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The NO-donor SNAP exerts cardioprotection against ischemia/reperfusion injury in human embryonic stem cell-derived cardiomyocytes
No full textTherapeutic potential of midkine in cardiovascular disease
No full textIschaemic heart disease, stroke and their pathological consequences are life-threatening conditions that account for about half
of deaths in developed countries. Pathology of these diseases includes cell death due to ischaemia/reperfusion injury, vascular
stenosis and cardiac remodelling. The growth factor midkine plays a pivotal role in these events. Midkine shows an acute
cytoprotective effect in ischaemia/reperfusion injury at least in part via its anti-apoptotic effect. Moreover, while midkine
promotes endothelial cell proliferation, it also recruits inflammatory cells to lesions. These activities eventually enhance
angiogenesis, thereby preventing cardiac tissue remodelling. However, midkine’s activity in recruiting inflammatory cells into
the vascular wall also triggers neointima formation, and consequently, vascular stenosis. Moreover, midkine is induced in
cancer tissues where it enhances angiogenesis. Therefore, midkine may promote tumour formation through its angiogenic
and anti-apoptotic activity. This review focuses on the roles of midkine in ischaemic cardiovascular disease and their
pathological consequences, that is angiogenesis, vascular stenosis, and cardiac remodelling, and discusses the possible
therapeutic potential of modulation of midkine in these disease
Közép-Európai műfajelméleteken túl: Rondóleírások a 19. századi francia zenei lexikográfiában
No full textOffenbach est mort, vive Várady? : Une étude de cas sur la réception d'Offenbach en Hongrie dans les années 1950
No full textEn Hongrie, entre 1949 et 1956, l’opérette est mise au service de
l’idéologie communiste, les œuvres étant largement réécrites.
Particulièrement intéressant est le cas de Monsieur Choufleuri restera chez lui
le… qui fait l’objet d’une adaptation au Théâtre municipal de la Gaîté à
Budapest en 1953 sous le titre Egy Marék boldogság. Les transformations sont
si profondes que c’est l’essence même de l’opérette-bouffe d’Offenbach qui est
perdue
Fadi El Hage: LE CHEVALIER DE BELLERIVE. UN PAUVRE DIABLE AU XVIIIe SIÈCLE (Chemins de la Mémoire, série XVIIIe siècle, L’Harmattan, Paris, 2015. 264 o. ISBN: 978-2-343-06943-2)
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