13 research outputs found
Insidensi dan Faktor Risiko Hipotensi pada Pasien yang Menjalani Seksio Sesarea dengan Anestesi Spinal di Rumah Sakit Dr. Hasan Sadikin Bandung
No full textThe most common serious complication associated with spinal anesthesia for C-section is hypotension. These hemodynamic changes result from a blockade of sympathetic vasomotor activity that is accentuated by the compression of the aorta and inferior vena cava by the gravid uterus when the patient is in the supine position. The purpose of this study was to describe the incidence of hypotension in patients undergoing cesarean section with spinal anesthesia in Dr. Hasan Sadikin General Hospital Bandung and to obtain a description of risk factors associated with the incidence of hypotension. A cross–sectional observational study was conducted on 90 subjects consisting of patients undergoing cesarean section with spinal anesthesia during the period of April–May 2015. The data processing performed was the univariable analysis to see the picture of the proportion of each variable, which were presented descriptively. The results showed 49% incidence of hypotension. There was an insignificant association between the risk factors of maternal hypotension after spinal anesthesia for cesarean section insignificant association with the incidence of hypotension (p>0.05). Differences in the incidence of maternal hypotension after spinal anesthesia and risk factors as stated in this study when compared to previous studies are due to differences sample size, definitions, place, and data collection methods
Perbandingan Nilai APGAR Bayi yang Lahir melalui Sectio Caesarea dengan Anestesia umum dan Anestesia Spinal dari Ibu Eklampsia di RSUP Dr. M. Djamil Padang
No full textPemilihan anestesia yang digunakan untuk pasien eklampsia masih menjadi kontroversi. Teknik anestesia spinal atau anestesia umum pada seksio sesarea dapat menpengaruhi luaran neonatus. Tujuan: Membandingkan nilai APGAR neonatus yang lahir melalui sectio caesarea antara anestesia umum dan anestesia spinal pada ibu eklampsia. Metode: Jenis penelitian ini adalah analitik dengan desain cross sectional. Sampel adalah 63 pasien yang dibagi menjadi dua kelompok, yaitu kelompok yang mendapat anestesia spinal sebanyak 30 dan anestesia umum sebanyak 33. Data diperoleh dari rekam medik RSUP Dr. M. Djamil Padang periode Januari 2015 sampai Desember 2018. Data dianalisis dengan uji Kolmogorov-Smirnov. Hasil: Pada menit pertama asfiksia (APGAR1<7) terjadi pada 12 (40%) neonatus kelompok spinal dan 32 (97%) neonatus kelompok umum. Sementara itu, pada menit kelima asfikasia (APGAR5<7) terjadi pada 5 (16,7%) neonatus kelompok spinal dan 18 (54,5%) neonatus kelompok umum. Terdapat perbedaan nilai APGAR yang bermakna dengan nilai p<0,01 pada menit pertama dan p=0,02 pada menit kelima (p<0,05). Simpulan: Penggunaan anestesia spinal untuk sectio caesarea pada ibu eklampsia memberikan luaran nilai APGAR yang lebih baik dibandingkan dengan penggunaan anestesia umum
Analisis Konsep Sejarah Masa Penjajahan Bangsa Eropa pada Siswa Sekolah Dasar
No full textThis article discusses the analysis of the concept of historical material during the European colonial period for elementary school students. It aims to analyze the concept of historical material during the European colonial period in elementary schools that is in accordance with the level of understanding of elementary level students. In compiling this article, the author collected data using quantitative methods. From the findings of the concept of historical material during the European colonial period for elementary school students, starting from exploring the ocean to look for spices to the arrival of Europeans to Indonesia to get spices. However, over time these Europeans began to arbitrarily occupy the government in Indonesia and make the Indonesian people miserable
Pengaruh Ekstrak Etanol Daun Sungkai (Penorema canescens jack) terhadap Apoptosis Sel HeLa
No full textPENGARUH EKSTRAK ETANOL DAUN SUNGKAI (PENOREMA CANESCENS JACK) TERHADAP APOPTOSIS SEL HeLa
Oleh
Rizka Farahiya, Dessy Arisanty, Hirowati Ali, Arni Amir, Rini Rustini, Julizar
Kanker serviks adalah kanker yang berasal dari serviks yang merupakan penyebab kematian nomor 4 karena kanker di dunia. Penyakit ini disebabkan oleh pertumbuhan sel yang tidak normal yang memiliki kemampuan berproliferasi abnormal dan menyebar ke bagian tubuh lain. Kanker serviks dapat ditatalaksana dengan histerektomi, radiasi, kemoterapi, dan terapi kombinasi. Akan tetapi, terapi kanker serviks dengan beberapa metode ini memiliki efek samping yang buruk pada tubuh. Efek samping dan risiko dari metode terapi tersebut, dapat dikurangi dengan pengobatan alternatif. Salah satu pengobatan alternatif tersebut adalah dengan menggunakan ekstrak etanol daun sungkai. Penelitian ini menggunakan ekstrak etanol daun sungkai untuk menginduksi apoptosis pada sel HeLa.
