18 research outputs found

    Identification and genetic characterization of a gibberellin 2-oxidase gene that controls tree stature and reproductive growth in plum

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    Several dwarf plum genotypes (Prunus salicina L.), due to deficiency of unknown gibberellin (GA) signalling, were identified. A cDNA encoding GA 2-oxidase (PslGA2ox), the major gibberellin catabolic enzyme in plants, was cloned and used to screen the GA-deficient hybrids. This resulted in the identification of a dwarf plum hybrid, designated as DGO24, that exhibits a markedly elevated PslGA2ox signal. Grafting ‘Early Golden’ (EG), a commercial plum cultivar, on DGO24 (EG/D) enhanced PslGA2ox accumulation in the scion part and generated trees of compact stature. Assessment of active GAs in such trees revealed that DGO24 and EG/D accumulated relatively much lower quantities of main bioactive GAs (GA1 and GA4) than control trees (EG/M). Moreover, the physiological function of PslGA2ox was studied by determining the molecular and developmental consequences due to ectopic expression in Arabidopsis. Among several lines, two groups of homozygous transgenics that exhibited contrasting phenotypes were identified. Group-1 displayed a dwarf growth pattern typical of mutants with a GA deficiency including smaller leaves, shorter stems, and delay in the development of reproductive events. In contrast, Group-2 exhibited a ‘GA overdose’ phenotype as all the plants showed elongated growth, a typical response to GA application, even under limited GA conditions, potentially due to co-suppression of closely related Arabidopsis homologous. The studies reveal the possibility of utilizing PslGA2ox as a marker for developing size-controlling rootstocks in Prunus

    Estudo comparativo do estado nutricional em pacientes cirróticos atendidos ambulatorialmente em um hospital de ensino

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    Dissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação Multidisciplinar em Saúde, Florianópolis, 2015.Introdução: A cirrose apresenta influência direta no estado nutricional predispondo o paciente ao surgimento da desnutrição. O diagnóstico precoce atua norteando a conduta dietoterápica, que visa prevenir ou recuperar as deficiências nutricionais. Objetivos: Investigar a evolução do estado nutricional e sua associação com indicadores de gravidade em portadores de cirrose acompanhados ambulatorialmente em dois momentos. Métodos: Estudo longitudinal com pacientes cirróticos adultos e idosos, de ambos os sexos, realizado em duas etapas, 2012 e 2014. O estado nutricional e risco nutricional foram avaliados através dos instrumentos Royal Free Hospital Global Assessment (RFH-GA) e Nutritional Risk Screening 2002 (NRS-2002), medidas antropométricas isoladas e consumo de calorias e macronutrientes. Foi utilizado como marcador de prognóstico o índice Child-Pugh. Na análise estatística foram utilizados testes para verificar a normalidade da distribuição dos dados, comparação das variáveis numéricas, e a diferença das variáveis. Resultados e discussão: De 60 pacientes avaliados a média de idade foi 56,25 ± 12 anos, com predominância do sexo masculino (65%), índice de prognóstico Child-Pugh A em 81,6% e B 16,6%. Não houve diferenças significativas no diagnóstico de desnutrição e risco nutricional quando comparado os dados de 2012 e 2014 para o RFH-GA; a NRS-2002, como também quando estratificado pelo índice prognóstico. Houve diminuição na prevalência de desnutrição pela CMB e aumento pela PTC. O consumo de energia e proteínas ficou abaixo do recomendado nos dois momentos de avaliação. Conclusões: Observou-se que métodos utilizados de forma isolada, no caso a CMB e PTC, apresentaram maior variação na avaliação nutricional, enquanto o IMC e NRS-2002, não foram bons métodos na detecção do risco ou diagnóstico de desnutrição. O RFH-GA não detectou diferença significativa no diagnóstico de desnutrição nas duas fases da pesquisa, entretanto novos estudos longitudionais devem ser implementados avaliando assim sua aplicabilidade. A ingestão adequada de lipídios e carboidratos foi demonstrada nas duas etapas, entretanto o consumo de calorias e proteínas foram abaixo das recomendações. Sugere-se mais estudos para avaliar e acompanhar o estado nutricional de pacientes cirróticos, a fim de identificar a forma mais adequada de avaliar estes pacientes.Abstract : Introduction: Cirrhosis has direct influence on nutritional status predisposes the patient to the emergence of malnutrition. Early diagnosis acts guiding the diet therapeutic conduct, which aims to prevent or recover nutritional deficiencies. Objectives: To investigate the evolution of nutritional status and its association with indicators of severity of cirrhosis in patients outpatients at two points. Methods: Longitudinal study of cirrhotic patients older adults, of both sexes, conducted in two stages, in 2012 and 2014. The nutritional status and nutritional risk were assessed using the instruments Royal Free Hospital Global Assessment (RFH-GA) and Nutritional Risk Screening 2002 (NRS-2002), isolated anthropometric measurements and consumption of calories and macronutrients. It was used as a prognostic marker of the Child-Pugh index. Statistical analysis tests were used to verify the normal distribution of data, comparison of numerical variables, and the difference of the variables. Results and Discussion: Of 60 patients evaluated the average age was 56.25 ± 12 years, predominantly male (65%), prognostic index Child-Pugh A and B in 81.6% 16.6%. There were no significant differences in the diagnosis of malnutrition and nutritional risk compared data from 2012 and 2014 for the RFH-GA; the NRS-2002, as well as stratified by prognostic index. There was a decrease in the prevalence of malnutrition by CMB and increased by PTC. The consumption of energy and protein was below the recommended levels in both time points. Conclusions: We found that methods used in isolation, if the CMB and PTC showed greater variation in nutritional assessment, while BMI and NRS-2002, were not good methods to detect the risk or diagnosis of malnutrition. The RFHGA detected no significant difference in diagnosing malnutrition in the two phases of the research, however longitudionais new studies should be implemented thus evaluating its applicability. Adequate intake of lipids and carbohydrates was demonstrated in two stages, however the consumption of calories and proteins were below the recommendations. It is suggested more studies to assess and monitor the nutritional status of cirrhotic patients in order to identify the most appropriate way to assess these patients

