849,021 research outputs found
Doubly magic nuclei from lattice QCD forces at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msub><mml:mi>M</mml:mi><mml:mi>PS</mml:mi></mml:msub><mml:mo>=</mml:mo><mml:mn>469</mml:mn><mml:mspace width="0.16em" /><mml:mi>MeV</mml:mi><mml:mo>/</mml:mo><mml:msup><mml:mi>c</mml:mi><mml:mn>2</mml:mn></mml:msup></mml:mrow></mml:math>
No full textWe perform ab initio self-consistent Green's function calculations of the closed shell nuclei He4, O16, and Ca40, based on two-nucleon potentials derived from lattice QCD simulations, in the flavor SU(3) limit and at the pseudoscalar meson mass of 469 MeV/c2. The nucleon-nucleon interaction is obtained using the hadrons-to-atomic-nuclei-from-lattice (HAL) QCD method, and its short-distance repulsion is treated by means of ladder resummations outside the model space. Our results show that this approach diagonalizes ultraviolet degrees of freedom correctly. Therefore, ground-state energies can be obtained from infrared extrapolations even for the relatively hard potentials of HAL QCD. Comparing to previous Brueckner Hartree-Fock calculations, the total binding energies are sensibly improved by the full account of many-body correlations. The results suggest an interesting possible behavior in which nuclei are unbound at very large pion masses and islands of stability appear at first around the traditional doubly magic numbers when the pion mass is lowered toward its physical value. The calculated one-nucleon spectral distributions are qualitatively close to those of real nuclei even for the pseudoscalar meson mass considered here
Measurement of the top-quark mass in all-jets events in pp collisions at = 7 TeV
No full textThe mass of the top quark is measured using a sample of candidate events with at least six jets in the final state. The sample is selected from data collected with the CMS detector in pp collisions at = 7 TeV in 2011 and corresponds to an integrated luminosity of 3.54 . The mass is reconstructed for each event employing a kinematic fit of the jets to a hypothesis. The top-quark mass is measured to be 173.49 0.69(stat.) 1.21(syst.) GeV. A combination with previously published measurements in other decay modes by CMS yields a mass of 173.54 0.33(stat.) 0.96(syst.) GeV
Improved Prediction of the Indian Ocean Dipole Mode by Use of Subsurface Ocean Observations
No full textThe numerical seasonal prediction system using the Scale Interaction Experiment-Frontier version 1 (SINTEX-F) ocean-atmosphere coupled model has so far demonstrated a good performance for prediction of the Indian Ocean dipole mode (IOD) despite the fact that the system adopts a relatively simple initialization scheme based on nudging only the sea surface temperature (SST). However, it is to be expected that the system is not sufficient to capture in detail the subsurface oceanic precondition. Therefore, the authors have introduced a new three-dimensional variational ocean data assimilation (3DVAR) method that takes three-dimensional observed ocean temperature and salinity into account. Since the new system has successfully improved IOD predictions, the present study is showing that the ocean observational efforts in the tropical Indian Ocean are decisive for improvement of the IOD predictions and may have a large impact on important socioeconomic activities, particularly in the Indian Ocean rim countries
Cellular-level versus receptor-level response threshold hierarchies in T-Cell activation
No full textPeptide-MHC (pMHC) ligand engagement by T-cell receptors (TCRs) elicits a variety of cellular responses, some of which require substantially more TCR-mediated stimulation than others. This threshold hierarchy could reside at the receptor level, where different response pathways branch off at different stages of the TCR/CD3 triggering cascade, or at the cellular level, where the cumulative TCR signal registered by the T-cell is compared to different threshold values. Alternatively, dual-level thresholds could exist. In this study, we show that the cellular hypothesis provides the most parsimonious explanation consistent with data obtained from an in-depth analysis of distinct functional responses elicited in a clonal T-cell system by a spectrum of biophysically defined altered peptide ligands across a range of concentrations. Further, we derive a mathematical model that describes how ligand density, affinity, and off-rate all affect signaling in distinct ways. However, under the kinetic regime prevailing in the experiments reported here, the TCR/pMHC class I (pMHCI) dissociation rate was found to be the main governing factor. The CD8 coreceptor modulated the TCR/pMHCI interaction and altered peptide ligand potency. Collectively, these findings elucidate the relationship between TCR/pMHCI kinetics and cellular function, thereby providing an integrated mechanistic understanding of T-cell response profiles
Increased percentages of regulatory T cells are associated with inflammatory and neuroendocrine responses to acute psychological stress and poorer health status in older men and women.
No full textThe percentage of regulatory T cells (TRegs)-a subtype of T lymphocyte that suppresses the immune response-appears to be reduced in a number of stress-related diseases. The role of the TReg in stress-disease pathways has not yet been investigated
Studies of dijet transverse momentum balance and pseudorapidity distributions in pPb collisions at √sNN=5.02 TeV
No full textOpen Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the
source are credited. Funded by SCOAP3 / License Version CC BY 4.0.Dijet production has been measured in pPb collisions at a nucleon–nucleon centre-of-mass energy of 5.02 TeV . A data sample corresponding to an integrated luminosity of 35 nb −1 was collected using the Compact Muon Solenoid detector at the Large Hadron Collider. The dijet transverse momentum balance, azimuthal angle correlations, and pseudorapidity distributions are studied as a function of the transverse energy in the forward calorimeters ( E 4<|η|<5.2 T ). For pPb collisions, the dijet transverse momentum ratio and the width of the distribution of dijet azimuthal angle difference are comparable to the same quantities obtained from a simulated pp reference and insensitive to E 4<|η|<5.2 T . In contrast, the mean value of the dijet pseudorapidity is found to change monotonically with increasing E 4<|η|<5.2 T , indicating a correlation between the energy emitted at large pseudorapidity and the longitudinal motion of the dijet frame. The pseudorapidity distribution of the dijet system in minimum bias pPb collisions is compared with next-to-leading-order perturbative QCD predictions obtained from both nucleon and nuclear parton distribution functions, and the data more closely match the latter
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
T-Cell Subsets Predict Mortality in Malnourished Zambian Adults Initiating Antiretroviral Therapy.
No full textThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedTo estimate the prognostic value of T-cell subsets in Zambian patients initiating antiretroviral therapy (ART), and to assess the impact of a nutritional intervention on T-cell subsets.This work was supported by European and Developing Countries Clinical Trials Partnership grant # IP.2009.33011.004; trial foods were prepared and supplied by Nutriset, Malauney, Franc
Registering a DataCite DOI on SORER - step-by-step guide
No full textPersistent identifiers (PIDs) are necessary to facilitate discoverability, citation, and re-use of research outputs today and in the future. A Digital Object Identifier (DOI) is one such a PID and helps research institutions and researchers to increase the visibility and impact of their publications. This webinar, organized by AfLIA and DataCite, gives an introduction to DataCite DOIs, addresses the relevance of DOI metadata, and shows step-by-step how to get a DataCite DOI.
In his presentation Mohamed Ali Ahmed gives a step-by-step introduction on how to register a DataCite DOI using SomaliREN.
A recording of the talk can be found here: https://www.youtube.com/watch?v=3FFWW4b37J0&t=1797
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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