33,081 research outputs found
Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial
No full textOral capecitabine (Xeloda<sup>®</sup>) is an effective drug with favourable safety in adjuvant and metastatic colorectal cancer. Oxaliplatin-based therapy is becoming standard for Dukes' C colon cancer in patients suitable for combination therapy, but is not yet approved by the UK National Institute for Health and Clinical Excellence (NICE) in the adjuvant setting. Adjuvant capecitabine is at least as effective as 5-fluorouracil/leucovorin (5-FU/LV), with significant superiority in relapse-free survival and a trend towards improved disease-free and overall survival. We assessed the cost-effectiveness of adjuvant capecitabine from payer (UK National Health Service (NHS)) and societal perspectives. We used clinical trial data and published sources to estimate incremental direct and societal costs and gains in quality-adjusted life months (QALMs). Acquisition costs were higher for capecitabine than 5-FU/LV, but higher 5-FU/LV administration costs resulted in 57% lower chemotherapy costs for capecitabine. Capecitabine vs 5-FU/LV-associated adverse events required fewer medications and hospitalisations (cost savings £3653). Societal costs, including patient travel/time costs, were reduced by >75% with capecitabine vs 5-FU/LV (cost savings £1318), with lifetime gain in QALMs of 9 months. Medical resource utilisation is significantly decreased with capecitabine vs 5-FU/LV, with cost savings to the NHS and society. Capecitabine is also projected to increase life expectancy vs 5-FU/LV. Cost savings and better outcomes make capecitabine a preferred adjuvant therapy for Dukes' C colon cancer. This pharmacoeconomic analysis strongly supports replacing 5-FU/LV with capecitabine in the adjuvant treatment of colon cancer in the UK
Yang Fu-mian Paul, S. J. : Chinese Dialectology : A Selected and classified bibliography
No full textSagart Laurent. Yang Fu-mian Paul, S. J. : Chinese Dialectology : A Selected and classified bibliography. In: Cahiers de linguistique - Asie orientale, vol. 12 1, 1983. pp. 95-96
Practical application of on-line partial discharge monitoring technique on 500kV shunt reactor
No full textConsidering the damage mechanism of oil-impregnated paper insulation in power transformers, shunt reactors and other high voltage electrical apparatus caused by partial discharge, a concept of “destructive partial discharge” is introduced in this paper. The intensity of this discharge is regarded as several thousands pico-coulomb (pC) and may cause the insulation a fatal damage. An oil-paper insulation is usually able to withstand this type of partial discharge for a period of time prior to failure. This provides engineers a time window to detect it. This paper describes an on-line partial discharge monitoring system for 500kV shunt reactors. The commission results from 3 single-phase shunt reactors either connected or disconnected to the grid showed that the on-line partial discharge detecting system has a high noise immunising ability. Two years later after the installation, a pre-warning signal was received from one shunt reactor indicating the existence of an intermittent discharge. The acoustic emission system located its position at the low end of the high voltage bushing in the oil. Dissolved gasses analysis (DGA) in the oil suggested the presence of partial discharge, as acetylene (C2H2) was as high as 20ppm. PD activity was further confirmed by a physical examination on the reactor
Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats
No full textThe fatty-acid ethanolamide, oleoylethanolamide (OEA), is a naturally occurring lipid that regulates feeding and body weight [Rodriguez de Fonseca, F., Navarro, M., Gomez, R., Escuredo, L., Nava, F., Fu, J., Murillo-Rodriguez, E., Giuffrida, A., LoVerme, J., Gaetani, S., Kathuria, S., Gall, C., Piomelli, D., 2001. An anorexic lipid mediator regulated by feeding. Nature 414, 209-212], and serves as an endogenous agonist of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) [Fu, J., Gaetani, S., Oveisi, F., Lo Verme, J., Serrano, A., Rodriguez De Fonseca, F., Rosengarth., A., Luecke, H., Di Giacomo, B., Tarzia, G., Piomelli, D., 2003. Oleoylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425, 90-93], a ligand-activated transcription factor that regulates several aspects of lipid metabolism [. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 20, 649-688]). OEA reduces food intake in wild-type mice, but not in mice deficient in PPAR-alpha (PPAR-alpha(-/-)), an effect that is also observed with the PPAR-alpha agonists Wy-14643 and GW7647 [Brown, P.J., Chapman, J.M., Oplinger, J.A., Stuart, L.W., Willson, T.M. and Wu, Z., 2000. Chemical compounds as selective activators of PPAR-alpha. PCT Int. Appl., 32; . The PPARs: from orphan receptors to drug discovery. J. Med. Chem. 43, 527-550]. By contrast, specific agonists of PPAR-delta/beta (GW501516) or PPAR-gamma (ciglitazone) have no such effect. In obese Zucker rats, which lack functional leptin receptors, OEA reduces food intake and lowers body-weight gain along with plasma lipid levels. Similar effects are seen in diet-induced obese rats and mice. In the present study, we report that subchronic OEA treatment (5mgkg(-1), intraperitoneally, i.p., once daily for two weeks) in Zucker rats initiates transcription of PPAR-alpha and other PPAR-alpha target genes, including fatty-acid translocase (FAT/CD36), liver fatty-acid binding protein (L-FABP), and uncoupling protein-2 (UCP-2). Moreover, OEA decreases neutral lipid content in hepatocytes, as assessed by Oil red O staining, as well as serum cholesterol and triglyceride levels. The results suggest that OEA regulates lipid metabolism and that this effect may contribute to its anti-obesity propertie
