1,906 research outputs found
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
A "tradução" do paradigma etiológico de criminologia no Brasil: um diálogo entre Cesare Lombroso e Nina Rodrigues da perspectiva centro-margem
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Jurídicas, Programa de Pós-Graduação em Direito, Florianópolis, 2015.A presente dissertação tem por objetivo principal compreender qual foi e como se operalizou a ?tradução? (processo complexo que inclui várias técnicas, se afastando, assim, da mera recepção) da teoria lombrosiana e principalmente do paradigma fundado pela Criminologia Positivista, funcional ao controle social no Centro (Europa), realizada por Raimundo Nina Rodrigues para o controle racial na Margem (Brasil) no pós-abolição. Em seu contexto original, aquele paradigma, consolidado na obra L?Uomo Delinquente, possibilitou a seleção e segregação de uma minoria ?anormal? visando seu disciplinamento através de estabelecimentos correcionais, mas sua concepção se encontra na primeira obra de Lombroso, L?uomo bianco e l?uomo do colore: letture sull?origine e la varietà delle razze umane, cuja tradução literal inédita se faz necessária para a compreensão pretendida, procurando, além do resgate de seu racismo negado, marcar as permanências e rupturas (se houver) durante a travessia atlântica. Nesse trajeto, desvelamos a construção de seus ?Outros? que nos leva à construção, muito além do centro, de sua espécie mais primitiva: o negro. Para ter sua funcionalidade assegurada em um contexto periférico singular, marcado pelo recente fim do maior sistema escravagista do mundo, a teoria do criminoso nato possibilitou a manutenção da ordem racial atravessando o quadro teórico liberal da jovem República ao ter retomada sua matriz racista, reforçada e potencializada pelo médico brasileiro, legítimo representante da classe escravagista, pelo ecletismo teórico-racial central, criando um discurso que considerou o negro e seus descendentes, a maioria da população brasileira, nossos criminosos natos e obstáculos ao desenvolvimento e progresso nacional. Neste sentido, Nina Rodrigues esboçou um modelo de controle racial projetado sob um paradigma original que atendia as necessidades de ordem da sociedade brasileira deslegitimando o discurso teórico liberal em relação aos ?inferiores? que deveria ser restrito aos ?superiores?, a raça branca e ariana, defendendo um apartheid brasileiro estribado na cientificidade racial central ao mesmo tempo em que endossava e desvelava as práticas punitivistas escravagistas responsáveis pela contenção do caos ao perseguir os negros em sua ?liberdade?.Resumen : Este trabajo tiene como objetivo principal entender que razón y cómo operalizou la "traducción" (proceso complejo que incluye varias técnicas, alejándose, así, la simple recepción) de la teoría lombrosiana y sobre todo el paradigma establecido por la Criminología Positivista, funcional para el control social en el Centro (Europa) ocupado por Raimundo Nina Rodrigues al control racial en el margen (Brasil) en el post-abolición. En su contexto original, el paradigma tiene sus raíces en la obra L'Uomo Delincuente, que permitió la selección y segregación de una minoría "anormal" en busca de su disciplina a través de los establecimientos penitenciarios, pero su concepción se encuentra en la primera obra de Lombroso, bianco L'uomo y l'uomo do colores: letture sull origine e la varietà delle razze umane, cuya traducción literal sin precedentes se requiere para la comprensión deseada, buscando, además de rescatar a su racismo negada, marque las continuidades y rupturas (si las hay) para la travesía del Atlántico. En este camino, develamos la construcción de su "otro" que nos lleva a la construcción, mucho más allá del centro, sus especies más primitivas: el negro. Para tener la seguridad de su funcionalidad en un contexto periférico especifico, marcado por un fin reciente del sistema esclavista más grande en el mundo, la teoría del delincuente nato posibilito mantener el orden racial a través del marco teórico liberal de la joven República, reanudó su matriz racista y mejorada impulsado por el médico brasileño, legítimo representante de la clase del esclavo, por el eclecticismo teórico y racial central, la creación de un discurso que considera el negro y sus descendientes, la mayoría de la población, los delincuentes y los obstáculos para el desarrollo y el progreso nacional. En este sentido, Nina Rodrigues dio un modelo de control racial diseñado en un paradigma único que respondía a las necesidades de orden de la sociedad brasileña, deslegitimando el discurso teórico liberal en relación con el "inferior" que debería limitarse a "superior", la raza blanca y aria la defensa de un apartheid brasileño estribado en la cientificidad racial del centro, tiempo que respalda y desvelava prácticas punitivistas esclavagistas responsables para la contención del caos para perseguir los negros en su "libertad"
Measurement of the polarization amplitudes and triple product asymmetries in the B0s → Φ Φ decay
No full text<p>Using 1.0 fb−1 of pp collision data collected at a centre-of-mass energy of s√=7 TeV with the LHCb detector, measurements of the polarization amplitudes, strong phase difference and triple product asymmetries in the B0s→ϕϕ decay mode are presented. The measured values are</p>
