2,589 research outputs found
Elevated serum concentrations of beta-tryptase, but not alpha-tryptase, in Sudden Infant Death Syndrome (SIDS). An investigation of anaphylactic mechanisms
No full textBackground
Sudden Infant Death Syndrome, (SIDS) or cot death, remains the most common category of post-perinatal death in the UK. By definition, the cause of death is unknown, but a long-standing theory is that some of these deaths could be the result of anaphylaxis.Objective
To investigate the potential contribution of anaphylactic mechanisms to deaths in infancy by determining relative levels of ?- and ?-tryptases and both total and allergen-specific IgE in sera from groups of infants whose deaths were attributed to SIDS or to other causes.Methods
Serum samples were collected at the time of post-mortem examination from infants whose death was classed as SIDS (n = 40) and from a comparison group in which cause of death had been established (n = 32). Serum tryptase concentrations were measured with a radioimmunoassay with monoclonal antibody G5 which detects primarily ?-tryptase or an ELISA with antibody AA5 which has equal sensitivity for ?- and ?-tryptases. Levels of total IgE and IgE specific for casein, ?-lactoglobulin, house dust mite and moulds were determined.Results
Analysis of the results of the two assays for tryptase indicated that levels of the ?-like tryptase (the form secreted on anaphylactic degranulation) were significantly higher in serum from infants with SIDS compared with those whose death was explained. There was no evidence for an increase in serum levels of ?-tryptase (the variant secreted constitutively from mast cells). Total levels of serum IgE did not differ between the two groups and, reflecting the low circulating IgE concentrations in infancy, an elevation in IgE specific for the panel of allergens was not detected.Conclusions
In a proportion of SIDS victims there may be increased serum levels of ?-like tryptase, a marker for anaphylaxis. The failure to detect an increase in ?-tryptase would suggest that mast cell hyperplasia is not a feature of cot death. The nature of the inciting agents remains unclear, but anaphylaxis deserves serious consideration as a possible cause of sudden death in infancy
Role of macrophage metalloelastase in gut inflammation. [Issue: Inflammatory Bowel Disease: Genetics, Barrier Function, Immunologic Mechanisms and Microbial]
No full textMatrix metalloproteinases (MMPs) are involved in a number of physiological and pathologic processes including the inflammation found in IBD. We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases
Active inference for fault tolerant control of robot manipulators with sensory faults
No full textWe present a fault tolerant control scheme for robot manipulators based on active inference. The proposed solution makes use of the sensory prediction errors in the free-energy to simplify the residuals and thresholds generation for fault detection and isolation and does not require additional controllers for fault recovery. Results validating the benefits in a simulated 2DOF manipulator are presented and the limitations of the current approach are highlighted.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Robot DynamicsTeam Jan-Willem van Wingerde
Dante poeta-profeta, pellegrino, autore : strutturazione espessiva della Commedia e visione escatologica dantesca
No full textLo studio del profetismo dantesco e del rapporto tra esso e la "lupa" (cioè la cupidigia-volontà di potenza, è condotto attraverso l'analisi dei momenti più intensamente profetici del poema: dagli aspetti escatologici, politici e sociali dell'antefatto, attraverso le intense reminiscenze da Ezechiele e da Apocalisse ricontestualizzate in Purg. XIX e XX, alle grandiose visioni escatologico-politiche di Purg. XXXII e XXXIII, alla sommessa e dolente speranza espressa negli ultimi canti di Beatrice.Il grido profetico di Dante è inseparabile dalle diverse immagini del poeta all'interno della Commedia: il poeta-pellegrino (l'agens); il poeta-scriba, addetto a riprodurre le esperienze vissute dal pellegrino; l'autore, cioè il poeta-profeta, il quale dice "io" anch'egli e intervienedal presente della scrittura per ammaestrare il lettore ed esecrare i vizi della cristianità sviata. Si esamina quindi la posizione di Dante tra i poeti-auctores antichi e l'auctoritas che spetta ai libri sacri di AT e di NT.The study of Dantean prophetism and of its relationship with the “she-wolf” (that is greed-lust for power), is carried out through the analysis of the most intensely prophetic moments of the poem: from the eschatological, political and social aspects of the background, through the intense reminiscences from Ezekiel and Apocalypse re-contextualized in Purgatory XIX and XX, to the great eschatological-political visions of Purgatory XXXII and XXXIII, to the quiet and sorrowful hope expressed in Beatrice's last cantos. Dante's prophetic cry is inseparable from the different images of the poet inside the Comedy : the pilgrim poet (the agens); the scribe poet, assigned to reproduce the experiences lived by the pilgrim; the author, that is the prophet poet, who also says “I” and intervenes from the present of the writing to teach the reader and execrate the vices of led astray Christianity. Then Dante's position is examined between the ancient auctores- poets and the auctoritas due to the holy books of the Old and New Testament
