355 research outputs found
Author's gift inscription, in The heather on fire; a tale of the Highland clearances
No full textThis edition includes an author's gift inscription, "To Mrs John Dillon with sincere esteem Mathilde Blind".Blind, Mathilde, 1841-189
Gender and pedagogics - Mathilde Vaerting, professor of educational science (Jena, 1923-1933)
Get PDFDer Aufsatz skizziert Leben und Karriere von Mathilde Vaerting (1884-1977), der ersten Professorin für Erziehungswissenschaft in Deutschland, Jena 1923-1933. Ihr Hauptwerk „Neubegründung der Psychologie von Mann und Weib", 1921ff., wird unter Aspekten der Forschungslogik analysiert und auf Konsequenzen für die Erziehungswissenschaft befragt. Ihre Forderung nach Gleichberechtigung und Abwehr jeglicher Herrschaft werden vor dem Hintergrund heutiger feministischer Forderungen diskutiert. Im Anschluß an die Betrachtung der zeitgenössischen Rezeption Mathilde Vaertings wird die Frage aufgeworfen, inwieweit ihr Leben und ihre Karriere die Stellung der Frau in der Wissenschaft während der zwanziger Jahre (und auch später?) spiegeln. (DIPF/Orig.)The author outlines the biography and career of Mathilde Vaerting (1884-1977), the first woman to hold a chair in educational science in Germany. Her major work - Neubegründung der Psychologie von Mannund Weib (1921 fol.) - is analyzed from a methodological point of view and with respect to its implications for educational research. Vaerting\u27s demands for equal rights for women and her rejection of any kind of domination are discussed within the framework of present feminist positions. After having studied how contemporaries reacted to Mathilde Vaerting\u27s writings, the author raises the question of whether Vaerting\u27s life and career reflect the Status of women in science during the 1920s (and later on?). (DIPF/Orig.
Effi Briest, Mathilde Möhring. The Development of Theodor Fontane's Female Characters on the Background of Women Emancipation.
No full textTheodore Fontane is best known as the author of numerous women's novels, which he wrote in the last ten years of his life. This diploma thesis deals with the topic of women's emancipation on the basis of textual analysis of two latter novels by Theodore Fontane - Effi Briest and Mathilde Möhring. In the first part, it characterizes the topic of the period women's emancipation and puts the author's biography into context. In the second part, it creates the picture of position of the main women characters. The last part describes the personal development of the women characters, on the basis of which I determine how much the women's emancipation reflects in the author's work and what is his attitude towards it. This thesis deals with the interpretation of the author's intent to illustrate the creation of an advanced character like Mathilde Möhring. Key words: Theodore Fontane, women's emancipation, Effi Briest, Mathilde Möhring, development of women's characters, women's novels, interpretation, author's intent, counterpoin
Utilité et tolérance de la réalisation d’une biopsie hépatique pour l’exploration des anomalies hépatiques après une allogreffe de cellules souches hématopoïétiques
No full textLiver blood tests abnormalities are common after allogeneic hematopoietic stem cell transplantation (allo-HSCT) but their cause often remains difficult to identify. Our objective was to evaluate the safety and utility of liver biopsy in patients who underwent allo-HSCT. In a retrospective single center cohort study, we reviewed all cases of patients who underwent liver biopsy between June 2005 and July 2017. During this period, 54 biopsies were performed in 45 patients; 38 patients underwent allo-HSCT for malignant and 7 for non-malignant hematological disorders. Median time between allo-HSCT and liver biopsy was 213 days. Seven biopsies were percutaneous and 47 transjugular. No adverse event related to the biopsy procedure occurred. Graft versus host disease was histologically demonstrated in 16 biopsies (30%), and sinusoidal obstruction syndrome in 3 (5%). Association between clinical, laboratory, imaging and pathological features was poor. Only 34% of physicians’ pre-biopsy hypotheses were confirmed by pathological findings. Patient management was influenced by liver biopsy results in 65% of the cases, allowing to identify a new diagnosis (n=13), ruled out a