2,388 research outputs found
Features of the system of antioxidant protection and lipid peroxidation in microangiopathies against type 2 diabetes mellitus
No full textSavitsky I. V., Gritsan I. I., Sarakhan V. M., Sirman Ya. V., Preys N. I. Features of the system of antioxidant protection and lipid peroxidation in microangiopathies against type 2 diabetes mellitus. Journal of Education, Health and Sport. 2020;10(10): 410-417. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.10.039
https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.10.039
https://zenodo.org/record/7439235
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2020;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
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provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
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The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 18.09.2020. Revised: 12.10.2020. Accepted: 30.10.2020.
UDC 616.379-008.64-09
Features of the system of antioxidant protection and lipid peroxidation in microangiopathies against type 2 diabetes mellitus
I. V. Savitsky, I. I. Gritsan, V. M. Sarakhan, Ya. V. Sirman, N. I. Preys
Odesa National Medical University
Correspondence author: Savytskyi Ivan Volodymyrovich, 65039, Odesa, Fountain road4-а/29, tel.+38050-381-21-83, [email protected]
Abstract
The article presents the results of an experimental study of the AOР and LPО system in animals simulated complications of the microcirculatory tract (diabetic retinopathy, diabetic nephropathy) on the background of type 2 diabetes. It was found that in the group of animals with type 2 diabetes increased the level of DC, TBCproducts and MDA; catalase and FG levels decreased. In animals with simulated DN, AOP disorders were more pronounced compared to animals with DR. This trend can be explained by the fact that in addition to hyperglycemia in these animals, the excessive formation of free radicals contributes to metabolic shifts in ischemic areas of tissues and organs. Disturbance of balance in AOP and LPO in type 2 diabetes triggers a pathogenetic cascade of development of complications of the microcirculatory tract and is accompanied by a tendency to further increase the generation of reactive oxygen species and activation of POL in microangiopathies.
Key words: antioxidant system; diabetes mellitus; diabetic retinopathy; diabetic nephropathy; lipid peroxidation
Constraining anomalous Higgs boson couplings to the heavy-flavor fermions using matrix element techniques
No full textIn this paper, we investigate anomalous interactions of the Higgs boson with heavy fermions, employing shapes of kinematic distributions. We study the processes pp→tt+H, bb+H, tq+H, and pp→H→τ+τ- and present applications of event generation, reweighting techniques for fast simulation of anomalous couplings, as well as matrix element techniques for optimal sensitivity. We extend the matrix element likelihood approach (MELA) technique, which proved to be a powerful matrix element tool for Higgs boson discovery and characterization during Run I of the LHC, and implement all analysis tools in the JHU generator framework. A next-to-leading-order QCD description of the pp→tt+H process allows us to investigate the performance of the MELA in the presence of extra radiation. Finally, projections for LHC measurements through the end of Run III are presented
Measurement of the CKM matrix element |V(ub)| with B ---> rho e nu decays
No full textWe present a measurement of the branching fraction for the rare decays B-->rhoenu and extract a value for the magnitude of V-ub, one of the smallest elements of the Cabibbo-Kobayashi-Maskawa quark-mixing matrix. The results are given for five different calculations of form factors used to parametrize the hadronic current in semileptonic decays. Using a sample of 55x10(6) B (B) over bar meson pairs recorded with the BABAR detector at the PEP-II e(+)e(-) storage ring, we obtain B(B-0-->rho(-)e(+)nu)=(3.29+/-0.42+/-0.47+/-0.55)x10(-4) and \V-ub\=(3.64+/-0.22+/-0.25(-0.56)(+0.39))x10(-3), where the uncertainties are statistical, systematic, and theoretical, respectively
New Charge-Transfer Complexes with 1,2,5-Thiadiazoles as Both Electron Acceptors and Donors Featuring an Unprecedented Addition Reaction
No full textThe design and synthesis of novel charge‐transfer (CT) complexes are of interest for fundamental chemistry and applications to materials science. In addition to the recently described first CT complex with both electron acceptor (A) and donor (D) groups belonging to the 1,2,5‐thiadiazole series (1; A: 4‐nitro‐2,1,3‐benzothiadiazole; D: 4‐amino‐2,1,3‐benzothiadiazole), herein novel CT complexes 2 and 3 with 1,2,5‐thiadiazoles as both A (4,6‐dinitro‐2,1,3‐benzothiadiazole and [1,2,5]thiadiazolo[3,4‐c][1,2,5]thiadiazole) and D (4‐amino‐2,1,3‐benzothiadiazole) were synthesized. The series is completed by complex 4 with [1,2,5]thiadiazolo[3,4‐c][1,2,5]thiadiazole as A and phenoxatellurine as D. Structures of complexes 2–4 were characterized by single‐crystal X‐ray diffraction (XRD), as well as solution and solid‐state UV/Vis spectroscopy. Thermodynamics of their formation were obtained by density functional theory (DFT) calculations, their bonding situations were analyzed by quantum theory of atoms in molecules (QTAIM) calculations and dimer model energies of interactions quantified in the framework of the Hirshfeld surface (HS) analysis. With DFT calculations, the largest value of CT between D and A was found for complex 2, with 0.027 e in the XRD structure and 0.150 e in the optimized structure in MeCN. In the UV/Vis