1,327 research outputs found
Un doux souvenir : mazurka pour piano / par Jean D. Barlan ; [ill. par] Lelogeais
No full textTitre uniforme : Barlan, Jean D. (18..-19.. ; compositeur). Compositeur. [Un doux souvenir. Piano]Mazurkas (piano) -- +* 1800......- 1899......+:19e siècle:Piano, Musique de -- +* 1800......- 1899......+:19e siècle
Da ideia de infância em Jean-Jacques Rousseau ou do "sono da razão"
Get PDFDissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciencias da Educação. Programa de Pós-Graduação em EducaçãoOs pensamentos expostos no século XVIII pelo genebrino Jean-Jacques Rousseau influenciaram de maneira decisiva a forma como o Ocidente passou a perceber a infância. Este autor provocou uma verdadeira divisão de águas ao publicar Emílio ou Da Educação (1762). Com este feito, mais que balançar os alicerces educacionais da época, ele delega à criança um lugar no mundo. A infância passa a ter um valor em si mesma, e a ser vista como etapa fundamental na constituição humana. Ao destacar este período da vida, além de romper definitivamente com o que vigorava em seu tempo, no qual a criança era tida como um erro passageiro - um infante (aquele que não fala); um "adulto em miniatura"; ou mero objeto de paparicação e prazer - Jean-Jacques cria uma ótica inovadora de conceber a criança. Dizia que: "A natureza quer que as crianças sejam crianças antes de serem homens." Ao elaborar um conceito de infância, Rousseau afirma que "a infância é o sono da razão". O que nos surpreende devido este autor ter vivido em pleno "Século das Luzes", justamente quando a razão era evocada como o guia seguro para o pensamento e para ação em todas as idades. Ao contrário do que possa parecer, Rousseau não desmerece o período infantil, associando-o à escuridão ou a inferioridade primeira da humanidade. Ele é considerado o "inventor da infância". Retomar pensamentos que versam sobre essas ideias rousseaunianas, inaugurais da concepção moderna de Infância, por meio de pesquisa teórica, é o objetivo traçado aqui, com intuito de avançar nas compreensões estabelecidas em torno das contribuições de Jean-Jacques Rousseau para temática em exame.The thoughts exposed in the eighteenth century by the genevan, Jean-Jacques Rousseau, influenced in a decisive way the West has to realize his childhood. This author has caused a real division of the waters or publish Emile, or On Education (1762). With this done more than shake the foundations of educational time, it leaves the child a place in the world. The child is given a value in itself, and be seen as key step in the human constitution. By highlighting this period of life, and the final break with that which prevailed in his time, in which the child was seen as a mistake passenger - an infant (who does not speak), a "miniature adult" or mere object of pampering and pleasure - Jean-Jacques creates a new perspective to conceive a child. He said: "Nature wants children to be children before being men." In developing a concept of childhood, Rousseau says that "childhood is the sleep of reason". What surprises us because this author has lived in the middle of "Age of Enlightenment", just when the reason was mentioned as the sure guide for thought and action in all ages. Contrary to what may seem, Rousseau does not diminish the infantile period, associating him to the darkness or the inferiority of humanity first. He is considered the "inventor of childhood." Resume thoughts that talk about these ideas Rousseau, the inaugural modern conception of childhood, through theoretical research, stroke is the goal here, with the aim to advance the understandings established around the contributions of Jean-Jacques Rousseau to thematic examination
Measurement of the D+/- production asymmetry in 7 TeV pp collisions
Get PDFThe asymmetry in the production cross-section \sigma of D+/- mesons, A_P = (\sigma(D+) - \sigma(D-))/(\sigma(D+) + \sigma(D-)), is measured in bins of pseudorapidity \eta and transverse momentum p_T within the acceptance of the LHCb detector. The result is obtained with a sample of D+ -> K_S pi+ decays corresponding to an integrated luminosity of 1.0 fb^-1, collected in pp collisions at a centre of mass energy of 7 TeV at the Large Hadron Collider. When integrated over the kinematic range 2.0 K_S pi+ decay is negligible. No significant dependence on \eta or p_T is observed
First observation of Bs0 → D*s2+Xμ-ν decays
