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Generation of the Intramolecular Hydrogen Bonding of a Parallel β-sheet Nucleated by a Rigid Bimetallic Ring
No full textClinical Molecular Pathology and Treatment Developments in Advanced Uveal Melanoma: State of the Art
No full textUveal melanoma (UM) is the most common intraocular cancer, with approximately 5.2 individuals per million affected annually in the United States. It represents approximately 3% of the global malignant melanoma cases, accounting for 80% of the overall noncutaneous melanomas. Clinically, it remains silent in about 30% of the cases; when symptomatic, it generally causes metamorphopsia (painless loss or distortion of vision) and/or photopsia (flashing or flickering of light in the visual field). Discoloration of the iris, astigmatism, glaucoma, and even blindness are other, less common clinical manifestations. Several pathophysiological mechanisms underlie the development of UM. Genetic mutations, involving especially the G protein subunit alpha q (GNAQ), guanine nucleotide-binding protein subunit alpha-11 (GNA11), BRCA1 associated deubiquitinase 1 (BAP1), splicing factor 3b subunit 1 (SF3B1), and eukaryotic translation initiation factor 1A, X-linked (EIF1AX) genes as well as the MAPK/ERK signaling pathway genes, have been largely associated with the development of UM. Chromosomal aberrations, inflammatory and immunological alterations are often concurrent factors for the development and progression of UM. Therapies targeting specific genetic alterations and immunotherapy agents have been recently developed and introduced in clinical practice for the management of advanced-stage UMs. This review aims to present the latest advances in the clinical molecular pathology of UM, along with the resulting targeted, immunological, and other therapies that have been introduced or are currently under investigation
Food neophobia correlates with motor cortex excitability in response to disgust-related stimuli
No full textDisgust is a negative emotion that can trigger rejection mechanisms which are important for survival when the disgusting stimulus is spoiled/contaminated food. In this context the anterior digastric (AD) muscle by opening the jaw has a role in expelling potentially harmful substances from the mouth. Whether disgusting gustative stimuli affect the excitability of the primary motor cortex (M1) innervating AD muscle is not known. In this study, by applying transcranial magnetic stimulation protocol, short-interval intracortical inhibition (SICI) was measured in AD M1, during passive viewing of pictures representing either unspoiled or spoiled food. As control disgusted or happy face expressions were also administered. To evaluate a specific muscle effect, the experiment was also performed in the first dorsal interosseous (FDI) representation area in M1. Disgust sensitivity, food neophobia and adherence to Mediterranean Diet were evaluated by validated questionnaires. Results evidenced that the passive view of gustatory disgust images does not modulate the excitability of AD M1. Correlation analysis showed an enhanced cortical excitability of the M1 innervating FDI, during the passive view of spoiled food, in higher food neophobic participants. This suggests that food neophobia could facilitate recognition of disgusting/rotten food and elicit avoidance mechanisms involving the hand but not the AD, associating for the first time, the heritable trait food neophobia with differences in M1 excitability
An accelerometer-based single-arm dynamic stability test for the assessment of the sensorimotor control of the shoulder
No full textCraft Non-Alcoholic and Low-Alcohol Beer (NABLAB): Perceived Role as Functional Foods Among Italian Consumers and a Focus on Benefits for Well-Being and Physical Activity
No full textThis study investigates Italian consumers' perceptions and generational differences regarding craft non-alcoholic/low-alcohol beers (NABLAB) as functional beverages. An online survey reveals growing interest linked to wellness benefits, though product familiarity remains limited. Receptiveness is highest among Baby Boomers and Millennials, while Generation Z shows curiosity.
The findings suggest that enhanced availability and health-focused communication could promote these products and support a cultural shift toward reduced alcohol consumption
The intersection of digital practices and environmental orientations: exploring digital-environmental habitus
No full textSustainable Water Governance: Insights from Living Lab Experiences
No full textCompeting demands from agriculture and tourism place significant strain on water governance in Mediterranean regions, highlighting the need for more inclusive and adaptive management strategies. This study examines participatory water governance through co-design processes, in the form of “Living Labs”, implemented at the Malia and Agia sites in Crete, Greece, as part of two PRIMA projects. Living Labs involved key stakeholders in addressing water management challenges related to tourism and agriculture at these Cretan sites. Participants participated in dynamic sessions mediated by digital tools such as Mentimeter and spatial mapping activities. These participatory activities and research experiments promoted social learning, facilitated open dialogue, built trust, and encouraged cross-sector collaboration, ensuring that stakeholder perspectives were integrated with scientific evidence and modeling results. The Living Labs identified key challenges, including competing water demands, governance fragmentation, and limited capacity, but also enabled stakeholders to propose context-specific solutions such as treated wastewater reuse, rainwater harvesting, and training in sustainable practices. This study demonstrates that participatory activities can create dynamic social learning spaces and strengthen stakeholder engagement in groundwater decision-making to address current and future challenges. The study offers a novel application of Living Labs for groundwater governance in Mediterranean tourism–agriculture contexts, providing insights transferable to other regions
Tourism Travel and Transport Law. Current Legal Issues
No full textBy analysing some crucial issues that tourism, travel and transport law must address in the contemporary age, the book provides an in-depth overview of key topics, highlighting the strengths and weaknesses of the current legal framework and presenting insights into future perspectives and challenges in an ever-evolving global landscape