13 research outputs found
Measurement of Time-dependent CP-Violating Asymmetries in Decays
No full text15 pages, 4 postscript figures. Submitted to International Europhysics Conference On High-Energy Physics (HEP 2005), Lisbon, Portugal Added one author, added references, changed two plotsWe present preliminary measurements of the CP asymmetry parameters in B^0 -> K^0_S K^0_S K^0_S decays, reconstructing two of the K^0_S into pi^+pi^- and one into pi^0pi^0. In a sample of 227M pairs collected by the BABAR detector at the PEP-II B-Factory at SLAC, we find the CP parameters to be S = -0.25^{+0.68}_{-0.61} (stat) +/- 0.05 (syst) and C = 0.56^{+0.34}_{-0.43} (stat) +/- 0.04 (syst). Combining this result with the previous BABAR measurement, obtained from events with three K^0_S decaying into pi^+pi^-, we get S = -0.63^{+0.32}_{-0.28} (stat) +/- 0.04(syst) C = -0.10 +/- 0.25 (stat) +/- 0.05 (syst
Environmental toxicity, redox signaling and lung inflammation:the role of glutathione
No full textGlutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is tightly regulated and has been implicated in redox signaling and also in protection against environmental oxidant-mediated injury. Changes in the ratio of the reduced and disulfide form (GSH/GSSG) can affect signaling pathways that participate in a broad array of physiological responses from cell proliferation, autophagy and apoptosis to gene expression that involve H(2)O(2) as a second messenger. Oxidative stress due to oxidant/antioxidant imbalance and also due to environmental oxidants is an important component during inflammation and respiratory diseases such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and asthma. It is known to activate multiple stress kinase pathways and redox-sensitive transcription factors such as Nrf2, NF-kappaB and AP-1, which differentially regulate the genes for pro-inflammatory cytokines as well as the protective antioxidant genes. Understanding the regulatory mechanisms for the induction of antioxidants, such as GSH, versus pro-inflammatory mediators at sites of oxidant-directed injuries may allow for the development of novel therapies which will allow pharmacological manipulation of GSH synthesis during inflammation and oxidative injury. This article features the current knowledge about the role of GSH in redox signaling, GSH biosynthesis and particularly the regulation of transcription factor Nrf2 by GSH and downstream signaling during oxidative stress and inflammation in various pulmonary diseases. We also discussed the current therapeutic clinical trials using GSH and other thiol compounds, such as N-acetyl-l-cysteine, fudosteine, carbocysteine, erdosteine in environment-induced airways disease
Inclusive decays B->DX and B->D*X
No full textComplete Author List: Gibbons L, Johnson SD, Kwon Y, Roberts S, Thorndike EH, Jessop CP, Lingel K, Marsiske H, Perl ML, Schaffner SF, Ugolini D, Wang R, Zhou X, Coan TE, Fadeyev V, Korolkov I, Maravin Y, Narsky I, Shelkov V, Staeck J, Stroynowski R, Volobouev I, Ye J, Artuso M, Efimov A, Frasconi F, Gao M, Goldberg M, He D, Kopp S, Horwitz N, Moneti GC, Mountain R, Mukhin Y, Schuh S, Skwarnicki T, Stone S, Thulasidas M, Viehhauser G, Xing X, Bartelt J, Csorna SE, Jain V, Marka S, Freyberger A, Godang R, Kinoshita K, Lai IC, Pomianowski P, Schrenk S, Bonvicini G, Cinabro D, Greene R, Perera LP, Barish B, Chadha M, Chan S, Eigen G, Miller JS, OGrady C, Schmidtler M, Urheim J, Weinstein AJ, Wurthwein F, Asner DM, Bliss DW, Brower WS, Masek G, Paar HP, Sharma V, Gronberg J, Kutschke R, Lange DJ, Menary S, Morrison RJ, Nelson HN, Nelson TK, Qiao C, Richman JD, Roberts D, Ryd A, Witherell MS, Balest R, Behrens BH, Cho K, Ford WT, Park H, Rankin P, Roy J, Smith JG, Alexander JP, Bebek C, Berger BE, Berkelman K, Bloom K, Cassel DG, Cho HA, Coffman DM, Crowcroft DS, Dickson M, Drell PS, Ecklund KM, Ehrlich R, Elia R, Foland AD, Gaidarev P, Gittelman B, Gray SW, Hartill DL, Heltsley BK, Kandaswamy J, Katayama N, Kim PC, Kreinick DL, Lee T, Liu Y, Ludwig GS, Masui J, Mevissen J, Mistry NB, Ng CR, Nordberg E, Ogg M, Patterson JR, Peterson D, Riley D, Soffer A, Ward C, Athanas M, Avery P, Jones CD, Lohner M, Prescott C, Yang S, Yelton J, Zheng J, Brandenburg G, Briere RA, Gao YS, Kim DYJ, Wilson R, Yamamoto H, Browder TE, Li F, Li Y, Rodriguez JL, Bergfeld T, Eisenstein BI, Ernst J, Gladding GE, Gollin GD, Hans RM, Johnson E, Karliner I, Marsh MA, Palmer M, Selen M, Thaler JJ, Edwards KW, Bellerive A, Janicek R, MacFarlane DB, McLean KW, Patel PM, Sadoff AJ, Ammar R, Baringer P, Bean A, Besson D, Coppage D, Darling C, Davis R, Hancock N, Kotov S, Kravchenko I, Kwak N, Anderson S, Kubota Y, Lattery M, ONeill JJ, Patton S, Poling R, Riehle T, Savinov V, Smith A, Alam MS, Athar SB, Ling Z, Mahmood AH, Severini H, Timm S, Wappler F, Anastassov A, Blinov S, Duboscq JE, Fisher KD, Fujino D, Fulton R, Gan KK, Hart T, Honscheid K, Kagan H, Kass R, Lee J, Spencer MB, Sung M, Undrus A, Wanke R, Wolf A, Zoeller MM, Nemati B, Richichi SJ, Ross WR, Skubic P, Wood M, Bishai M, Fast J, Gerndt E, Hinson JW, Menon N, Miller DH, Shibata EI, Shipsey IPJ, Yurko M</p