<p>|A0|2=0.365±0.022(stat)±0.012(syst),|A⊥|2=0.291±0.024(stat)±0.010(syst),cos(δ∥)=−0.844±0.068(stat)±0.029(syst),AU=−0.055±0.036(stat)±0.018(syst),AV=0.010±0.036(stat)±0.018(syst).</p>
Measurement of the branching fraction
No full textThe B
0
s
→ J/ψK
0
S
branching fraction is measured in a data sample corresponding to 0.41 fb−1
of integrated luminosity collected with the LHCb detector at the LHC. This channel is sensitive to
the penguin contributions affecting the sin 2β measurement from B
0
→ J/ψK
0
S
. The time-integrated
branching fraction is measured to be B(B
0
s
→ J/ψK
0
S
) = (1.83±0.28)×10−5
. This is the most precise
measurement to date
Modeling neuronal consequences of autism-associated gene regulatory variants with human induced pluripotent stem cells
No full textGenetic factors contribute to the development of autism spectrum disorder (ASD), and although non-protein-coding regions of the genome are being increasingly implicated in ASD, the functional consequences of these variants remain largely uncharacterized. Induced pluripotent stem cells (iPSCs) enable the production of personalized neurons that are genetically matched to people with ASD and can therefore be used to directly test the effects of genomic variation on neuronal gene expression, synapse function, and connectivity. The combined use of human pluripotent stem cells with genome editing to introduce or correct specific variants has proved to be a powerful approach for exploring the functional consequences of ASD-associated variants in protein-coding genes and, more recently, long non-coding RNAs (lncRNAs). Here, we review recent studies that implicate lncRNAs, other non-coding mutations, and regulatory variants in ASD susceptibility. We also discuss experimental design considerations for using iPSCs and genome editing to study the role of the non-protein-coding genome in ASD
Rational identification of a colorectal cancer targeting peptide through phage display
No full textColorectal cancer is frequently diagnosed at an advanced stage due to the absence of early clinical indicators. Hence, the identification of new targeting molecules is crucial for an early detection and development of targeted therapies. This study aimed to identify and characterize novel peptides specific for the colorectal cancer cell line RKO using a phage-displayed peptide library. After four rounds of selection plus a negative step with normal colorectal cells, CCD-841-CoN, there was an obvious phage enrichment that specifically bound to RKO cells. Cell-based enzyme-linked immunosorbent assay (ELISA) was performed to assess the most specific peptides leading to the selection of the peptide sequence CPKSNNGVC. Through fluorescence microscopy and cytometry, the synthetic peptide RKOpep was shown to specifically bind to RKO cells, as well as to other human colorectal cancer cells including Caco-2, HCT 116 and HCT-15, but not to the normal non-cancer cells. Moreover, it was shown that RKOpep specifically targeted human colorectal cancer cell tissues. A bioinformatics analysis suggested that the RKOpep targets the monocarboxylate transporter 1, which has been implicated in colorectal cancer progression and prognosis, proven through gene knockdown approaches and shown by immunocytochemistry co-localization studies. The peptide herein identified can be a potential candidate for targeted therapies for colorectal cancer.Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2019 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte and the Project FCOMP-01–0124-FEDER-021053 (PTDC/SAU-BMA/121028/2010). Débora Ferreira is recipient of a fellowship supported by a doctoral advanced training (call NORTE-69-2015-15) funded by the European Social Fund under the scope of Norte2020 - Programa Operacional Regional do Norte. Franklin L. Nobrega, Sara Granja and Ligia R Rodrigues acknowledge FCT for the grants SFRH/BD/86462/2012, SFRH/BPD/117858/2016 and SFRH/BSAB/142991/2018, respectively. Catarina Barbosa-Matos also acknowledge her research grant UMINHO/BI/395/2018info:eu-repo/semantics/publishedVersio
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Measurement of the fragmentation fraction ratio fs/fd and its dependence on B meson kinematics
No full textThe relative production rate of B0s and B 0 mesons is determined with the hadronic decays B0s→D−sπ+ and B 0 → D − K +. The measurement uses data corresponding to 1.0 fb−1 of pp collisions at a centre-of-mass energy of s√=7 TeV recorded in the forward region with the LHCb experiment. The ratio of production rates, f s /f d , is measured to be 0.238 ± 0.004 ± 0.015 ± 0.021, where the first uncertainty is statistical, the second systematic, and the third theoretical. This is combined with a previous LHCb measurement to obtain f s /f d = 0.256 ± 0.020. The dependence of f s /f d on the transverse momentum and pseudorapidity of the B meson is determined using the decays B0s→D−sπ+ and B 0 → D −π+. There is evidence for a decrease with increasing transverse momentum, whereas the ratio remains constant as a function of pseudorapidity. In addition, the ratio of branching fractions of the decays B 0 → D − K + and B 0 → D −π+ is measured to be 0.0822 ± 0.0011 (stat) ± 0.0025 (syst)