    Relação entre estado de saúde bucal e estado nutricional em pacientes submetidos à cirurgia bariátrica tipo Bypass Gástrico y de Roux

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    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2009.Introdução A obesidade pode influenciar o estado nutricional e o estado de saúde bucal. Objetivo deste estudo foi avaliar o efeito da perda de peso cirúrgica sobre alterações da cavidade bucal e o estado nutricional. Material e Métodos O estudo caracterizou-se como estudo transversal e estudo prospectivo com segmento, ambos realizados com indivíduos submetidos à gastroplastia com Bypass em Y de Roux. O estudo transversal foi realizado com 101 indivíduos, com idade média de 39,9±9,2 anos, sendo 80% de sexo feminino e 20% do sexo masculino, realizado entre janeiro a março de 2007. O estudo prospectivo com segmento de 12 meses (novembro/2007 a novembro/2008 realizado no período pré-operatório (basal), 1º, 3º, 6º e 12º mês pós-cirurgia foi com uma amostra de 16 indivíduos (13 mulheres e 03 homens), com idade média de 43,6±10,5 anos. Resultados No estudo transversal o tempo médio pós-cirúrgico foi de 14,8 meses. A perda de peso média foi de 35,9±15,9 kg com o índice de massa corporal (IMC) médio de 33,7±6,3 kg/m2 e a circunferência da cintura média de 95,5±15,4 cm. O índice de dentes cariados perdidos e restaurados (CPO-D) médio foi de 17,19±0,85 com redução após seis meses de cirurgia para 16,7±1,07. Houve maior prevalência significativa para dentes perdidos nos primeiros seis meses (10,52±1,53; P=0,026), e dentes restaurados após seis meses de cirurgia (7,96±0,86; P= 0,028). Os indivíduos com IMC acima de 30 kg/ m2 tiveram maior valor do índice de CPO-D (17,6±1,03), assim como, nos componentes: cariado (2,33±0,47) e perdido (8,63±1,1). A circunferência da cintura (CC) correlacionou-se significativamente com o peso (0,429; P<0,001), perda de peso (-0,226; P=0,023), IMC (0,608; P<0,001) e índice CPO-D (0,205; P=0,39) após a cirurgia. No estudo prospectivo com segmento houve diminuição de 31,5% (P<0,05) do peso e do índice de massa corporal após a cirurgia. Na avaliação do índice CPO-D verificou-se redução de 57,7 % (P=0,037) do número de dentes cariados aos 12 meses, ao mesmo tempo em que houve aumento de 20% (P=0,005) no número de dentes restaurados, quando comparado com o período basal. O fluxo salivar reduziu 25% (P=0,044) no 1º mês pós-cirurgia e aumentou em 50% (P=0,006) no 3º mês, se comparado ao basal, atingindo a normalização (1,2±0,3 ml/min). A capacidade tampão reduziu 21,7% (P<0,001) no 6º mês, com classificação de #moderada# e houve aumento da ocorrência de regurgitação (P=0,046), vômito (P=0,008) e acidez (P=0,005) logo no 1º mês, se comparado com o período basal. Conclusões A redução de peso por meio da cirurgia influenciou a redução do risco à doença periodontal. Após a cirurgia bariátrica houve normalização do fluxo salivar, mas a capacidade tampão da saliva foi classificada como moderada provavelmente pelo aumento na incidência de vômitos, acidez e regurgitação permitindo um meio bucal ácido. O índice de massa corporal e a circunferência da cintura são indicadores antropométricos que podem ser considerados fator de risco para doenças bucais.Introduction Obesity may influence both nutritional and oral health status. This work#s objective was to evaluate the effect of post-surgery weight loss over alterations in the oral cavity and the nutritional status. Materials and Methods One transversal and one prospective follow-up study were conducted, both with patients submitted to Roux-en-Y gastric bypass. The transversal study evaluated 101 individuals aged 39.9±9.2 years, 80% female, between January and March 2007. The 12-month prospective follow-up study (November 2007 to November 2008) evaluated pre-surgery stage (basal), as well as 1st, 3rd, 6th, and 12th months post-surgery in a sample of 16 individuals aged 43.6±10.5 years (81% female). Results In the