differential diagnosis (n=14) or confirmed the main hypothesis (n=6). In conclusion, liver biopsy is a safe and useful technique to investigate liver blood test abnormalities following allo-HSCT.Les anomalies du bilan hépatique sont fréquentes après une allogreffe de cellules souches hématopoïétiques (CSH) mais leur étiologie reste parfois difficile à identifier. Notre objectif était d’évaluer la sécurité et l’utilité des ponctions biopsies hépatiques (PBH) chez des patients allogreffés. Dans cette étude rétrospective mono-centrique, nous avons identifié 54 biopsies réalisées chez 45 patients entre juin 2005 et juillet 2017 après une allogreffe de CSH. Le délai médian entre l’allogreffe et la PBH était de 213 jours [7-8 642]. Sept PBH ont été réalisées par voie percutanée et 47 par voie trans-jugulaire. Aucun effet indésirable lié à la procédure n’a été rapporté. 94,5% des biopsies (51/54) ont permis d’obtenir un diagnostic histologique. 30% des biopsies ont permis le diagnostic de maladie du greffon contre l’hôte cholestéatique, 17% celui d’hépatite allo-immune, 5% celui de syndrome d’obstruction sinusoïdale. Les données cliniques (hépatomégalie, hypertension portale, prise de poids), biologiques (cytolyse, cholestase, hyper-bilirubinémie, PCR virales sanguines et autoanticorps) ou radiologiques ne permettaient pas de prédire le diagnostic histologique. Seules 34% des hypothèses pré-biopsies émises par les cliniciens ont été confirmées par l’histologie. La biopsie a modifié la prise en charge de 65% des patients : nouveau diagnostic (n=13), élimination de diagnostic différentiel (n=14), confirmation diagnostique (n=6). En conclusion, la réalisation d’une PBH pour explorer des anomalies du bilan hépatique post-allogreffe de CSH est une procédure sûre dont les résultats ont un impact significatif sur la prise en charge des patients allogreffés
Décrypter les mécanismes d'action du traitement par anticorps monoclonal anti-PD-1 dans le ganglion drainant de la tumeur
No full textL'utilisation d'anticorps monoclonaux inhibant les checkpoints immunitaires, famille de molécule dont fait partie PD-1, est l'une des avancées thérapeutiques majeures en Oncologie ces dernières années. Il est généralement admis que les anticorps anti-PD-1 ont une action ciblée et restreinte au micro-environnement tumoral, où ils induisent l'activation et la prolifération d'une catégorie particulière de lymphocytes T CD8+. Néanmoins, des études récentes montrent que les anticorps anti-PD-1 entraînent le recrutement au sein du micro-environnement tumoral de nouveaux clonotypes de lymphocytes T CD8+ spécifiques, suggérant que ce traitement agirait également en périphérie. Toutefois, cet éventuel mode d'action complémentaire reste mal compris. Dans ce travail, nous montrons que les anticorps anti-PD-1 amplifient la réponse des lymphocytes T CD8+ dans les ganglions drainants des tumeurs via la production d'interleukine 4 (IL-4) par les lymphocytes T follicular helper (Tfh). Dans deux modèles différents de tumeur, nous avons observés que les anticorps anti-PD-1 augmentent la prolifération et les fonctions effectrices des lymphocytes T CD8+ spécifiques de la tumeur dans le ganglion drainant. De manière surprenante, les anticorps anti-PD-1 ne ciblent pas directement les lymphocytes T CD8+ mais se fixent spécifiquement sur les lymphocytes Tfh, qui sont les cellules qui expriment le plus intensément PD-1 dans le ganglion. En outre, les anticorps anti-PD-1 promeuvent la prolifération des Tfh, modifient leur localisation au sein du ganglion drainant et augmentent leur production d'IL-4. Bloquer l'IL-4 ou inhiber Bcl6, qui est un facteur de transcription primordial pour le fonctionnement des Tfh, abroge l'activité des anticorps anti-PD-1 dans les ganglions drainants des tumeurs alors que l'injection de complexe IL-4 est suffisante pour reproduire l'activité du traitement par anti-PD-1. De manière intéressante, nous avons observé le même mécanisme dans un modèle murin de vaccination, suggérant que c'est un mécanisme général d'action en péripherie de ce traitement. Pour aller plus loin, dans un modèle de souris humanisées ayant une reconstitution immunitaire robuste au sein des ganglions, nous avons observé que l'injection de nivolumab augmente le pourcentage et la prolifération des Tfh au sein des ganglions. En conclusion, ce travail suggère