37,826 research outputs found
Depolarization and decreased surface expression of K+ channels contribute to NSAID-inhibition of intestinal restitution
No full textNon-steroidal anti-inflammatory drugs (NSAIDs) contribute to gastrointestinal ulcer formation by inhibiting epithelial cell migration and mucosal restitution; however, the drug-affected signaling pathways are poorly defined. We investigated whether NSAID inhibition of intestinal epithelial migration is associated with depletion of intracellular polyamines, depolarization of membrane potential (Em) and altered surface expression of K+ channels. Epithelial cell migration in response to the wounding of confluent IEC-6 and IEC-Cdx2 monolayers was reduced by indomethacin (100μM), phenylbutazone (100μM) and NS-398 (100μM) but not by SC-560 (1μM). NSAID-inhibition of intestinal cell migration was not associated with depletion of intracellular polyamines. Treatment of IEC-6 and IEC-Cdx2 cells with indomethacin, phenylbutazone and NS-398 induced significant depolarization of Em, whereas treatment with SC-560 had no effect on Em. The Em of IEC-Cdx2 cells was: −38.5±1.8mV under control conditions; −35.9±1.6mV after treatment with SC-560; −18.8±1.2mV after treatment with indomethacin; and −23.7±1.4mV after treatment with NS-398. Whereas SC-560 had no significant effects on the total cellular expression of Kv1.4 channel protein, indomethacin and NS-398 decreased not only the total cellular expression of Kv1.4, but also the cell surface expression of both Kv1.4 and Kv1.6 channel subunits in IEC-Cdx2. Both Kv1.4 and Kv1.6 channel proteins were immunoprecipitated by Kv1.4 antibody from IEC-Cdx2 lysates, indicating that these subunits co-assemble to form heteromeric Kv channels. These results suggest that NSAID inhibition of epithelial cell migration is independent of polyamine-depletion, and is associated with depolarization of Em and decreased surface expression of heteromeric Kv1 channels.ID: S0006295207001931; M3: Article; Accession Number: S0006295207001931; Author: L.C. Freeman (b); Author: D.F. Narvaez (a); Author: A. McCoy (a); Author: F.B. von Stein (c); Author: S. Young (b); Author: K. Silver (a); Author: S. Ganta (b); Author: D. Koch (b); Author: R. Hunter (b); Author: R.F. Gilmour (c); Author: J.D. Lillich (a, ⁎); Affiliation: Department of Clinical Sciences, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan, KS 66506, United States; Affiliation: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, United States; Keyword: Non-steroidal anti-inflammatory drugs; Keyword: Intestinal epithelial cells; Keyword: Membrane potential; Keyword: Potassium channels; Number of Pages: 12; Language: English;Source type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=edselp&AN=S0006295207001931&site=eds-live&scope=sit
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
Get PDFThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
Mulla Sadra and the mind-body problem: A critical assessment of Sadra’s approach to the dichotomy of soul and spirit
Get PDFAbstract
The presence of some ambiguity about the two terms of soul and spirit, which up until now has not been considered, has been investigated in this research. This ambiguity has created problems in different fields of study such as philosophy, psychology and commentaries of religious texts. This is because the two words are usually used synonymously.
The main aim of this research is to investigate whether the human being has an independent spirit in addition to the body and the soul or not. In other words it is attempting to establish if man is a tripartite existence made of body, soul and spirit.
In order to attain this aim the ideas of various philosophers are discussed on different subjects regarding the soul with particular attention to the philosophical system introduced in the seventeenth century AD by the Muslim philosopher, Sadr al-din Shirazi. This consisted of two other philosophical systems in Islamic philosophy, peripatetic (mashā‟) and illuminative („ishrāq) combined with mystical and religious teachings. His idea about the soul was set as the basis for the arguments regarding the soul and the ideas of other philosophers were compared to it.
This research explores the principles that form Sadra‟s beliefs about the soul. One of Sadra‟s principles, the fundamentality of existence, is explained. This principle aims to prove the reality of the external world and the soul as one of these realities. The topics of motion and time and the views of philosophers about these are cited. In addition, another Sadra‟s important principles, trans-substantial motion, is mentioned and explained and it is suggested that the difference between Sadra‟s and other philosophers‟ ideas about the soul lies in accepting or rejecting motion in substance. According to Sadra, the soul which is material at the beginning of its creation moves towards immateriality by trans-substantial motion.
Then philosophers‟ ideas about the soul are mentioned as well as their disagreements regarding different issues such as immateriality, motion, origination of the soul etc. In addition, the problem that Sadra‟s philosophical system faces in regard to the soul is discussed in particular since it is the main aim of this research.