transversal study, mean post-surgery time was 14.8 months. Mean weight loss was 35.9±15.9 kg, mean Body Mass Index (BMI) value was 33.7±6.3 kg/m2 and mean waist circumference (WC) value was 95.5±15.4 cm. Mean DMFT index value was 17.19±0.85, decreasing to 16.7±1.07 six months after surgery. Significantly higher prevalences of lost teeth and filled teeth were observed in the first six months (10.52±1.53; P= 0,026) and after six months of surgery (7.96±0.86; P= 0,028), respectively. Individuals whose BMI values were above 30 kg/ m2 had higher DMFT index values, (17.6±1.03), as well as decayed (2.33±0.47) and lost (8.63±1.1) components. WC values were significantly correlated with weight (0.429; P<0.001), weight loss (-0.226; P=0.023), BMI (0.608; P<0.001) and DMFT index (0.205; P=0.39) after surgery. In the prospective follow-up study there was a 51.5% (P<0.05) reduction in weight and BMI after surgery. DMFT index evaluation showed a decrease of 57.7% (P=0.037) in the number of decayed teeth at 12 months when compared to the basal period, while at the same time the number of filled teeth increased 20% (P=0.005). Salivary flow decreased 25% (P=0.044) in the first month and increased 50% (P=0.006) in the third month post-surgery when compared to the basal period, attaining normal levels (1.2±0.3 ml/min). Buffer capacity decreased 21.7% (P<0.001) in the 6th month, when it was classified as #moderate#. Increased occurrence of regurgitation (P=0.046), vomiting (P=0.008) and acidity (P=0.005) were observed early in the 1st month when compared to the basal period. Weight reduction through surgery influenced the reduction of risk of periodontal disease. After gastric bypass, salivary flow was reestablished, but salivary buffer capacity was classified as moderate probably because of increased incidence of vomiting, acidity and regurgitation, leading to an acid oral environment. Body mass index and waist circumference are anthropometric indicators which can be considered as risk factors for oral diseases

    Explaining child malnutrition in developing countries: a cross-country analysis

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    "One in three pre-school children in the developing world is undernourished. As a consequence, their human rights are violated. In addition, they are more likely to have impaired immune systems, poorer cognitive development, lower productivity as adults, and greater susceptibility to diet-related chronic diseases such as hypertension and coronary heart disease later in life. Undernourished female preschoolers are likely to grow into undernourished young women who are more likely to give birth to babies who are undernourished even before they are born, thus perpetuating the inter-generational transmission of deprivation. Reducing these unacceptably high numbers remains a tremendous challenge to public policy. As a guide to the direction of future efforts, this research report examines the success of the efforts of the past 25 years to reduce preschooler undernutrition. The report uses an econometric model to identify the factors associated with the reduction in undernutrition. The formulation of the econometric model is guided by the widely accepted food-care-health conceptual model of child growth. The contributions of both underlying and basic determinants to reductions in undernutrition are assessed using the model. The potential of these factors to further reduce undernutrition is evaluated in a region-by-region priority-setting exercise. In addition, projections of child nutrition are made under various scenarios to the year 2020. What will it take to dramatically reduce undernutrition in the next 20 years? The report attempts some broad answers to these questions..." (Forward by Per Pinstrup-Andersen)Malnutrition in children Developing countries., Malnutrition in children Developing countries Prevention., Developing countries., Econometric models., Gender, Health and nutrition,

