53,127 research outputs found
THE INVESTIGATION OF GENE POLYMORPHISM β2 - ADRENOCEPTORS IN CHILDREN WITH BRONCHIAL ASTHMA
Get PDFBanadyha N. V., Voloshyn S. B. The investigation of gene polymorphism β2 - adrenoceptors in children with bronchial asthma. Journal of Education, Health and Sport. 2015;5(12):417-423. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.35565
http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2812%29%3A417-423
http://pbn.nauka.gov.pl/works/683080
Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive
Deklaracja.
Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.
Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).
© The Author (s) 2015;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 10.11.2015. Revised 15.12.2015. Accepted: 17.12.2015.
THE INVESTIGATION OF GENE POLYMORPHISM
β2 - ADRENOCEPTORS IN CHILDREN WITH BRONCHIAL ASTHMA
N. V. Banadyha, S. B. Voloshyn
Department of Pediatrics of Education-Research Instituteof Postgraduate training of the I.Ya. Horbachevsky Ternopil State Medical University, Ternopil, Ukraine
Abstract
Given the importance of genetic factors in causing bronchial asthma (BA), should be noted that according to some researchers it stands on the importance of the role of adverse environmental factors and a lifestyle. Genetic factors contribute to human health by 40%, in the case of BA - in 60% of cases it is due to hereditary.
Objective: to analyze the frequency of polymorphic loci associations rs 1042713 (Arg16Gly) of ADRβ2 gene in children with BA.
Materials and Methods. In-depth clinical examination using the special methods of investigation, conducted to 62 children suffering from BA, older than 5 years.
The results of investigation. As a result of depth collection of anamnesis, it was revealed that in 73,68% of patients the anamnesis was unburdened. Mostly the family inheritance depends on mother health (57,14%), regardless of the severity of BA. Іt was found that in both types of inheritance (paternal and maternal) dominated genotype Arg16Gly (respectively: 58,33% and 60,00%). However, genotype Arg16Arg was observed in individual patients and in the case of intermittent disease. In case of allergen-induced and virus-induced phenotypes the genotype Arg16Gly (respectively: 44,70%; 58,30%) was more often diagnosed. Among the examined patients, BA manifested at the early age in 18 children (33,96%) in preschool age in 17 children (32,08%), and in a primary school in 18 children (33,96%). The early debut of disease associated with genotype Arg16Gly manifested at the early age in 66,67% of children and in preschool age – in 58,82%, while late manifestation observed in children with genotype Gly16Gly. It was clarified that intermittent flow associated with two genotypes: Arg16Gly (47,37%) and Gly16Gly (42,11%) The persistent mild course of BA replied to genotype Gly16Gly (64,71%), but with moderate persistent - to Arg16Gly (57,69%). Found that girls often associated with asthma genotype Gly16Gly (56,52%) and Arg16Gly (39,13%) while the boys with genotype Arg16Gly (53,84%), less with Gly16Gly (38,89%).
Conclusions. When treating the patient, the established differences in allele polymorphisms gene ADRβ2, regarding the age and gender, should be taken into account.
Keywords: children, bronchial asthma, β2 – adrenoceptors, polymorphism of the gene
Scientometric Portrait of Nobel Laureate S. Chandrasekhar
Get PDFScientometric analysis of the publications productivity of Nobel Laureate S. Chandrasekhar is documented
Observations of Bºs→ψ(2S)η and Bº(s)→ψ(2S)π+π- decays
Get PDFFirst observations of the B0s
→ψ(2S)η, B0 →ψ(2S)π
+
π
− and B0s
→ψ(2S)π
+
π
− decays are made
using a dataset corresponding to an integrated luminosity of 1.0 fb−1 collected by the LHCb experiment in
proton–proton collisions at a centre-of-mass energy of
√
s = 7 TeV. The ratios of the branching fractions
of each of the ψ(2S) modes with respect to the corresponding J/ψ decays are
B(B0s
→ψ(2S)η)
÷
B(B0s
→J/ψη)
= 0.83± 0.14 (stat)±0.12 (syst) ±0.02 (B),
;
B(B0→ψ(2S)π
+
π
−
)
÷
B(B0→J/ψπ
+
π
−
)
= 0.56± 0.07 (stat)±0.05 (syst)± 0.01 (B),
;
B(B0s
→ψ(2S)π
+
π
−
)
÷
B(B0s
→J/ψπ
+
π
−
)
= 0.34± 0.04 (stat)±0.03 (syst)± 0.01 (B),
where the third uncertainty corresponds to the uncertainties of the dilepton branching fractions of the J/ψ
and ψ(2S) meson decays
Mýty a realita v procese s J. A. Baťom