Branching fraction and CP asymmetry of the decays B+→K0Sπ+ and B+→K0SK+
No full textAn analysis of B+ → K0
Sπ+ and B+ → K0
S K+ decays is performed with the LHCb experiment. The pp
collision data used correspond to integrated luminosities of 1 fb−1 and 2 fb−1 collected at centre-ofmass
energies of
√
s = 7 TeV and
√
s = 8 TeV, respectively. The ratio of branching fractions and the
direct CP asymmetries are measured to be B(B+ → K0
S K+
)/B(B+ → K0
Sπ+
) = 0.064 ± 0.009 (stat.) ±
0.004 (syst.), ACP(B+ → K0
Sπ+
) = −0.022 ± 0.025 (stat.) ± 0.010 (syst.) and ACP(B+ → K0
S K+
) =
−0.21 ± 0.14 (stat.) ± 0.01 (syst.). The data sample taken at
√
s = 7 TeV is used to search for
B+
c
→ K0
S K+ decays and results in the upper limit ( fc · B(B+
c
→ K0
S K+
))/( fu · B(B+ → K0
Sπ+
)) <
5.8 × 10−2 at 90% confidence level, where fc and fu denote the hadronisation fractions of a ¯b
quark
into a B+
c or a B+ meson, respectively
Measurement of the prompt J/ψ and ψ(2S) polarizations in pp collisions at s=7 TeV
No full textThis is the pre-print version of the final published paper that is available from the link below.The polarizations of prompt J/ψ and ψ(2S) mesons are measured in proton-proton collisions at s=7 TeV, using a dimuon data sample collected by the CMS experiment at the LHC, corresponding to an integrated luminosity of 4.9 fb. The prompt J/ψ and ψ(2S) polarization parameters λ, λ, and λ, as well as the frame-invariant quantity λ~, are measured from the dimuon decay angular distributions in three different polarization frames. The J/ψ results are obtained in the transverse momentum range 14<p<70 GeV, in the rapidity intervals |y|<0.6 and 0.6<|y|<1.2. The corresponding ψ(2S) results cover 14<p<50 GeV and include a third rapidity bin, 1.2<|y|<1.5. No evidence of large polarizations is seen in these kinematic regions, which extend much beyond those previously explored
Observation of Bs0→J/ψK*(892)0 [B subscript s superscript 0 → J / psi K* (892) superscript 0] and Bs0→J/ψKS0 [B subscript s superscript 0 → J / psi K subscript s superscript 0 ] decays
No full textWe report the first observation of two Cabibbo-suppressed decay modes of the Bs0 [B subscript s superscript 0] meson. Using a sample of pp̅ collisions at √s=1.96 [square root of 1.96] TeV corresponding to 5.9 fb-1 [fb superscript -1] of integrated luminosity collected with the CDF II, the collider detector at the Fermilab Tevatron, we search for new Bs0 [B subscript s superscript 0] decay modes in a sample of events containing J/ψ→μ+μ- [J / psi→mu superscript + mu superscript -] decays. We reconstruct a Bs0→J/ψK*(892)0 [B subscript s superscript 0→J / psi K subscript s superscript 0] signal with K*(892)0→K+π- [K* (892) superscript 0 →K superscript + pi superscript -], observing a yield of 151±25 events with a statistical significance of 8.0σ [8.0 delta]. We also reconstruct a Bs0→J/ψKS0 [B subscript s superscript 0→J / psi K subscript s superscript 0] signal with KS0→π+π- [K subscript s superscript 0→ pi superscript + pi superscript -], observing a yield of 64±14 events with a statistical significance of 7.2σ [7.2 delta]. From these yields, we extract the branching ratios B(Bs0→J/ψK*(892)0)=(8.3±3.8)×10-5 [B (B subscript s superscript 0→J / psi K* (892) superscript 0) = (8.3±3.8) × 10 superscript -5] and B(Bs0→J/ψK0)=(3.5±0.8)×10-5 [B (B subscript s superscript 0→J / psi K superscript 0) = (3.5 ± 0.8) × 10 superscript -5], where statistical, systematic, and fragmentation-fraction uncertainties are included in the combined uncertainty.United States. Dept. of EnergyNational Science foundation (U.S.)Alfred P. Sloan Foundatio
Study of B c + → J / ψ D s + and B c + → J / ψ D s ∗ + decays in pp collisions at √s = 13 TeV with the ATLAS detector
No full textA study of B+
c → J/ψD+
s and B+
c → J/ψD∗+
s decays using 139 fb−1 of integrated luminosity collected with the ATLAS detector from √
s = 13 TeV pp collisions
at the LHC is presented. The ratios of the branching fractions of the two decays to the
branching fraction of the B+
c → J/ψπ+ decay are measured: B(B+
c → J/ψD+
s
)/B(B+
c →
J/ψπ+) = 2.76 ± 0.47 and B(B+
c → J/ψD∗+
s
)/B(B+
c → J/ψπ+) = 5.33 ± 0.96. The ratio
of the branching fractions of the two decays is found to be B(B+
c → J/ψD∗+
s
)/B(B+
c →
J/ψD+
s
) = 1.93 ± 0.26. For the B+
c → J/ψD∗+
s decay, the transverse polarization fraction,
Γ±±/Γ, is measured to be 0.70 ± 0.11. The reported uncertainties include both the statistical and systematic components added in quadrature. The precision of the measurements
exceeds that in all previous studies of these decays. These results supersede those obtained
in the earlier ATLAS study of the same decays with √s = 7 and 8 TeV pp collision data. A
comparison with available theoretical predictions for the measured quantities is presented
Topophilia : la perception de l'environnement - Tuan Yi-Fu, 1974, Topophilia. A study of environmental perception, attitudes and values. Englewood Cliffs (N. J.)
