58 research outputs found
The air microwave yield (AMY) experiment - A laboratory measurement of the microwave emission from extensive air showers
No full textThe AMY experiment aims to measure the microwave bremsstrahlung radiation (MBR) emitted by air-showers secondary electrons accelerating in collisions with neutral molecules of the atmosphere. The measurements are performed using a beam of 510 MeV electrons at the Beam Test Facility (BTF) of Frascati INFN National Laboratories. The goal of the AMY experiment is to measure in laboratory conditions the yield and the spectrum of the GHz emission in the frequency range between 1 and 20 GHz. The final purpose is to characterise the process to be used in a next generation detectors of ultra-high energy cosmic rays. A description of the experimental setup and the first results are presented. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence
F-SSCP Screening for Two Common Mutations HIS1070GLN and GLY1267LYS in French Wilson Patients, and Report of Two Novel Mutations
No full textCompositional Approximate Markov Chain Aggregation for PEPA Models
No full textApproximate Markov chain aggregation involves the construction of a smaller Markov chain that approximates the behaviour of a given chain. We discuss two different approaches to obtain a nearly optimal partition of the state-space, based on different notions of approximate state equivalence. Both approximate aggregation methods require an explicit representation of the transition matrix, a fact that renders them inefficient for large models. The main objective of this work is to investigate the possibility of compositionally applying such an approximate aggregation technique. We make use of the Kronecker representation of PEPA models, in order to aggregate the state-space of components rather than of the entire model
Isolation and characterization of renal cancer stem cells from patient-derived xenografts
No full textInternational audienceAs rapidly developing patient-derived xenografts (PDX) could represent potential sources of cancer stem cells (CSC), we selected and characterized non-cultured PDX cell suspensions from four different renal carcinomas (RCC). Only the cell suspensions from the serial xenografts (PDX-1 and PDX-2) of an undifferentiated RCC (RCC-41) adapted to the selective CSC medium. The cell suspension derived from the original tumor specimen (RCC-41-P-0) did not adapt to the selective medium and strongly expressed CSC-like markers (CD133 and CD105) together with the non-CSC tumor marker E-cadherin. In comparison, PDX-1 and PDX-2 cells exhibited evolution in their phenotype since PDX-1 cells were CD133high/CD105-/Ecadlow and PDX-2 cells were CD133low/CD105-/Ecad-. Both PDX subsets expressed additional stem cell markers (CD146/CD29/OCT4/NANOG/Nestin) but still contained non-CSC tumor cells. Therefore, using different cell sorting strategies, we characterized 3 different putative CSC subsets (RCC-41-PDX-1/CD132+, RCC-41-PDX-2/CD133-/EpCAMlow and RCC-41-PDX-2/CD133+/EpCAMbright). In addition, transcriptomic analysis showed that RCC-41-PDX-2/CD133− over-expressed the pluripotency gene ERBB4, while RCC-41-PDX-2/CD133+ over-expressed several tumor suppressor genes. These three CSC subsets displayed ALDH activity, formed serial spheroids and developed serial tumors in SCID mice, although RCC-41-PDX-1/CD132+ and RCC-41-PDX-2/CD133+ displayed less efficiently the above CSC properties. RCC-41-PDX-1/CD132+ tumors showed vessels of human origin with CSC displaying peri-vascular distribution. By contrast, RCC-41-PDX-2 originated tumors exhibiting only vessels of mouse origin without CSC peri-vascular distribution.Altogether, our results indicate that PDX murine microenvironment promotes a continuous redesign of CSC phenotype, unmasking CSC subsets potentially present in a single RCC or generating ex novo different CSC-like subsets
GIGAS: a set of microwave sensor arrays to detect molecular Bremsstrahlung radiation from extensive air shower
