71,124 research outputs found
Randomized, Controlled Trial of the Long Term Safety, Immunogenicity and Efficacy of RTS,S/AS02(D) Malaria Vaccine in Infants Living in a Malaria-Endemic Region.
No full textThe RTS,S/AS malaria candidate vaccine is being developed with the intent to be delivered, if approved, through the Expanded Programme on Immunization (EPI) of the World Health Organization. Safety, immunogenicity and efficacy of the RTS,S/AS02(D) vaccine candidate when integrated into a standard EPI schedule for infants have been reported over a nine-month surveillance period. This paper describes results following 20 months of follow up. This Phase IIb, single-centre, randomized controlled trial enrolled 340 infants in Tanzania to receive three doses of RTS,S/AS02(D) or hepatitis B vaccine at 8, 12, and 16 weeks of age. All infants also received DTPw/Hib (diphtheria and tetanus toxoids, whole-cell pertussis vaccine, conjugated Haemophilus influenzae type b vaccine) at the same timepoints. The study was double-blinded to month 9 and single-blinded from months 9 to 20. From month 0 to 20, at least one SAE was reported in 57/170 infants who received RTS,S/AS02(D) (33.5%; 95% confidence interval [CI]: 26.5, 41.2) and 62/170 infants who received hepatitis B vaccine (36.5%; 95% CI: 29.2, 44.2). The SAE profile was similar in both vaccine groups; none were considered to be related to vaccination. At month 20, 18 months after completion of vaccination, 71.8% of recipients of RTS,S/AS02(D) and 3.8% of recipients of hepatitis B vaccine had seropositive titres for anti-CS antibodies; seroprotective levels of anti-HBs antibodies remained in 100% of recipients of RTS,S/AS02(D) and 97.7% recipients of hepatitis B vaccine. Anti-HBs antibody GMTs were higher in the RTS,S/AS02(D) group at all post-vaccination time points compared to control. According to protocol population, vaccine efficacy against multiple episodes of malaria disease was 50.7% (95% CI: -6.5 to 77.1, p = 0.072) and 26.7% (95% CI: -33.1 to 59.6, p = 0.307) over 12 and 18 months post vaccination, respectively. In the Intention to Treat population, over the 20-month follow up, vaccine efficacy against multiple episodes of malaria disease was 14.4% (95% CI: -41.9 to 48.4, p = 0.545). The acceptable safety profile and good tolerability of RTS,S/AS02(D) in combination with EPI vaccines previously reported from month 0 to 9 was confirmed over a 20 month surveillance period in this infant population. Antibodies against both CS and HBsAg in the RTS,S/AS02(D) group remained significantly higher compared to control for the study duration. Over 18 months follow up, RTS,S/AS02(D) prevented approximately a quarter of malaria cases in the study population. CLINICAL TRIALS: Gov identifier: NCT00289185
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Measurement of the B0–B0 oscillation frequency Δmd with the decays B0→D−π+ and B0→ J/ψK∗0
No full textThe B
0
–B
0
oscillation frequency Δmd is measured by the LHCb experiment using a dataset corresponding
to an integrated luminosity of 1.0 fb−1
of proton–proton collisions at √
s = 7 TeV, and is found to be
Δmd
=0.5156±0.0051 (stat.)±0.0033 (syst.) ps−1
. The measurement is based on results from analyses
of the decays B
0
→ D
−π
+ (D
−
→ K
+π
−π
−) and B
0
→ J/ψK
∗0
(J/ψ →μ
+μ
−,K
∗0
→ K
+π
−) and
their charge conjugated modes
Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
No full textThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
Measurement of CP observables in B-+/- -> D(*)K-+/- and B-+/- -> D(*)pi(+/-) decays
No full textMeasurements of CP observables in B-+/- -> D(*)K-+/- and B-+/- -> D(*)pi(+/-) decays are presented, where D(*) indicates a neutral Dor D* meson that is an admixture of D(*)(0) and (D) over bar(*)(0) states. Decays of the D* meson to the D pi(0)and D gamma final states are partially reconstructed without inclusion of the neutral pion or photon, resulting in distinctive shapes in the Bcandidate invariant mass distribution. Decays of the D meson are fully reconstructed in the K-+/-pi(-/+), K+K- and pi(+)pi(-) final states. The analysis uses a sample of charged Bmesons produced in ppcollisions collected by the LHCb experiment, corresponding to an integrated luminosity of 2.0, 1.0 and 2.0fb- 1taken at centre- of- mass energies of root s = 7, 8 and 13 TeV, respectively. The study of B-perpendicular to -> D*K-perpendicular to and B-perpendicular to -> D*pi(perpendicular to) decays using a partial reconstruction method is the first of its kind, while the measurement of B-+/- -> DK +/- and B-+/- -> D pi(+/-) decays is an update of previous LHCb measurements. The B-+/- -> DK +/- results are the most precise to date. (c) 2017 The Author. Published by Elsevier B. V
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
El cabildo catedralicio de Lima contra el párroco Alonso de Huerta por las rentas eclesiásticas (1592-1606)
