6 research outputs found
Geographical Indications and Designations of Origin linked Agricultural Products: Current Statistics from Turkey
Get PDFGeographical indications and designation of origins is an industrial property right describing a product originated from any region or attributable to any region due to its quality, reputation or other characteristics. Particularly, the geographical indications (GI) provide information about the raw material or final products’ geographical roots to consumers and characterize the degree of its quality. Two types of GI were defined: Protected Designations of Origin (PDO) and Protected Geographical Indication (PGI). On the other hand, the products that cannot be registered as a designation of origin or geographical indication could be registered as Traditional Speciality Guaranteed (TSG) products specialty guaranteed if it can be proven that the product is on the traditional market for at least 30 years. The main goal of this research is to examine Turkey’s current status about labelled geographic agricultural material with a comparative statistic overview
The effect of homogenization practice on the microstructure of AA6063 alloys
No full textHomogenization is an essential step in the preparation of aluminum billets for extrusion and is performed to produce a homogeneous solid solution and to transform the beta-AlFeSi particles to the finer and more equiaxed and thus more acceptable a variety. Homogenized billets require lower extrusion pressures and give extrusions with better surface finish and higher strength than as-cast billets. The extrudability of the billet is maximized once the solutionizing of the Mg2Si particles is optimized and the beta-->alpha transformation is complete. The latter takes higher temperatures and longer times and often requires help through revision of the alloy chemistry, i.e. addition of some Mn. The cooling practice in a homogenization treatment is just as significant as soaking and a variety of microstructures ranging from a fully solutionized homogeneous matrix to a heterogeneous one with a coarse dispersion of Mg2Si particles can be produced by simply adjusting the cooling rate. The optimum rate is that which gives Mg2Si precipitation readily redissolvable during subsequent processing and is dictated by the preheating, practice. The present work was undertaken to identify the optimum homogenization soaking and cooling practice for a semicontinous DC-cast AA6063 billet which, due to its composition (very low Mn), relies solely on the soaking practice for the beta-->alpha transformation
Anti-Inflammatory, Antioxidant, and Anti-Atherosclerotic Effects of Natural Supplements on Patients With Fmf-Related Aa Amyloidosis: a Non-Randomized 24-Week Open-Label Interventional Study
No full textGARCIA-BOURNISSEN, FACUNDO/0000-0002-8732-247X; Poddighe, Dimitri/0000-0001-6431-9334; Ucuncuoglu, Didar/0000-0002-2640-5976; Demirkaya, Erkan/0000-0003-4525-1789; sezer, siren/0000-0002-7326-8388; Stenvinkel, Peter/0000-0002-8785-4820; honca, tevfik/0000-0003-3723-1374We aimed to evaluate the effect of a combination of natural products on parameters related to inflammation, endothelial dysfunction, and oxidative stress in a cohort of familial Mediterranean fever (FMF) patients with Serum Amyloid A amyloidosis, in a non-randomized, 24-week open-label interventional study. Morinda citrifolia (anti-atherosclerotic-AAL), omega-3 (anti-inflammatory-AIC), and extract with Alaskan blueberry (antioxidant-AOL) were given to patients with FMF-related biopsy-proven AA amyloidosis. Patients were >18 years and had proteinuria (>3500 mg/day) but a normal estimated glomerular filtration rate (eGFR). Arterial flow-mediated dilatation (FMD), carotid intima media thickness (CIMT), and serum biomarkers asymmetric dimethylarginine (ADMA), high sensitivity C-reactive protein (hs-CRP), pentraxin (PTX3), malondialdehyde (MDA), Cu/Zn-superoxide dismutase (Cu/Zn-SOD), and glutathione peroxidase (GSH-Px) were studied at baseline and after 24 weeks of treatment. A total of 67 FMF-related amyloidosis patients (52 male (77.6%); median age 36 years (range 21-66)) were enrolled. At the end of a 24-week treatment period with AAL, AIC, and AOL combination therapy, ADMA, MDA, PTX3, hsCRP, cholesterol, and proteinuria were significantly decreased compared to baseline, while CuZn-SOD, GSH-Px, and FMD levels were significantly increased. Changes in inflammatory markers PTX3, and hsCRP were negatively correlated with FMD change, and positively correlated with decreases in proteinuria, ADMA, MDA, cholesterol, and CIMT. Treatment with AAL, AIC and AOL combination for 24 weeks were significantly associated with reduction in inflammatory markers, improved endothelial functions, and oxidative state. Efficient control of these three mechanisms can have long term cardiovascular and renal benefits for patients with AA amyloidosis.Department of Pediatrics, University of Western Ontario, CanadaThe authors thank all the patients who took part in this study. M.R. is the recipient of matching the fund (Department of Pediatrics, University of Western Ontario, Canada) bursary for international clinical fellowship in Behcet and Autoinflammatory Disease Center
Pol I processivity measured by TPM.