    Cirurgia bariátrica: efeitos sobre o estado antioxidante e estresse oxidativo

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    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pos-Graduação em Nutrição.Oxidative stress is associated with obesity. Although bariatric surgery is the predominant treatment for individuals with morbid obesity, implications of the surgical weight loss to the antioxidant balance and oxidative stress are not clarified yet. The objective of this study was to evaluate the effect of surgical weight loss on caloric ingestion, sanguineous levels of vitamin C, â-carotene, vitamin E, reduced glutathione (GSH), catalase (CAT) and myeloperoxidase (MPO) activities and thiobarbituric acid-reactive substances (TBARS). A clinical study was realized in the University Hospital of the Federal University of Santa Catarina with a control group (GC) and a bariatric group (GB), both with 20 individuals. The mean age was 38±11 years in both groups and Body Mass Index (BMI) was 22,4±2,4 kg/m2 and 48±8,7 kg/m2, respectively. The GC was evaluated in only one moment and GB was evaluated before surgery (baseline), 3 and 6 months after Roux-en-Y gastric bypass. The caloric ingestion (3119±799 to 1164±429 calories/day) and MPO (384,18±18,20 to 32,79±69,20 mU/mL) significantly decreased in six after surgical months in relation to baseline. Moreover, the study showed an increase in vitamin C (0,46±0,14 to 0,76±0,35 mg/dL), â-carotene (0,51±0,53 to 1,72±0,23 ìM), vitamin E - corrected ratio - (0,006±0,003 to 0,013±0,007 ìmol/ mg), CAT (15,98±6,41 to 24,86±9,78 mmol H2O2/ min/mL) and TBARS (14,59±2,42 to 26,89±6,70 nmol/ mL) in six after surgical months. These results had been similar to the GC. The significant correlations in GB were demonstrated between BMI and vitamin C, â-carotene, TBARS and MPO (rho= -0,269; -0,492; -0,346 e 0,576, respectively). Concluding, this study evidenced weight reduction and caloric ingestion decrease after surgery. It presented an improvement in vitamin E, vitamin C and â-carotene levels, a reduction in MPO levels and an increase in CAT and TBARS levels after surgical intervention

    Uso de prebiótico em pacientes com neoplasias hematológicas submetidos à quimioterapia

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    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Nutrição.Os pacientes com neoplasias hematológicas são submetidos a tratamento quimioterápico que induz uma intensa alteração na integridade da mucosa intestinal, favorecendo um aumento da morbi-mortalidade desses indivíduos. O objetivo desse estudo foi avaliar o efeito do frutooligossacarídeo (FOS) nos indivíduos com neoplasias hematológicas submetidos à quimioterapia. Foi realizado um estudo clínico randomizado duplo cego envolvendo 25 pacientes distribuídos em 2 grupos que receberam por 15 dias, 12g de FOS (n=14) ou placebo (maltodextrina) (n=11). Foram avaliados o consumo alimentar de energia, proteína e fibra pelo método de pesagem direta dos alimentos e os dados foram analisados no software Nutwin. O estado nutricional foi classificado segundo o Índice de Massa Corpórea (IMC) e o percentual de alteração de peso, bem como, os níveis séricos de albumina, pré-albumina, proteína C reativa e hemoculturas foram determinados. As análises do conteúdo de bifidobactérias e pH fecal foram realizadas antes e após a suplementação. Foi verificada a presença de diarréia e de constipação, além da incidência de sepse e infecção. Os dados foram analisados no programa estatístico SPSS 10.0 para Windows. Os resultados mostraram predomínio do sexo masculino (72%) e a idade média de 34 anos na população estudada. 52% dos pacientes apresentaram-se eutróficos, porém, verificou-se perda de peso intensa em ambos os grupos, sendo estatisticamente maior no grupo controle. Os níveis séricos de albumina e pré-albumina apresentaram-se significativamente reduzido no grupo controle, entretanto, os níveis séricos de proteína C reativa foram mais elevados neste grupo. O grupo suplementado apresentou um aumento significante no conteúdo de bifidobactérias (P<0,05) e o pH fecal não foi alterado em ambos os grupos. O conteúdo de bifidobactérias correlacionou-se negativamente com a freqüência de diarréia (r= -0,420; P=0,04) e com os níveis séricos de proteína C reativa (r= -0,504; P=0,01). Embora a incidência de sepse e de infecção tenha sido superior no grupo suplementado, não houve diferença significante entre os grupos. A presença de diarréia e constipação não foi significativamente diferente nos grupos estudados. Verificou-se que a suplementação aumentou o conteúdo de bifidobactérias interferindo na composição da microbiota intestinal e o consumo alimentar reduzido influenciou o estado nutricional dos pacientes estudados