No full textInternational audienceWe present the GIGAS (Gigahertz Identification of Giant Air Shower) microwave radio sensor arrays of the EASIER project (Extensive Air Shower Identification with Electron Radiometers), deployed at the site of the Pierre Auger cosmic ray observatory. The aim of these novel arrays is to probe the intensity of the molecular bremsstrahlung radiation expected from the development of the extensive air showers produced by the interaction of ultra high energy cosmic rays in the atmosphere. In the designed setup, the sensors are embedded within the surface detector array of the Pierre Auger observatory allowing us to use the particle signals at ground level to trigger the radio system. A series of seven, then 61 sensors have been deployed in the C-band, followed by a new series of 14 higher sensitivity ones in the C-band and the L-band. The design, the operation, the calibration and the sensitivity to extensive air showers of these arrays are described in this paper
Determination of the Pa(n,f) reaction cross section from 0,5 to 10 MeV neutron energy using the transfer reaction Th(He,p)Pa
No full textThe fission probability distributions of 232, 233, 234Pa and 231Th have been measured up to an excitation energy of 15 MeV, using the transfer reactions 232Th(3He, t)232Pa, 232Th(3He, d)233Pa, 232Th(3He, p)234Pa and 232Th(3He, 4He)231Th. From these measurements, the neutron induced fission cross sections of 231Pa, 233Pa and 230Th have been determined from the product of the fission probabilities of 232Pa, 233Pa and 231Th respectively with the calculated compound nucleus formation cross sections in the 231Pa+n, 233Pa+n and 230Th+n reactions. The validity of the applied method has been successfully tested with the existing neutron induced fission cross sections of 230Th and 231Pa. Special emphasis is put on the 233Pa(n, f) reaction which is of importance for thorium fueled nuclear reactors. Based on a statistical model analysis of the neutron induced fission cross section as a function of neutron energy, it has been possible to determine the barrier parameters of the 234Pa fissioning nucleus. Cross sections for the compound nucleus inelastic scatttering 233Pa(n, n′) and radiative capture 233Pa(n, γ) reactions have also been calculated and compared with recent evaluations
Solute transport dynamics in small, shallow groundwater-dominated agricultural catchments: insights from a high-frequency, multisolute 10 yr-long monitoring study
No full textHigh-frequency, long-term and multisolute measurements are required to assess the impact of human pressures on water quality due to (i) the high temporal and spatial variability of climate and human activity and (ii) the fact that chemical solutes combine short- and long-term dynamics. Such data series are scarce. This study, based on an original and unpublished time series from the Kervidy-Naizin headwater catchment (Brittany, France), aims to determine solute transfer processes and dynamics that characterise this strongly human-impacted catchment. The Kervidy-Naizin catchment is a temperate, intensive agricultural catchment, hydrologically controlled by shallow groundwater. Over 10 yr, five solutes (nitrate, sulphate, chloride, and dissolved organic and inorganic carbon) were monitored daily at the catchment outlet and roughly every four months in the shallow groundwater. The concentrations of all five solutes showed seasonal variations but the patterns of the variations differed from one solute to another. Nitrate and chloride exhibit rather smooth variations. In contrast, sulphate as well as organic and inorganic carbon is dominated by flood flushes. The observed nitrate and chloride patterns are typical of an intensive agricultural catchment hydrologically controlled by shallow groundwater. Nitrate and chloride originating mainly from organic fertilisers accumulated over several years in the shallow groundwater. They are seasonally exported when upland groundwater connects with the stream during the wet season. Conversely, sulphate as well as organic and inorganic carbon patterns are not specific to agricultural catchments. These solutes do not come from fertilisers and do not accumulate in soil or shallow groundwater; instead, they are biogeochemically produced in the catchment. The results allowed development of a generic classification system based on the specific temporal patterns and source locations of each solute. It also considers the stocking period and the dominant process that limits transport to the stream, i.e. the connectivity of the stocking compartment. This mechanistic classification can be applied to any chemical solute to help assess its origin, storage or production location and transfer mechanism in similar catchments