Get PDFUsing data collected with the LHCb detector in proton–proton collisions at a centre-of-mass energy of 7 TeV, the semileptonic decays B0s→D+sXμ−ν and B0s→D0K+Xμ−ν are detected. Two structures are observed in the D0K+ mass spectrum at masses consistent with the known Ds1(2536)+ and D∗s22573)+ mesons. The measured branching fractions relative to the total B0s semileptonic rate are B(B0s→D∗+s2Xμ−ν)/B(B0s→Xμ−ν) = (3.3±1.0±0.4)%, and B(B0s→D+s1Xμ−ν)/B(B0s→Xμ−ν) = (5.4±1.2±0.5)%, where the first uncertainty is statistical and the second is systematic. This is the first observation of the D∗+s2 state in B0s decays; we also measure its mass and width
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
Get PDFFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
Measurement of the B0–B0 oscillation frequency Δmd with the decays B0→D−π+ and B0→ J/ψK∗0
Get PDFThe B
0
–B
0
oscillation frequency Δmd is measured by the LHCb experiment using a dataset corresponding
to an integrated luminosity of 1.0 fb−1
of proton–proton collisions at √
s = 7 TeV, and is found to be
Δmd
=0.5156±0.0051 (stat.)±0.0033 (syst.) ps−1
. The measurement is based on results from analyses
of the decays B
0
→ D
−π
+ (D
−
→ K
+π
−π
−) and B
0
→ J/ψK
∗0
(J/ψ →μ
+μ
−,K
∗0
→ K
+π
−) and
their charge conjugated modes
The effectiveness of interventions to treat severe acute malnutrition in young children: a systematic review
No full textSevere acute malnutrition (SAM) arises as a consequence of a sudden period of food shortage and is associated with loss of a person’s body fat and wasting of their skeletal muscle. Many of those affected are already undernourished and are often susceptible to disease. Infants and young children are the most vulnerable as they require extra nutrition for growth and development, have comparatively limited energy reserves and depend on others. Undernutrition can have drastic and wide-ranging consequences for the child’s development and survival in the short and long term. Despite efforts made to treat SAM through different interventions and programmes, it continues to cause unacceptably high levels of mortality and morbidity. Uncertainty remains as to the most effective methods to treat severe acute malnutrition in young children.ObjectivesTo evaluate the effectiveness of interventions to treat infants and children aged < 5 years who have SAM.Data sourcesEight databases (MEDLINE, EMBASE, MEDLINE In-Process & Other Non-Indexed Citations, CAB Abstracts Ovid, Bioline, Centre for Reviews and Dissemination, EconLit EBSCO and The Cochrane Library) were searched to 2010. Bibliographies of included articles and grey literature sources were also searched. The project expert advisory group was asked to identify additional published and unpublished references.Review methodsPrior to the systematic review, a Delphi process involving international experts prioritised the research questions. Searches were conducted and two reviewers independently screened titles and abstracts for eligibility. Inclusion criteria were applied to the full texts of retrieved papers by one reviewer and checked independently by a second. Included studies were mapped to the research questions. Data extraction and quality assessment were undertaken by one reviewer and checked by a second reviewer. Differences in opinion were resolved through discussion at each stage. Studies were synthesised through a narrative review with tabulation of the results.ResultsA total of 8954 records were screened, 224 full-text articles were retrieved, and 74 articles (describing 68 studies) met the inclusion criteria and were mapped. No evidence focused on treatment of children with SAM who were human immunodeficiency virus sero-positive, and no good-quality or adequately reported studies assessed treatments for SAM among infants < 6 months old. One randomised controlled trial investigated fluid resuscitation solutions for shock, with none adequately treating shock. Children with acute diarrhoea benefited from the use of hypo-osmolar oral rehydration solution (H-ORS) compared with the standard World Health Organization-oral rehydration solution (WHO-ORS). WHO-ORS was not significantly different from rehydration solution for malnutrition (ReSoMal), but the safety of ReSoMal was uncertain. A rice-based ORS was more beneficial than glucose-based ORSs, and provision of zinc plus a WHO-ORS had a favourable impact on diarrhoea and need for ORS. Comparisons of different diets in children with persistent diarrhoea produced conflicting findings. For treating infection, comparison of amoxicillin with ceftriaxone during inpatient therapy, and routine provision of antibiotics for 7 days versus no antibiotics during outpatient therapy of uncomplicated SAM, found that neither had a significant effect on recovery at the end of follow-up. No evidence mapped to the next three questions on factors that affect sustainability of programmes, long-term survival and readmission