    Waist Circumference Is Better Associated With High Density Lipoprotein (hdl-c) Than With Body Mass Index (bmi) In Adults With Metabolic Syndrome [circunferencia De La Cintura Es Mejor Asociado Con Lipoproteínas De Alta Densidad (lad-c) Que Con El índice De Masa Corporal (imc) En Adultos Con Síndrome Metabólico]

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    Background: The measurement of waist circumference (WC) is the most prevalent cause of the metabolic syndrome (MS). Objective: The aim of this study was to correlate WC and BMI with high-density lipoprotein (HDL-c) levels in patients with MS being consulted by the Family Health Program (PSF), Brazil. Methods: This cross-sectional study was conducted from September to November 2008 with 42 patients (29 women and 13 men) from 35 to 77 years. Dietary intake was reported, and biochemical and body composition measures were taken. Results: The HDL-c levels were higher in women when compared to men (48.4 ± 8.1 mg/dL vs. 36.4 ± 7.8 mg/dL). However, the triglycerides (TG)/HDL-c ratio and TG concentrations were lower in women (3.8 ± 1.5 and 178.0 ± 57.8 mg/dL, respectively) than in men (9.4 ± 8.5 and 471.5 ± 501.5 mg/dL, respectively). Regarding skinfold profile, the triceps was greater in females (37.0 ± 8.4 cm vs. 20.7 ± 10.5 cm). The dietetic profile showed that women had a lower intake of energy, fiber, phosphorus and sodium. The fruits and vegetables intake was dimi -nished in the participants of this study, as less than 60% of the women and 50% of men met the daily recommendations. Approximately 54% of men and 28% of women had a lower intake of dairy products daily. Moreover, the results shows that the WC was negatively correlated to HDL-c (r = -0.41, p 0.06). Conclusion: Our findings showed that WC is a better predictor of changes in HDL-c than BMI.26613281332IV Brazilian guideline for dyslipidemia and atherosclerosis prevention: Department of atherosclerosis of brazilian society of cardiology (2007) Arq Bras Cardiol, 88 (SUPPL. I), pp. 2-19. , Brazilian Society of CardiologyOlinto, M.T., Nacul, L.C., Gigante, D.P., Costa, J.S., Menezes, A.M., Macedo, S., Waist circumference as a determinant of hypertension and diabetes in Brazilian women: A population-based study (2004) Public Health Nutr, 7 (5), pp. 629-635Klein, S., Allison, D.B., Heymsfield, S.B., Kelley, D.E., Leibel, R.L., Nonas, C., Kahn, R., Waist circumference and cardiometabolic risk: A consensus statement from Shaping America's Health (2007) Am J Clin Nutr, 85 (5), pp. 1197-1202. , Association for Weight Management and Obesity PreventionNAASO, The Obesity Societythe American Society for Nutritionand the American Diabetes AssociationPimentel, G.D., Portero-McLellan, K.C., Corrente, J.E., Burini, R.C., Accuracy of sagittal abdominal diameter as predictor of abdominal fat among Brazilian adults: A comparation with waist circumference (2010) Nutr Hosp, 25 (4), pp. 656-661Brenner, D.R., Tepylo, K., Eny, K.M., Cahill, L.E., El-Sohemy, A., Comparison of body mass index and waist circumference as predictors of cardiometabolic health in a population of young Canadian adults (2010) Diabetol Metab Syndr, 2, p. 28I Brazilian guidelines on diagnosis and treatment of metabolic syndrome (2005) Arq Bras Cardiol, 4 (SUPPL. 1), pp. 1-28. , Brazilian Society of CardiologyHeyward, V.H., Storlarczyk, L.M., (2000) Avaliação Da Composição Corporal Aplicada, , São Paulo: ManoleObesity: Preventing and managing the global epidemic Report of the WHO Consultation On Obesity, p. 1998. , World Health Organization (WHO), Geneva: World Health OrganizationCallaway, C.W., Chumlea, W.C., Bouchard, C., Himes, J.H., Lohman, T.G., Martin, A.D., (1988) Circunferences, Anthropometric Standardizations Reference Manual, , Edited by: Lohman TG, Roche AF, Martorell R. 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    Search for heavy stable and longlived particles in e+ e- collisions at s**(1/2) = 189-GeV

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    A search for stable and long-lived heavy charged particles was performed using the data taken by the DELPHI experiment at an energy of 189 GeV. The Cherenkov light detected in the Ring Imaging Cherenkov Detector and the ionisation loss measured in the Time Projection Chamber were used to identify heavy particles passing through the detector. No evidence for the production of such particles has been found, therefore exclusion limits at 95% confidence level were derived on the masses of left and right handed smuons and staus. The results were combined with previous DELPHI searches in this channel. Including previous DELPHI results, masses of left (right) handed stable smuons and staus can be excluded between 2 GeV/c2 and 88 (87.5) GeV/c2 at 95% CL.0info:eu-repo/semantics/publishe

