefs in teaching, the Teacher Irrational Beliefs Scale, was applied, the version of (TIBS) that Calvete and Villa translated and adapted to spanish was used. Results and discussion: The results show a high level of Burnout and Irrational Beliefs in teaching especially in the Attitude toward School Organization and a significant positive correlation between the two. Specifically all irrational beliefs play a key role in Burnout levels especially in the emotional exhaustion. Conclusions: The teaching profession becomes a risk when teacher cognition is not fully rational.Objetivo: Estudiar la prevalencia del síndrome de burnout en los docentes y valorar su relación con creencias irracionales. Metodología: La muestra estuvo formada por 116 docentes. El Síndrome de Burnout se analizó mediante el cuestionario de Maslach Burnout Inventory (MBI), para identificar las creencias irracionales en el docente se aplicó la Escala de Creencias Irracionales del Profesor (TIBS) que Calvete y Villa tradujeron y adaptaron al castellano. Resultados y discusión: Los resultados muestran un elevado nivel de Burnout y Creencias Irracionales en los docentes sobre todo en la Actitud hacia la Organización Escolar y una correlación positiva significativa entre ambos. En concreto todas las Creencias Irracionales juegan un papel fundamental en los niveles de Burnout sobre todo en el Agotamiento emocional. Conclusiones: La docencia se convierte en una profesión de riesgo cuando la cognición del docente no es completamente racional
Measurement of the muon charge asymmetry in inclusive pp →W + X production at s=7 TeV and an improved determination of light parton distribution functions
No full textPublished by the American Physical Society under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published articles title, journal citation, and DOI.Measurements of the muon charge asymmetry in inclusive pp → W + X production at root s= 7 TeV are
presented. The data sample corresponds to an integrated luminosity of 4.7 fb−1 recorded with the CMS
detector at the LHC. With a sample of more than 20 million W → μν events, the statistical precision is
greatly improved in comparison to previous measurements. These new results provide additional
constraints on the parton distribution functions of the proton in the range of the Bjorken scaling variable
x from 10−3 to 10−1. These measurements and the recent CMS measurement of associated W þ charm
production are used together with the cross sections for inclusive deep inelastic e p scattering at HERA in
a next-to-leading-order QCD analysis. The determination of the valence quark distributions is improved,
and the strange-quark distribution is probed directly through the leading-order process g þ s → W þ c in
proton-proton collisions at the LHC.the Austrian Federal Ministry of Science and Research and the Austrian Science Fund; the Belgian Fonds de la Recherche Scientifique, and Fonds voor Wetenschappelijk Onderzoek; the Brazilian Funding Agencies (CNPq, CAPES, FAPERJ, and FAPESP); the Bulgarian Ministry of Education and Science; CERN; the Chinese Academy of Sciences, Ministry of Science and Technology, and National Natural Science Foundation of China; the Colombian Funding Agency (COLCIENCIAS); the Croatian Ministry of Science, Education and Sport, and the Croatian Science Foundation; the Research Promotion Foundation, Cyprus; the Ministry of Education and Research, Recurrent financing contract SF0690030s09 and European Regional Development Fund, Estonia; the Academy of Finland, Finnish Ministry of Education and Culture, and Helsinki Institute of Physics; the Institut National de Physique Nucléaire et de Physique des Particules/CNRS, and Commissariat à l’Énergie Atomique et aux Énergies Alternatives/CEA, France; the Bundesministerium für Bildung und Forschung, Deutsche Forschungsgemeinschaft, and Helmholtz-Gemeinschaft Deutscher Forschungszentren, Germany; the General Secretariat for Research and Technology, Greece; the National Scientific Research Foundation, and National Innovation Office, Hungary; the Department of Atomic Energy and the Department of Science and Technology, India; the Institute for Studies in Theoretical Physics and Mathematics, Iran; the Science Foundation, Ireland; the Istituto Nazionale di Fisica Nucleare, Italy; the Korean Ministry of Education, Science and Technology and the World Class University program of NRF, Republic of Korea; the Lithuanian Academy of Sciences; the Mexican Funding Agencies (CINVESTAV, CONACYT, SEP, and UASLP-FAI); the Ministry of Business, Innovation and Employment, New Zealand; the Pakistan Atomic Energy Commission; the Ministry of Science and Higher Education and the National Science Centre, Poland; the Fundação para a Ciência e a Tecnologia, Portugal; JINR, Dubna; the Ministry of Education and Science of the Russian Federation, the Federal Agency of Atomic Energy of the Russian Federation, Russian Academy of Sciences, and the Russian Foundation for Basic Research; the Ministry of Education, Science and Technological