56 research outputs found
The modifying factors that help improve anterior cruciate ligament reconstruction rehabilitation: A narrative review
No full textBackground: : The goal of a rehabilitation programme after anterior cruciate ligament (ACL) reconstruction is to manage a patient's goals and expectations (i.e., returning to physical activities and sports) while minimizing the risk of new injury, particularly a new ACL injury. Although general rehabilitation programmes have been proposed, some factors can lead to adapting each programme to each patient. Objective: : To describe how different variables, including surgical techniques, sports participation, psychosocial and contextual factors can modify the rehabilitation programme. Methods: : We performed a narrative review with input from experts in the field (level of evidence 5). Conclusions: : Modifying factors of the ACL rehabilitation programme are related to the initial lesion or surgery, to sports, or to psychological or social aspects. Regarding the type of graft, the rehabilitation is mainly different in the early postoperative phase; the other phases are not graft-based but rather goal-based rehabilitation. Depending on the meniscal or cartilage repair, the rehabilitation protocol will initially take priority over the anterior cruciate ligament reconstruction protocol. The ACL reconstruction rehabilitation programme should meet the requirements of the anticipated sports, to optimize the athlete's ability to return to the expected level and minimize the risk of reinjury. Psycho-social and contextual factors must also be considered in rehabilitation care to individualize and optimize each patient's programme. (C) 2021 Elsevier Masson SAS. All rights reserved
Intra-rater Reliability of a Qualitative Landing Scale for the Single-Hop Test: A Pilot Study
No full text# Background
The test battery classically used for return-to-sport (RTS) decision-making after anterior cruciate ligament (ACL) reconstruction (ACLR) may not be sufficient, as it does not include a qualitative analysis of movement. Therefore, the Landing Error Scoring System (LESS) scale was adapted to a primary functional test in the typical RTS test battery: the single leg hop for distance (SHD).
# Hypothesis/ Purpose
The aim of this study was to determine the intra-rater reliability of the LESS scale adapted to the SHD (SHD-LESS scale) in healthy young athletes.
# Study Design
Reliability analysis
# Methods
Nineteen healthy individuals (14 men, 5 women; mean age: 22.4 years) participated in the study. Participants performed the SHD tasks on both limbs (dominant and non-dominant) using a standardized protocol in two sessions that were one week apart (single reviewer; 2-dimensional video). Intra-class correlation coefficients (ICC2,1) were used to measure the reproducibility of the scale in the dominant (dom) and non-dominant (nondom) limbs. Additionally, limb data (dom and nondom) were pooled and evaluated collectively with intra-class correlation coefficients. The Kappa coefficient was used to assess the reproducibility of each individual item of SHD-LESS scale.
# Results
The intra-rater reliability was good (ICCdom = 0.77; ICCnondom = 0.87; ICCpooled = 0.87) for the overall SHD-LESS scale scores. Agreement of SHD-LESS individual items ranged from 62% to 100%. Dorsiflexion at initial contact (97% agreement; kappa value=0.79) and knee valgus after landing (88% agreement; kappa value=0.65) had excellent agreement and kappa values.
# Conclusion
The newly-adapted SHD-LESS scale showed good intra-rater reliability overall. Further studies should evaluate the impact of using the SHD-LESS scale within the RTS test battery on outcomes in patients after ACLR.
# Level of Evidence
Quadriceps Activation After Anterior Cruciate Ligament Reconstruction: The Early Bird Gets the Worm!