No full textElongation complexes arrested after transcribing different distances along the DNA template, with only seven out of sixty-five complexes reaching the expected run-off site and releasing DNA. The percentage of elongation complexes that reached a given position along the template is plotted for single molecule experiments with (purple) or without (gold) added RNAse. Note that position 556 corresponds to the halt site and 2444 nucleotides can be transcribed before runoff at position 2500.</p
Anti-Inflammatory, Antioxidant, and Anti-Atherosclerotic Effects of Natural Supplements on Patients with FMF-Related AA Amyloidosis: A Non-Randomized 24-Week Open-Label Interventional Study
Get PDFWe aimed to evaluate the effect of a combination of natural products on parameters related to inflammation, endothelial dysfunction, and oxidative stress in a cohort of familial Mediterranean fever (FMF) patients with Serum Amyloid A amyloidosis, in a non-randomized, 24-week open-label interventional study. Morinda citrifolia (anti-atherosclerotic-AAL), omega-3 (anti-inflammatory-AIC), and extract with Alaskan blueberry (antioxidant-AOL) were given to patients with FMF-related biopsy-proven AA amyloidosis. Patients were >18 years and had proteinuria (>3500 mg/day) but a normal estimated glomerular filtration rate (eGFR). Arterial flow-mediated dilatation (FMD), carotid intima media thickness (CIMT), and serum biomarkers asymmetric dimethylarginine (ADMA), high sensitivity C-reactive protein (hs-CRP), pentraxin (PTX3), malondialdehyde (MDA), Cu/Zn-superoxide dismutase (Cu/Zn-SOD), and glutathione peroxidase (GSH-Px) were studied at baseline and after 24 weeks of treatment. A total of 67 FMF-related amyloidosis patients (52 male (77.6%); median age 36 years (range 21–66)) were enrolled. At the end of a 24-week treatment period with AAL, AIC, and AOL combination therapy, ADMA, MDA, PTX3, hsCRP, cholesterol, and proteinuria were significantly decreased compared to baseline, while CuZn-SOD, GSH-Px, and FMD levels were significantly increased. Changes in inflammatory markers PTX3, and hsCRP were negatively correlated with FMD change, and positively correlated with decreases in proteinuria, ADMA, MDA, cholesterol, and CIMT. Treatment with AAL, AIC and AOL combination for 24 weeks were significantly associated with reduction in inflammatory markers, improved endothelial functions, and oxidative state. Efficient control of these three mechanisms can have long term cardiovascular and renal benefits for patients with AA amyloidosis
An integrated methodology for customer relationship management customization
Get PDFThe importance and presence of technological solutions in organizations supporting CRM are a vital business fact from the late nineties. Presently, the manufacturers figure in the market has dramatically decreased because of continuous takeovers and merges, but it has on the other hand gained momentum because of the sudden open-source and on-demand solutions appearance. In this scope, a unified methodology centered on CRM solutions is of paramount importance since it has traditionally been linked to either system integration or overall solution design. Based on the two de-facto complementary standards for the implementation and development of Information Systems, namely the ESA and Dyché CRM systems implementation methodology, in this paper, we provide a CRM business solutions customization methodology which pertains independently to the integration and tool maker perspective.Publicad
