470 research outputs found
Recommended from our members
Mersenne numbers
No full textThese notes have been issued on a small scale in 1983 and 1987 and on request at other times. This issue follows two items of news. First, WaIter Colquitt and Luther Welsh found the 'missed' Mersenne prime M110503 and advanced the frontier of complete Mp-testing to 139,267. In so doing, they terminated Slowinski's significant string of four consecutive Mersenne primes. Secondly, a team of five established a non-Mersenne number as the largest known prime. This result terminated the 1952-89 reign of Mersenne primes. All the original Mersenne numbers with p < 258 were factorised some time ago. The Sandia Laboratories team of Davis, Holdridge & Simmons with some little assistance from a CRAY machine cracked M211 in 1983 and M251 in 1984. They contributed their results to the 'Cunningham Project', care of Sam Wagstaff. That project is now moving apace thanks to developments in technology, factorisation and primality testing. New levels of computer power and new computer architectures motivated by the open-ended promise of parallelism are now available. Once again, the suppliers may be offering free buildings with the computer. However, the Sandia '84 CRAY-l implementation of the quadratic-sieve method is now outpowered by the number-field sieve technique. This is deployed on either purpose-built hardware or large syndicates, even distributed world-wide, of collaborating standard processors. New factorisation techniques of both special and general applicability have been defined and deployed. The elliptic-curve method finds large factors with helpful properties while the number-field sieve approach is breaking down composites with over one hundred digits. The material is updated on an occasional basis to follow the latest developments in primality-testing large Mp and factorising smaller Mp; all dates derive from the published literature or referenced private communications. Minor corrections, additions and changes merely advance the issue number after the decimal point. The reader is invited to report any errors
and omissions that have escaped the proof-reading, to answer the unresolved questions noted and to suggest additional material associated with this subject
Corrigendum to “Feasibility and acceptability of Autism Adapted Safety Plans: an external pilot randomised controlled trial”
No full text\ua9 2025 The Author(s)Dr Emma Nielsen was originally acknowledged in the paper. However, on discussion and reflection, and agreement with Dr Nielsen and all co-authors, we have added Dr Nielsen as a co-author in recognition of their contributions as a full-time post-doc during the first eight months of the study to methodology, investigation and project administration. Dr Nielsen has been added to the author list in the position shown above, and their affiliation is added to the affiliations list. Furthermore, mention of Dr Nielsen in the Acknowledgements section has now been removed. The Contributors and Declaration of interests sections have been updated as follows to add the respective information for EN. JR is the chief investigator who with SAC developed the study protocol alongside the other co-applicants (RC, ET, LV, SR, PH, EO, CW). JR and SC had overall responsibility for the management and delivery of the trial. EN and IG were the researchers at University of Nottingham and JG and MP were the researchers at Newcastle University. EN, IG and JG contributed to recruitment and data collection. MP and IG curated the data. Formal analysis was undertaken by JW, NB, IG and MP. The original draft of this paper was written by JR, SC, MP, JW, NB and IG. All authors reviewed the final submitted manuscript. JR, JW, NB, IG and MP accessed and verified the underlying data
Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms
No full textA genomewide linkage scan was carried out in eight clinical samples of informative schizophrenia families. After all quality control checks, the analysis of 707 European-ancestry families included 1615 affected and 1602 unaffected genotyped individuals, and the analysis of all 807 families included 1900 affected and 1839 unaffected individuals. Multipoint linkage analysis with correction for marker-marker linkage disequilibrium was carried out with 5861 single nucleotide polymorphisms (SNPs; Illumina version 4.0 linkage map). Suggestive evidence for linkage ( European families) was observed on chromosomes 8p21, 8q24.1, 9q34 and 12q24.1 in nonparametric and/or parametric analyses. In a logistic regression allele-sharing analysis of linkage allowing for intersite heterogeneity, genomewide significant evidence for linkage was observed on chromosome 10p12. Significant heterogeneity was also observed on chromosome 22q11.1. Evidence for linkage across family sets and analyses was most consistent on chromosome 8p21, with a one-LOD support interval that does not include the candidate gene NRG1, suggesting that one or more other susceptibility loci might exist in the region. In this era of genomewide association and deep resequencing studies, consensus linkage regions deserve continued attention, given that linkage signals can be produced by many types of genomic variation, including any combination of multiple common or rare SNPs or copy number variants in a region. Molecular Psychiatry (2009) 14, 786-795; doi:10.1038/mp.2009.11; published online 17 February 2009</p
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
Get PDFWe conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis
Cite Share Publisher Correction: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
No full textIn the version of this article initially published, the footnote number 17 was missing from the author list for the two authors who contributed equally. Also, the authors have added a middle initial for author Justin R. Fallon and an acknowledgement to the Babraham Institute Imaging Facility and Sequencing Core Facility. The errors have been corrected in the HTML and PDF versions of the articl
British immigration control procedures and Jewish refugees 1933-1942.
No full textPhDThis thesis is an historical account of the British
government's regulation of the immigration to the United
Kingdom of Jewish refugees in flight from Nazi persecution.
The focus of the study is the administration of immigration
controls, with particular emphasis on the groups of refugees
for whom entry was possible and the conditions subject to
which they were admitted. The administrative process is also
examined in the context of policy. The results of the
government's efforts to control the influx are set against
policy goals, in order to assess both the extent to which
the quest for control was successful, and the extent to
which it led to unintended consequences. The relationship
between policy and procedure is thus a key theme of this
study.