No full textThe author of this paper deals with the retribution trial proceeding with J. A. Baťa, in 1947 at the National Court in Prague. Especially in recent years, questions related to this process raise again. There are many hypotheses that try to prove respectively point out the injustice and the political background of this case. Author argues against the violation of fundamental rights in criminal proceedings, procedural errors and predetermined and targeted punishment. The author looked at some of the most resonating hypothesis and tried to confirm or disprove its validity.Autorka sa v príspevku zaoberá retribučným procesom s J. A. Baťom, ktorý prebiehal v roku 1947 pred Národným súdom v Prahe. Najmä v posledných rokoch sa opäť vynárajú otázky, ktoré sa uvedeného procesu týkajú. Existuje veľké množstvo hypotéz, ktoré sa snažia dokázať resp. poukázať na nespravodlivosť a na politické pozadie konania. Polemizujú s porušovaním základných práv v trestnom konaní, s procesnými chybami a s vopred určeným a cieleným trestom. Autorka sa zamerala na niektoré, najviac rezonujúce hypotézy a snažila sa potvrdiť, či vyvrátiť ich správnosť
Interactive assistance support for university applicants
No full textThe bachelor's thesis is focused on the implementation of the project of interactive assistance support for applicants and students at the University of Economics. The main goal of this work is the design and implementation of a chatbot that could aid users in finding information about the study. An analysis of the professional literature and acquaintance of the reader with the issue of chatbot is performed to fulfill the set goals. Subsequently, an analysis of the market for tools for chatbot implementation and qualitative research was performed. At the application design stage, all the requirements for chatbot and the programming languages used were defined. The final part of the work was devoted to the implementation of the application and testing of functionality, in which the author concluded that the chatbot meets the specified requirements.Bakalářská práce je zaměřena na realizaci projektu interaktivní asistenční podpora pro uchazeče o studium a studenty na Vysoké Škole Ekonomické. Hlavním cílem práce je návrh a implementace chatbota, který by dokázal poskytnou pomoc uživatelům ve vyhledávání informací týkající studia. Pro naplnění stanovených cílů je provedená analýza odborné literatury a seznámení čtenáře s problematikou chatbota. Následné byla provedená analýza trhu nástrojů pro implementaci chatbota a kvalitativní výzkum. Na etapu návrhu aplikace byli definování veškeré požadavky kladené na chatbota a použité programovací jazyky. Finální část práce byla věnovaná samotné implementaci aplikace a testování funckionality, při kterém autor dospěl k závěru, že chatbot odpovídá stanoveným požadavkům
The Worldview and the Author´s (Self)Reflection in Czech Contemporary Historiography
No full textCílem studie je představit možnosti, jak na základě publikovaných autorských textů zkoumat světový názor historiků a historiček, zejména v oboru soudobých dějin, kde lze předpokládat vliv jejich hodnotového horizontu na interpretaci relativně nedávné minulosti. Autor nejprve vymezuje pojetí světového názoru vzhledem ke stanovenému záměru a zdůvodňuje analytické užití tohoto pojmu v historiografickém textu, v daném kontextu se také zamýšlí nad vztahem paměti, dějin a historiografie. Konstatuje, že poměrně málo českých historiků a historiček dosud reflektuje vztah (individuální či kolektivní) paměti a práce dějepisce, zvláště s ohledem na jeho pozici v současné společnosti, která bývá často redukována na roli objektivního „objevitele historické pravdy“. Taková (sebe)reflexe předpokládá přiznání vlivu individuálního světového názoru historika (komplexu názorů a postojů formovaných výchovou, vzděláním, vzpomínkami, generační příslušností a podobně) na jeho vědeckou činnost. Autor studie nabízí dvě možné a vzájemně se doplňující cesty k poznání historikova světového názoru: jednak prostřednictvím vlastních svědectví a prohlášení z jeho osobněji laděných textů a egodokumentů (eseje, rozhovory, vzpomínky, příspěvky na sociálních sítích), jednak analýzou jeho vědeckých textů (časopiseckých studií, knižních monografií, recenzí). Oba přístupy autor dokumentuje na konkrétních příkladech z produkce historiků a historiček českých soudobých dějin. V závěru studie pak nastiňuje cíle a smysl zkoumání historikova světového názoru.The aim of this study is to present the opportunities for research into the worldview of historians, especially historians focused on contemporary history, where it can be assumed that their set of values may influence their interpretation of the rela-tively recent past. The author first defines the notion of worldview and justifies the analytical use of this concept in historiographical texts. He also considers the relationship between memory, history and historiography in the given context. The author states that not many Czech historians have so far reflected on the relationship between (individual and collective) memory and the work of the historian, especially with regard to his or her position in contemporary society, which is often reduced to the role of an objective “discoverer of historical truth”. Such (self)reflection presupposes the acknowledgement of the influence of the historian’s individual worldview (a complex of opinions and attitudes shaped by upbringing, education, memories, generational affiliation and so on) on his or her scholarly activity. The author of the study offers two possible and complementary ways to learn about the historian’s worldview: first, through his or her own testimonies and statements from more personal texts and ego-documents (essays, interviews, memoirs or social me-dia posts), and second, through the analysis of his or her scholarly texts (journal studies, monographs and book reviews). The author demonstrates both approaches with concrete examples of works by historians of Czech contemporary history and concludes by outlining the aims and purpose of examining the historian’s worldview. © 2022, Institute of Contemporary History of the Czech Academy of Sciences. All rights reserved
