7,347 research outputs found
Search for CP violation in D+->K-K+π+ decays
No full textA model-independent search for direct CP violation in the Cabibbo-suppressed decay D+→K-K+π+ in a sample of approximately 370 000 decays is carried out. The data were collected by the LHCb experiment in 2010 and correspond to an integrated luminosity of 35 pb-1. The normalized Dalitz plot distributions for D+ and D- are compared using four different binning schemes that are sensitive to different manifestations of CP violation. No evidence for CP asymmetry is found
Inclusive decays B->DX and B->D*X
No full textComplete Author List: Gibbons L, Johnson SD, Kwon Y, Roberts S, Thorndike EH, Jessop CP, Lingel K, Marsiske H, Perl ML, Schaffner SF, Ugolini D, Wang R, Zhou X, Coan TE, Fadeyev V, Korolkov I, Maravin Y, Narsky I, Shelkov V, Staeck J, Stroynowski R, Volobouev I, Ye J, Artuso M, Efimov A, Frasconi F, Gao M, Goldberg M, He D, Kopp S, Horwitz N, Moneti GC, Mountain R, Mukhin Y, Schuh S, Skwarnicki T, Stone S, Thulasidas M, Viehhauser G, Xing X, Bartelt J, Csorna SE, Jain V, Marka S, Freyberger A, Godang R, Kinoshita K, Lai IC, Pomianowski P, Schrenk S, Bonvicini G, Cinabro D, Greene R, Perera LP, Barish B, Chadha M, Chan S, Eigen G, Miller JS, OGrady C, Schmidtler M, Urheim J, Weinstein AJ, Wurthwein F, Asner DM, Bliss DW, Brower WS, Masek G, Paar HP, Sharma V, Gronberg J, Kutschke R, Lange DJ, Menary S, Morrison RJ, Nelson HN, Nelson TK, Qiao C, Richman JD, Roberts D, Ryd A, Witherell MS, Balest R, Behrens BH, Cho K, Ford WT, Park H, Rankin P, Roy J, Smith JG, Alexander JP, Bebek C, Berger BE, Berkelman K, Bloom K, Cassel DG, Cho HA, Coffman DM, Crowcroft DS, Dickson M, Drell PS, Ecklund KM, Ehrlich R, Elia R, Foland AD, Gaidarev P, Gittelman B, Gray SW, Hartill DL, Heltsley BK, Kandaswamy J, Katayama N, Kim PC, Kreinick DL, Lee T, Liu Y, Ludwig GS, Masui J, Mevissen J, Mistry NB, Ng CR, Nordberg E, Ogg M, Patterson JR, Peterson D, Riley D, Soffer A, Ward C, Athanas M, Avery P, Jones CD, Lohner M, Prescott C, Yang S, Yelton J, Zheng J, Brandenburg G, Briere RA, Gao YS, Kim DYJ, Wilson R, Yamamoto H, Browder TE, Li F, Li Y, Rodriguez JL, Bergfeld T, Eisenstein BI, Ernst J, Gladding GE, Gollin GD, Hans RM, Johnson E, Karliner I, Marsh MA, Palmer M, Selen M, Thaler JJ, Edwards KW, Bellerive A, Janicek R, MacFarlane DB, McLean KW, Patel PM, Sadoff AJ, Ammar R, Baringer P, Bean A, Besson D, Coppage D, Darling C, Davis R, Hancock N, Kotov S, Kravchenko I, Kwak N, Anderson S, Kubota Y, Lattery M, ONeill JJ, Patton S, Poling R, Riehle T, Savinov V, Smith A, Alam MS, Athar SB, Ling Z, Mahmood AH, Severini H, Timm S, Wappler F, Anastassov A, Blinov S, Duboscq JE, Fisher KD, Fujino D, Fulton R, Gan KK, Hart T, Honscheid K, Kagan H, Kass R, Lee J, Spencer MB, Sung M, Undrus A, Wanke R, Wolf A, Zoeller MM, Nemati B, Richichi SJ, Ross WR, Skubic P, Wood M, Bishai M, Fast J, Gerndt E, Hinson JW, Menon N, Miller DH, Shibata EI, Shipsey IPJ, Yurko M</p
Mortality in New Zealand workers exposed to phenoxy herbicides and dioxins.