que les Tfh et les cytokines qu'ils produisent jouent un rôle majeur dans l'activité périphérique du traitement par anti-PD-1.Anti-PD-1 monoclonal antibodies (mAbs), and other immune checkpoint inhibitors, represent a major breakthrough in cancer treatment these last years. The mechanisms by which anti-PD-1 mAbs target CD8+ T cells at the tumor site to promote clinical responses in cancer patients have been analyzed in detail. Remarkably, recent studies suggest an additional activity in the periphery, particularly in the tumor-draining lymph node. To this day, how anti-PD-1 mAbs could directly act in lymphoid organs remains an open question. Here, we show that anti-PD-1 mAbs enhance CD8+ T cell responses in tumor-draining lymph nodes by stimulating interleukin 4 (IL-4) production by follicular helper T cells (Tfh). In two different tumor models, we observe that anti-PD-1 mAbs increase the proliferation and effector functions of tumor-specific CD8+ T cells in the draining lymph node. Surprisingly, we show anti-PD-1 mAbs did not primarily target CD8+ T cells but instead specifically bound Tfh cells in vivo, the population expressing the highest levels of PD-1 in lymph nodes. Moreover, anti-PD-1 mAbs induced Tfh proliferation, modified their localization, and, most importantly, their IL-4 production. Blocking IL-4 or inhibiting the Tfh-master transcription factor Bcl6 abrogated anti-PD-1 mAb activity in lymph nodes while injection of IL-4 complex was sufficient to recapitulate anti-PD-1 mAbs' activity. Interestingly, a similar mechanism was observed in a mouse vaccine model. Finally, in mice with a humanized immune system, anti-PD-1 Abs increased the accumulation and proliferation of human Tfh cells in lymph nodes. We propose that Tfh cells and associated cytokines play a key role in the peripheral activity of anti-PD-1 mAbs
Effi Briest, Mathilde Möhring. Vývoj postavy žen na pozadí dobové emancipace ve stejnojmenných románech Theodora Fontana.
Get PDFTheodore Fontane is best known as the author of numerous women's novels, which he wrote in the last ten years of his life. This diploma thesis deals with the topic of women's emancipation on the basis of textual analysis of two latter novels by Theodore Fontane - Effi Briest and Mathilde Möhring. In the first part, it characterizes the topic of the period women's emancipation and puts the author's biography into context. In the second part, it creates the picture of position of the main women characters. The last part describes the personal development of the women characters, on the basis of which I determine how much the women's emancipation reflects in the author's work and what is his attitude towards it. This thesis deals with the interpretation of the author's intent to illustrate the creation of an advanced character like Mathilde Möhring. Key words: Theodore Fontane, women's emancipation, Effi Briest, Mathilde Möhring, development of women's characters, women's novels, interpretation, author's intent, counterpointTheodor Fontane je známý především jako autor četných ženských románů, které psal ve svém pokročilém věku. Tato práce zpracovává na základě analýzy textu téma ženské emancipace v jeho dvou pozdějších románech - Manželství Effi Briestové a Mathilda Möhringová. V první části charakterizuje téma dobové ženské emancipace a zasazuje autorovu biografii do kontextu. V druhé části utváří obraz pozice hlavních románových hrdinek. V poslední části je shrnut osobní vývoj ženských postav, na jejímž základě má být zodpovězena otázka, nakolik se ženská emancipace odráží v autorově díle a jaký je jeho postoj k ní. Práce se zároveň zabývá intepretací autorova záměru, který vytvořil postavu pokročilé Mathildy Möhringové, čímž dosáhl kontrapunktu k tomu, co doposud psal. Klíčová slova: Theodor Fontane, ženská emancipace, Effi Briest, Mathilde Möhring, vývoj ženských postav, interpretace, ženské romány, záměr autora, kontrapunktInstitute of Germanic StudiesÚstav germánských studiíFilozofická fakultaFaculty of Art
Tunisian Politics in France: Long-Distance Activism since the 1980s