No full textInternational audienceArthrogenic Muscle Inhibition (AMI) is a phenomenon observed in individuals with joint injury or pathology, characterized by a reflexive inhibition of surrounding musculature, altered neuromuscular control, and compromised functional performance. After anterior cruciate ligament reconstruction (ACLR) one of the most obvious consequences of AMI is the lack of quadriceps activation and strength. Understanding the underlying mechanisms of AMI is crucial for developing effective therapeutic interventions. The surgical procedure needed to reconstruct the ACL has biochemical et physiological consequences such as inflammation, pain, and altered proprioception. These alterations contribute to the development of AMI. Therapeutic interventions aimed at addressing AMI encompass a multidimensional approach targeting pain reduction, inflammation management, proprioceptive training, and quadriceps activation. Early management focusing on pain modulation through modalities like ice, compression, and pharmacological agents help mitigate the inflammatory response and alleviate pain, thereby reducing the reflexive inhibition of quadriceps. Quadriceps activation techniques such as neuromuscular electrical stimulation (NMES) and biofeedback training aid in overcoming muscle inhibition and restoring muscle strength. NMES elicits muscle contractions through electrical stimulation, bypassing the inhibitory mechanisms associated with AMI, thus facilitating muscle activation and strength gains. Comprehensive rehabilitation programs tailored to individual needs and stage of recovery are essential for optimizing outcomes in AMI. The objective of this clinical viewpoint is to delineate the significance of adopting a multimodal approach for the effective management of AMI, emphasizing the integration of pain modulation, proprioceptive training, muscle activation techniques, and manual therapy interventions. Highlighting the critical role of early intervention and targeted rehabilitation programs, this article aims to underscore their importance in restoring optimal function and mitigating long-term complications associated with AMI
PESI - a taxonomic backbone for Europe
No full textThis is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The attached file is the published version of the article.NHM Repositor
Criteria for return to running after anterior cruciate ligament reconstruction: a scoping review
No full textInternational audienceObjective To describe the criteria used to guide clinical decision-making regarding when a patient is ready to return to running (RTR) after ACL reconstruction.Design Scoping review. Data sources The MEDLINE (PubMed), EMBASE, Web of Science, PEDro, SPORTDiscus and Cochrane Library electronic databases. We also screened the reference lists of included studies and conducted forward citation tracking. Eligibility criteria for selecting studies Reported at least one criterion for permitting adult patients with primary ACL reconstruction to commence running postoperatively.Results 201 studies fulfilled the inclusion criteria and reported 205 time-based criteria for RTR. The median time from when RTR was permitted was 12 postoperative weeks (IQR=3.3, range 5\textendash39 weeks). Fewer than one in five studies used additional clinical, strength or performance-based criteria for decision-making regarding RTR. Aside from time, the most frequently reported criteria for RTR were: full knee range of motion or \textgreater95% of the non-injured knee plus no pain or pain \textless2 on visual analogue scale; isometric extensor limb symmetry index (LSI)\textgreater70% plus extensor and flexor LSI\textgreater70%; and hop test LSI\textgreater70%.Conclusions Fewer than one in five studies reported clinical, strength or performance-based criteria for RTR even though best evidence recommends performance-based criteria combined with time-based criteria to commence running activities following ACL reconstruction
The Effect of Blood Flow Restriction Training on Quadriceps Activity After Anterior Cruciate Ligament Reconstruction: A Preliminary Randomized Controlled Trial
No full textBackground
After anterior cruciate ligament reconstruction, a crucial priority is restoring knee muscle strength, especially the quadriceps, to reach the pre-injury strength levels as fast as possible. A feasible alternative to heavy loading might be blood flow restriction training that may elicit quadriceps muscle strength adaptations using low external loads. This study assessed whether quadriceps strengthening using low load blood flow restriction (LL-BFR) would enhance electromyographic (EMG) activity of the vastus medialis (VMO), vastus lateralis (VLO), and rectus femoris (RF) similar to quadriceps strengthening using heavy loads resistance training (HLRT). The secondary objective was to assess intra-quadriceps regional EMG differences between the 3 quadriceps muscle heads.
Methods
Twenty-six patients were recruited after anterior cruciate ligament reconstruction and divided into 2 groups (LL-BFR and HLRT) 3 months after surgery. Patients performed 1 set of 12 repetitions of knee extension during which the EMG activity of the VMO, VLO, and RF was measured with the FREEEMG electromyographic system. The maximal voluntary isometric contraction normalized the EMG results.
