124,753 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Gloria Palomar f, Mariana Nogueira b,f,Núria Gómez-Barros b,f,
No full textwww.elsevier.com/locate/euroneuro Evaluation of common variants in 16 genes involved in the regulation of neurotransmitter release in ADHD Cristina Sanchez-Mora a,b,c, Bru Cormand c,d,e
Pragmatic Case Studies as a Source of Unity in Applied Psychology
No full textTo unify or not to unify applied psychology: that is the question. In this article we review pendulum swings in the historical efforts to answer this question—from a comprehensive, positivist, “top-down,” deductive yes between the 1930s and the early 60s, to a postmodern no since then. A rationale and proposal for a limited, “bottom-up,” inductive yes in applied psychology is then presented, employing a case-based paradigm that integrates both positivist and postmodern themes and components. This paradigm is labeled “pragmatic psychology” and, its specific use of case studies, the “Pragmatic Case Study Method” (“PCS Method”). We call for the creation of peer-reviewed journal-databases of pragmatic case studies as a foundational source of unifying applied knowledge in our discipline. As one example, the potential of the PCS Method for unifying different angles of theoretical regard is illustrated in an area of applied psychology, psychotherapy, via the case of Mrs. B. The article then turns to the broader historical and epistemological arguments for the unifying nature of the PCS Method in both applied and basic psychology.Peer reviewe
Dr. Edwin Wright Collection: Author Unknown
No full textNotes - The author relates several short stories about his neighbours including Alex McDonell, homesteading and life around Meanook and Athabasca (1 page
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Análisis genético y molecular del síndrome de Maroteaux-Lamy
No full text[spa] Esta tesis es una contribución al conocimiento del síndrome de Maroteux-Lamy en el terreno de la genética molecular. El síndrome de Maroteaux-Lamy o mucopolisacaridosis de tipo VI (MPS VI) es una grave enfermedad hereditaria muy poco frecuente en humanos, provocada por la deficiencia de un único gen, que codifica la hidrolasa lisosómica N-acetilgalactosamino-4-sulfatasa o arilsulfatasa B (ARSB). La primera publicación incluída en la tesis engloba los resultados del análisis de las mutaciones encontradas en el gen ARSB de pacientes españoles y argentinos con MPS VI. Se han identificado todos los alelos responsables de la enfermedad, de los cuales 9 no habían sido publicados anteriormente. Mediante estudios de RT-PCR se han obtenido evidencias de que algunas de las mutaciones podían provocar la destrucción del correspondiente transcrito mutado mediante el mecanismo de nonsense-mediated RNA decay . El estudio también ofrece datos relativos a la clínica de los pacientes analizados, incluyendo la edad de diagnóstico, los principales síntomas fenotípicos y la concentración de glicosaminoglicanos totales excretados en orina, que constituyen datos importantes a la hora de intentar establecer relaciones genotipo-fenotipo. Cumpliendo con otro de los objetivos de la tesis, se realizó el análisis haplotípico de cuatro mutaciones comunes identificadas en pacientes españoles y argentinos con MPS VI y se apuntó a un posible origen único para dichos cambios. La segunda publicación presenta los estudios de expresión y caracterización bioquímica de la mayor parte de las proteínas mutadas que no habían sido descritas con anterioridad por otros autores. Por primera vez en la bibliografía, se explicitó que el cDNA mutado se había expresado en el mismo contexto haplotípico que en el paciente en relación con los dos cambios exónicos presentes en las bases de datos de SNPs, p.V358M y p.S384N. Ambas variantes se expresaron también de forma individual, siendo de especial interés los resultados obtenidos para el cambio p.S384N, que tradicionalmente se ha considerado como mutación patogénica sin que se hayan realizado estudios de expresión. El análisis bioquímico de la actividad enzimática in vitro de las proteínas mutadas se completó mediante análisis de western blot. También se realizaron estudios de inmunofluorescencia indirecta para valorar el grado de localización de la proteína ARSB mutada en los lisosomas de fibroblastos de pacientes. Finalmente se realizaron estudios a nivel de RNA para las mutaciones que introducen codones de parada prematuros en la secuencia codificante (sin sentido, de splicing). Mediante el tratamiento de cultivos de fibroblastos de pacientes con el inhibidor de la síntesis proteica cicloheximida, se puso de manifiesto que el mecanismo de nonsense-mediated RNA decay era responsable de la degradación de los transcritos portadores de cuatro de las mutaciones. El trabajo que ocupa el tercer artículo es una aproximación a una forma de terapia complementaria a la de sustitución enzimática ya establecida para los pacientes de MPS VI, que se podría aplicar a los pacientes portadores de mutaciones sin sentido. Se trata del primer intento en esta enfermedad de intentar suprimir los codones de terminación prematura mediante el uso de antibióticos aminoglicósidos. Los ensayos se realizaron tanto en células transfectadas como en una línea de fibroblastos humanos. Las mutaciones escogidas permitieron ensayar la influencia del contexto nucleotídico del codón de parada en la determinación de la eficacia de la supresión de terminación. Las células se incubaron en presencia de gentamicina y se compararon los niveles de mRNA y de actividad enzimática con los obtenidos en células sin tratar. Los resultados evidenciaron que, en líneas generales, el tratamiento con gentamicina para la supresión de codones sin sentido incrementa, aunque poco, la capacidad catalítica de la ARSB, y que la eficacia del proceso parece depender del contexto nucleotídico.