Penelitian ini merupakan penelitian eksperimental dengan menggunakan 28 well sel HeLa yang konfluens. Sampel dibagi menjadi 4 kelompok perlakuan (K, P1, P2, dan P3). Sel HeLa yang telah konfluens diberikan ekstrak etanol daun sungkai dengan konsentrasi IC25, IC50, IC75 dan diinkubasi selama 24 jam. Setelah diinkubasi, dilakukan pewarnaan dengan menggunakan Acridine Orange dan Propidium Iodide. Hasil penelitian kemudian dianalisis dengan menggunakan One Way Annova dan Pos Hoc Bonferroni.
Pada penelitian ini diperoleh rerata persentase sel yang mengalami apoptosis pada kelompok K, P1, P2, dan P3 berturut-turut 3,17; 5,12; 49,80; dan 75,62. Dari hasil uji statistik didapatkan perbedaan yang bermakna antara kelompok K, P2, dan P3 dengan nilai p = 0,000 (p<0,05). Akan tetapi, pada kelompok P1 dengan kelompok kontrol tidak terdapat perbedaan.
Pada penelitian ini dapat disimpulkan bahwa pemberian ekstrak etanol daun sungkai pada sel HeLa dengan dosis yang bervariasi dapat menginduksi apoptosis sel HeLa. Terjadinya peningkatan apoptosis sel HeLa seiring dengan peningkatan konsentrasi dosis ekstrak daun sungkai yang diberikan.
Kata Kunci: Ekstrak Etanol Daun Sungkai, Apoptosis, Sel HeLa, Penorema canescens jac
Perkembangan Pendidikan IPS di Indonesia pada Tingkat Sekolah Dasar
No full textSocial Sciences Education is a study of the social sciences and humanities that aims to improve citizens' abilities. The social studies disciplines in Indonesia are aimed at helping students gain information, awareness, and analytical skills regarding a society's social conditions as they prepare to enter a dynamic society. The foundation of social studies is reality and social phenomena, which are achieved through an interdisciplinary approach from many social science areas. Over time, social studies education in elementary schools has undergone various developments and curriculum changes. In Indonesia, social science education was introduced in 1975 and used the 1975–2006 curriculum. With the materials separately, the development and renewal of the curriculum took place so as to create the 2013 curriculum, which packs social studies education materials in an integrated manner. These changes and developments aim to improve the quality of Indonesian education and create students who can think critically in order to meet the challenges of the times so that they can compete globally. The author collects data through a literature review in order to write this scientific essay. It is intended that by writing this article, the author will be able to describe the evolution of social studies education in Indonesia at the primary school level, as well as the advantages of the many curricula utilized
INTRODUCTION TO MICROCONTROLLER AND PLC TO IMPROVE MINIMAL COMPETENCY ASSESSMENT LOGIC ABILITY STUDENTS OF SMAN 1 LUMAJANG
No full textThe Minimum Competency Assessment is one of the national assessments used in 2021 by the Ministry of Education and Culture to replace the high school level national exam. It focuses on measuring literacy and numeric skills through students' logical abilities and reading comprehension. To trigger an increase in logic skills, SMAN 1 Lumajang students are given additional knowledge outside the curriculum. One of them is through the introduction of microcontrollers and PLCs, namely logic-based programming devices. This activity is also able to increase digital, technological and human literacy competencies in the era of the industrial revolution 4.0 because Microcontrollers and PLCs are widely used in the field of industrial automation. From the implementation of the activity it is known that the results of the participants' quizzes on each subject matter showed very satisfactory results with an average score of 76 and the results of the participants' tests at the end of the lesson also showed satisfactory results with an average score. out of 74. In addition, the results of the participant questionnaire in response to the implementation of the activity showed very good results. With these activities, the microcontroller and PLC can be used as one of the extracurricular activities to improve the competence of SMAN 1 Lumajang students
Perbandingan Lama Rawatan Pasien Sectio Caesarea Metode ERACS dengan Metode Konvensional di RSIA Restu Ibu Padang
No full textLatar Belakang. Angka sectio caesarea yang mengalami peningkatan dari tahun ke tahun mendorong banyaknya potensi yang timbul untuk mengembangkan pelayanan, salah satunya dari aspek kecepatan pemulihan yang ditawarkan metode ERACS (Enhanced Recovery After Caesarean Surgery). Metode ERACS memiliki beberapa perbedaan dari metode konvensional, dan menurut penelitian terdahulu, metode ERACS menunjukan lebih banyak keunggulan yang dapat menguntungkan pasien, salah satunya dari segi lama rawatan.
Objektif. Mengetahui perbandingan lama rawatan pasien sectio caesarea metode ERACS dengan metode konvensional di RSIA Restu Ibu Padang.
Metode. Jenis penelitian ini adalah analitik observasional dengan desain kohort. Data diambil secara retrospektif dari rekam medik pasien sectio caesarea di RSIA Restu Ibu periode November-Desember 2021. Sampel berjumlah 67 pasien yang dipilih menggunakan total samplingberdasarkan kriteria inklusi dan eksklusi.