Discovery of an optical counterpart to the hyperluminous X-ray source in ESO 243-49
No full textThe existence of black holes of masses similar to 10(2)-10(5)M(circle dot) has important implications for the formation and evolution of star clusters and supermassive black holes. One of the strongest candidates to date is the hyperluminous X-ray source (HLX1), possibly located in the S0- a galaxy ESO 243-49, but the lack of an identifiable optical counterpart had hampered its interpretation. Using the Magellan telescope, we have discovered an unresolved optical source with R = 23.80 +/- 0.25 mag and V = 24.5 +/- 0.3 mag within HLX1's positional error circle. This implies an average X-ray/optical flux ratio similar to 500. Taking the same distance as ESO 243-49, we obtain an intrinsic brightness M-R = -11.0 +/- 0.3 mag, comparable to that of a massive globular cluster. Alternatively, the optical source is consistent with a main-sequence M star in the Galactic halo (for example an M4.4 star at approximate to 2.5 kpc). We also examined the properties of ESO 243-49 by combining Swift/Ultraviolet/Optical Telescope (UVOT) observations with stellar population modelling. We found that the overall emission is dominated by a similar to 5-Gyr-old stellar population, but the UV emission at approximate to 2000 angstrom is mostly due to ongoing star formation at a rate of similar to 0.03M(circle dot) yr(-1). The UV emission is more intense (at least a 9 sigma enhancement above the mean) north-east of the nucleus, in the same quadrant as HLX1. With the combined optical and X-ray measurements, we put constraints on the nature of HLX1. We rule out a foreground star and a background AGN. Two alternative scenarios are still viable. HLX1 could be an accreting intermediate mass black hole in a star cluster, which may itself be the stripped nucleus of a dwarf galaxy that passed through ESO 243-49, an event which might have caused the current episode of star formation. Or, it could be a neutron star in the Galactic halo, accreting from an M4-M5 donor star
Publicação dos pesquisadores da agronomia no Brasil: um estudo dos periódicos
No full textTCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Educação. Curso de Biblioteconomia.Este trabalho tem como objetivo conhecer a preferência de publicação dos pesquisadores com bolsa de produtividade e pesquisa classificado como 1A nas Ciências Agrárias, adotando como foco a subárea da Agronomia. Analisa os periódicos científicos onde 34 pesquisadores publicaram seus artigos no ano de 2013. Tem como objetivos específicos: a) Identificar os pesquisadores 1A na Agronomia, as instituições nas quais atuam e o número de artigos publicados em 2013; b) Identificar os periódicos eletrônico onde foram publicados artigos e descrevê-los de acordo com seu país de procedência e instituição/entidade editora; c) Apontar o tipo de acesso aos periódicos e sua avaliação no Qualis/Capes. Como metodologia foi utilizado o método exploratório e descritivo, bibliográfico e documental. O corpus da pesquisa é composto por 129 periódicos. Os dados foram coletados nos meses de junho e julho de 2014 com referência ao ano de 2013. A pesquisa revelou que os periódicos brasileiros foram os mais procurados pelos pesquisadores para publicar seus artigos, seguido por EUA, Reino Unido e Holanda. Quanto à opção por editoras, as comercias se mantem forte na preferência de publicação seguida pelas editoras universitárias. O tipo de acesso o mais utilizado ainda é o Restrito/Opção Autor paga seguido pela opção do Acesso Aberto. Com relação ao Qualis percebeu-se que os periódicos brasileiros, apesar de serem bastantes procurados para publicação, nenhum obteve nível 1A.This study aims to know the preference of researchers with scholarship in publication productivity and research 1A inside Agricultural Sciences, targeting the subarea of Agronomy. Analyzes the scientific journals where 34 researchers published their articles in 2013. Its specific objectives are: a) Identify the 1A researchers in agronomy, the institutions in which they work and the number of articles published in 2013; b) Identify the electronic journals where articles were published and describe them according to their country of origin and institution / publishing entity; c) Direct the type of access to journals and their evaluation in Qualis / CAPES. The methodology used in this paper is based in the exploratory-descriptive and bibliographical-documentary method. The research corpus is composed of 129 journals. Data were collected between June and July 2014 with reference to the year 2013. The survey revealed that the Brazilian journals were the most sought after by researchers to publish their articles, followed by USA, UK and Holland. Regarding the choice of publishers, the commercial keeps strong preference for publication followed by university presses. The access type most used is still the Restricted / Option Author Pays followed by the Open Access option. Regarding the Qualis, it was realized that the Brazilian journals, despite the sought for publication, none have achieved level 1A
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