4 research outputs found

    Adalimumab in active ulcerative colitis: a "real-life" observational study

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    The effectiveness of adalimumab in the treatment of ulcerative colitis is under debate. Although controlled trials have shown that adalimumab is significantly better than placebo, the absolute clinical benefit is modest. We report data on the effectiveness of adalimumab in a cohort of ulcerative colitis patients treated in 22 Italian centres

    Predictions for the rates of compact binary coalescences observable by ground-based gravitational-wave detectors

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    We present an up-to-date, comprehensive summary of the rates for all types of compact binary coalescence sources detectable by the initial and advanced versions of the ground-based gravitational-wave detectors LIGO and Virgo. Astrophysical estimates for compact-binary coalescence rates depend on a number of assumptions and unknown model parameters and are still uncertain. Themost confident among these estimates are the rate predictions for coalescing binary neutron stars which are based on extrapolations from observed binary pulsars in our galaxy. These yield a likely coalescence rate of 100 Myr(-1) per Milky Way Equivalent Galaxy (MWEG), although the rate could plausibly range from 1 Myr(-1) MWEG(-1) to 1000 Myr(-1) MWEG(-1) (Kalogera et al 2004 Astrophys. J. 601 L179; Kalogera et al 2004 Astrophys. J. 614 L137 ( erratum)). We convert coalescence rates into detection rates based on data from the LIGO S5 and Virgo VSR2 science runs and projected sensitivities for our advanced detectors. Using the detector sensitivities derived from these data, we find a likely detection rate of 0.02 per year for Initial LIGO-Virgo interferometers, with a plausible range between 2 x 10(-4) and 0.2 per year. The likely binary neutron-star detection rate for the Advanced LIGO-Virgo network increases to 40 events per year, with a range between 0.4 and 400 per year