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
with regard to author´s performance
No full textBakalářská práce na téma Porovnání inscenací Kouzelné flétny s přihlédnutím na své účinkování se soustředí na komparativní analýzu dvou různých zpracování Kouzelné flétny v režii Davida Radoka a Vladimíra Morávka ve Stavovském divadle v Praze. Práce představuje skladatele Wolfganga Amadea Mozarta, jeho život a dílo, dále pak libretistu Emanuela Schikanedera a okolnosti vzniku opery, a nakonec vlastní komparaci inscenací. Nejprve je vedle sebe postaveno celkové pojetí inscenací, poté jednotlivé divadelní složky – scéna, kostýmy, hudební nastudování, jazyk, taneční soubor a práce s režiséry. Přínosem je v první řadě skutečnost, že analýza tohoto rozsahu dosud nebyla provedena, ale také osobní angažovanost autorky, která vystupovala v obou inscenacích a může tak nabídnout cenné zkušenosti obohacené o osobní výpověď dirigentů a ostatních účinkujících.The bachelor thesis on Comparison of productions of The Magic Flute with regard to author´s performance focuses on a comparative analysis of two different adaptations of The Magic Flute directed by David Radok and Vladimír Morávek at the Estates Theatre in Prague. The thesis introduces the composer Wolfgang Amadeus Mozart, his life and work, then the librettist Emanuel Schikaneder and the circumstances of the opera's creation, and finally the actual comparison of the productions. Firstly the overall concept of the productions is juxtaposed, then the individual theatrical components – scene, costumes, musical staging, language, dance ensemble and work with the directors. The contribution is firstly the fact that an analysis on this scale has not been made before, and secondly the personal involvement of the author, who has performed in both productions and can thus offer valuable experience enriched by the personal testimony of the conductors and other performers.
Healthcare associated infection after legal induced abortions in ukraine: results a multicenter study
Get PDFHealthcare associated infection after legal induced abortions in ukraine: results a multicenter study / A. G. Salmanov, S. M. Baksheev, D. V. Kuflovskyi, L. V. Manzhula, O. A. Voloshyn, S. M. Korniyenko, O. I. Tsyhanenko // Wiadomości Lekarskie. – 2021. – Vol. 74(7). – P.1559-1565.The aim: To determine trend of legal induced surgical abortion and to assess the frequency of infection complications after termination of pregnancy in Ukraine. Materials and methods: We conducted a prospective multicentre cohort study was based on surveillance data of healthcare-associated infection (HAI) after legal induced surgical abortion in women’s from January 2017 to 2019 in Ukraine. Definitions of HAI after induced abortion were used from the CDC/ NHSN.
Results: The number of surgical abortions in Ukraine increased by 32.8%. A total of 25.9% HAIs were identified after surgical abortion. Of these HAIs, 25.9 were Endometritis, 21.8% Bacterial Vaginitis, 14.3% Parametritis, 13.1% Cervicitis, 9.9% Adnexa utery, 7.8% Salpingitis, 6.3% Chorioamnionitis, and 0.9% other reproductive tract infections. E.coli were most commonly reported, accounting for 25.9% of all organisms, followed by Enterococcus spp. (16.2%), Staphylococcus aureus (15.5%), P. aeruginosa (10.9%), and Enterobacter spp. (10.1%). Antimicrobial resistance in the isolates associated with HAIs showed, among the gram-positive bacteria, that 19.1% and 3.6% of coagulase-negative staphylococci isolates were b-lactam (oxacillin) − and glycopeptide-resistant, respectively. Meticillin resistance was reported in 23.2% of S aureus isolates. Vancomycin resistance was reported in 3.7% of isolated enterococci. Among the gram-negative bacteria, third-generation cephalosporins resistance was found in 33.1% of Klebsiella spp and in 24.1% of E.coli isolates.
Conclusions: The results of this study revealed high rates of HAIs after surgical abortion and most causing pathogens were associated with resistant to antibiotic strains. This knowledge is essential to develop targeted strategies to surveillance and reduce the incidence of post-abortion infections
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