No full textAIMS: To evaluate mortality in New Zealand phenoxy herbicide producers and sprayers exposed to dioxins. METHODS: Phenoxy herbicide producers (n = 1025) and sprayers (n = 703) were followed up from 1 January 1969 and 1 January 1973 respectively to 31 December 2000. A total of 813 producers and 699 sprayers were classified as exposed to dioxin and phenoxy herbicides. Standardised mortality ratios (SMR) were calculated using national mortality rates. RESULTS: At the end of follow up, 164 producers and 91 sprayers had died. Cancer mortality was reduced for sprayers (SMR = 0.82, 95% CI 0.57 to 1.14) and increased in exposed production workers (SMR = 1.24, 95% CI 0.90 to 1.67), especially for synthesis workers (SMR = 1.69), formulation and lab workers (SMR = 1.64), and maintenance/waste treatment/cleaning workers (SMR = 1.46). Lymphohaematopoietic cancer mortality was increased in exposed production workers (SMR = 1.65, 95% CI 0.53 to 3.85), especially for multiple myeloma (SMR = 5.51, 95% CI 1.14 to 16.1). Among sprayers, colon cancer (SMR = 1.94, 95% CI 0.84 to 3.83) showed increased mortality. CONCLUSIONS: Results showed 24% non-significant excess cancer mortality in phenoxy herbicide producers, with a significant excess for multiple myeloma. Associations were stronger for those exposed to multiple agents including dioxin during production. Overall cancer mortality was not increased for producers and sprayers mainly handling final technical products, although they were likely to have been exposed to TCDD levels far higher than those currently in the general New Zealand population
sj-docx-1-nms-10.1177_14614448211058468 – Supplemental material for Direct and indirect relationships between social media use and body satisfaction: A prospective study among adolescent boys and girls
No full textSupplemental material, sj-docx-1-nms-10.1177_14614448211058468 for Direct and indirect relationships between social media use and body satisfaction: A prospective study among adolescent boys and girls by Hannah K Jarman, Siân A McLean, Amy Slater, Mathew D Marques and Susan J Paxton in New Media & Society</p
Cooperative calcium and zinc signaling underlies oxidant-induced neuronal injury
No full textIntracellular zinc release triggered by oxidative injury leads to cellular K+ efflux and neuronal apoptosis. Low intracellular K+ enables protease and nuclease activation during cell death processes. Our laboratory has demonstrated that the reduction in cytosolic K+ occurs via zinc-dependent phosphorylation of Kv2.1 by Src kinase and p38 MAPK, leading to the insertion of new Kv2.1 channels into the plasma membrane of dying neurons. As calcium dyshomeostasis is also observed in many models of neuronal injury, I tested the hypothesis that zinc- and Kv2.1-mediated apoptosis also depended on increased intracellular calcium. I observed that oxidant exposure triggered release of calcium from the endoplasmic reticulum, which led to the activation of the calcium/calmodulin-dependent protein kinase II (CaMKII). Molecular or pharmacological inhibition of CaMKII prevented both the oxidant-induced K+ current enhancement and, importantly, subsequent cell death. Further, I found that CaMKII regulated apoptosis by its direct association with the SNARE protein syntaxin, with syntaxin mediating the plasma membrane insertion of Kv2.1 via enhanced association with the phosphorylated channel. As such, Kv2.1/syntaxin binding was enhanced under conditions that promoted apoptosis, and inhibiting CaMKII prevented this interaction. Moreover, expression of a Kv2.1-derived peptide containing the channel’s c-terminal syntaxin binding site (C1a) was also sufficient to disrupt Kv2.1/syntaxin binding, preventing both the oxidant-induced K+ current enhancement and downstream apoptosis. Together, these findings support a novel role for calcium and CaMKII in an established zinc-mediated injury cascade. Further, they suggest that the metals work in concert to elicit the pro-apoptotic Kv2.1 channel activity necessary for oxidative stress-induced apoptosis. Finally, disruption of the pro-apoptotic syntaxin/Kv2.1 interaction may lead to novel therapeutic approaches for neurological disorders associated with oxidant-induced signaling
A large geometric distortion in the first photointermediate of rhodopsin, determined by double-quantum solid-state NMR
No full textDouble-quantum magic-angle-spinning NMR experiments were performed on 11,12-C-13(2)-retinylidene-rhodopsin under illumination at low temperature, in order to characterize torsional angle changes at the C11-C12 photoisomerization site. The sample was illuminated in the NMR rotor at low temperature (similar to 120 K) in order to trap the primary photointermediate, bathorhodopsin. The NMR data are consistent with a strong torsional twist of the HCCH moiety at the isomerization site. Although the HCCH torsional twist was determined to be at least 40A degrees, it was not possible to quantify it more closely. The presence of a strong twist is in agreement with previous Raman observations. The energetic implications of this geometric distortion are discussed
First observation of the decay Bs0→K*0K*0
No full textThe first observation of the decay B0s→K∗0K∗0 is reported using 35 pb−1 of data collected by LHCb in proton–proton collisions at a centre-of-mass energy of 7 TeV. A total of 49.8±7.5 B0s→(K+π−)(K−π+) events are observed within ±50 MeV/c2 of the B0s mass and 746 MeV/c2 < mKπ < 1046 MeV/c2, mostly coming from a resonant B0s→K∗0K∗0 signal. The branching fraction and the CP-averaged K∗0 longitudinal polarization fraction are measured to be B(B0s→K∗0K∗0)=(2.81±0.46(stat.)±0.45(syst.)±0.34(fs/ fd))×10−5 and fL =0.31±0.12(stat.)±0.04(syst.)
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
Chirality effects at each amino acid position on tripeptide self-assembly into hydrogel biomaterials
No full textHydrogels formed by ultrashort peptides are emerging as cost-effective materials for cell culture. However, L-peptides are labile to proteases, while their D-isomers are thought to not support cell growth as well. In contrast, the self-assembly behaviour and biological performance of heterochiral peptides (i.e., made of both D and L amino acids) are largely unknown. In this study, we evaluate the effects of amino acid chirality on tripeptide self-assembly and hydrogelation at physiological pH, and cytocompatibility in fibroblast cell culture. A series of uncapped hydrophobic tripeptides with all combinations of D, L amino acids was prepared, tested for self-assembly under physiological conditions, and analysed by circular dichroism, FT-IR, cryo-TEM, AFM, and Thioflavin T fluorescence imaging. Amino acid chirality has a profound effect on the peptides' supramolecular behaviour. Only selected isomers form hydrogels, and of amyloid structure, as confirmed by rheology and XRD. Importantly, they are able to maintain the viability and proliferation of fibroblasts in vitro. This study identifies two heterochiral gels that perform well in cell culture and will assist in the design of innovative and cost-effective peptide gel biomaterials
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