Cateteres venosos centrais totalmente implantáveis para quimioterapia em 100 pacientes portadores de neoplasia maligna
No full textTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina. Dapartamento de Clínica Cirúrgica
Recent progress of JT-60SA project toward plasma operation
No full textSuperconducting (SC) tokamak JT-60SA plays an essential role in fusion research and development by supporting and complementing the ITER project, providing directions to the DEMO design activity and fostering next generation scientists and engineers. Since the short circuit incident at the terminal joints of equilibrium field coil #1 during the integrated commissioning (IC) in March 2021, both EU and JA implementing agencies (IAs) have examined how to ensure safe operation of JT-60SA by mitigating the risk of possible discharge occurrence inside the cryostat. Based on the experience of the global Paschen tests, the IAs have established a strategy of risk mitigation measures, which is a combination of (i) reinforcement of insulation, (ii) avoiding unnecessary voltage application to the coil systems and (iii) immediate de-energization of the coils when deteriorated vacuum conditions are detected. Thanks to the considerable efforts of the Integrated Project Team members, the IC restarted in May 2023. After confirmation of the SC state of the coil systems (TF, EF and CS), the coil energization test and the plasma operation phase 1 (OP-1) started. The first plasma was successfully achieved on 23 October 2023 with a limited value of voltage and current applied to the coils. The plasma configuration control was also confirmed with low plasma current and low auxiliary heating power conditions. Based on the IO–F4E–QST collaboration, activities of JT-60SA have been shared with the IO and provided an important lesson for ITER assembly and commissioning, and will provide an outstanding contribution to fusion research at large. After OP-1, maintenance & enhancement phase 1 (M/E-1) starts from January 2024, in which in-vessel components are installed, and heating and diagnostic systems are extensively upgraded to allow a high power heating experiment planned in OP-2. In order to make the best use of JT-60SA, a newly organized JT-60SA experiment team will refine the research plan for the future high heating power operation phase.The authors gratefully acknowledge members of EU-IA, JAIA, Project Team and voluntary contributors for their strenuous efforts to get over a lot of technical difficulties with the JT-60SA Project over the past years. The authors also appreciate the members of the European and Japanese fusion communities who have made great contributions in examination of detailed research targets in the operational phases and patiently waited for the restart of the IC.Article signat per 434 autors/es: H. Shirai, K. Takahashi, E. Di Pietro, D. Abate, W. Abdel Maksoud, H. Abe, N. Aiba, T. Abe, M. Akimitsu, J. Ayllon-Guerola, T. Arai, J.-F. Artaud, N. Asakura, N. Ashikawa, L. Balbinot, P. Barabaschi, O. Baulaigue, E. Belonohy, A. Belpane, W. Bin, F. Bombarda, T. Bolzonella, F. Bonne, M. Bonotto, J. Botija, J. Buermans, S. Cabrera-Pérez, A. Cardella, D. Carralero, L. Carraro, J. Cavalier, M. Cavinato, M. Chernyshova, S. Chiba, S. Clement-Lorenzo, V. Cocilovo, S. Coda, R. Coelho, I. Coffey, B. Collin, V. Corato, A. Cucchiaro, T. Czarski, M. Dairaku, S. Davis, C. Day, E. Dela Luna, G. De Tommasi, P. Decool, L. Di