It is concluded that Sadra‟s idea is more complete than the other ideas regarding the soul. The existence of the soul found a better justification in this idea. The problem of dualism of the soul and body with which other philosophers were faced has been resolved. Meanwhile the problem of this philosophical idea which sees the soul to be the same as the spirit was investigated and it was stated that this problem has caused many diversities of opinion between philosophers in subjects related to the soul. The propounded solution for all the cases was to accept the dichotomy of the soul and spirit. Religious texts have been classified, analysed and used to support this idea and by using different evidences it was confirmed that the soul and the spirit are two independent substances and that the human being is a tripartite existence
Correction to: Bican, R., Christensen, C., Fallieras, K., Sagester, G., O’Rourke, S., Byars, M., & Tanner, K. (2021). Rapid Implementation of Telerehabilitation for Pediatric Patients During COVID-19
Get PDFCorrection to: Bican, R., Christensen, C., Fallieras, K., Sagester, G., O’Rourke, S., Byars, M., & Tanner, K. (2021). Rapid Implementation of Telerehabilitation for Pediatric Patients During COVID-19. International Journal of Telerehabilitation, 13(1). https://doi.org/10.5195/ijt.2021.6371
The affiliation for each author was incorrectly stated as: Physical Medicine & Rehabilitation, Children’s Minnesota, Minneapolis, Minnesota, USA
The correct affiliation for each author is: Clinical Therapies, Nationwide Children’s Hospital, Columbus, Ohio, USA
The metadata for the original article has been corrected
The Reconciliation of the r-K, and C-S-R-Models for Life-History Strategies
Get PDFAbstract. The author attempts to accomplish a reconciliation of the r-K and C-S-R models to identify life-history strategies. He mapped the primary and secondary strategies of the latter model in the linear r-K continuum, using his algorithm COMPTO, for multi-attribute decision--making. He proposes a reinterpretation of the r-K model that accommodates the seven life--history strategies depicted by the C-S-R model. Key words: C-S-R model; epistemic reconciliation; life-history strategy; r-K model Uma Reconciliação dos Modelos r-K e C-S-R para as Estratégias Bionómicas Sumário. O autor propõe uma reconciliação dos modelos r-K e C-S-R, para as estratégias bionómicas. Faz o mapeamento das estratégias primárias e secundárias do segundo modelo no contínuo linear r-K, recorrendo ao seu algoritmo COMPTO, para tomada de decisão em situações de atributos múltiplos. Apresenta uma reinterpretação do contínuo r-K que acomoda as sete estratégias bionómicas do modelo C-S-R. Palavras-chave: estratégias bionómicas; modelo C-S-R; modelo r-K; reconciliação epistémica Une Réconciliation des Modèles r-K et C-S-R pour les Stratégies Biologiques Résumé. L'auteur propose une réconciliation des modèles r-K et C-S-R pour les stratégies biologiques. Il fait la transposition des stratégies primaires et secondaires du modèle C-S-R dans le continuum linéaire r-K, utilisant son algorithme COMPTO. Il présente une réinterpréta-tion du continuum r-K qui accommode les sept stratégies biologiques du modèle C-S-R
Intermittency in Weak Magnetohydrodynamic Turbulence
No full textThree-dimensional incompressible magnetohydrodynamic (MHD) turbulence with a strong uniform magnetic field b0 may be governed by the regime of weak turbulence. At leading order, it is known that the asymptotic regime of weak MHD turbulence is achieved via three-wave resonant interactions with the scattering of two of these waves on a third/2D mode for which k//=0. For zero cross-helicity, the expected exact solution is an energy spectrum in . Higher-order statistics has, however, never been reported in the literature. Therefore, we have recently investigated this question with high resolution direct numerical simulations (Meyrand et al., 2014). We found the presence of strong intermittency when the vector separation of structure functions is taken transverse to b0. This result may be explained by the influence of the 2D modes whose regime belongs to strong turbulence. In addition to shed light on the origin of this intermittency, we derived a log-Poisson law, , which fits perfectly the data and highlights the important role of parallel current sheets
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Branching fraction and CP asymmetry of the decays B+→K0Sπ+ and B+→K0SK+
Get PDFAn analysis of B+ → K0
Sπ+ and B+ → K0
S K+ decays is performed with the LHCb experiment. The pp
collision data used correspond to integrated luminosities of 1 fb−1 and 2 fb−1 collected at centre-ofmass
energies of
√
s = 7 TeV and
√
s = 8 TeV, respectively. The ratio of branching fractions and the
direct CP asymmetries are measured to be B(B+ → K0
S K+
)/B(B+ → K0
Sπ+
) = 0.064 ± 0.009 (stat.) ±
0.004 (syst.), ACP(B+ → K0
Sπ+
) = −0.022 ± 0.025 (stat.) ± 0.010 (syst.) and ACP(B+ → K0
S K+
) =
−0.21 ± 0.14 (stat.) ± 0.01 (syst.). The data sample taken at
√
s = 7 TeV is used to search for
B+
c
→ K0
S K+ decays and results in the upper limit ( fc · B(B+
c
→ K0
S K+
))/( fu · B(B+ → K0
Sπ+
)) <
5.8 × 10−2 at 90% confidence level, where fc and fu denote the hadronisation fractions of a ¯b
quark
into a B+
c or a B+ meson, respectively
Investigation of route to martensitic transition in Ni-Mn-In shape memory alloys
No full textThe temperature dependent x-ray diffraction and magnetization measurements on the off stoichiometric Ni2Mn1+xIn1-xalloys have confirmed the appearance of martensite at critical Mn concentration of x=0.35. The high temperature phase of all the alloys have cubic L21structure with the lattice constant steadily decreasing with increase in Mn concentration. Martensitic transition begins to appear in Ni2Mn1.35In0.65at about 197K and the structure seems to adopt two phases including the major cubic along with the modulated monoclinic phase. This has been explained on the basis of number of Mn-Ni-Mn hybridized pairs that are responsible for inducing martensitic transition
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