No full textEl objetivo de este trabajo es reconstruir las tensiones políticas entre una oligarquía eclesiástica local, centrada en el Cabildo metropolitano, y el segundo arzobispo de Lima, Toribio Alfonso de Mogrovejo (1538-1606), y el párroco Alonso de Huerta, uno de sus más fieles colaboradores. Aunque el Cabildo era una especie de senado o consejo permanente al servicio del clero diocesano, en ningún momento actuó como una institución de apoyo a la labor evangélica del Arzobispo Mogrovejo. Muy al contrario, sus miembros cerraron filas contra lo que consideraron una violación de sus privilegios económicos, y en numerosas ocasiones denunciaron al Arzobispo y al párroco Alonso de Huerta por considerar que se entrometían en el fuero interno del Cabildo.The aim of this contribution is the presentation of the political conflicts between the Archbishop of Lima, Toribio Alfonso de Mogrovejo (1538-1606), together with his faithful collaborator the parish priest Alonso de Huerta, and the cathedral
chapter. Though the chapter was a sort of senate or permanent council of the diocese clergy, it by no means acted as an institution involved in the missionary
commitments of Archbishop Mogrovejo. On the contrary, its members rallied around against what they considered to be a violation of their economic privileges, and on several instances they denounced the Archbishop, as well as the parish priest Alonso de Huerta, arguing that they intruded in the internal rules of the chapter.Publicad
Alona azorica Frenzel & Alonso 1988
No full textAlona azorica Frenzel & Alonso, 1988. (Figs 6, 8– 10) Alona azorica Frenzel & Alonso, 1988: 449 –465, figs 1–8; Alonso, 1996: 331 –332, fig. 147. Holotype. Female at the Zoological Museum of Hamburg University, K- 32354. Studied populations were collected in: Laguna Grande de Gredos (Gredos Range, Ávila, August 1983); Marzagón pond (Marzagón, Huelva, May 1979); Rocío pond (El Rocío, Huelva, May 1979); Laguna de Antela (R. Margalef leg., Orense, July, 1954); Laguna Corrubedu (Corrubedu, A Coruña, May, 1980); Las Naciones pond (Saucedilla, Cáceres, April, 1986). Short description: Parthenogenetic female. Body. In lateral view similar to that of previous species, regular oval (Fig. 8 A–B, 9 A), of moderate height, moderately compressed laterally. Maximum height at middle of body, in adults height/length ratio about 0.65–0.72. Dorsal margin uniformly curved; postero-dorsal and postero-ventral angles broadly rounded; posterior margin uniformly curved; ventral margin almost straight; antero-ventral angle rounded. Ventral margin with about 35–45 setae, the first ten setae long, next ten setae short, other setae of moderate length. Postero-dorsal angle (Fig. 9 B) as in previous species. Valves oblique or with small tubercules in dorsal portion, fully tuberculated specimens not recorded. Head same as in the previous species. Head shield (Fig. 8 C) similar to that of previous species, but its posterior margin forms a protruding angle with pointed tip, in large specimens posterior portion of head shield elongates and became more narrow. Three major head (Fig. 8 D, 9 C–D) pores with a narrow connection between two anterior pores; in smaller specimens broken connection sometimes present between middle and posterior pore (Fig 9 C). Distance between medium and posterior pore greatly increases with the size of specimen, varying from 1.5 to 2.5 distances between anterior and middle pore. Minute lateral head pores located at level before anterior major head pore. Labrum (Fig. 10 A) same as in previous species. Postabdomen (Fig. 8 E, 9 E–F) same as in previous species. Antennula and antenna same as in the previous species. Thoracic limbs. Limbs I–III (Fig. 10 B–F) same as in the previous species. Limb IV (Fig. 10 G–H) similar to in previous species but with the following differences: setae 5–6 of exopodite longer, seta 5 as long as seta 4, flame-torch setae of endite IV shorter, more robust and less differentiated in size. Limb V (Fig. 10 I) as in previous species. Male. For full description see Frenzel & Alonso, 1988, and Alonso, 1996. Body similar to that of the previous species. Postabdomen (Fig. 8 F) similar to that of previous species, but with much less prominent postanal angle, weakly narrowing in postanal portion and postanal angle not developed. Antennule and limb I same as in previous species. Size. According to Frenzel & Alonso (1988), minimum length of juvenile female 0.19 mm, maximum length of adult female 0.48 mm, length of adult male 0.28–0.34 mm.Published as part of Sinev, Artem Y., Alonso, Miguel, Miracle, Maria Rosa & Sahuquillo, Maria, 2012, The West Mediterranean Alona azorica Frenzel & Alonso, 1988 (Cladocera: Anomopoda: Chydoridae) is composed of two species, pp. 51-68 in Zootaxa 3276 on pages 60-61, DOI: 10.5281/zenodo.20963
Branching fraction and CP asymmetry of the decays B+→K0Sπ+ and B+→K0SK+
No full textAn analysis of B+ → K0
Sπ+ and B+ → K0
S K+ decays is performed with the LHCb experiment. The pp
collision data used correspond to integrated luminosities of 1 fb−1 and 2 fb−1 collected at centre-ofmass
energies of
√
s = 7 TeV and
√
s = 8 TeV, respectively. The ratio of branching fractions and the
direct CP asymmetries are measured to be B(B+ → K0
S K+
)/B(B+ → K0
Sπ+
) = 0.064 ± 0.009 (stat.) ±
0.004 (syst.), ACP(B+ → K0
Sπ+
) = −0.022 ± 0.025 (stat.) ± 0.010 (syst.) and ACP(B+ → K0
S K+
) =
−0.21 ± 0.14 (stat.) ± 0.01 (syst.). The data sample taken at
√
s = 7 TeV is used to search for
B+
c
→ K0
S K+ decays and results in the upper limit ( fc · B(B+
c
→ K0
S K+
))/( fu · B(B+ → K0
Sπ+
)) <
5.8 × 10−2 at 90% confidence level, where fc and fu denote the hadronisation fractions of a ¯b
quark
into a B+
c or a B+ meson, respectively
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