33,370 research outputs found
Early growth response gene-2 (Egr-2) regulates the development of B and T cells
No full textThe study was supported by Arthritis Research UK.
Copyright @ 2011 Li et al.BACKGROUND: Understanding of how transcription factors are involved in lymphocyte development still remains a challenge. It has been shown that Egr-2 deficiency results in impaired NKT cell development and defective positive selection of T cells. Here we investigated the development of T, B and NKT cells in Egr-2 transgenic mice and the roles in the regulation of distinct stages of B and T cell development. METHODS AND FINDINGS: The expression of Egr1, 2 and 3 were analysed at different stages of T and B cell development by RT-PCT and results showed that the expression was strictly regulated at different stages. Forced expression of Egr-2 in CD2+ lymphocytes resulted in a severe reduction of CD4+CD8+ (DP) cells in thymus and pro-B cells in bone marrow, which was associated with reduced expression of Notch1 in ISP thymocytes and Pax5 in pro-B cells, suggesting that retraction of Egr-2 at the ISP and pro-B cell stages is important for the activation of lineage differentiation programs. In contrast to reduction of DP and pro-B cells, Egr-2 enhanced the maturation of DP cells into single positive (SP) T and NKT cells in thymus, and immature B cells into mature B cells in bone marrow. CONCLUSIONS: Our results demonstrate that Egr-2 expressed in restricted stages of lymphocyte development plays a dynamic, but similar role for the development of T, NKT and B cells.This article is provided by the Brunel Open Access publishing fund
Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
No full textThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Chemokine Receptors of T Cells and of B Cells in Lymphatic Filarial Infection: A role for CCR9 in Pathogenesis
No full textWe examined the expression of chemokine receptors on the surfaces of T cells and B cells from 27 individuals
either with lymphatic filarial disease (lymphedema), with the asymptomatic or subclinical form of filarial
infection, or without filarial infection. Individuals with lymphedema exhibited increased percentages of CCR9-
expressing T cells and CCR9-expressing B cells and decreased percentages of both CXCR1-and-CXCR3–expressing
T cells and CXCR1-and-CXCR3–expressing B cells, compared with asymptomatic or uninfected individuals.
A significant correlation was found between the grade of lymphedema and the percentage of
CCR9-expressing T cells and CCR9-expressing B cells. The percentages of CCR9-expressing T cells and CCR9-
expressing B cells from patients with lymphedema was significantly up-regulated in response to live, infectivestage
larvae of Brugia malayi but not to microfilariae of this parasite. Finally, individuals with lymphedema
had significantly higher concentrations of interleukin-8, macrophage inflammatory protein (MIP)–1a, MIP-
1b, monocyte chemotactic protein 1, thymus-and-activation–regulated chemokine, and interferon-inducible
protein 10 in their serum than did uninfected individuals. These results suggest that chemokine receptors
(particularly CCR9) are involved in the pathogenesis of lymphatic filarial disease and that trafficking of
particular cellular subsets may influence clinical outcome
Measurement of the CKM angle gamma from a combination of B->Dh analyses
No full textA combination of three LHCb measurements of the CKM angle gamma is presented. The decays B->DK and B->Dpi are used, where D denotes an admixture of D0 and D0-bar mesons, decaying into K+K-, pi+pi-, K+-pi-+, K+-pi-+pi+-pi-+, KSpi+pi-, or KSK+K- final states. All measurements use a dataset corresponding to 1.0 fb-1 of integrated luminosity. Combining results from B->DK decays alone a best-fit value of gamma = 72.0 deg is found, and confidence intervals are set gamma in [56.4,86.7] deg at 68% CL, gamma in [42.6,99.6] deg at 95% CL. The best-fit value of gamma found from a combination of results from B->Dpi decays alone, is gamma = 18.9 deg, and the confidence intervals gamma in [7.4,99.2] deg or [167.9,176.4] deg at 68% CL, are set, without constraint at 95% CL. The combination of results from B->DK and B->Dpi decays gives a best-fit value of gamma = 72.6 deg and the confidence intervals gamma in [55.4,82.3] deg at 68% CL, gamma in [40.2,92.7] deg at 95% CL are set. All values are expressed modulo 180 deg, and are obtained taking into account the effect of D0-D0bar mixing
Measurements of t(t)over-bar cross sections in association with b jets and inclusive jets and their ratio using dilepton final states in pp collisions at root s=13 TeV
No full textThe cross sections for the production of t (t) over bar b (b) over bar and t (t) over bar jj events and their ratio sigma(t (t) over bar b (b) over bar)/sigma(t (t) over bar jj) are measured using data corresponding to an integrated luminosity of 2.3 fb(-1) collected in pp collisions at root s = 13 TeV with the CMS detector at the LHC. Events with two leptons (e or mu) and at least four reconstructed jets, including at least two identified as b quark jets, in the final state are selected. In the full phase space, the measured ratio is 0.022 +/- 0.003 (stat) +/- 0.006 (syst), the cross section sigma(t (t) over bar b (b) over bar) bis 4.0 +/- 0.6 (stat)+/- 1.3 (syst) pb and sigma(t (t) over bar jj) is 184 +/- 6 (stat)+/- 33 (syst) pb. The measurements are compared with the standard model expectations obtained from a POWHEG simulation at next-to-leading-order interfaced with PYTHIA. (c) 2017 The Author. Published by Elsevier B.V
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
Measurement of the t(t)over-barb(b)over-bar production cross section in the all-jet final state in pp collisions at root s=13 TeV
No full textA measurement of the production cross section of top quark pairs in association with two b jets (t (t) over barb (b) over bar) is presented using data collected in proton-proton collisions at root s=13 TeV by the CMS detector at the LHC corresponding to an integrated luminosity of 35.9 fb(-1). The cross section is measured in the all-jet decay channel of the top quark pair by selecting events containing at least eight jets, of which at least two are identified as originating from the hadronization of b quarks. A combination of multivariate analysis techniques is used to reduce the large background from multijet events not containing a top quark pair, and to help discriminate between jets originating from top quark decays and other additional jets. The cross section is determined for the total phase space to be 5.5 +/- 0.3 (stat)(-1.3)(+)(1.6) (syst)pb and also measured for two fiducial t (t) over barb (b) over bar, definitions. The measured cross sections are found to be larger than theoretical predictions by a factor of 1.5-2.4, corresponding to 1-2 standard deviations. (C) 2020 The Author. Published by Elsevier B.V
Letter from Carl Hayden to J. B. Rickel
No full textLetter from Carl T. Hayden to J. B. Rickel concerning proposed changes to Grand Canyon National Park boundaries
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