spectra, the λmax of the CT bands of 2–4 varied in the range λ=517–705 nm. Model energy calculations for 1–4 revealed the importance of both dispersion interactions and hydrogen bonding between D and A as contributors to CT in the crystalline state. In an attempt to enlarge the CT value with bis[1,2,5‐thiadiazolo][3,4‐b;3′,4′‐e]pyrazine as A and 4‐amino‐2,1,3‐benzoselenadiazole as D, an unprecedented 1:1 addition reaction was observed upon formation of a C−N bond between atom C7 of D and pyrazine atom N4 of A, accompanied by hydrogen atom transfer from C7 to another pyrazine atom N8 (compound 5). According to DFT calculations, the reaction is a multistep process featuring diradical intermediates and hydrogen atom intramolecular migration over four positions. Molecular and crystal structures of 5 (solvate with toluene) were elucidated by XRD and the crystal structure revealed a rather unusual porous framework
Measurement of the branching fractions of the radiative leptonic tau decays tau -> e gamma v(v)over-bar and tau -> mu gamma v(v)over-bar at BABAR
No full textWe perform a measurement of the tau -> l gamma v (v) over bar (l = e, mu) branching fractions for a minimum photon energy of 10 MeV in the tau rest frame, using 431 fb(-1) of e(+) e(-) collisions collected at the center-of-mass energy of the Upsilon(4S) resonance with the BABAR detector at the PEP-II storage rings. We find B(tau -> mu gamma v (v) over bar = (3.69 +/- 0.03 +/- 0.10) x 10(-3) and B(tau -> e gamma v (v) over bar = (1.847 +/- 0.015 +/- 0.052) x 10(-2), where the first quoted error is statistical and the second is systematic. These results are substantially more precise than previous measurements
Measurement of the branching fractions of the radiative leptonic tau decays tau -> e gamma v(v)over-bar and tau -> mu gamma v(v)over-bar at BABAR
No full textWe perform a measurement of the tau -> l gamma v (v) over bar (l = e, mu) branching fractions for a minimum photon energy of 10 MeV in the tau rest frame, using 431 fb(-1) of e(+) e(-) collisions collected at the center-of-mass energy of the Upsilon(4S) resonance with the BABAR detector at the PEP-II storage rings. We find B(tau -> mu gamma v (v) over bar = (3.69 +/- 0.03 +/- 0.10) x 10(-3) and B(tau -> e gamma v (v) over bar = (1.847 +/- 0.015 +/- 0.052) x 10(-2), where the first quoted error is statistical and the second is systematic. These results are substantially more precise than previous measurements
Sedation of patients in intensive care units
No full textThe guidelines for sedation of patients in intensive care units (ICU) are presented in the article. Indications for sedative therapy, main tasks and approaches to sedation are highlighted. Principles of sedative medications selection, characteristics of effects and adverse reactions of sedative drugs are presented. Tactics for sedation in critically ill patients including patients with hypoxic enceph-alopathy is described. Recommendations on prophylaxis of agitation in patients in ICU are set out. Basic criteria of medical care quality control are presented
Measurement of the B+ -> omega l(+) v and B+ -> eta l(+) v branching fractions
No full textWe present a study of the charmless semileptonic B-meson decays B+ -> omega l(+) v and B+ -> eta l(+) v. The analysis is based on 3.83 x 10(8) B (B) over bar B pairs recorded at the Gamma(4S) resonance with the BABAR detector. The omega mesons are reconstructed in the channel omega -> pi(+)pi(-)pi(0) and the eta mesons in the channels eta -> pi(+)pi(-)pi(0) and eta -> gamma gamma. We measure the branching fractions B(B+ -> omega l(+) v) = (1.14 +/- 0.16(stat) +/- 0.08(syst)) x 10(-4) and B(B+ -> eta l(+) v) = (0.31 +/- 0.06(stat) +/- 0.08(syst)) x 10(-4)
Search for the decay B+-> K+ v(v)over-bar
No full textWe search for the rare flavor-changing neutral-current decay B+ -> K+ v (v) over tilde in a data sample of 82 fb(-1) collected with the BABAR detector at the PEP-II B-factory. Signal events are selected by examining the properties of the system recoiling against either a reconstructed hadronic or semileptonic charged-B decay. Using these two independent samples we obtain a combined limit of B(B+ -> K+ v (v) over bar) pi(+) v (v) over bar) < 1.0 x 10(-4) using only the hadronic B reconstruction method
Evacuation of Critically Ill Obstetric and Gynecological Patients
No full textObjective: to assess the results of evacuation of critically ill obstetric and gynecological patients by ground and air transports to improve the quality of a specialized medical aid on the basis of the technology developed by the Obstetric Resuscitative Advisory Center (ORAC). Subjects and methods. The study was based on the prospective and retrospective analysis of the results of evacuation of 358 critically ill obstetric and gynecological patients in the presence of severe gestosis (n=162), obstetric hemorrhages (n=74), abdominal (obstetric) sepsis (n=68), as well as pregnant women and puerparas with extragenital pathology (n=54) via ground (26.5%) and air (75.3%) transports by the workers of the ORAC in the period of 1998-2006. Results. Complex intensive care aimed at correcting major critical states, performed during evacuation by a resuscitative-advisory team, could provide the steady-state values of vital functions during transportation of obstetric and gynecological patients. Conclusion. A scheme has been developed for safe evacuation of critically ill obstetric and gynecological patients via ground and air transports by the ORAC workers. Key words: patient evacuation, gestosis, hemorrhage, sepsis, obstetrics, gynecology
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