The SCUBA half-degree extragalactic survey - I. Survey motivation, design and data processing
No full textThe Submillimetre Common-User Bolometer Array ( SCUBA) Half-Degree Extragalactic Survey ( SHADES) is a major new blank-field extragalactic submillimetre (submm) survey currently underway at the James Clerk Maxwell Telescope (JCMT). Ultimately, SHADES aims to cover half a square degree at 450 and 850 mu m to a 4 sigma depth of similar or equal to 8 mJy at 850 mu m. Two fields are being observed, the Subaru/XMM-Newton Deep Field (SXDF) (02(h)18(m) - 05 degrees.) and the Lockman Hole East (10(h)52(m) + 57 degrees). The survey has three main aims: (i) to investigate the population of high-redshift submm galaxies and the cosmic history of massive dust-enshrouded star formation activity; (ii) to investigate the clustering properties of submm-selected galaxies in order to determine whether these objects could be progenitors of present-day massive ellipticals; and (iii) to investigate the fraction of submm-selected sources that harbour active galactic nuclei. To achieve these aims requires that the submm data be combined with cospatial information spanning the radio-to-X-ray frequency range. Accordingly, SHADES has been designed to benefit from ultra-deep radio imaging obtained with the Very Large Array (VLA), deep mid-infrared observations from the Spitzer Space Telescope, submm mapping by the Balloon-borne Large Aperture Submillimetre Telescope ( BLAST), deep near-infrared imaging with the United Kingdom Infrared Telescope, deep optical imaging with the Subaru Telescope and deep X-ray observations with the XMM-Newton observatory. It is expected that the resulting extensive multiwavelength data set will provide complete photometric redshift information accurate to delta(z) 3 sigma at 850 mu m. Although uncorrected for Eddington bias, this source density is more than sufficient for providing enough sources to answer the science goals of SHADES, once half a square degree is observed. A refined reanalysis of the original 8-mJy survey Lockman hole data was carried out in order to evaluate the new data-reduction pipeline. Of the 17 most secure sources in the original sample, 12 have been reconfirmed, including 10 of the 11 for which radio identifications were previously secured
The safety and effectiveness of different methods of ear wax removal: a systematic review and economic evaluation
No full textEar wax (cerumen) is a natural secretion produced to protect the inner ear from dirt and other fragments by moving these particles towards the outer ear. If this process does not happen properly, wax may build up causing blockage in the ear canal and the possibility of impaction. People with a build up of ear wax may suffer from hearing loss, discomfort and, on occasions, infection. It may present problems in assessing hearing, blocking the view of the ear drum during medical examination and interfering with the fitting or function of hearing aids. Although it is thought to affect between 2% and 6% of the population in the England and Wales, some groups may be at a higher risk, such as those using hearing aids or with small ear canals and/or skin conditions. Recurrence is thought to be high among some of these groups. The consequences of the build up of ear wax in the ear canal are thought to be a common reason for consultation and cost in general practice with over 2 million consultations per year in the NHS.Methods of removal of ear wax include drops, flushing with water in general practice, and removal with suction or probes in specialist clinics. The relative safety and benefits of these different methods of removal remains uncertain. This research will systematically review published and unpublished evidence on the clinical and cost effectiveness of different methods for the removal of ear wax. Where appropriate, it will develop an economic model using data from this systematic review and other relevant sources to estimate the relative costs and benefits of different methods. In addition, the project will provide recommendations for future research to try to help answer any remaining areas of uncertainty
(diamine)(diphosphine) System