rates, the clinical effectiveness of management strategies for treating children with comorbidities such as tuberculosis and Helicobacter pylori infection and the factors that limit the full implementation of treatment programmes. Comparison of treatment for SAM in different settings showed that children receiving inpatient care appear to do as well as those in ambulatory or home settings on anthropometric measures and response time to treatment. Longer-term follow-up showed limited differences between the different settings. The majority of evidence on methods for correcting micronutrient deficiencies considered zinc supplements; however, trials were heterogeneous and a firm conclusion about zinc was not reached. There was limited evidence on either supplementary potassium or nicotinic acid (each produced some benefits), and nucleotides (not associated with benefits). Evidence was identified for four of the five remaining questions, but not assessed because of resource limitation.LimitationsThe systematic review focused on key questions prioritised through a Delphi study and, as a consequence, did not encompass all elements in the management of SAM. In focusing on evidence from controlled studies with the most rigorous designs that were published in the English language, the systematic review may have excluded other forms of evidence. The systematic review identified several limitations in the evidence base for assessing the effectiveness of interventions for treating young children with severe acute malnutrition, including a lack of studies assessing the different interventions; limited details of study methods used; short follow-up post intervention or discharge; and heterogeneity in participants, interventions, settings, and outcome measures affecting generalisability.ConclusionsFor many of the most highly ranked questions evidence was lacking or inconclusive. More research is needed on a range of topic areas concerning the treatment of infants and children with SAM. Further research is required on most aspects of the management of SAM in children < 5 years, including intravenous resuscitation regimens for shock, management of subgroups (e.g. infants < 6 months old, infants and children with SAM who are human immunodeficiency virus sero-positive) and on the use of antibiotics.FundingThe National Institute for Health Research Technology Assessment programme.<br/
Identification of Plasmodium falciparum var1CSA and var2CSA domains that bind IgM natural antibodies
No full textMalaria in pregnancy is responsible for maternal anaemia, low-birth-weight babies and infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental pathology by adhering to host receptors such as chondroitin sulphate A (CSA). CSA binding infected erythrocytes also bind IgM natural antibodies from normal human serum, a process that may facilitate placental adhesion or promote immune evasion. The parasite ligands that mediate placental adhesion are thought to be members of the variant erythrocyte surface antigen family P. falciparum erythrocyte membrane protein 1 (PfEMP1), encoded by the var genes. Two var gene sub-families, var1CSA and var2CSA, have been identified as parasite CSA binding ligands and are leading candidates for a vaccine to prevent pregnancy-associated malaria. We investigated whether these two var gene subfamilies implicated in CSA binding are also the molecules responsible for IgM natural antibody binding. By heterologous expression of domains in COS-7 cells, we found that both var1CSA and var2CSA PfEMP1 variants bound IgM, and in both cases the binding region was a DBL epsilon domain occurring proximal to the membrane. None of the domains from a control non-IgM-binding parasite (R29) bound IgM when expressed in COS-7 cells. These results show that PfEMP1 is a parasite ligand for non-immune IgM and are the first demonstration of a specific adhesive function for PfEMP1 epsilon type domains
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Get PDFObesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation
Measurement of the CP-violating phase \phi s in Bs->J/\psi\pi+\pi- decays
Get PDFMeasurement of the mixing-induced CP-violating phase phi_s in Bs decays is of prime importance in probing new physics. Here 7421 +/- 105 signal events from the dominantly CP-odd final state J/\psi pi+ pi- are selected in 1/fb of pp collision data collected at sqrt{s} = 7 TeV with the LHCb detector. A time-dependent fit to the data yields a value of phi_s=-0.019^{+0.173+0.004}_{-0.174-0.003} rad, consistent with the Standard Model expectation. No evidence of direct CP violation is found
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