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Formulation and Development of Clinically Relevant Drugs
Get PDFThis dissertation makes contributions to the fields of anticancer drug formulation, synthesis and applications of nanoparticle adjuvants, and structure-activity relationships in drug discovery. Many drugs that are promising clinical candidates are potent in vitro, however their solubility and pharmacokinetic properties are suboptimal. Here we used various nano-formulations, primarily mesoporous silica nanoparticles, to improve the solubility and release properties of these drugs. In vivo results show that these nanoparticles are safe, multifunctional carriers that can be used for clinical imaging using positron emission tomography. In the second part of this work, porous aluminum oxide nanoparticles were synthesized for applications as immunological adjuvants, and polymer-coated mesoporous silica nanoparticles were used to deliver cyclic dinucleotides to stimulate the innate immune response. Lastly, UV-Vis spectroscopic assays were developed and used to understand how electronic properties of iron-binding heterocyclic thiosemicarbazone analogs are related to their inhibition of ribonucleotide reductase, an important target for cancer therapy. The structure-activity relationships that were discovered led to a promising drug scaffold for the treatment of cancers sensitive to nucleotide deprivation
Operator's manual for SHEBA powered tether balloon system
Get PDFApril 1998.The Surface Heat and Energy Budget of the Arctic (SHEBA) was an intensive field project which took place in the Arctic Ocean from October 1997 through October 1998. Its purpose was to measure as many facets of the Arctic environment as possible so that we would be able to better understand the interaction between the ice, atmosphere, and ocean and their interactions with global climate. One aspect of the atmospheric field component was launching tethered balloons to monitor the profiles of temperature, wind, pressure, and humidity, as well as examine the vertical structure of cloud droplet sizes and distributions. The tethered balloon that we used was one specially designed for use in freezing climates by SPEC Corporation in Boulder, Colorado. A special winch that was able to withstand Arctic temperature and weather became necessary when the testing of simple winch systems used in warmer climates failed under these extreme conditions. The purpose of this manual is to acquaint any new user to the powered tethered balloon system deployed at the Surface Heat and Energy Budget of the Arctic (SHEBA) ice camp. It includes a description of the preparations necessary to get ready for a launch, the mechanics of the actual launch, and an account of the proper procedure for taking down the equipment when finished. It will also include tips on how to minimize potential equipment failures, some trouble shooting, and some safety ideas. This manual is designed so that new operators can use the system with minimal previous training. At the end of this manual, the reader will find a quick checklist.Sponsored by the National Science Foundation under grant number OPP-9504246; and the National Aeronautics & Space Administration under grant numbers NAG1-2081 and NAG1-1701
A queen in many guises : The depiction of the Queen of Sheba in the role as “the other”
No full textThe aim of this essay is to examine how the biblical Queen of Sheba has been depicted in a selection of artworks. The main focus is on how her otherness has been visualized, in relation to King Solomon in particular but also to the Western, European, christian and white self-image at large. The material that has been analyzed comprises the following artworks: Solomon and the Queen of Sheba by Nicholas of Verdun (1181), Procession of the Queen of Sheba; Meeting between the Queen of Sheba and King Solomon by Piero della Francesca (ca 1452-1466), The Visit of the Queen of Sheba to King Solomon by Lavinia Fontana (1599) and The Visit of the Queen of Sheba to King Solomon by Edward Poynter (1890). In examining the artworks Erwin Panofsky's three- step analysis model has been applied in combination with a theoretical framework consisting of postcolonial studies and critical white theories. The results show that the Queen of Sheba has been depicted in a variety of ways. In the artwork by Nicholas of Verdun, the Queen is black, carrying the symbolic notion of sin; in Piero and Fontanas artworks she is depicted as white. In Piero's depiction, only small signals, such as clothes, marks her status as “the other”, in Fontanas case, her signs of otherness seem in contrast completely absent. Poynters artwork contains a spectacular display of exotic elements and the Queen has been given a sensual appearance in line with the image of the erotic Orient. One conclusion that the author reaches is that, as Edward Said has argued, in attempting to represent “the other” the Occident documents itself. This is also similar to how the dichotomy between black and white is constructed and how whiteness in relation to black individuals in these pictures gathers its strength and is, rather than being neutral, imbued with meaning.