No full textThe potential energy surface (PES) of H 2 addition to the Ru=N bond of a model five-coordinate ruthenium amide (Ru=N), leading to an octahedral trans-Ru(H) 2(diamine)(diphosphine) (HRu-NH) and subsequent acetophenone hydrogenation, is studied using M06 density functional theory methods. A qualitative molecular orbital analysis reveals that H 2 addition to the ground state of Ru=N (which has a distorted trigonal-bipyramidal geometry) fits the criterion of a symmetry-forbidden reaction. A transition state (TS) for H 2 heterolytic splitting by Ru=N corresponds to the reaction taking place on an excited state of the Ru=N having a square-pyramidal geometry and gives δG° ∥ = 19.5 kcal-mol. The reaction between HRu-NH and acetophenone proceeds by a localized hydride-transfer TS with δG° ∥ = 11.5 kcal-mol. This TS leads to an ion pair between a square-pyramidal d 6 ruthenium amino cation and the alkoxide and is uphill from the separated reactants by 3.5 kcal-mol. Subsequent abstraction of the amino proton by the alkoxide within the ion pair is barrierless, but it also lacks any thermodynamic driving force. In contrast, reorientation of the alkoxide within the ion pair to form an octahedral ruthenium alkoxide is calculated to be exoergic by 7.1 kcal-mol. These features of the PES suggest that the known rapid production of ruthenium alkoxides when stoichiometric amounts of acetophenone and HRu-NH are reacted at low temperatures proceeds by a simple direct route following hydride transfer. For the simplified model complex, ruthenium alkoxide is calculated to be the thermodynamic product of the hydrogenation reaction (exoergic by 3.6 kcal-mol). 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Studies of dijet transverse momentum balance and pseudorapidity distributions in pPb collisions at √sNN=5.02 TeV
No full textOpen Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the
source are credited. Funded by SCOAP3 / License Version CC BY 4.0.Dijet production has been measured in pPb collisions at a nucleon–nucleon centre-of-mass energy of 5.02 TeV . A data sample corresponding to an integrated luminosity of 35 nb −1 was collected using the Compact Muon Solenoid detector at the Large Hadron Collider. The dijet transverse momentum balance, azimuthal angle correlations, and pseudorapidity distributions are studied as a function of the transverse energy in the forward calorimeters ( E 4<|η|<5.2 T ). For pPb collisions, the dijet transverse momentum ratio and the width of the distribution of dijet azimuthal angle difference are comparable to the same quantities obtained from a simulated pp reference and insensitive to E 4<|η|<5.2 T . In contrast, the mean value of the dijet pseudorapidity is found to change monotonically with increasing E 4<|η|<5.2 T , indicating a correlation between the energy emitted at large pseudorapidity and the longitudinal motion of the dijet frame. The pseudorapidity distribution of the dijet system in minimum bias pPb collisions is compared with next-to-leading-order perturbative QCD predictions obtained from both nucleon and nuclear parton distribution functions, and the data more closely match the latter
Probing color coherence effects in pp collisions at √s = 7 TeV
No full textOpen Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the
source are credited. Funded by SCOAP3 / License Version CC BY 4.0.A study of color coherence effects in pp collisions at a center-of-mass energy of 7TeV is presented. The data used in the analysis were collected in 2010 with the CMS detector at the LHC and correspond to an integrated luminosity of 36 pb-1. Events are selected that contain at least three jets and where the two jets with the largest transverse momentum exhibit a back-to-back topology. The measured angular correlation between the second- and third-leading jet is shown to be sensitive to color coherence effects, and is compared to the predictions of Monte Carlo models with various implementations of color coherence. None of the models describe the data satisfactorily.BMWF and FWF (Austria); FNRS and FWO(Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil);MES
(Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES (Croatia); RPF(Cyprus); MoER, SF0690030s09 and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland);
CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NIH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Republic of
Korea); LAS (Lithuania); CINVESTAV, CONACYT, SEP, andUASLPFAI (Mexico); MBIE (New Zealand); PAEC (Pakistan); MSHE and NSC (Poland); FCT (Portugal); JINR (Dubna); MON, RosAtom, RAS and RFBR(Russia);MESTD (Serbia); SEIDI and CPAN(Spain); Swiss Funding Agencies (Switzerland); NSC (Taipei); ThEPCenter, IPST, STAR and NSTDA (Thailand); TUBITAK and TAEK (Turkey); NASU (Ukraine); STFC (United Kingdom); DOE and NSF (USA)
Measurement of WZ and ZZ production in pp collisions at √s = 8 TeV in final states with b-tagged jets
No full textOpen Access This article is distributed under the terms of the Creative
Commons Attribution License which permits any use, distribution, and
reproduction in any medium, provided the original author(s) and the
source are credited.