Development of Serbia; the Secretaría de Estado de Investigación, Desarrollo e Innovación and Programa Consolider-Ingenio 2010, Spain; the Swiss Funding Agencies (ETH Board, ETH Zurich, PSI, SNF, UniZH, Canton Zurich, and SER); the National Science Council, Taipei; the Thailand Center of Excellence in Physics, the Institute for the Promotion of Teaching Science and Technology of Thailand, Special Task Force for Activating Research and the National Science and Technology Development Agency of Thailand; the Scientific and Technical Research Council of Turkey, and Turkish Atomic Energy Authority; the Science and Technology Facilities Council, UK; the U.S. Department of Energy, and the U.S. National Science Foundation. Individuals have received support from the Marie-Curie programme and the European Research Council and EPLANET (European Union); the Leventis Foundation; the A. P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the Ministry of Education, Youth and Sports (MEYS) of Czech Republic; the Council of Science and Industrial Research, India; the Compagnia di San Paolo (Torino); the HOMING PLUS programme of Foundation for Polish Science, cofinanced by EU, Regional Development Fund; and the Thalis and Aristeia programmes cofinanced by EU-ESF and the Greek NSRF
The evolution of poverty and welfare in Nigeria, 1985-92
No full textThe authors profile Nigerian poverty, showing its evolution from 1985 to 1992. This paper is divided into 6 sections, beginning with an overview. Section 2 looks at the sources of data used. Section 3 examines household income and expenditure distribution, interprets poverty indices, and calculates relative poverty lines for Nigeria. Section 4, the paper's core, presents the spatial characteristics of poverty in Nigeria and their evolution over the seven-year period, indicating in which regions and states the poor are located and the extent and severity of their poverty; lays out the poor's basic demographic characteristics including time use and employment patterns, detailing how these have evolved; features the roles the poor play in various sectors of the economy; and discuss how changes in poverty could be explained by growth-related and redistribution factors. Section 5 discusses the evolution of expenditures and explains how expenditure patterns correspond to poverty. Section 6 presents conclusions, among them: the extremely poor -who dominate the ranks of the uneducated- became poorer, while all other income groups had a higher standard of living; an increase in mean per capita household spending reduced the proportion of the population in poverty but different regions did not share equally in the benefits of growth; household spending grew faster in southern and central Nigeria and slower in the north; and poverty was overwhelmingly rural and regional, but also greatly influenced by age, educaton, and the nature of employment.Public Health Promotion,Environmental Economics&Policies,Health Economics&Finance,Poverty Reduction Strategies,Services&Transfers to Poor,Poverty Assessment,Environmental Economics&Policies,Achieving Shared Growth,Health Economics&Finance,Poverty Lines
PACE-UP (Pedometer and consultation evaluation - UP) – a pedometer-based walking intervention with and without practice nurse support in primary care patients aged 45–75 years: study protocol for a randomised controlled trial
No full text© 2013 Harris et al.; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background - Most adults do not achieve the 150 minutes weekly of at least moderate intensity activity recommended for health. Adults’ most common physical activity (PA) is walking, light intensity if strolling, moderate if brisker. Pedometers can increase walking; however, most trials have been short-term, have combined pedometer and support effects, and have not reported PA intensity. This trial will investigate whether pedometers, with or without nurse support, can help less active 45–75 year olds to increase their PA over 12 months. Methods/design: Design: Primary care-based 3-arm randomized controlled trial with 12-month follow-up and health economic and qualitative evaluations. Participants: Less active 45–75 year olds (n = 993) will be recruited by post from six South West London general practices, maximum of two per household and households randomised into three groups. Step-count and time spent at different PA intensities will be assessed for 7 days at baseline, 3 and 12 months by accelerometer. Questionnaires and anthropometric assessments will be completed. Intervention: The pedometer-alone group will be posted a pedometer (Yamax Digi-Walker SW-200), handbook and diary detailing a 12-week pedometer-based walking programme, using targets from their baseline assessment. The pedometer-plus-support group will additionally receive three practice nurse PA consultations. The handbook, diary and consultations include behaviour change techniques (e.g., self-monitoring, goal-setting, relapse prevention planning). The control group will receive usual care.