    0001

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    ow PAGE TWO DAILY PALO ALTO TIMES. SATURDAY, FEB. 27. lotj. ©aibg iXimee Editorial lpage H. W. 8IMKIN8- -W. H. KEI-t-Y THK KXPOSITK»N The exposition ta opened Tbe ureal gate**, swung back on Saturday morning nt the jir**cti>e moment appointed and a vast army of clll- sent and visitors pus-.*)*] Into the much finer thing than pleaaure. In a world seemingly bent upon destruction. San Francisco and the Pa- • Iflr toast In general have supplied the one- contrasting note of con- ■■ii*'i-*tJi»h. and. It N a construction grounds and bultdtn*. and found < tn nrfwnj* to he measured by yard- tfaem good. Five "ears of manful *Mt*V or the delights of the eye It effort, perhaps not always unmixed Is a construction that will prevail with some human misgivings, . had, antl contlnus long after the expo- justlfled themselves. --dtlon has passed .Into history, tour Tbe event I* Indeed a great and a' after tbe canal has become, a worn memorable *tn* It may lie said to nnd trodden highway, mark the apex of a* triangle of' And partialis it Is Just this feature achievement, the ..ther two points ot of rontrast that may momentarily the triangle being the building of ibe overlooked lo the exhilaration* the Panama canal and the re-con* of tbe day. There are certain pres ages that from time to time make their appearance In human affairs anil are noted, usually In silence, by the wise. And we have such presage here. There Is now broad dividing line In human thought, and there is an old and tired race and a new and virile one. There la a power In tbe world that builds and another power that tears down. The new end vlrlls race, the race that builds. Is to be fpund 00 the Pacific coast. It built the -canal; It built the city of San Francisco; It built the exposition. It la building also something of amity and good fellowship. Ther must Indeed be blind to tbe tnsan* atructlon of the city of Ban Francisco. When the time shall come to write the history of the present century these three triumphs will stand out boldly conspicuous among tha things that humanity willingly and proudly remembers Tbem will be much that humanity will gladly forget and will try to forget, but It will not forget these permanent ad* dltlons to the wellbelng of tbe world. The work of the exposition build* errs has been well done. Thert It stands for the Judgment of civilisation, and mere conventional praise would therefore be futile. Wherever constructive skill, wherever creative art. or Imagination, I or originality, or daring, or energy.] Ing of things, to tbe march of or Industry, or besuty could be events, to the passage of the sun found, they hav-* been Incited to. who fall rightly to Interpret this give ot their best and allowed an, concentration of constructive ambl unfettered band to do It. There tlon that did these things, that have been no prejudices or precon*' moved forward In defiance of i eeptlons. and tr self-Interests have'world Intent upon moving backward tried to Intrude- and of this there There Is such a. thing aa the prole no sign—they have net been al- gresalve spirit nf a race, and wher- lowed to prevail. Nothing Is more'aver that spirit settles there we see vwldsnt than the confidence given a colosaat Idealism antl colossal freety and without stint lo those achievements, there we see the reeponslbte ror the execution of the great permanent things tbat make -work and the abundance with which - for the well-being of men that confidence lias been Justified.'only such things that Justify proph- N'ever before has aueh a task been eey. nut prophecy Is abundantly performed more harmoniously, with Jimmied when we see, aa we see a more anxious observance of obll-lnow, that the stars in their <*oursei gations. or under a fuller pressure are fighting for us.— The Argonaut, of kindly public support. Pertiap3 -■ * ■ - we are still too close to these facts THK HOMK MKIITIIAN'T to appreciate their full significance.'. The home merchant Who is he? but that w|ll come with time and He Is tbe chap who gives you pers-iecilve. The executive of the-credlt when you are financially exposition may well rest satisfied, broke, and .imi-. your account iin- not only with the production of a til you are able to pay. gorgeous piece ot mechanical work, j He is the chap who gives you but wllh the knowledge that their Lhack your money or makes ex. aervlce* are recognized and npprecl- j changes when you nre not satisfied aled nnd that the future months with what you have bought. will add to the applause that Is al- Ile Is tbe chap who stands behind ready theirs this guaranty, and makes restora- Of the sucresn of the exposition j Hon of nil lu.