Funded by SCOAP3 / License Version CC BY 4.0.Measurements are reported of the WZ and ZZ production cross sections in proton-proton collisions at s √ =8 TeV in final states where one Z boson decays to b-tagged jets. The other gauge boson, either W or Z, is detected through its leptonic decay (either W→eν , μν or Z→e + e − , μ + μ − , or νν ¯ ). The results are based on data corresponding to an integrated luminosity of 18.9 fb −1 collected with the CMS detector at the Large Hadron Collider. The measured cross sections, σ(pp→WZ)=30.7±9.3(stat.)±7.1(syst.)±4.1(th.)±1.0(lum.)pb and σ(pp→ZZ)=6.5±1.7(stat.)±1.0(syst.)±0.9(th.)±0.2(lum.)pb , are consistent with next-to-leading order quantum chromodynamics calculationsBMWF and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil);
MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES and CS (Croatia); RPF (Cyprus); MoER, SF0690030s09 and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF(Germany);GSRT(Greece);OTKAand NIH(Hungary);DAEand DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Republic of Korea); LAS (Lithuania);MOE and UM(Malaysia); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); MBIE (New Zealand); PAEC (Pakistan); MSHE and NSC (Poland); FCT (Portugal); JINR (Dubna); MON, RosAtom, RAS and RFBR (Russia); MESTD (Serbia); SEIDI and CPAN (Spain); Swiss Funding Agencies (Switzerland);
NSC (Taipei); ThEPCenter, IPST, STAR and NSTDA(Thailand); TUBITAK and TAEK (Turkey); NASU and SFFR (Ukraine); STFC (United Kingdom); DOE and NSF (USA)
The impact of illness and the impact of school closure on social contact patterns.
No full textBACKGROUND: Mathematical models, based on data describing normal patterns of social mixing, are used to understand epidemics in order to predict patterns of disease spread and plan interventions and responses. However, individuals who are ill show behavioural changes that affect their social mixing patterns and predictive models should take into account these changes if they are to be effective. OBJECTIVES: To describe and quantify the changes in (1) social contact behaviour experienced by individuals when they are ill with pandemic H1N1 influenza (swine flu) and (2) mixing patterns of school children that take place as a result of swine flu-related school closures. METHODS: For the first part of the study, a self-completed questionnaire-based study was carried out in the autumn/winter of 2009-10. The study population was individuals who had been diagnosed with swine flu and who received a swine flu antiviral prescription from an antiviral distribution centre (ADC). It consisted of an initial survey to be filled in when participants were symptomatic with swine flu and a follow-up survey to be filled in when they had recovered. Each part of the questionnaire had two sections: patient details and a contact diary. The second part of the study was adapted to quantify the difference in mixing patterns of pupils between the school term and the half-term holiday as school closures did not occur during the study period. Eight schools participated and questionnaire packs were distributed to them, containing two surveys: one to be filled in during the school term and one during the spring half-term holiday. RESULTS: For the patient study, approximately 3800 surveys were distributed by 31 ADCs. Overall, 317 responses to the initial survey were received and 179 participants returned the follow-up survey. For all types of a contact, except contacts made at home, there were highly significant differences in contact behaviour (Wilcoxon signed-rank test, p < 0.001). Individuals made substantially fewer contacts when they were ill than when they were well. Analysis showed that returning to work was the most significant predictor of increased numbers of contacts. Also, the greater the change in the number of symptoms reported, the greater the change in the number of contacts. For the school study, approximately 1100 questionnaire packs were distributed and 134 responses were received, with 119 paired contact diaries. Pupils reported on average 18.51 contacts each day during term time and 9.24 during the half-term holiday - a reduction of over 50% and a highly significant change (Wilcoxon signed-rank test, p < 0.0001). CONCLUSIONS: The evidence from this study suggests that ill individuals make substantial changes to their social contact patterns. These changes are strongly linked to absence from work and the severity of the reported illness. Epidemiological modellers should therefore consider the implications of illness-related behavioural changes on model predictions. Future studies to measure the extent of behavioural change in a broader cross-section of infected cases could be valuable, along with more detailed studies of the social contact patterns of school children, focusing on differences between school terms and school holidays