The bulk of the thesis is concerned with policy-making and
administration within government, and is based on documents
in the Public Record Office(PRO). Other sources used include
private papers of ministers and officials, records of Jewish
organisations, archives of refugee committees and
interviews, listed in the bibliography. The material largely
concerns the work of Whitehall departments, interdepartmental
relations and activities at Cabinet-level. Home
Office policy and practice are covered in particular detail.
The contributions of other government departments,
particularly the Foreign Office, the Ministry of Labour and
the Treasury, are also discussed. Another important topic is
the policy-making and administrative role of nongovernmental
organisations, especially refugee committees.
The introduction is followed by a chapter outlining the
legal and administrative history of immigration control
since 1905. succeeding chapters deal chronologically with
the British response to the immigration of Jewish refugees
from 1933 to 1942. The conclusion discusses whether British
policy was humanitarian or self-interested. Two appendixes
contain brief biographical notes on persons relevant to the
thesis and a list of Home Secretaries and Home Office
Permanent Under Secretaries
Modification of Loop 1 Affects the Nucleotide Binding Properties of Myo1c, the Adaptation Motor in the Inner Ear
Get PDFMyo1c is one of eight members of the mammalian myosin I family of actin-associated molecular motors. In stereocilia of the hair cells in the inner ear, Myo1c presumably serves as the adaptation motor, which regulates the opening and closing of transduction channels. Although there is conservation of sequence and structure among all myosins in the N-terminal motor domain, which contains the nucleotide- and actin-binding sites, some differences include the length and composition of surface loops, including loop 1, which lies near the nucleotide-binding domain. To investigate the role of loop 1, we expressed in insect cells mutants of a truncated form of Myo1c, Myo1c1IQ, as well as chimeras of Myo1c1IQ with the analogous loop from other myosins. We found that replacement of the charged residues in loop 1 with alanines or the whole loop with a series of alanines did not alter the ATPase activity, transient kinetics properties, or Ca2+ sensitivity of Myo1c1IQ. Substitution of loop 1 with that of the corresponding region from tonic smooth muscle myosin II (Myo1c1IQ-tonic) or replacement with a single glycine (Myo1c1IQ-G) accelerated the release of ADP from A.M 2?3-fold in Ca2+, whereas substitution with loop 1 from phasic muscle myosin II (Myo1c1IQ-phasic) accelerated the release of ADP 35-fold. Motility assays with chimeras containing a single ?-helix, or SAH, domain showed that Myo1cSAH-tonic translocated actin in vitro twice as fast as Myo1cSAH-WT and 3-fold faster than Myo1cSAH-G. The studies show that changes induced in Myo1c via modification of loop 1 showed no resemblance to the behavior of the loop donor myosins or to the changes previously observed with similar Myo1b chimeras
First observation of Bs → J/ψf0(980) decays
Get PDFUsing data collected with the LHCb detector in proton–proton collisions at a centre-of-mass energy of 7 TeV, the hadronic decay is observed. This CP eigenstate mode could be used to measure mixing-induced CP violation in the system. Using a fit to the π+π− mass spectrum with interfering resonances gives . In the interval ±90 MeV around 980 MeV, corresponding to approximately two full f0 widths we also find , where in both cases the uncertainties are statistical and systematic, respectively
Revealing the history of sheep domestication using retrovirus integrations
Get PDFThe domestication of livestock represented a crucial step in human history. By using endogenous retroviruses as genetic markers, we found that sheep differentiated on the basis of their "retrotype" and morphological traits dispersed across Eurasia and Africa via separate migratory episodes. Relicts of the first migrations include the Mouflon, as well as breeds previously recognized as "primitive" on the basis of their morphology, such as the Orkney, Soay, and the Nordic short-tailed sheep now confined to the periphery of northwest Europe. A later migratory episode, involving sheep with improved production traits, shaped the great majority of present-day breeds. The ability to differentiate genetically primitive sheep from more modern breeds provides valuable insights into the history of sheep domestication
Long-term reduced functional capacity and quality of life in hospitalized COVID-19 patients
No full textPersistent symptoms and exercise intolerance have been reported after COVID-19, even months after the acute disease. Although, the long-term impact on exercise capacity and health-related quality of life (HRQoL) is still unclear.Funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Brazilian Ministry of Health, through the Institutional Development Program of the Brazilian National Health System (PROADI-SUS) in collaboration with Hospital Moinhos de Vento. Financial partial support for this work was also provided by public research grants and scholarships from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). The authors also received scholarships from the Special Research Fund (BOF) from Hasselt University/Belgium (Number: BOF23DOCBL10
and BOF23KV10). This study was partially funded by the Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior (CAPES) - Brasil - Finance Code 001. This study was partially funded by Hospital de Clínicas de Porto Alegre (Fundo de Incentivo à
Pesquisa e Eventos; FIPE/HCPA).
Acknowledgments
We thank the assistance team, laboratory team, and local staff from Hospital Moinhos de Vento. We also thank the support from the coordinators and the staff of Brazilian National Immunization Program and the Coordination of Surveillance of Respiratory Transmitted Diseases and Chronic Conditions from the Brazilian Ministry of Health. We thank to the COVIDa study group staff for the support. Amanda Paz Santos, Caroline Nespolo de David, Luciane Beatriz Kern, Fernanda Lutz Tolves, Jaina da Costa Pereira, Shirlei Villanova Ribeiro, Ingrid Rodrigues Fernandes, Fernanda Hammes Varela, Márcia Polese-Bonatto, and Thais Raupp Azevedo
- …
