114,181 research outputs found

    Editorial: The metabolic challenges of immune cells in health and disease

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    Copyright: © 2015 Frezza and Mauro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.CM is supported by the British Heart Foundation Fellowship FS/12/38/29640. CF is funded by the UK Medical Research Council

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    A proposal for the digital storage and sharing of remotely sensed archaeological data

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    Currently Internet is one of the instruments more effective than transmission of the data and seems to set off to become one of the channels privileges of information’s diffusion. Through outline of standard communication, its architecture guarantees the compatibility of dialogue between the different site that they shape the net, concurring the sharing of experiences, services, computer science resources and exceeding the physical distance between the customers. The knowledge of the enormous potentialities of Internet has capacities to develop a plan to us that previews the realization of an informative system in net based on a DBMS (Data Base Management System), that is, a distributed system that it allows to record, to update and to extract information from a database of vertical air photographs of the Tuscany, managed from an interactive graphical interface. The DBMS is already, for its nature, an instrument that considers the data like one on hand common resource of an organization of various customers, satisfying in this way the more and more obvious requirement of spreading and sharing of the acquaintances. Indispensable property of every DBMS are, in fact: the recording, the organization and the management of the data, according to criteria that answer directly to the necessities of the context in which it is developed. the spread and the sharing - the customers must be able to approach to one data bank that can be consulted second opportune modalities the reliability, therefore the system capacity to conserve the content of the DBMS through rescue functions and restoration. the privacy, guaranteed through mechanisms of authorization and shapes of control. It must be, moreover, efficient, that is necessarily able to carry out the operations employing with of resources - space and time - permissible for all the customers, and effective, in a position to rendering the activities of the customers productive. A DBMS is substantially one layer software that insert between the true and own customer and data. Thanks to this intermediate layer the customer and the applications not approach the data therefore as they are registered effectively, that is to their physical representation, but of it they see only one logical representation. That allows to an elevated degree of independence between the applications and the physical memorization of the data. Thanks to these characteristics the applications that are developed can count on one sure, reliable and generally scalable source given. Such property are favorable for applications that use Internet like infrastructure and that they have therefore obvious problems of emergency and scalability. The choice of to insert the DBMS in the net has been, moreover, encouraged from the opportunity to widen in considerable way its attitude to the transmission and usability of the information. The net is a system that puts on hand of the public, in the tightest times, the various acquaintances and therefore allows to consult the documentation and to render it object of critics and interpretations; moreover simple and immediate verification gives to the protection organs the advantage of one. The insertion of the data bank in Internet admits, moreover, the access to the information to a net of customers is capillary diffused in the territory, extending the spreading of the knowledge also to who is not one specialist in the archaeological field. It allows, moreover, the 'popolamento' of the DBMS in real time from not fixed emplacements and you dislocate in various points; concurring the different breaking in experiences in the same data bank, rendering them immediately that can be consulted, and accelerating the process of communication and exchange of the acquaintance

    Inquiry into the interlocution of students engaged with mathematics: appreciating links between research and practice

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    For either to be useful, links between research and practice are critical. Just as important are connections between the practice of students engaged in mathematical activity and research that seeks to understand that practice. This research report explores lessons that researchers and practitioners can learn from an inquiry into the interlocution of students working collaboratively in small groups when engaged in talking and listening to each other. We use the term interlocution to denote discursive practices of learners in conversational exchanges. Questions that motivate this research included the following. What discursive practices do interlocutors employ as they work collaboratively to understand and resolve mathematical tasks? How do these practices influence the growth of their mathematical ideas? In what ways do their discursive practices help them move from a contextualized, situated task to generalize the task or their solution? Do students' discursive practices assist them to connect and generalize ideas from a new problem to others on which they have worked?Powell, A. B., & Maher, C. A. (2002). Inquiry into the interlocution of students engaged with mathematics: Appreciating links between research and practice. In D.S. Mewborn, P. Sztajn, D.Y. White, H.G. Wiegel, R.L. Bryant & K. Nooney (Eds.), Proceedings of the twenty-fourth annual meeting of the North American Chapter of the International Group for the Psychology of Mathematics Education (Athens, Georgia) (Vol. 1, pp. 317-329). Columbus, OH: ERIC Clearinghouse for Science, Mathematics, and Environmental Education

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Measurement of the CKM angle gamma from a combination of B->Dh analyses

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    A combination of three LHCb measurements of the CKM angle gamma is presented. The decays B->DK and B->Dpi are used, where D denotes an admixture of D0 and D0-bar mesons, decaying into K+K-, pi+pi-, K+-pi-+, K+-pi-+pi+-pi-+, KSpi+pi-, or KSK+K- final states. All measurements use a dataset corresponding to 1.0 fb-1 of integrated luminosity. Combining results from B->DK decays alone a best-fit value of gamma = 72.0 deg is found, and confidence intervals are set gamma in [56.4,86.7] deg at 68% CL, gamma in [42.6,99.6] deg at 95% CL. The best-fit value of gamma found from a combination of results from B->Dpi decays alone, is gamma = 18.9 deg, and the confidence intervals gamma in [7.4,99.2] deg or [167.9,176.4] deg at 68% CL, are set, without constraint at 95% CL. The combination of results from B->DK and B->Dpi decays gives a best-fit value of gamma = 72.6 deg and the confidence intervals gamma in [55.4,82.3] deg at 68% CL, gamma in [40.2,92.7] deg at 95% CL are set. All values are expressed modulo 180 deg, and are obtained taking into account the effect of D0-D0bar mixing

    Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ

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    The ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd), where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5. The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%. Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations

    Branching fraction and CP asymmetry of the decays B+→K0Sπ+ and B+→K0SK+

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    An analysis of B+ → K0 Sπ+ and B+ → K0 S K+ decays is performed with the LHCb experiment. The pp collision data used correspond to integrated luminosities of 1 fb−1 and 2 fb−1 collected at centre-ofmass energies of √ s = 7 TeV and √ s = 8 TeV, respectively. The ratio of branching fractions and the direct CP asymmetries are measured to be B(B+ → K0 S K+ )/B(B+ → K0 Sπ+ ) = 0.064 ± 0.009 (stat.) ± 0.004 (syst.), ACP(B+ → K0 Sπ+ ) = −0.022 ± 0.025 (stat.) ± 0.010 (syst.) and ACP(B+ → K0 S K+ ) = −0.21 ± 0.14 (stat.) ± 0.01 (syst.). The data sample taken at √ s = 7 TeV is used to search for B+ c → K0 S K+ decays and results in the upper limit ( fc · B(B+ c → K0 S K+ ))/( fu · B(B+ → K0 Sπ+ )) < 5.8 × 10−2 at 90% confidence level, where fc and fu denote the hadronisation fractions of a ¯b quark into a B+ c or a B+ meson, respectively
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