Archivio istituzionale della Ricerca - Università degli Studi di Parma
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Mixed local and nonlocal eigenvalues
No full textWe discuss some basic properties of eigenfunctions for a class of mixed local and nonlocal
operators whose prototype is
−Δpu− (−Δp)su= λ|u|p−2 u,
for any summability exponent p∈ (1,∞) and any differentiability order s∈ (0,1)
Diritto Pubblico dell'Economia
No full textIl volume Diritto pubblico dell’economia muove dal processo evolutivo che ha interessato
la materia, per poi offrire un’analisi delle principali aree tematiche centrali per lo studio
di questa branca del diritto: la libertà di iniziativa economica privata, l’obiettivo della
semplificazione, le Autorità amministrative indipendenti, la tutela del consumatore, i
servizi pubblici, l’impresa pubblica e le società a partecipazione pubblica
Exploring new buccal films based on hydroxyethyl cellulose and Linecaps® combination for the pediatric delivery of hydrophobic molecules
No full textPolysaccharides and starch derivatives can play a role in the development of buccal films and patches. Buccal films are a valid approach to the transmucosal administration of drugs. These drug-delivery systems are adaptable to the mucosal surface, while being particularly suitable for the pediatric population. This study explores the combination of polysaccharide-based films for the buccal administration of the poorly soluble drug, ibuprofen. The films were obtained via the freeze-thaw technique using an innovative combination of two filmforming polymers of natural origin, i.e. hydroxyethylcellulose and a pea starch derivate (Linecaps (R)). Ibuprofen was selected as model drug to be loaded into the buccal formulation as a beta-cyclodextrin complex. The produced films showed good physico-chemical and functional properties including homogeneous drug content, thickness, mechanical strength, mucoadhesion, thus guaranteeing suitable drug loading and applicability. In vitro, permeation studies of Ibuprofen buccal films were carried out using a synthetic biomimetic membrane, and rabbit mucosae tissue exhibited values of permeability fluxes in the same order of magnitude for the two tested membranes (1.51 x 10- 2 +/- 0.33 x 10- 2 mu g/cm2*s vs 1.21 x 10- 2 +/- 0.18 x 10- 2 mu g/cm2*s). The release of the drug from the buccal film, the taste-masking and permeation properties suggested that the proposed combination of polysaccharides represent a potential formulation of mucoadhesive buccal films
Structural insights into nucleation and grain orientation in β-Ga2O3 films grown by MOVPE on off-axis 4H-SiC substrates
No full textIn this work, β-Ga2O3 was deposited by low-pressure metal organic vapour phase epitaxy on 4◦ off-axis 4H-SiC. This substrate has a high thermal conductivity and can enable a more effective heat dissipation in vertical power devices compared to the low-conductivity β-Ga2O3 homo-substrates. The obtained heteroepitaxial films were characterized by X-ray diffraction and transmission electron microscopy. Results show that β-Ga2O3 films are
composed of grains with three specific in-plane orientations, all characterized by planes of oxygen atoms arranged in a pseudo hexagonal geometry, namely the (-201), which is the main orientation, the (101), which remains confined near the interface, and the two equivalent (310) and (3-10), which instead tend to expand laterally and grow up to the film surface. The interface between β-Ga2O3 and 4H-SiC was thoroughly investigated by electron diffraction and high-resolution scanning transmission electron microscopy. The outcome of this work provides a deeper understanding of the nucleation and growth of β-Ga2O3 on 4◦ off-axis 4H-SiC substrates, focusing on the competition between step-flow and island growth mechanisms
Efficient near infrared absorbers made easy: Benzodithiophene-based donors in tailored organic-inorganic hybrid architectures for near infrared photodetectors
No full textOrganic It-conjugated materials have revolutionized the landscape of optoelectronics and are now widely used in key technologies such as organic light-emitting diodes (OLEDs), organic photovoltaic cells (OPVs), organic fields transistors (OFETs) and sensors. Today, there is a growing interest in pushing the frontier of organic optoelectronics towards the near infrared (NIR) region, unlocking new applications. In this work, we introduce a novel NIR photoresponsive material active in the 700-1500 nm range, based on inorganic-organic heterojunction architecture. This system pairs molybdenum oxide (MoO3) with a newly developed large band-gap donor molecule featuring a benzodithiophene core and triarylamine unit. The ease of synthesis, good thermal stability and optimal film forming properties of the new donor material make this approach extremely appealing. We show the processing of the heterostructure by vacuum-evaporation, realizing an interfacial charge transfer complex with impressive NIR absorption properties, whose main features have been studied by photoemission and optical absorption techniques. We demonstrated that the hybrid material can be effectively employed in NIR photodetectors
Unveiling the relationships between solitary experiences and problematic social media use in young adults: a network approach to investigating underlying motivations