That thing we call a heart
No full text"This young adult novel by Sheba Karim, author of Skunk Girl, is a funny and affecting coming-of-age story for fans of Jenny Han, Megan McCafferty, and Sara Farizan. Shabnam Qureshi is facing a summer of loneliness and boredom until she meets Jamie, who scores her a job at his aunt's pie shack. Shabnam quickly finds herself in love, while her former best friend, Farah, who Shabnam has begun to reconnect with, finds Jamie worrying. In her quest to figure out who she really is and what she really wants, Shabnam looks for help in an unexpected place--her family, and her father's beloved Urdu poetry. That Thing We Call a Heart is a funny and fresh story about the importance of love - in all its forms."--AmazonHigh school has ended, and Shabnam Qureshi is facing a summer of loneliness and boredom. She's felt alienated from her gutsy best friend, Farah, ever since Farah started wearing the Muslim head scarf -- without even bothering to discuss it with Shabnam first. But no one else comes close to understanding her, especially not her parents. All Shabnam wants to do is get through the summer. Get to Penn. Begin anew. Not look back. That is, until she meets Jamie... In her quest to figure out who she really is and what she really wants, Shabnam looks for help in an unexpected place -- her famil
Book Review: \u3ci\u3eArabia Felix: From the Time of the Queen of Sheba (Eighth Century B.C. to the First Century A. D.)\u3c/i\u3e
No full textArabia Felix is a book about Sheba, “modern Yemen” with added highlights on the broader region of Arabia. The author gives an in-depth analysis on how Arabia captured the attention of ancient empires. Arabia also conducted rich trade with her contemporary civilizations such as the Egyptians, Assyrians, and Persians who “encountered caravans of aromatic products coming from South Arabia.
The Story of David and Bat Sheba According to Rabbinic Literature
Get PDFAutor uz pomoć rabinske literature analizira jednu od najzanimljivijih pripovijesti iz Biblije, onu o kralju Davidu i Bat-Šebi. Kralj David bio je vladar, duhovni vođa, pjesnik koji je spjevao Psalme, velik poznavatelj Tore, začetnik židovske kraljevske dinastije, a prema židovskoj tradiciji, jedan od njegovih potomaka bit će čak i Mesija. No, prema biblijskoj pripovijesti, očito je da je David teško griješio, počinivši grijeh preljuba i umorstva nedužna čovjeka. Takvi grijesi ne odgovaraju slici koju imamo o njemu. Rad nastoji na temelju rabinske literature objasniti što se zapravo dogodilo u ovoj pripovijesti. Je li kralj David doista tako sagriješio? Nakon uvoda slijedi biblijska pripovijest, a potom tumačenje Mudraca o vezi kralja Davida i Bat-Šebe te rasprava o odnosu Urije i Bat-Šebe i o pitanju preljuba. Slijedi analiza grijeha i kazne te raznih pitanja koja nastaju kao posljedica toga grijeha. U svom istraživanju autor se služi raznovrsnim izvorima rabinske književnosti, koji su nastajali od vremena Talmuda, preko srednjega vijeka sve do modernih vremena. Velik dio te literature prvi se put ovdje objavljuje u autorovu prijevodu s hebrejskoga i aramejskog jezika na hrvatski jezik.In this article the author analyses one of the most interesting stories in the Bible, the affair of King David and Bat-Sheba according to sources from rabbinic literature. King David was a king, a spiritual lider, composer of Psalms, a great Torah scholar, the progenitor of the Jewish kingly dynasty and, according to the Jewish tradition, even the Messiah is supposed to be his descendant. However, according to the biblical story, David sinned severely. He committed sins of adultery and murder of an innocent, sins that don’t fit his image. The main task of this work is to explain, based on rabbinic literature, what exactly happened. Did king David fall from heavenly hights into a deep pit? The first part of the article consists of a general introduction, followed by a review of the biblical episode. The central part of this article is the Sages’ interpretation of king David and Bat Sheba affair, discussing the relationship between Uriah and Bat Sheba and the question of the adultery, followed by an analysis of the sin and punishment and various questions it raises. The author uses many sources from the rabbinical literature since Talmudic times through the middle Ages until modern times. Much of this literature is translated into Croatian from Hebrew and Aramaic for the first time by the author
DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
Get PDFSingle Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be
associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose
polymerase), and both BRCA1 and BRCA2. In the present study, we have performed a comprehensive analysis of 18 genes involved in BER using a tagging SNP approach in a large series of BRCA1 and BRCA2 mutation carriers. 144 SNPs were analyzed in a two stage study involving 23,463 carriers from the CIMBA consortium (the Consortium of Investigators of Modifiers of BRCA1 and BRCA2). Eleven SNPs showed evidence of association with breast and/or ovarian cancer at p,0.05 in the combined analysis. Four of the five genes for which strongest evidence of association was observed were DNA glycosylases. The strongest evidence was for rs1466785 in the NEIL2 (endonuclease VIII-like 2) gene (HR: 1.09, 95% CI (1.03– 1.16), p = 2.761023) for association with breast cancer risk in BRCA2 mutation carriers, and rs2304277 in the OGG1 (8-guanine DNA glycosylase) gene, with ovarian cancer risk in BRCA1 mutation carriers (HR: 1.12 95%CI: 1.03–1.21,
p = 4.861023). DNA glycosylases involved in the first steps of the BER pathway may be associated with cancer risk in BRCA1/ 2 mutation carriers and should be more comprehensively studied
Esoteric Encounters. The Queen of Sheba in Solomon’s Temple
Get PDFHow do literary motifs migrate and translate into esoteric
imagination? What is their mutual interdependence? The case
discussed in this article, an episode in the half-fictitious,
half-documentary Voyage en Orient (1851) by French protosurrealist
author Gérard de Nerval (1808–1855) provides us
with an example where such an adaptation has taken place
over the course of one and a half century. Furthermore, Nerval
incorporates the Queen of Sheba (henceforward Balkis) into
one of the foundational myths of freemasonry, which prompts
another, albeit larger question of role of female characters in
literary esoteric imagination. The ritual centerpiece of the third
or master’s degree in freemasonry is crafted around the biblical
account of the construction of Solomon’s temple with an
apocryphal extension, the ‘Hiramic legend’, treating the murder
of the temple architect Hiram. Whereas from the late 1720s
and onwards the ritual narrative does not feature any female
protagonists at all, Nerval introduces Balkis as a central and
fundamentally plot-changing character. In this article, I will
introduce Nerval’s version of the Hiramic legend, present a
likely explanation how it migrated to the writings of anthroposophist
Rudolf Steiner (1861–1925) and discuss Balkis’ role
as a ‘female principle’ introduced in the hyper-masculine ritual
narrative of freemasonry. My reading of the literary sources
is informed by both genealogical and comparative approaches
by which I trace the elements of the Hiramic mythology from
its eighteenth-century origins to their transformation at the
end of the nineteenth and early twentieth century. A necessary
limitation of this project at this stage is to omit context in favor
of content. Whereas the interplay between these two levels of
understanding certainly would merit deeper analysis, I will
in this piece only discuss the suggestion of French historian
Hivert-Messeca: that Nerval’s adapted masonic mythology
aimed at to create an inclusive and secularized spirituality for
the age of modernity
Resilience of Gendered Spheres in Transnational Migration: An Interpretive Book Review of Sheba Mariam George’s When Women Come First: Gender and Class in Transnational Migration
Get PDFDr. Sheba George’s ethnographic study based using participant observation and purposive sampling and an insider transnational journey to examine changes in family and social roles that result when nurses from Kerala, India immigrate to the US ahead of their husbands. The author concludes that the economic and political gain immigration affords nurses does not translate into enhanced social status for their family in India or for their husbands in the US when they undergo gender transferral to homemaker. This transference causes a shift in gender structure from the home to the community, in this case the church as a way of counteracting the social emasculation Kerali men experience. This review cross culturally examines the resilience of patriarchal cultural mores and gender roles when Kerali and Puerto Rican immigrant men face the prospect of social emasculation; Puerto Ricans are examined from an insiders perspective
Une source nouvelle de l’Histoire de la Reine du Matin et de Soliman, Prince des Génies de Gérard de Nerval
Get PDFIn his work about Solomon and the Queen of Sheba, Gérard de Nerval brings three characters together, Solomon, the Queen and Adoniram. He was interested in a French author of the XVIIIth century, Nicolas Lenglet-Dufresnoy. Nerval seems to have read in a book of the same, about Hermetism, the title of a work from Michael Maier, German alchemist of the late Renaissance, the Septimana Philosophica which consists of a philosophical dialogue between Solomon, the Queen of Sheba and Hyram, Prince of Tyre, about Nature’s aenigma. It is suggested that the French writer could have known also two other works from Michael Maier
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