Sant'Ambrogio nella letteratura religiosa slava orientale del Sei e Settecento : per uno studio preliminare delle citazioni ambrosiane nell'omiletica rutena barocca
No full textThe aim of this study is to investigate the reception of Ambrose in the writings of three Ukrainian baroque preachers, viz. Ioannikij Galjatovs’kyj, Antonij Radyvylovs’kyj and Dimitrij Rostovskij. The method that has been adopted in the presentation of the results of our survey can be outlined as follows. First, we focused on the thematic aspects of the process of reception, which generally fall into two categories: 1. Exegetical themes, based on motives drawn from the Scriptures; 2. Philosophical-doctrinal themes. Furthermore, for all the writers which we examined we tried to determine whether an author made a direct or indirect usage of Ambrose’s oeuvre. Indirect use is generally to be ascribed to the influence of either exegetic Comments on the Bible, such as those of Cornelius A Lapide and Didacus de Baeza, or of emblematic literature produced in the West, such as Hemannus Hugo’s Pia desideria (1624).
A second question to be addressed is how the intellectual and ecclesiastical context of the Ukrainian lands, whose distinctive features were pluriconfessionalism and the close ties to Western Renaissance and Baroque, influenced our authors in the way they made use of Ambrose, especially as far as the relationship between Orthodoxy and Catholicism is concerned
Evidence of mast-cell activation in a subset of patients with eosinophilic chronic obstructive pulmonary disease
No full textAlthough asthma has been viewed mainly as an eosinophilic disease, and chronic obstructive pulmonary disease (COPD) as a neutrophilic disease, recent studies have shown increased neutrophil counts in severe asthma and sputum eosinophilia in some COPD patients.In an attempt to further characterise these two syndromes according to pathology, the current authors have conducted a study of induced sputum in 15 subjects with COPD, 17 asthmatics, and 17 nonatopic healthy individuals. Sputum was analysed for cytology and levels of eosinophil cationic protein (ECP), albumin, tryptase and soluble intercellular adhesion molecule‐1.The COPD subjects differed from the asthmatics as they had higher sputum neutrophil and lower columnar epithelial cell counts, but there were no differences in any soluble marker studied. When compared to control subjects, both the asthmatic and COPD subjects had raised eosinophil counts and ECP levels. In a subset of COPD subjects with sputum eosinophilia (>3% of total cells), significantly increased levels of tryptase were detected.In conclusion, although chronic obstructive pulmonary disease is a more neutrophilic disease than asthma, the two diseases are difficult to distinguish on the basis of sputum levels of the soluble markers traditionally associated with asthma. However, a subset of patients with chronic obstructive pulmonary disease with airway eosinophilia and mast-cell activation might represent a distinct pathological phenotype.</p
Fammi del tuo valor sì fatto vaso, come dimandi a dar l'amato alloro
No full textIl contributo esamina lo sviluppo della possibilità di esistenza di poeti e autori volgari (accanto e in competizione con i classici soprattutto latini)nelle opere di Dante antecedenti la Commedia. Quindi argomenta le ragioni per cui Dante, nella Commedia, si proclama poeta ma non si definisce mai autore (tale in particolare è Virgilio).The contribution considers the development of the possibility of existence of vulgar poets and authors (beside and in competition with the classics, mostly Latin) in Dante's works prior to the Comedy.
Then it argues the reasons why Dante, in the Comedy, declares himself a poet but he never calls himself an author (such is particularly Virgil)
Measurement of the top quark mass with the template method in the t<span style="text-decoration: overline">t</span> →lepton+jets channel using ATLAS data
No full textContains fulltext :
103516.pdf (Publisher’s version ) (Open Access
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