-.- thnt yon may sua- we need have no manner of doubt.] tain on the goods you buy. It Is already a success In the unanimity nf sentiment tbat called it forth nnd In the magnificence of Its form and color. Hut there will be other auccess*** of an even more abiding kind. It is the single vivid and hsrmonlous patch In a world torn by wars and rumors o( wara. and rent by hatreds nml hy dreads. It I* almost the only oasis In a desert of distrust and dismay. And of this there will lie no lack of recognition. Seutlmcnt la still Ihe motor power, the driving force, of human lite, however much it may seem -submerged by baser things. And aentltuent will nun tlie step* uf a tint!. Iiii,, a; ni> toward Sain Fran* Cisco ThfJ v.1'1 be tn xiyit.h m.t onij tor pleasure t.ut Foi nacotir- agements to happiness, and happiness bj p moch mora abiding, .1 Ile Is the chap who meets you at the door with a handshake, and lets you out with a message to the "kids." and a real comc-ngalir good- hy. He Is the chap who meets and greets vou Of) tl*.- --.treet every dny In the year ..nd lakes a neighborly nt In Inlr fairs. He 1* the l*4M.kk'-i'|.i>i, In I'ulo Alto with Pie. .ou tr family und you hap whose cleric- nd other employe* ml spend their 11 ■Aith other home af charily organizations, and Pslo Alto lodrce-t and commercial clubs, and talk* for Palo Alto aod boosts for our town every day in the )-»r. Ile la tbe chap who visits vou when you are slrk. sends flowt-ra to yonr family when you die, and follow* yoor body out among the trees and tombs, as far as human feet may travel with the dead He la the home merchant—yoor neighbor- your friend your helper in times of need. Don't you thiol that you ought to trade with him nnd tie hi* friend and hi* helper In tbe time of hla need? Don't you know thst every dollar that you aend out of Palo Alto for merchandise Is sent to strangers— to men who never spend a dollar In Palo Alio, to men who would not trust you for a box of matches, to men who would turn you over to the police If you should enter tbelr offices? You don't save much, frequently nothing, wben you send your money out of Palo Alto, and you take all the risk yourself of short weight or measure and of getting damaged or Inferior goods. And don't yon know that the growth and prosperity of Palo Alto depends very largely upon the sure--*-, sod prosperity of the home merchants? Out-of- town people Judge our city by tl.e appearance of our store* and tbe degree of enterprise abown by onr merchants. And our home merchants cannot succeed unless home folks give them loyal support.—Contributed The PcnintuU Club j The membership of the Peninsula jClub at present includes the- following men: H. J. Allen. Professor J. lli*. Bingham, O. P. Drown, H. F. Congdon. C. H.*-**Crawro**d. O. B. Crmnc A T. de Forest. D. Dris- eol! (Menlo Park*. John Dudfield. it I„ Dunshee, C. B. Evans, Rev. D. J. Brans, Professor It. B. Fair- elmigh (Stanford University). D 3. Fatris. D. K. Fotsow. James Fraxer. Uev. J. M. Oteason, 0. F. Cra*/ (Monndsvltle. wr*Va.>. W. H. Haley. Dr. 0. B Hall. W. F. Hanra- Kan. Rev. Walter Hays. C. E. Hen- son CSan Franclaco), R. B. Herd- man. Professor L. M. Ilosklns, J. S. Hutchinson. C. K. Jordan. W. H. Kelly. R. M. Kingman. Guitar l-au- metster. R. H. Lee. Captain H 0. JLooney. Captain M. M. I-ooney. C,uy C Miller. J. R. Montgomery, J. J. Morris. R. I.tndtey Murray. L. E. McClellan, J. M. Mcpheeters. A. C. Mclaughlin, J. P. Newton. O. R. Parkinson, Major H. F. Perry. A. B. Peterson. Dr. I*. M. Place. A. A. Prior. John F. Prior. A. A. Reed. Harry B. Robinson. Walter Rod gen. John R. 8elby (San Franclaco). W. A. Shedd, W. J. Sheldon. Dr. R. B. sib- ley (San Mateo). J. E. Sloan. Fred H. Smith. Professor H 0. Bpanldlng (Stsnford University). Dr. John C. Spencer, E. J. Stanley Jr., B. A. Stainlnger. A. M. Stereos, H. I*. Terwltllger. E. C. Tholu. Walter E. Vail, E. A. vming. C. M. Wade. Dr. T. M. Williams. Ernest Wilson. Frank Woodard. W. .C. Cooper. jFloor Coverings If you have Con***ol**i*jn on your floors, yoo an run a mop over them and they will be cleaner than any swept floor- Congoleum U waterproof nght through—water .cannot injure it Compared with printed linoleum, Congoleum is more durable, more attractive, more waterproof, yet the poce is lest. CongciJcum require, no fastening—any one can lay it —it won't curl up. C>***o#oleta*n Rug Border*, laid next to a rug or carpet, give the actual appearance of polished oak. Palo Alto Furniture Co. •£22 tnlversity Avenue, Vlxome lie la the chap who puy„ he taxes to help atupboii oar echo ..n.l build our street.i. uml niiilut ■mr fire department and pnlii.