[eng] Maroteaux-Lamy syndrome or mucopolysaccharidosis type VI (MPS VI) is a rare lysosomal, autosomal recessive storage disorder caused by a deficiency of the lysosomal enzyme N-acetylgalactosamine 4-sulfatase or arylsulfatase B (ARSB). The first aim of the thesis was to analyze the spectrum of mutations responsible for the disorder in Spanish and Argentinian MPS VI patients. We identified all the ARSB mutant alleles, nine of them novel. Clinical data of Spanish and Argentinian patients was also provided. Haplotype analysis indicated a common origin for most of the mutations found more than once. It was very difficult to stablish genotype-phenotype correlations. RT-PCR studies showed that some of these alleles could be responsible of the degradation of the ARSB mRNA transcripts by the mechanism of nonsense-mediated RNA decay. In the second study, functional characterization of seven missense mutations and polyporphisms found in the ARSB gene was presented. All the ARSB mutations studied had a significant effect on enzyme activity. Mutations were expressed on COS-7 cells in their original haplotype context with respect two non-synonymous SNPs, p.V358M and p.S384N. Our results showed that change p.S384N, formerly described as a pathogenic mutation, should be considered a functional polymorphism. Western blot analyses showed that the expressed mutations significantly reduced the amount of mature protein. Sub-cellular localization studies of ARSB proteins in fibroblasts from MPS VI patients were performed. RNA analysis confirmed that nonsense-mediated RNA decay had taken place for all mutant alleles which were candidates for causing RNA degradation by this mechanism. Finally, we reported the preliminary in vitro assays for restoring some amount of full-length and active ARSB protein, by means of gentamicin-induced translational read-through of premature stop codon mutations on different termination contexts. Gentamicin treatment on transfected COS-7 cells and fibroblasts from a MPS VI patient showed a slight recovery of ARSB activity and cDNA levels
Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
No full textThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
The construction of Karen Karnak: The multi-author-function
No full textThis thesis is situated within the comparatively recent developments of Web 2.0 and the emergence of interactive WikiMedia, and explores the mode of authorship within a Read/Write culture compared to that of a Read/Only tradition. The hypothesis of this study is that the role of the audience has become merged with the author, and as such, represents new functions and attributes, distinct from a more conventional concept of authorship, in which the roles of audience and author are more separate. Read/Write and participatory culture, as defined by this study, is focused on collaboration, and includes the influences of D.I.Y. culture, Open-Source practices and the production of text by multiple authors. Multi-authorship presents a re-thinking of several concepts which support the notion of the individual author, since the focus of multi-authorship is not on attribution and ownership of a finished text, but on the continued malleability of a text. Modes of multi-authorship, demonstrated in the use of the pseudonyms Alan Smithee and Karen Eliot, represent declarative authors whose names signify multiple origins, whilst concurrently indicating a distinct body of work. The function of these names form an important context to this study, since primary research involves the construction of an experimental mode of multi-authorship utilising WikiMedia technology and the interaction of thirty nine participants, who are invited to create a body of work under the collective pseudonym Karen Karnak. The data generated by this experiment is analysed using aspects of Michel Foucault's author-function to identify and determine power structures inherent in the WikiMedia context. The interplay of power structures, including concepts such as identity, ownership and the body of work, affect the resulting mode of authorship and contribute to the construction of Karen Karnak, suggesting further areas of research into the emerging multi-author
Branching fraction and CP asymmetry of the decays B+→K0Sπ+ and B+→K0SK+
No full textAn analysis of B+ → K0
Sπ+ and B+ → K0
S K+ decays is performed with the LHCb experiment. The pp
collision data used correspond to integrated luminosities of 1 fb−1 and 2 fb−1 collected at centre-ofmass
energies of
√
s = 7 TeV and
√
s = 8 TeV, respectively. The ratio of branching fractions and the
direct CP asymmetries are measured to be B(B+ → K0
S K+
)/B(B+ → K0
Sπ+
) = 0.064 ± 0.009 (stat.) ±
0.004 (syst.), ACP(B+ → K0
Sπ+
) = −0.022 ± 0.025 (stat.) ± 0.010 (syst.) and ACP(B+ → K0
S K+
) =
−0.21 ± 0.14 (stat.) ± 0.01 (syst.). The data sample taken at
√
s = 7 TeV is used to search for
B+
c
→ K0
S K+ decays and results in the upper limit ( fc · B(B+
c
→ K0
S K+
))/( fu · B(B+ → K0
Sπ+
)) <
5.8 × 10−2 at 90% confidence level, where fc and fu denote the hadronisation fractions of a ¯b
quark
into a B+
c or a B+ meson, respectively
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