62,962 research outputs found
Explorando el uso de herramientas de sensores remotos y tecnologías geoespaciales aplicadas al problema multidimensional de la seguridad alimentaria
No full textEl objetivo de este estudio fue analizar qué papel pueden jugar las tecnologías de teledetección para estudiar los factores multidimensionales que influyen en la seguridad alimentaria y nutricional (SAN), en Córdoba Argentina. [Metodología] El área de estudio comprende la ciudad de Córdoba, Argentina. Se obtuvieron datos epidemiológicos de la prevalencia de bajo peso, sobrepeso y obesidad (malnutrición) durante el 2013 de 23 centros de atención primaria de la ciudad. Se exploraron las condiciones ambientales de los centros en un radio de 1000 m. Se clasificaron imágenes SPOT 5, se utilizaron características espectrales y espaciales y se evidencia cómo una clasificación no supervisada puede dar información para describir la dimensión social y el acceso económico a los alimentos. Se realizó una regresión lineal multivariante para examinar la relación entre la prevalencia de malnutrición y las variables ambientales y espaciales, derivadas de las imágenes SPOT. [Resultados] Los resultados de la clasificación no supervisada de imágenes muestran la diferencia en el patrón espectral-espacial de los barrios, evidencian cómo una simple clasificación de imágenes de satélite puede convertirse en una herramienta de discriminación útil. Se obtienen análisis de regresión múltiple con R2 ajustados de 0,70 y 0,6435 respectivamente para desnutrición, y sobrepeso y obesidad. A partir de los modelos obtenidos, se construyen mapas continuos de prevalencia. [Conclusiones] El método propuesto en este trabajo puede discriminar socialmente diferentes áreas relacionadas con la SAN. Es innovador y necesario aprovechar las herramientas de teledetección y las tecnologías geoespaciales, en nuestra región, aplicadas a la SAN.Di Fino, E., Scavuzzo, C., Campero, M., Scavuzzo, C., & Defagó, M. (2022). Exploring the use of remote sensing tools and geospatial technologies applied to the multidimensional food security problem. Uniciencia, 36(1), 1-15. https://doi.org/10.15359/ru.36-1.4
the mystery of colour for the young Le Corbusier, chromatic memories from voyage d'orient to maison blanche
No full textIl bisogno di Le Corbusier di vincolare l’opera a principi di validità universale radicati nella cultura e nella storia, lo ha condotto a ricercare continue conferme nelle opere del passato.
Anche per questo la sua opera, pur nella sua eccezionalità, è emblematica della cultura occidentale per il lungo tratto che ne ha percorso.
Il rapporto con il colore è, in questo senso, paradigmatico.
Molta cultura occidentale ha combattuto l’inquietudine per il potere misterioso del colore, ha tentato di depotenziarne la minaccia, sminuendone il ruolo, relegando il colore al decorativo, al femminile, all’infantile o al primitivo.
Le Corbusier è stato attraversato sia dall’attrazione inebriata che dalla ripulsa quasi fobica per il colore, come le alterne e contraddittorie affermazioni in proposito dimostrano, cercando di risolvere questo dissidio elaborando quel complesso strumento di controllo che sono i Claviers de couleurs.
Si è cercato di ripercorrere alcuni momenti di questo intenso rapporto esaminando la casa in cui il giovane Jeanneret applica le memorie dei cromatismi descritti nei carnets del viaggio in Oriente, la Maison Blanche,
e poi la casa considerata “soglia” verso l’applicazione dei principi della nuova architettura, è la Maison La Roche. In entrambe l’esterno bianco racchiude elaborati esercizi di policromia architettonica
SPANX-B and SPANX-C (Xq27 region) gene dosage analysis in Down's syndrome subjects with undescended testes
No full textDown’s syndrome (DS) is one of the most common numer-
ical chromosomal aberrations, usually caused by trisomy of
chromosome 21, and is frequently complicated with congen-
ital heart defects, duodenal obs
truction and other conditions
including undescended testis (UDT) (Fonkalsrud 1970). The
incidence of undescended testes in DS was reported to be
6.52% (Chew and Hutson 2004) while the incidence of UDT
in the first year is approximately 0.2%–0.8% in the nor-
mal population (Benson
et al
. 1991; Ichiyanagi
et al
. 1998).
Rapley
et al
. (2000) provided evidence for a testicular germ-
cell tumours (TGCT) predisposition locus at Xq27; the au-
thors obtained an hlod score of 4.7 from families with at least
one bilateral case, corresponding to a genome-wide signifi-
cance level of
P
=
0
.
034. The proportion of families with
undescended testis linked to this locus was 74%.
SPANX
(sperm protein associated with the nucleus in the X chro-
mosome) gene family maps in the same chromosomal region
and seven highly homologous genes belonging to this fam-
ily have been described (
SPANX-A1, SPANX-A2, SPANX-B1,
SPANX-B2, SPANX-C, SPANX-D
and
SPANX-E
) according
to the human genome database build 36.2. These genes,
made up of two exons separated by a small intron of
≈
650
bp, are expressed in sperm cells (Westbrook
et al
. 2000) and
in many tumours (Wang
et al
. 2003; Zendman
et al
. 2003;
Westbrook
et al
. 2004). Moreover, expression of
SPANX genes has been demonstrated in TGCT (Salemi
et al
. 2006).
