51 research outputs found

    Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (Nature Medicine, (2020), 26, 5, (750-759), 10.1038/s41591-020-0807-6)

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    An amendment to this paper has been published and can be accessed via a link at the top of the paper. © 2020, The Author(s)

    Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (Nature Medicine, (2020), 26, 5, (750-759), 10.1038/s41591-020-0807-6)

    No full text
    An amendment to this paper has been published and can be accessed via a link at the top of the paper. © 2020, The Author(s)

    Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (Nature Medicine, (2020), 26, 5, (750-759), 10.1038/s41591-020-0807-6)

    No full text
    An amendment to this paper has been published and can be accessed via a link at the top of the paper. © 2020, The Author(s)

    Historical trends in human dietary intakes of endosulfan and toxaphene in China, Korea and Japan

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    Recently, the Stockholm Convention prohibited the use of toxaphene and has been reviewing endosulfan. The historical use of these pesticides may contaminate food and tend to accumulate in the food chain. In this study, to evaluate the spatial and temporal trends of food contamination, the endosulfan and toxaphene levels were measured in pooled 24-h food composite samples from Chinese (n = 10), Korean (n = 10) and Japanese (n = 40) adults in the 1990s and 2007-2009. Endosulfan was detected in 32 of 40 samples from Japan, but its levels (sum of alpha- and beta-isomers) were low in both the 1990s and 2009 (range as geometric mean (geometric standard deviation) [GM (GSD)]: 0.96 (1.6)-1.42 (1.4) ng kg(-1) d(-1)). The dietary intakes of endosulfan in Seoul as GM (GSD) were 38.68 (1.3) ng kg bw(-1) d(-1) in 1994 and 92.17 (4.4) ng kg bw(-1) d(-1) in 2007, and significantly higher than those in Japan (p < 0.05). The samples from Beijing showed a 50-fold increase in the endosulfan levels from 1993 (GM: 0.58 ng kg(-1) d(-1)) to 2009 (GM: 24.91 ng kg bw(-1) d(-1)) (p < 0.05). Toxaphene was detected in 33 of 40 samples from Japan. The dietary intake of toxaphene in Japan (sum of Parlars #26, #50 and #62) was 0.32-1.21 ng kg bw(-1) d(-1) (range as geometric mean) and no temporal trend was observed. The dietary intake of toxaphene in Seoul increased significantly from 0.2 ng kg bw(-1) d(-1) (GM) in 1994 to 3.6 ng kg bw(-1) d(-1) (GM) in 2007 (p < 0.05). Only one of 10 pooled samples from Beijing contained a detectable level of toxaphene (0.3 ng kg bw(-1) d(-1)). For the entire population, the risk of adverse health effects from dietary intakes of endosulfan and toxaphene is unlikely. However, the concentrations of endosulfan in several samples exceeded 10% of the acceptable daily intake limit value of 6 mu g kg bw(-1) d(-1) set by the World Health Organization (WHO). It appears important to refine dietary intake estimates targeting food types and source identification to ensure safe food for consumers. (C) 2011 Elsevier Ltd. All rights reserved.Environmental SciencesSCI(E)EI8ARTICLE101398-14058

    The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017

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    Background Efforts to quantify the global burden of enteric fever are valuable for understanding the health lost and the large-scale spatial distribution of the disease. We present the estimates of typhoid and paratyphoid fever burden from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, and the approach taken to produce them. Methods For this systematic analysis we broke down the relative contributions of typhoid and paratyphoid fevers by country, year, and age, and analysed trends in incidence and mortality. We modelled the combined incidence of typhoid and paratyphoid fevers and split these total cases proportionally between typhoid and paratyphoid fevers using aetiological proportion models. We estimated deaths using vital registration data for countries with sufficiently high data completeness and using a natural history approach for other locations. We also estimated disability-adjusted life-years (DALYs) for typhoid and paratyphoid fevers. Findings Globally, 14.3 million (95% uncertainty interval [UI] 12.5-16.3) cases of typhoid and paratyphoid fevers occurred in 2017, a 44.6% (42.2-47.0) decline from 25 . 9 million (22.0-29.9) in 1990. Age-standardised incidence rates declined by 54 . 9% (53 . 4-56.5), from 439.2 (376.7-507.7) per 100 000 person-years in 1990, to 197.8 (172.0-226.2) per 100 000 person-years in 2017. In 2017, Salmonella enterica serotype Typhi caused 76.3% (71.8-80.5) of cases of enteric fever. We estimated a global case fatality of 0.95% (0.54-1.53) in 2017, with higher case fatality estimates among children and older adults, and among those living in lower-income countries. We therefore estimated 135.9 thousand (76.9-218.9) deaths from typhoid and paratyphoid fever globally in 2017, a 41.0% (33.6-48.3) decline from 230.5 thousand (131.2-372.6) in 1990. Overall, typhoid and paratyphoid fevers were responsible for 9.8 million (5.6-15.8) DALYs in 2017, down 43.0% (35.5-50.6) from 17.2 million (9.9-27.8) DALYs in 1990. Interpretation Despite notable progress, typhoid and paratyphoid fevers remain major causes of disability and death, with billions of people likely to be exposed to the pathogens. Although improvements in water and sanitation remain essential, increased vaccine use (including with typhoid conjugate vaccines that are effective in infants and young children and protective for longer periods) and improved data and surveillance to inform vaccine rollout are likely to drive the greatest improvements in the global burden of the disease. Copyright (C) 2019 The Author(s). Published by Elsevier Ltd.N

    Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (Nature Medicine, (2020), 26, 5, (750-759), 10.1038/s41591-020-0807-6)

    No full text
    An amendment to this paper has been published and can be accessed via a link at the top of the paper

    Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

    No full text

    Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

    No full text
    A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4 (62.3 (55.1–70.8) million) to 6.4 (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5 in over half of LMICs by 2025. Prevalence of overweight increased from 5.2 (30 (22.8–38.5) million) in 2000 to 6.0 (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic. © 2020, The Author(s)

    Mapping disparities in education across low- and middle-income countries

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    Educational attainment is an important social determinant of maternal, newborn, and child health1–3. As a tool for promoting gender equity, it has gained increasing traction in popular media, international aid strategies, and global agenda-setting4–6. The global health agenda is increasingly focused on evidence of precision public health, which illustrates the subnational distribution of disease and illness7,8; however, an agenda focused on future equity must integrate comparable evidence on the distribution of social determinants of health9–11. Here we expand on the available precision SDG evidence by estimating the subnational distribution of educational attainment, including the proportions of individuals who have completed key levels of schooling, across all low- and middle-income countries from 2000 to 2017. Previous analyses have focused on geographical disparities in average attainment across Africa or for specific countries, but—to our knowledge—no analysis has examined the subnational proportions of individuals who completed specific levels of education across all low- and middle-income countries12–14. By geolocating subnational data for more than 184 million person-years across 528 data sources, we precisely identify inequalities across geography as well as within populations. © 2019, The Author(s)

    The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019

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    Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95% uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4% (41.3-48.4) of all cancer deaths and 42.0% (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6% [47.8-54.1] of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% [32.5-41.3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% [27.9-42.8] and 33.3% [25.8-42.0]). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.AuthorOverflow(1014
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