1,325,219 research outputs found

    [Transcript of Letter from E. B. Nichols to William M. Rice - April 10, 1867]

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    Transcript of Letter from E. B. Nichols to William M. Rice discussing his disappointment at not yet getting the order for the $2000 bonds so that their debt can be settled. He also mentions various transactions on William's accounts. Continuation of same letter [Transcript of Letter from E. B. Nichols to William M. Rice - April 10, 1867]

    Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ

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    The ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd), where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5. The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%. Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations

    [Letter from E. B. Nichols to William M. Rice - April 10, 1867]

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    Letter from E. B. Nichols to William M. Rice discussing his disappointment at not yet getting the order for the $2000 bonds so that their debt can be settled. He also mentions various transactions on William's accounts. Continuation of same letter [Letter from E. B. Nichols to William M. Rice - April 10, 1867]

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Cholera toxin subunit B inhibits IL-12 and IFN-gamma production and signaling in experimental colitis and Crohn's disease

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    Background and aims: Cholera toxin B subunit (CT-B) is a powerful modulator of immune responses. The authors have previously demonstrated that oral administration of recombinant CT-B (rCT-B) is able to prevent and cure the Crohn's disease (CD)-like trinitrobenzene sulfonic acid (TNBS) mediated colitis. In this study they extended their observations and examined if rCT-B interferes with the molecular signaling underlying the Th1 type response both in TNBS colitis and in ex vivo human CD explants. Methods: TNBS treated mice were fed with rCT-B, and IFN-gamma and IL-12 production by colonic lamina propria mononuclear cells (LPMC) was examined by ELISA. In vitro culture of mucosal explants from CD patients and non-inflammatory bowel disease controls, pre-incubated with rCT-B, were examined for IFN-gamma and IL-12 production by ELISA and semiquantitative reverse transcription polymerase chain reactions. STAT-1, -4, -6 activation and T-bet expression were examined following rCT-B treatment by western blotting both in TNBS treated mice and in human mucosal explants. Results: rCT-B significantly reduced IL-12 and IFN-gamma secretion by LPMC from TNBS treated mice. Consistent with this, rCT-B inhibited both STAT-4 and STAT-1 activation and downregulated T-bet expression. Inhibition of Th1 signaling by CT-B associated with no change in IL-4 synthesis and expression of active STAT-6 indicating that rCT-B does not enhance Th2 cell responses. Moreover, in vitro treatment of CD mucosal explants with rCT-B resulted in reduced secretion of IL-12/IFN-gamma and inhibition of STAT-4/STAT-1 activation and T-bet expression. Conclusions: These studies indicate that CT-B inhibits mucosal Th1 cell signaling and suggest that rCT-B may be a promising candidate for CD therapy

    [Report to R. H. Lunday by B. M. Waters #1]

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    Report by B. M. Waters, Detective in Charge, to R. E. Lunday, Deputy Chief Commanding of the Criminal Investigation Division. In the report, Waters describes a phone call received from Mr. James Hacker. Hacker believed that Oswald was paid to kill Governor Connolly by Jack Ruby

    A s s e s s m e n t o f t h e L e v e l s o f P a r a t h y r o i d H o r m o n e , O e s t r o g e n a n d S e l e c t e d B o n e M i n e r a l s i n M e n o p a u s a l W o m e n

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    M e n o p a u s e i s a s s o c i a t e d w i t h v a r i o u s p h y s i o l o g i c a l a n d b i o c h e m i c a l c h a n g e s t h a t h a v e e f f e c t s o n b o n e m i n e r a l s a n d t h e i r m e t a b o l i s m . T h e r e h a v e b e e n a l o t o f c o m p l a i n t s a b o u t b o n e p a i n s a n d b o n e r e l a t e d p r o b l e m s e s p e c i a l l y a m o n g m i d d l e a g e d w o m e n . T h u s , t h e w o r k w a s d e s i g n e\ud d t o a s s e s s a n d c o m p a r e t h e l e v e l s o f p a r a t h y r o i d h o r m o n e ( P T H ) , o e s t r o g e n a n d s e l e c t e d b o n e m i n e r a l s ( c a l c i u m a n d p h o s p h a t e ) i n p r e - a n d p o s t - m e n o p a u s a l w o m e n . A t o t a l o f o n e h u n d r e d s u b j e c t s w e r e i n v e s t i g a t e d . T h e y c o m p r i s e d f i f t y p r e - m e n o p a u s a l w o m e n w i t h i n t h e a g e s o f 2 0 y e a r s a n d 4 5 y e a r s a n d f i f t y p o s t - m e n o p a u s a l w o m e n w i t h i n t h e a g e s o f 5 0 y e a r s a n d 6 5 y e a r s . T h e l e v e l s o f p a r a t h y r o i d h o r m o n e , o e s t r o g e n , c a l c i u m a n d p h o s p h a t e w e r e m e a s u r e d i n t h e s u b j e c t s . P a r a t h y r o i d h o r m o n e a n d o e s t r o g e n w e r e a n a l y z e d u s i n g e n z y m e i m m u n o a s s a y t e c h n i q u e w h i l e c a l c i u m a n d p h o s p h a t e w e r e a n a l y z e d u s i n g s p e c t r o p h o t o m e t r i c m e t h o d . T h e r e s u l t s s h o w e d t h a t p a r a t h y r o i d h o r m o n e , c a l c i u m a n d p h o s p h a t e w e r e s i g n i f i c a n t l y i n c r e a s e d ( p < 0 . 0 5 ) w h i l e t h e r e w a s d e c r e a s e i n o e s t r o g e n i n p o s t - m e n o p a u s a l w o m e n c o m p a r e d w i t h p r e m e n o p a u s a l w o m e n . P T H a n d o e s t r o g e n c o r r e l a t e d s i g n i f i c a n t l y a t ( p < 0 . 0 1 ) i n b o t h p r e - a n d p o s t m e n o p a u s e . T h i s s t u d y c o n c l u d e d t h a t p o s t m e n o p a u s a l w o m e n h a v e i n c r e a s e d s e r u m l e v e l s o f p a r a t h y r o i d h o r m o n e , c a l c i u m a n d p h o s p h a t e b u t d e c r e a s e d s e r u m l e v e l o f o e s t r o g e n . S i g n i f i c a n t p o s i t i v e c o r r e l a t i o n e x i s t s b e t w e e n P T H a n d o e s t r o g e n i n b o t h p r e - a n d p o s t m e n o p a u s e b u t n o s i g n i f i c a n t r e l a t i o n s h i p b e t w e e n P T H a n d o e s t r o g e n w i t h c a l c i u m a n d p h o s p h a t

    Geologic atlas of the United States : topography, areal geology, economic geology, structure sections / 164 Belle Fourche Folio : South Dakota

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    E. M. Douglas ; W. H. Herron ; Chester Irvine ; J. E. Blackburn ; S. P. Floore ; R. M. La Follette ; A. E. Dunnington ; R. B. RobertsonList of Sheets: Topographic Map, Areal Geology Map, Structure-Section Sheet, Artesian Water Ma

    Measurement of the mass difference m(B-0)-m(B+)

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    Using 230 x 10(6) B (B) over bar events recorded with the BABAR detector at the e(+)e(-) storage rings PEP-II, we reconstruct approximately 4100 B-0 -> J/psi K+pi(-) and 9930 B+ -> J/psi K+ decays with J/psi -> mu(+)mu(-) and e(+)e(-). From the measured B-momentum distributions in the e(+)e(-) rest frame, we determine the mass difference m(B-0) - m(B+) = (+0.33 +/- 0.05 +/- 0.03) MeV/c(2)
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