Results
On EMG data, significant in-between group differences were found, highlighting a higher activation for the HLRT group (p = 0.01), VMO (p = 0.002), and VLO (p = 0.002), as compared to the LL-BFR group. No significant differences were observed between RF and vasti muscle activation in the LL-BFR group (p = 0.89) and HLRT group (p = 0.12)
Conclusion
These findings indicate that HLRT may elicit a significant increase in quadriceps EMG activity, an effect not seen in the LL-BFR grou
Avaliação do potencial efeito protetor do probucol em modelos experimentais da doença de Huntington
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em BioquímicaA doença de Huntington (DH) é uma patologia neurodegenerativa, autossômica dominante caracterizada por sintomas atribuídos à morte de neurônios estriatais e corticais no cérebro. O mecanismo de neurodegeneração na DH parece estar relacionado com excitotoxicidade, disfunção mitocondrial e estresse oxidativo. O probucol (PB) é um composto fenólico antilipêmico, que apresenta propriedades anti-inflamatória e antioxidante em diferentes modelos experimentais de toxicidade/patologia. O objetivo deste estudo foi investigar o possível efeito protetor do PB sobre a neurotoxicidade e estresse oxidativo em modelos experimentais de DH in vitro e in vivo. Inicialmente, foi avaliada a relação entre prejuízo no metabolismo energético, excitotoxicidade e estresse oxidativo em fatias de estriado de ratos expostas ao ácido quinolínico (AQ), ácido 3-nitropropiônico (3-NP) e ao modelo combinado (AQ + 3-NP). Os dados sugerem que os modelos utilizados podem gerar um padrão complexo de dano, que envolve comprometimento metabólico, formação de espécies reativas de oxigênio (ERO) e estresse oxidativo. O PB preveniu o estresse oxidativo nas três condições experimentais e foi capaz de proteger contra disfunção mitocondrial induzida pelo AQ e AQ + 3-NP. Além disso, o potencial efeito protetor do probucol foi avaliado sobre a neurotoxicidade do 3-NP em ratos. O pré-tratamento com probucol (por 60 dias) aumentou a atividade da glutationa peroxidase (GPx) no estriado e no córtex e preveniu o prejuízo motor e o estresse oxidativo induzido pelo 3-NP em ratos. O efeito do PB sobre a GPx e suas propriedades antioxidantes estão provavelmente associados ao seu efeito benéfico neste modelo. Também foi verificado o possível efeito protetor do succinobucol, um análogo do PB, sobre a toxicidade induzida pelo 3-NP em preparações mitocondriais de cérebro de ratos in vitro. O probucol e o succinobucol preveniram o estresse oxidativo induzido pelo 3-NP, mas apenas o succinobucol foi capaz de prevenir a disfunção mitocondrial induzida pela toxina. Juntos este resultados sugerem um novo papel para o probucol e seu análogo succinobucol como potenciais agentes neuroprotetores em modelos de DH
Ecological and Specific Evidence-Based Safe Return To Play After Anterior Cruciate Ligament Reconstruction In Soccer Players: A New International Paradigm
No full textExisting return to play (RTP) assessments have not demonstrated the ability to decrease risk of subsequent anterior cruciate ligament (ACL) injury after reconstruction (ACLR). RTP criteria are standardized and do not simulate the physical and cognitive activity required by the practice of sport. Most RTP criteria do not include an ecological approach. There are scientific algorithms as the "5 factor maximum model" that can identify risk profiles and help reduce the risk of a second anterior cruciate ligament injury. Nevertheless, these algorithms remain too standardized and do not include the situations experienced in games by soccer players. This is why it is important to integrate ecological situations specific to the environment of soccer players in order to evaluate players under conditions closest to their sporting activity, especially with high cognitive load. One should identify high risk players under two conditions: Clinical analyses commonly include assessments such as isokinetic testing, functional tests (hop tests, vertical force-velocity, profile), running, clinical assessments (range of motion and graft laxity), proprioception and balance (Star Excursion Balance Test modified, Y-Balance, stabilometry) and psychological parameters (kinesophobia, quality of life and fear of re-injury). Field testing usually includes game simulation, evaluation under dual-task conditions, fatigue and workload analysis, deceleration, timed-agility-test and horizontal force-velocity profiles. Although it seems important to evaluate strength, psychological variables and aerobic and anaerobic capacities, evaluation of neuromotor control in standard and ecological situations may be helpful for reducing the risk of injury after ACLR. This proposal for RTP testing after ACLR is supported by the scientific literature and attempts to approximate the physical and cognitive loads during a soccer match. Future scientific investigation will be required to demonstrate the validity of this approach.
# Level of Evidence
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
No full textApproaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups
Implementing Velocity-Based Training to Optimize Return to Sprint After Anterior Cruciate Ligament Reconstruction in Soccer Players: A Clinical Commentary
No full textAfter anterior cruciate ligament reconstruction (ACLR), return to sprint is poorly documented in the literature. In soccer, return to sprint is an essential component of return to play and performance after ACLR. The characteristics of running in soccer are specific (velocity differences, nonlinear, intensity). It is important to address these particularities, such as curvilinear running, acceleration, deceleration, changes of direction, and variations in velocity, in the patient's rehabilitation program. Force, velocity, and acceleration capacities are key elements to sprint performance. Velocity-based training (VBT) has gained much interest in recent years and may have a role to play in optimizing return to play and return to sprint after ACLR. Force, velocity, and acceleration can be assessed using force-velocity-power and acceleration-speed profiles, which should inform rehabilitation. The purpose of this commentary is to describe a velocity-based return to sprint program which can be used during ACLR rehabilitation
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