Outcomes: Changes in average daily step-count (primary outcome), time spent sedentary and in at least moderate intensity PA weekly at 12 months, measured by accelerometry. Other outcomes include change in body mass index, body fat, self-reported PA, quality of life, mood and adverse events. Cost-effectiveness will be assessed by the incremental cost of the intervention to the National Health Service and incremental cost per change in step-count and per quality adjusted life year. Qualitative evaluations will explore reasons for trial non-participation and the interventions’ acceptability. Discussion- The PACE-UP trial will determine the effectiveness and cost-effectiveness of a pedometer-based walking intervention delivered by post or practice nurse to less active primary care patients aged 45–75 years old. Approaches to minimise bias and challenges anticipated in delivery will be discussed.This project was funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) Programme (project number HTA 10/32/02) and will be published in full in Health Technology Assessment
Regresión y aprendizaje multimodal como ayuda al diagnóstico en oftalmologı́a e histopatologı́a
No full textilustraciones, diagramasThe main contribution of this thesis is the development of probabilistic machine learning models to support disease diagnosis from medical data sources. We show how a probabilistic approach offers great versatility in exploiting all available information about the target task. Based on the mathematical formalism of quantum mechanics, we develop and apply machine learning models that allow us to handle the flow of information using density matrices in different ways. We develop mechanisms that can naturally encode not only categorical but also ordinal information, and can also merge different data modalities. Furthermore, we show that the proposed models are naturally interpretable, which allows and facilitates their use in sensitive domains such as health applications. In particular, our models are tested in the diagnosis of several eye diseases and prostate cancer. First, we show the effectiveness and benefit of using regression models in the diagnosis of eye diseases of genetic origin. We then demonstrate the importance of including disease grading information and performing discrete regression to improve the performance of the binary diagnosis of diabetic retinopathy and prostate cancer. We show that a probabilistic interpretation of the results provides information on the uncertainty of the models, which can also be used in training processes. Finally, the proposed framework allows us to encode information using kernel functions, which in turn allows us to naturally introduce flexible information fusion mechanisms and thus to address multimodal tasks. Overall, we show that incorporating ordinal and multimodal information using probabilistic kernel-based frameworks allows learning better data representations, which improves the performance of the models and provides them with a higher level of interpretability.La principal contribución de esta tesis es el desarrollo de modelos probabilísticos de aprendizaje de máquina para apoyar el diagnóstico de enfermedades a partir de información médica. Mostramos cómo un enfoque probabilístico ofrece una gran versatilidad al momento de aprovechar toda la información disponible sobre la tarea objetivo. Basándonos en el formalismo matemático de la mecánica cuántica, desarrollamos y aplicamos modelos de aprendizaje que nos permiten manejar el flujo de información utilizando matrices de densidad de diferentes maneras. Desarrollamos mecanismos que pueden codificar de forma natural no sólo información categórica, sino también ordinal, y que también pueden fusionar distintas modalidades de información. Además, demostramos que los modelos propuestos son naturalmente interpretables, lo que permite y facilita su aplicación en dominios sensibles como las aplicaciones médicas. Precisamente, en este trabajo probamos nuestros modelos en tareas específicas de diagnóstico de enfermedades oculares y cáncer de próstata. En primer lugar, mostramos la eficacia y el beneficio de usar modelos de regresión en el diagnóstico de enfermedades oculares de origen genético. A continuación, demostramos la importancia de incluir información sobre el estadio de las enfermedades y realizar una regresión discreta para mejorar el rendimiento del diagnóstico binario de la retinopatía diabética y el cáncer de próstata. Demostramos que la interpretación probabilística de los resultados proporciona información sobre la incertidumbre de los modelos, que puede utilizarse también en los procesos de entrenamiento. Por último, los modelos propuestos nos permiten codificar la información mediante funciones kernel, que a su vez nos permiten introducir de forma natural mecanismos de fusión de información, flexibles y versátiles, y con estos abordar tareas multimodales. En conjunto, demostramos que la incorporación de información ordinal y multimodal mediante modelos probabilísticos basados en funciones de kernel permite aprender mejores representaciones de los datos, lo que mejora el rendimiento de los modelos y les proporciona un mayor nivel de interpretabilidad. (Texto tomado de la fuente).DoctoradoDoctor en IngenieríaSistemas Inteligente
Adaptive vs. visionary-advocacy approaches in scenario planning : implications of contrasting purposes and constraint conditions
No full textIncludes bibliographical references.Scenario planning has steadily grown to become a significant part of business and organisational foresight processes, particularly where planning situations demand approaches beyond traditional forecasting, due to extent of uncertainty variables or length of future time under consideration. However, despite general consensus as to the importance of the scenario approach in general, and rapid growth in both theory and practice in the field, fundamental questions remain over which situations are most tractable to scenario planning and why; and, in the face of uneven success in application, which among an apparent myriad scenario planning approaches best serves different planning situations, or organisations holding different goals. This dissertation makes an intervention into this problem, investigating to what extent scenario planning projects can be separated by underlying project purpose, and, based on original primary case studies and case-based structured interviews, finds that two meta-categories of purpose exist, which are here referred to as 'adaptive' and 'visionary-advocacy' purposes. It is argued that a purpose-based distinction of scenario modes provides part-explanation of the effective basis, or absence thereof, of scenario work for different situations - a basis which is achieved via congruence of scenario project purpose with (a) underlying organisational planning purpose, and (b) the extent of organisational influence over external conditions, including macro-variables of change, that constrain it. These findings suggest additions to scenario method as currently understood, particularly pre-project analysis (audits) of both an organisation's planning purpose and its external constraint conditions, to ascertain the presence of absence of necessary congruencies, so as to inform adoption of the purpose platform (and allied methodology) more likely to produce successful outcomes in application
- …