The function of
SPANX
gene-encoded proteins is currently
unknown, and it is also not known if all the members or
some of them are normally expressed in the testis (West-
brook
et al
. 2000). Evidence suggests that
CTp11
,which
is 100% homologous to
SPANX-C
, is expressed in tumours
such as melanoma (Zendman
et al
. 2003), and
SPANX-B
in
myeloma and other haematological malignancies (Wang
et
al
. 2003; Zendman
et al
. 2003).
SPANX-C
mRNA was found
expressed in normal tissues and in embryonal carcinomas of
the testis (Salemi
et al
. 2006). Further, it is very di
ffi
cult to
design primers adequate for gene-specific PCR amplification
within the SPANX locus. For this reason, we decided to fo-
cus our study on
SPANX-C
and
SPANX-B
genes. The aim of
this study is to evaluate the genetic variability of
SPANX-B
and
SPANX-C
in D.UDT (Down’s syndrom patients a
ff
ected
by undescended testis) compared with D (Down’s syndrom
patients without undescended testis) and Nm (normal popu-
lation)
Deep into the niche: Deciphering local endoderm-microenvironment interactions in development, homeostasis, and disease of pancreas and intestine
No full textThis is the Accepted Version of the following article: Szlachcic, W. J., Letai, K. C., Scavuzzo, M. A., & Borowiak, M. (2023). Deep into the niche: Deciphering local endoderm-microenvironment interactions in development, homeostasis, and disease of pancreas and intestine. BioEssays, 45, e2200186, which has been published at https://doi.org/10.1002/bies.202200186. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [http://www.wileyauthors.com/self-archiving].
The read-only version of Final Published Version can be accessed here: https://onlinelibrary.wiley.com/share/author/3J48826BWNJ6KJPECKIR?target=10.1002/bies.202200186Unraveling molecular and functional heterogeneity of niche cells within the developing endoderm could resolve mechanisms of tissue formation and maturation. Here, we discuss current unknowns in molecular mechanisms underlying key developmental events in pancreatic islet and intestinal epithelial formation. Recent breakthroughs in single-cell and spatial transcriptomics, paralleled with functional studies in vitro, reveal that specialized mesenchymal subtypes drive the formation and maturation of pancreatic endocrine cells and islets via local interactions with epithelium, neurons and microvessels. Analogous to this, distinct intestinal niche cells regulate both epithelial development and homeostasis throughout life. We propose how this knowledge can be used to progress research in the human context using pluripotent stem cell-derived multilineage organoids. Overall, understanding the interactions between the multitude of microenvironmental cells and how they drive tissue development and function could help us make more therapeutically relevant in vitro models.Narodowe Centrum Nauki (OPUS UMO-2019/33/B/NZ3/01226, OPUS UMO-2020/37/B/NZ3/01917, OPUS UMO-2020/39/B/NZ3/01408 dla M.B., SONATA UMO-2021/43/D/NZ3/02294 dla W.J.Sz.), Fundacja na Rzecz Nauki Polskiej - Program TEAM (POIR.04.04.00-00-20C5/16-00) dla M.B., HHMI Hana Gray Fellowship i NYSCF Druckenmiller Fellowship dla M.A.S
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
"Mezziuomini, mezzedonne e piglianculo". Rappresentazioni e relazioni nella Sicilia Occidentale
No full textSe nei confronti degli “uomini” è possibile attribuire, per inferenza, qualità quali la coerenza, la libertà di giudizio e l'onestà, sia i “mezzi uomini” che, di rimando, le “mezze donne” e i “piglianculo” nascondono un lato oscuro, una percentuale imprecisata di disvalore. Essa è fornita dalle stigmatizzazioni periodiche a cui sono sottoposti nell’incontro con gli altri. Perché, se gli ominicchi scimmiottano, i pigliainculo non avendo, dal termine che li addita, una “integrità autoriflessiva”, e subendo una espropriazione relazionale del proprio sé autentico, sperimentano in modi differenti l’incontro con l’altri. Il sagggio ripercorre alcuni lemmi che dalla vita quotidiana alla letteratura siciliana ripercorrono le rappresentazioni che dell'omosessualità la società insulare ha a lungo conservato. Svolge poi, attraverso i risultati una ricerca condotta fra giovani omossessuali dichiarati siciliani, un confronto con le attuali rappresentazioni dell'omosessualità
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Faust : Romance Of The Secret Tribunals / By George W. M. Reynolds, Author Of "The Mysteries Of London", "Pickwick Abroad", &c. Illustrated In The First Style Of The Art
No full textFAUST : ROMANCE OF THE SECRET TRIBUNALS / BY GEORGE W. M. REYNOLDS, AUTHOR OF "THE MYSTERIES OF LONDON", "PICKWICK ABROAD", &C. ILLUSTRATED IN THE FIRST STYLE OF THE ART
Faust : Romance Of The Secret Tribunals / By George W. M. Reynolds, Author Of "The Mysteries Of London", "Pickwick Abroad", &c. Illustrated In The First Style Of The Art (1)
Cover (1)
Umschlagtitel (8)
Titelseite (9)
Contents (10)
Illustrations / Prologue (11)
Prologue (12)
Chapter I.-XCV. (14)
Epilogue (119
Erratum to: Effects of nutraceuticals on quality of life and sexual function of perimenopausal women (Journal of Endocrinological Investigation, (2017), 40, 1, (27-32), 10.1007/s40618-016-0500-2)
No full textUnfortunately, one of the co-author first name was wrongly published in the original version. The complete correct name of the co-author is given below. A. M. C. Rapisarda. The original version of this article is also updated
- …