No full textPrevious research has shown that subjective and negative solitary experiences, such as loneliness, are associated with increased problematic social media use (PSMU). However, further research is needed to examine the role of other solitary experiences and motivations for solitary behavior in PSMU. Accordingly, the current study investigated the relationships between various solitary experiences (i.e., trait loneliness, perceived isolation, lack of relational connectedness, positive solitude, and frequency of solitary behavior), motivations for solitary behavior (i.e., autonomous and controlled), motives for social media use (i.e., enhancement, coping, conformity, and social), and core and peripheral symptoms of PSMU in young adults. Eight hundred twenty-nine young adults (65 % females), aged 18 to 30 years (M = 23.76, SD = 3.16), completed self-report measures assessing the variables of interest. Psychometric network analysis was performed to estimate regularized partial correlations among variables across the entire sample. Gender differences in network properties were evaluated using the network comparison test. Results showed that controlled motivations for solitary behavior and perceived isolation were indirectly linked to core symptoms of PSMU through conformity motives. Additionally, perceived isolation was also associated with core PSMU symptoms through coping motives. No significant gender differences were found in the network properties. These findings suggest that PSMU might serve as a maladaptive strategy to temporarily compensate for involuntary solitary experiences and to seek relief from perceived isolation
The Crafts of Orpheus. Memory, Politics, and Theater, Milan: Mimesis-International Book Series
No full textIn Silico molecular insights into CYP3A-mediated monensin detoxification across species
No full textMonensin is an ionophore antibiotic widely used in veterinary medicine, known for its marked species-specific toxicity with Equus caballus being the most sensitive species, Sus scrofa partially tolerant, while Gallus genus is the most tolerant. It has been reported that such variability may depends on differences in CYP3A-mediated metabolism, particularly related to the O-demethylation reaction, which plays a key role in monensin detoxification. In this study, we applied a 3D modelling-based pipeline, including molecular docking, dynamics simulations and machine learning driven post-processing analysis, to investigate the interaction of monensin with CYP3A isoforms from chickens, pigs, and horses. The data collected unveiled interspecies and isoform-specific differences in both monensin binding and stability within CYP3A isoforms, providing a molecular basis for the species-related toxicity profile and O-demethylation efficiency previously described. These results were also corroborated by differences in terms of amino acid residues shaping the tested CYP3A catalytic sites. These findings provide mechanistic insights into interspecies variability regarding monensin detoxification and highlight the impact of in silico approaches on mechanistic toxicology studies related to risk assessment
Crystal structure, DFT-guided design, and selective antibacterial activity of a calcium-based hybrid for spray coating applications
No full textWe report the synthesis and comprehensive characterization of a calcium-based organic-inorganic hybrid material derived from ethylenediaminetetraacetic acid (EDTA), a polyaminocarboxylate ligand, specifically designed to harness weak coordination interactions for antimicrobial and surface coating applications. Structural and spectroscopic analyses including single-crystal X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and thermal studies, including Differential Scanning Calorimetry (DSC) revealed a supramolecular framework stabilized by extended weak contacts between calcium and ethylenediaminetetraacetic acid (EDTA) moieties. Hirshfeld surface analysis confirmed the prevalence of non-covalent interactions such as hydrogen bonding and electrostatic forces, while density functional theory (DFT) calculations provided detailed insights into the electronic structure, orbital distribution, and charge localization. coccus haemolyticus (Gram-positive) than Escherichia coli (Gram-negative), a behavior attributed to calciummediated interactions with bacterial membranes. Upon deposition via physical spray coating onto glass substrates, the hybrid retained its supramolecular integrity and bioactivity, while exhibiting favorable surface wettability and adhesion characteristics. These findings highlight the strategic potential of EDTA-derived calcium hybrids in tuning physicochemical and biological functionalities through weak coordination chemistry. This integrated experimental-computational approach offers a versatile platform for the development of next-generation antimicrobial coatings applicable to biomedical surfaces and protective industrial materials
Probabilistic Branch-and-Bound for Clusterwise Linear Regression
No full textClusterwise linear regression, a supervised learning technique that aims at finding latent groups with distinct linear relationships, has numerous applications across diverse scientific and applied domains. However, it often leads to optimization challenges due to the combinatorial nature of the problem. This paper introduces pclustreg, a novel approach based on probabilistic branch-and-bound optimization that maximizes the log-likelihood of a Gaussian mixture model. We show that, under suitable conditions, pclustreg guarantees (with a user-defined probability s<1) a solution with log-likelihood at least as good as the infeasible oracle estimator, which knows the true cluster assignments. Additionally, pclustreg can be used as a computationally lean heuristic, as showcased on simulated and real-world datasets