Pace, M. Dibon, G. Disset, F. D'Lsa, A. Ejiri, Y. Endo, N. Ezumi, G. Falchetto, A. Fassina, P. Fejoz, A. Ferro, W. Fietz, L. Figini, T. Fornal, G. Frello, T. Fujita, T. Fukuda, K. Fukui, M. Fukumoto, H. Funaba, M. Furukawa, S. Futatani, L. Gabellieri, E. Gaio, K. Galazka, J. Garcia, J. Garcia-Dominguez, J. Garcia-Lopez, M. Garcia-Munoz, L. Garzotti, F. Gasparini, S. Gharafi, L. Giacomelli, G. Ginoulhiac, G. Giruzzi, L. Giudicotti, J. Gonzalez-Martin, R. Guillén-González, N. Hajnal, S. Hall, K. Hamada, K. Hanada, M. Hanada, K. Hasegawa, S. Hatakeyama, V. Hauer, N. Hayashi, T. Hayashi, R. Heller, J. Hidalgo-Salaverri, S. Higashijima, J. Hinata, S. Hiranai, J. Hiratsuka, R. Hiwatari, C. Hoa, H. Homma, A. Honda, M. Honda, K. Hoshino, H. Hurzlmeier, M. Iafrati, K. Ibano, H. Ichige, M. Ichikawa, M. Ichimura, K. Ida, S. Ide, H. Idei, M. Iguchi, T. Iijima, S. Iio, R. Ikeda, Y. Ikeda, T. Imai, R. Imazawa, S. Inagaki, M. Inomoto, S. Inoue, A. Isayama, S. Ishida, Y. Ishii, M. Isobe, F. Janky, E. Joffrin, A. Jokinen, S. Kado, S. Kajita, K. Kajiwara, Y. Kamada, I. Kamata, A. Kaminaga, K. Kamiya, D. Kanapienyte, Y. Kashiwa, M. Kashiwagi, K. Katayama, Y. Kawamata, G. Kawamura, K. Kawano, Y. Kazakov, K. Kimura, F. Kin, M. Kisaki, S. Kitajima, K. Kiyono, K. Kizu, Y. Ko, K. Kobayashi, M. Kobayashi, S. Kobayashi, Ta. Kobayashi, To. Kobayashi, G. Kocsis, A. Kojima, S. Kokusen, M. Komata, K. Komuro, S. Konishi, A. Kovacsik, I. Ksiazek, M. Kubkowska, G. Kühner, M. Kuramochi, K. Kurihara, T. Kurki-Suonio, A.B. Kurniawan, T. Kuwata, B. Lacroix, V. Lamaison, A. Lampasi, P. Lang, P. Lauber, K. Lawson, Q. LeCoz, A. Louzguiti, R. Maekawa, T. Maekawa, S. Maeyama, G. Maffia, P. Maget, J. Mailloux, I. Maione, A. Maistrello, K. Malinowski, A. Mancini, G. Marchiori, J.-L. Marechal, V. Massaut, S. Masuzaki, R. Matoike, G. Matsunaga, S. Matsunaga, A. Matsuyama, Ch Mayri, M. Mattei, M. Medrano, A. Mele, I. Meyer, F. Michel, T. Minami, Y. Miyata, J. Miyazawa, Y. Miyo, T. Mizuuchi, K. Mogaki, J. Morales, P. Moreau, T. Morisaki, S. Morishima, S. Moriyama, A. Moro, H. Murakami, M. Murayama, S. Murakami, K. Nagasaki, O. Naito, N. Nakamura, S. Nakamura, T. Nakano, Y. Nakashima, V. Nardino, E. Narita, Y. Narushima, K. Natsume, S. Nemoto, R. Neu, S. Nicollet, M. Nishikawa, S. Nishimura, T. Nishitani, M. Nishiura, T. Nishiyama, M. Nocente, Y. Nobuta, L. Novello, F. Nunio, S. Ochoa, K. Ogawa, T. Ogawa, Y. Ogawa, S. Ohdachi, Y. Ohmori, N. Ohno, Y. Ohtani, K. Ohtsu, M. Ohzeki, T. Oishi, J. Okano, K. Okano, Y. Onishi, M. Osakabe, T. Oshima, V. Ostuni, A. Owada, M. Oya, Y. Oya, T. Ozeki, M.M. Parody Guzmán, R. Pasqualotto, S. Pelli, E. Perelli, E. Peretti, G. Phillips, C. Piccinni, L. Pigatto, A. Pironti, A. Pizzuto, B. Plöckl, G. Polli, J.-M. Poncet, P. Ponsot, G. Pucella, M. Puiatti, D. Radloff, V. Raimondi, F. Ramos, P. Rancsik, D. Ricci, S. Ricciarini, N. Richermoz, E. Rincon, A. Romano, P. Rossi, P. Roussel, G. Rubino, H. Saeki, A. Sagara, S. Sakakibara, H. Sakamoto, Miki Sakamoto, Mizu Sakamoto, Y. Sakamoto, A. Sakasai, S. Sakata, R. Sakurai, B. Salanon, A. Salmi, G. Sannazzaro, R. Sano, A. Sanpei, T. Sasajima, S. Sasaki, H. Sasao, F. Sato, M. Sato, T. Sato, M. Sawahata, A. Scherber, S. Scully, J. Segado-Fernandez, M. Seki, N. Seki, S. Seki, Y. Shibama, Y. Shibata, T. Shikama, K. Shimada, M. Shimono, J. Shinde, T. Shinya, K. Shinohara, J. Shiraishi, S. Soare, A. Soleto, Y. Someya, S. Sonoda, C. Sozzi, E. Streciwilk-Kowalska, H. Strobel, M. Sueoka, A. Sukegawa, S. Sumida, H. Suzuki, Ma Suzuki, Mi Suzuki, S. Suzuki, T. Suzuki, Y. Suzuki, J. Svoboda, T. Szabolics, T. Szepesi, Y. Takase, M. Takechi, K. Takeda, Y. Takeiri, H. Takenaga, C. Taliercio, N. Tamura, Hiro Tanaka, Hito Tanaka, K. Tanaka, Y. Tanaka, K. Tani, H. Tanigawa, M. Tardocchi, A. Terakado, M. Terakado, T. Terakado, B. Teuchner, B. Tilia, H. Tobari, H. Tobita, K. Tobita, K. Toi, N. Toida, H. Tojo, M. Tokitani, T. Tokuzawa, V. Tormarchio, M. Tomine, A. Torre, T. Totsuka, K. Tsuchiya, N. Tsujii, D. Tsuru, H. Tsutsui, M. Uchida, Y. Ueda, J. Uno, H. Urano, K. Usui, H. Utoh, M. Valisa, M. Vallar, R. Vallcorba-Carbonel, J.-C. Vallet, J. Varela, J. Vega, M. Verrecchia, L. Vieillard, F. Villone, P. Vincenzi, K. Wada, R. Wada, T. Wakatsuki, M. Wanner, F. Watanabe, K. Watanabe, S. Watanabe, T. Wauters, S. Wiesen, M. Wischmeier, M. Yagi, J. Yagyu, M. Yajima, S. Yamamoto, H. Yamanaka, K. Yamauchi, Y. Yamauchi, H. Yamazaki, K. Yamazaki, R. Yamazaki, S. Yamoto, S. Yanagi, K. Yanagihara, S. Yokooka, M. Yokoyama, T. Yokoyama, M. Yoshida, M. Yoshimura, N. Yoshizawa, K. Yuinawa, L. Zani, P. Zito.Postprint (published version
- …