    0005

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    FUaiDKWT JORDAN RETURNS A* O. Prusidem Jordan relumed Friday from s throe months' trip through Japan, where be succeeded In securing the largest snd moat oo_p_te collection ot Jspsseae Babe* ever obtained by scientists. I . ofeesnr J. O. Snyder, of tbe xool- ogy department, wbo accompanied him, gave out tbs following Information regarding tbs trip: "Tbe IdeS In going to Japan wa* to stake as complete a oollecUon and study of th*> H*-h,ln Japanese wsteiVas possible, snd, Incidentally, to lesrn something of tbe oondltlon of tbe Japanese people. In Japan were ae* cui.il over 7000 specimens, which be La taking back with him. Among tbem sre 70 different kinds of nab, 125 of, which sre unknown to science. ' aipta/ "TbeJspaoeaefiah bsve been studied. NtW a . real tt*5m\ ny the Hutch, (German snd Kngllsh, but tbe litersture Is very . -at- tared, besldoa being product, in so many different lavngi _gsw. It is th. Intention of Dr. Jordan to get together a lsrge eollectloii and write a book on Japanese fishes. It will lie in tbu nature of s tegt book, so tbat the Ja*_n_*_ esn work with It, aa It Is alrunst Impos-' sl bis for tbem to do anything with the CH.ASt* flab of their own country at prt**»*-tit. Two paper* have already been gotten out by Dr. Jordan ou Che subjt_t, one is Japan, now in press, and tbe otber recently published hy the National Museum. "Mueb territory wss covered by tu in tbe time at our dls.sal We visited both the neat and seat oosst* and collected both salt and frueti water Ha be**. We went aa far north as tb« Island Hokkaido and as far south aa the Island l.i.-ukii-n Tht- largest coll actions were in i'lf at Nagasaki, Wakantiurs. Toklo snd at llakodatl. foil*. _tii_a or descriptions wnni made of all hut fifteen known species, besides VZ'< spraiee unknown to sclent.. Some si-rt- tld«- pool, some off-abort-, some dt_p-ses fishes and many were fresh-water fishes, obtained from rivers antl Inland lakes. Tbe party stopped at Honolulu, both going and coming, where collections were also made. "We were aided in our Held work by- Mr. Abe snd by Mr. Utakl, both form _- stutleuts at stanfi.nl They acted aa guidia* snd IntSM-preters, sod were ol great assistance as it ii almost Impossible to make any progreas without such aiii. Tho local missionaries also gave ua valuable aid. Tbey are a well* sduosted people and seem to lie doing good work. Probably tbe greatest aa- sistsnee given ua, however, was by tbe Imperial universities and by tbe officers of the Imperial Pish Commission. Ws _u Univeralty The Oak Home Bakery Freeh Bras., Hot Rolls, Pie* snd Cakes delivered lo any part ot loan daily. Strictly Home Baking Salo Alto Agency of The San Jose Laundry Association At SLAOE'S BARBER SHOP Next _ Bus W.jftin will call for and dr.':-.—r -.uudry M_U ordsr. promptly .llM.de. to- PMONC SV 210 Homer Ave. 8c D. UNCLE JOHN'S STABLES Uncle John Is now in buslneaa for himself snd the traveling public will find him on band with CARRIAGES and undiminished fund of stories about all the points of I uteri, t. ^ 0 .0T Lumber ^ _ _? Millwork, Doors, Windows, Moulding, Tanks ...and all kinds of Building Material.,, 0r_ _ Yard ALMA STREET opp. DEPOT PALO ALTO PALO ALTO BILLIARD PARLOR ri.BA. J, SOU* *> ATBB. rata Billiard •**> Pool . •'" ■*— Farntln & Slado, Props. PALO ALTO H. L. UPHAM J Contractor j and Builder Meat Market A. A. DULION, Proprietor Government Inspected Refrigerated Meats ii.-its. . ■-...-.; Sas_t_ aad Ur. .1 Mt-ai* CHOI. K FlH'LTRY Tel. Main IS .'nivemtv Ave. PLANS ruNNISMCO Stop Paying Kent .Ml Wi.fkt.ua.ai.li-i'.l Hon- ■;■-.- S_S i) V«a_ l. _- ii.-i.i.' If y.tii ai-li t build a fasHi we t_u assist vim; don't pay for a l_ndlo_.V houiat*. but pay for a house >A your own. See John F. Bysboe .. nt for th.- Renter's Co-Operative investment Co. ■»*■ hsa mtrney t>t Itian and st*ick for sale in tbia sulid and suecesaful .--.rp.ir.tt. n. See him also for Insurance. as«I bargain, in town property & fruit ranches. Rtaic-.ee 7ji tSlNSON ST. P O. SOSStSS SOU 1ST SALO ALTO Oeod Loaoa N ..tiaisd fur Hulldlac ITirpnsns LIGHT CYCLERY Y\ heels to lleot lUcych* Supplies All kinds of Repairing solicited m. A. Dlnemore were ffiren five scerea to all the universities ssd I'alo Alto museums and tbe r«*ry where sra on r so ter prise everywhere aeooed very friend people lly w- 1 The expedition was a complete suc- ssaa. Tbe University now bss the largest collection of Jspsnoae flab _ In the world—In fact, the coUectlon st 8t*o- fo-tl Is larger than all the others In ths world together. The I'nl versity already bss a txiDsctionJtbat waa mauV by lhe United Ststea steamer Albatross for tbe National Museum. The oolleo- tlon just msde was carried free by tbe Japanese steamers, ao that thu cost of transportation will bs very small. Dr. Jordan Is highly elated over the sikhvs* of the trip, and It Is to be res re-ted that his present sorrow should i .tm* to cloud bis pleasure "We were beautifully entertslned while In Japan, tbe people were courte- oua sod extremely hind to us. We lived for the most part In Jai __-•*• hotels, snd were enabled to study tbe oomtntHt people as well aa tbe srlstoc- raey The country it. -11 is fsr ad- vsnosd In civilization snd eatreme ly Interesting. "Is Honolulu Dr. Jordso vlsiu*d tho fish market, securing somessmplea cf ] the fish there. Dr. Jordsn did sot so so China, but be had many opportunities to study the situation In the Ksr Esat. He declares thst tbe partition Of Chios is ss lmposalbillfs. that al) Europe bss no* men snd mooey enough lo divide Chins ssd keep It divided.•* , J. E. FLANNELLY CI ■f. *-. w O rH 00 e a '/J C R I_-__IMD_. Eastman B/crcus Kodaks ud A A L. L' BICYCLES R Pishing Tackle V mm tr © QBB 6 •d •_■ s— Jt' X I.KAI.V.K IN RAMBLERS Hay and Grain Wood and Coal Feed, Flour. Bran and Produce of all kinds. Iti.h atraat. Palo Alto G. W. Mosher Contractor * Builder Kstimst-a promptly furnisbsd on sny kind of buildings - 1 PO Bo* 808 Pslo Alto j Bstbs. Baths st Lsrkia's. ~~ LADIES tUnne I «rl> W. an niakinn Pall Suiu in Twenty Different l"r_*ij.na and are ,,fft-rmi.- Special Hari-ains li> making Suits to Order (rijht here) including material Jacket silk linad at $15.00 A. R. Allison Ladies Tailor I thi. pape. we SBM to. io*. .. IRA A. SWAIN <_r Palo till lid Umiiersitg .MESSENGER nd fUrchasing tjtit orr i eta l _lo Atfc_-_t_a_ a Sbos Stert* ■aa rrsacla*_-40 Third Htn. i OvSar bos oonsar «*taa__ f_i»»r»it*t puau TCLCSNONKS *as rvaarlaao-TsI Ctav . Pale Atie-TBl. Oaatral •Bvra a_.r* an takra st w

    Embedded Software of the KM3NeT Central Logic Board

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    The KM3NeT Collaboration is building and operating two deep sea neutrino telescopes at the bottom of the Mediterranean Sea. The telescopes consist of latices of photomultiplier tubes housed in pressure-resistant glass spheres, called digital optical modules and arranged in vertical detection units. The two main scientific goals are the determination of the neutrino mass ordering and the discovery and observation of high-energy neutrino sources in the Universe. Neutrinos are detected via the Cherenkov light, which is induced by charged particles originated in neutrino interactions. The photomultiplier tubes convert the Cherenkov light into electrical signals that are acquired and timestamped by the acquisition electronics. Each optical module houses the acquisition electronics for collecting and timestamping the photomultiplier signals with one nanosecond accuracy. Once finished, the two telescopes will have installed more than six thousand optical acquisition nodes, completing one of the more complex networks in the world in terms of operation and synchronization. The embedded software running in the acquisition nodes has been designed to provide a framework that will operate with different hardware versions and functionalities. The hardware will not be accessible once in operation, which complicates the embedded software architecture. The embedded software provides a set of tools to facilitate remote manageability of the deployed hardware, including safe reconfiguration of the firmware. This paper presents the architecture and the techniques, methods and implementation of the embedded software running in the acquisition nodes of the KM3NeT neutrino telescopes
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