Hasil. Frekuensi lama rawatan paling tinggi pada pasien sectio caesarea dengan metode konvensional adalah lebih dari atau sama dengan 3 hari, sedangkan lama rawatan pada metode ERACS menunjukan paling banyak pasien dirawat selama 2 hari. Hasil analisis dengan uji Chi-square pada perbandingan lama rawatan antara metode ERACS dengan metode konvensional di rumah sakit tempat penelitian menunjukan nilai p=0,002.
Kesimpulan. Kesimpulan dari penelitian ini adalah terdapat hubungan yang signifikan (p<0,05) dari perbandingan lama rawatan antara metode ERACS dengan metode konvensional di RSIA Restu Ibu Padang
The Burn Wound Healing Process : A Review
No full textBurn wounds are a serious injury that can lead to significant morbidity and mortality. The burn wound healing process is a complex and dynamic process that involves a number of different cellular and molecular events. The three main stages of burn wound healing are inflammation, proliferation, and remodeling. Inflammation is the first stage of burn wound healing. During this phase, white blood cells (WBCs) and other immune cells are recruited to the wound site to remove dead tissue and bacteria. The inflammatory response also produces a number of growth factors that stimulate the growth of new tissue. The proliferative phase of burn wound healing begins about 3-4 days after the injury. During this phase, new blood vessels, connective tissue, and epithelial cells are formed. The epithelial cells eventually form a new layer of skin over the wound. The remodeling phase of burn wound healing begins about 2 weeks after the injury and can last for months or even years. During this phase, the new tissue is reorganized and remodeled. The scar tissue that forms during this phase is usually thicker and less elastic than the original skin. The healing of burn wounds can be affected by a number of factors, including the size and depth of the burn, the patient's age and overall health, and the presence of infection. Complications of burn wound healing can include infection, sepsis, and death. The latest advances in burn wound treatment include the use of skin grafts, growth factors, and artificial skin substitutes. These advances have improved the healing of burn wounds and reduced the risk of complications
Characterization of 18S Ribosomal RNA Fragment from Solanum tuberosum Var. Granola Potato
No full textPotato (Solanum tuberosum L.) is a prime horticultural commodity. One of the varieties of potato that widely cultivated in Indonesia is Granola. This study characterized the variety Granola based on the 18S sequences of rRNA gene fragment. The 18S sequences were used to distinguish the Granola and determine the differentiating characters from other Solanum based on those sequences data. The characterization was completed in three main steps including DNA isolation from potato leaf using Doyle & Doyle method, amplification of the 18S gene fragment, and DNA sequencing. The amplification of 18S gene fragment by a PCR method obtained 528 bp sequences. The BLAST search using NCBI web service confirmed that Granola potato has 99% matching sequence with S. tuberosum. The phylogenetic reconstruction further indicates the S. tuberosum var. Granola used in this study deeply nested with the reference sequence X67238.1, a potato from Europe. KEY WORDS: Granola, 18S rRNA, phylogenetic, Solanum tuberosum L.
Corresponding author: HERMIN PANCASAKTI KUSUMANINGRUM | [email protected] Submitted: 09-01-2018 | Accepted: 22-02-201
A Promising Ultra-Small Unilamellar Carrier System for Enhanced Skin Delivery of α-Mangostin as an Anti-Age-Spot Serum
No full textIf it can be effectively delivered to its site of action, α-mangostin has potential in development of novel cosmeceuticals due to its melanogenesis-blocking activity. The aim of this study was to develop an ultra-small unilamellar carrier system for α-mangostin and to evaluate its effect as an anti-age-spot serum on humans in vivo. The ultra-small unilamellar carrier bases were optimized using a 25 factorial design, with five factors (virgin coconut oil, soy lecithin, Tween 80, and stirring duration and speed) and two levels (low and high); response of droplet size was analyzed using Design Expert 12®. The anti-spot examination was conducted via capturing digital images of the human skin after topical application of an α-mangostin-loaded ultra-small unilamellar carrier at night for two consecutive weeks. The results thereof were analyzed using Motic Live Imaging 3.0 and a standard red, green, and blue score. The optimized serum formula was confirmed with a composition of 2.3% virgin coconut oil, 1% lecithin, and 28.3% Tween 80 (polysorbate 80) at a stirring speed of 1500 revolutions per minute for 15 min. Incorporation of 3% α-mangostin to the optimized base formula produced an ultra-small unilamellar carrier globule size of 16.5 nm, with zeta potential of −25.8 mV and a polydispersion index of 0.445. Physical characterization of an α-mangostin-loaded ultra-small unilamellar carrier comprised 90.94% transmittance, a pH value of 6.5, a viscosity of 38 cP, specific gravity of 1.042 g/mL and 72.46% entrapment efficiency. A transmission electron microscope confirmed spherical nanosized droplets in the system. Topical application of an α-mangostin-loaded ultra-small unilamellar carrier at night for 2 consecutive weeks demonstrated anti-age-spot activity shown through a significant reduction in intensity and area of spots in human volunteers (p < 0.05)