No full textBailly Antoine S.Bailly Antoine S. Topophilia : la perception de l'environnement - Tuan Yi-Fu, 1974, Topophilia. A study of environmental perception, attitudes and values. Englewood Cliffs (N. J.). In: L'Espace géographique, tome 5, n°1, 1976. p. 19
Suppression of non-prompt J/ψ, prompt J/ψ, and Y(1S) in PbPb collisions at √s NN = 2.76 TeV
No full textThis is the Pre-print verison of the Article. The official published version can be accessed from the link below - Copyright @ 2012 Springer VerlagYields of prompt and non-prompt J/ψ, as well as U (1S) mesons, are measured by the CMS experiment via their μ + μ − decays in PbPb and pp collisions at Ö{s\textNN} = 2.76 sNN=276 TeV for quarkonium rapidity |y| < 2.4. Differential cross sections and nuclear modification factors are reported as functions of y and transverse momentum p T, as well as collision centrality. For prompt J/ψ with relatively high p T (6.5 < p T < 30 GeV/c), a strong, centrality-dependent suppression is observed in PbPb collisions, compared to the yield in pp collisions scaled by the number of inelastic nucleon-nucleon collisions. In the same kinematic range, a suppression of non-prompt J/ψ, which is sensitive to the in-medium b-quark energy loss, is measured for the first time. Also the low-p T U (1S) mesons are suppressed in PbPb collisions.This work was supported by the Austrian Federal Ministry of Science and Research; the Belgium Fonds de la Recherche Scientifique, and Fonds voor Wetenschappelijk
Onderzoek; the Brazilian Funding Agencies (CNPq, CAPES, FAPERJ, and FAPESP); the Bulgarian Ministry of Education and Science; CERN; the Chinese Academy of Sciences, Ministry of Science and Technology, and National Natural Science Foundation of China; the Colombian Funding Agency (COLCIENCIAS); the Croatian Ministry of Science, Education and Sport; the Research Promotion Foundation, Cyprus; the Estonian Academy of Sciences and NICPB; the Academy of Finland, Finnish Ministry of Education and Culture, and Helsinki Institute of
Physics; the Institut National de Physique Nucl´eaire et de Physique des Particules / CNRS, and Commissariat a l’Energie Atomique et aux Energies Alternatives / CEA, France; the Bundesministerium fur Bildung und Forschung, Deutsche Forschungsgemeinschaft, and Helmholtz-Gemeinschaft Deutscher Forschungszentren, Germany; the General Secretariat for Research and Technology, Greece; the National Scientific Research Foundation, and National Office for
Research and Technology, Hungary; the Department of Atomic Energy and the Department of Science and Technology, India; the Institute for Studies in Theoretical Physics and Mathematics, Iran; the Science Foundation, Ireland; the Istituto Nazionale di Fisica Nucleare, Italy; the Korean
Ministry of Education, Science and Technology and the World Class University program of NRF, Korea; the Lithuanian Academy of Sciences; the Mexican Funding Agencies (CINVESTAV, CONACYT, SEP, and UASLP-FAI); the Ministry of Science and Innovation, New Zealand; the Pakistan Atomic Energy Commission; the Ministry of Science and Higher Education and the National Science Centre, Poland; the Fundac¸ ao para a Ciencia e a Tecnologia, Portugal; JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); the Ministry of Education and Science of the Russian Federation, the Federal Agency of Atomic Energy of the Russian Federation, Russian Academy of Sciences, and the Russian Foundation for Basic Research; the Ministry of Science and Technological Development of Serbia; the Ministerio de Ciencia e Innovacion, and Programa Consolider-Ingenio 2010, Spain; the Swiss Funding Agencies (ETH Board, ETH Zurich, PSI, SNF, UniZH, Canton Zurich, and SER); the National Science Council, Taipei; the Scientific and Technical Research Council of Turkey, and Turkish Atomic Energy Authority; the Science and Technology Facilities Council, UK; the US Department of Energy, and the US National Science Foundation
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