- l»u t iiii-iit ami parks. • He b> the chap who help* mi-.* locttl .inn-i..-. -uul hoapltali 1 A IHHKAMK WK Ml'HT AVOID A worklngman, a phyalrlan and a priest teatlOed before a leglalaUve investigating committee regarding conditions among the employee of the American Agricultural Company. tmrtlon of whose profits goes to tbe Rockefeller Foundation. The physician said conditions were so desperate that mothers were almost ..l t.i when their children died. The doctor waa called "more lo Insure a proper death certificate than with any hotie of saving the life of the >.■■■•:■■*> Families lived tn crowded, unllghted. un'ventllated rooma, amidst fllth and horrible odors. Malaria and tuberculosis were ao com- 1 thst they attracted no attention. The chemical fumes at the factory weakened Ihe throat, lunga and IntesHnes of the workmen and1 often were a cause of death. Wage.t: were st> low that, even under these j unspeakable conditions, a family ofj ordinary size could not live on them, j The priest, the physician and the worklngman agieed regarding these, facta. We have no rt unlit Ions in Callfor. | nla as bad as these, although the' Immigration and housing com mis- ■ nlon ha* i-olntcd out some fairly, ahockhtg symptoms within ■ mite of Market street. But no state ts safe] *o long as there are Ml h plague I spot* In the nation ns exist In the In-luM-inl centers of the east Vn- remittltig v Iglhtnre during these f coming years of increasing tmmtgra-' Hon will lie n.-. .*--.,. > to save us j from similar degeneration and dis* MM BOO l'ran.l-co Bulletin Mra. laora I. laSManee. national W. C. T. U. lecturer, wbo la at pros* ent In a suffrage campaign In West Virginia, writes to her relative* In Pslo Alio than aha had- **a«eraUr hoan In a hot local option, campaign In Taney eounty, Mlasourt, In the Ozark mountains, where ahe wu the guest overnight or Old Matt and Aunt Molly In their home, the bouM In which "Tbe Shepherd of the Hills'' was written. Mrs. LaMance has been tn seventy county and state prohibition campaigns and has msde over 30u temperance sp4>*sches, sometimes making four talks In one day. She waa tn tbe West Virginia campaign, and Is now one of the leader*, ln tha fight for suffrage In that statr-. Mrs. lenience Is a sister of J. J Nichols of Palo Alto. EARLE & CO. GROCERS Phones 837 and 538 Masonic Temple Bldg: Built not to a price -But to an IDEAL When you come to look at this Studebaker FOUR, forget that price of $985. For price was NEVER one of the objects in the building of the FOUR "' From lbs vary atari of th* design, th* car was built to llv* up J to Stud*b«k*r'a Id-***,! of what a POUR nAould b* - and th* prica Is m*r*lf ■ rt*sult of Studebaker'i -nanufscititing '■- II tti** a resuh ol Its b«ing built in the largest snd most •*om- pltHsly -*.*.ii|ipril automobtl* :■'-:■• on the tsc* of th* sarth. And it'* thai id*al ot Studebaker that seeking to put Into this csr ALL that any man on want In a FOUR, that has mad* It not only aa handao-r.* a car si you *v«- rod* in. but a powerful, easily driven car with nurvclous riding qualltl*-* — anJ abova all. LOW cost nf tnaintetianc*. But wa'd tika you to *** thia FOUR and judg* It for your- aatL Wa'd lik* you to rida In it and driv* It and KNOW how much you csn gat in a car that's t--j.lt not to a pric* — but to an IDEAL -faauA* i&<* high -ib which the game was pis*... * *ol ficiil tills morning ui Bun defeated tti-*; Another Prize Jingle "You are Luscious" cried her suitor, "You are dainty, you are sweet, You are plump, and Oh! so tempting;, And you always look so neat. • I can never get too much of you, I long for you each day— You're like a CO-ED CHOCOLATE, that's The most that I can say!" WILSON'S 'Where the Best If Always Found" \^*lit****'- -■■ri, T**t.<J Rear ffm-ftnti■ . . !•/•** Tajf*. MtXCEi UCMT SIX. . . .IMS si*«**m±**_*>ix _7.rt******.**; \X%t *_**_*. ........ F. O. ■. b*tt*.i UNIVERSITY GARAGE 542 High Street Phone Palo Alto 24
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