No full textInternational audienceWhat does it mean to oppose or support an authoritarian regime from afar? During the years of Ben Ali's dictatorship in Tunisia between 1987 and 2011, diaspora activism played a key role in the developments of post-independence Tunisian politics. Centring this study on long-distance activism in France, where the majority of leftist and Islamist exile groups took refuge, Mathilde Zederman explores how this activism helps to shed new light on Tunisia's political history. Tunisian Politics in France closely explores the interactions and conflicts between different constellations of pro-regime and oppositional actors in France, examining the dynamics of what the author persuasively describes as a 'trans-state space of mobilisation'. In doing so, Zederman draws attention to the constraints and possibilities of long-distance activism. Utilising material gathered from extensive fieldwork in France and Tunisia, this study considers how the evolution of diaspora activism both challenges and reinforces the boundaries of Tunisian politics
Book review: Photography of protest and community: the radical collectives of the 1970s by Noni Stacey
No full textIn Photography of Protest and Community: The Radical Collectives of the 1970s, Noni Stacey shows how a 1970s network of London-based photography collectives raised fundamental questions about the politics of photography, the role and responsibilities of photographers in relation to local communities and the uses of photography in the context of social activism. This book is a welcome addition to the expanding field of research on the photography of protest, writes Mathilde Bertrand, contributing to the ongoing documentation of this strong current in British photographic history. If you are interested in this book review, you can read an LSE RB interview with author Dr Noni Stacey. The archive of the Exit Photography Group is held at LSE Library; readers can find out more about the archive and the catalogue. Photography of Protest and Community: The Radical Collectives of the 1970s. Noni Stacey. Lund Humphries. 2020
Piano music of Mathilde Kralik von Meyrswalden (1857-1944)
No full textThesis (D.M.A.)--Boston University
PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at [email protected]. Thank you.This dissertation examines the life and music of Mathilde Kralik von Meyrswalden (1857-1944), with a focus on her piano solo works. This project is intended to bring new light to the forgotten late-romantic Austrian composer. As a pupil of Anton Bruckner, and as a colleague of Gustav Mahler, Kralik's style belongs to the late Romantic period in Vienna. Her musical aesthetics are similar to the styles of Schubert, Liszt, Schumann, Wolf, Mahler, and StraufS; however she had her
own unique voice from the beginning of her musical career. Though she was an active composer, performer, and musical figure of her time and was recognized and respected by the Viennese society, her life and work remain greatly understudied.
Chapter 1 presents a detailed biographical background of Mathilde Kralik von Meyrswalden. Chapter 2 provides a complete list of work by Mathilde Kralik. Chapter 3 depicts the political background of her time, and then discusses the situation of women as artists in Vienna between 1850 and 19 50. Chapter 4 focuses on two people in her closest circle: her elder brother, Richard Kralik, who was a renowned writer and cultural commentator; and her friend, Alice Scarlates, who was a lecturer for Roman language at the University of Vienna and lived with Kralik in the same house in Wiener Cottage-Viertel for over 30 years. Chapter 5 analyzes her 5 Klavierstiicke- Festmarsh, Triiumerei, Liedchen, Intermezzo, and Gavotte. Chapter 6 continues the analysis with her other major piano solo work: Priiludium, Passacaglia, und Fugato. Lastly, Chapter 7 discusses the public and critical reception of her music, both during her time and in the modern era.
The purpose of this project is first, to discover new sounds from a past style; second, to give credit to a serious, prolific, and independent female composer, who bravely chose a career with special challenges in her time and her surroundings; third, to encourage further research and performances of Kralik's works
" Critique d'art au féminin au 19e siècle : Mathilde Stevens "
No full textInternational audienceMathilde Stevens started being really famous with Les Impressions d'une femme au Salon de 1859, which was first published as a serial. She wrote about the paintings in Le Salon and about painting generally. The artistic world was well-known to her: her husband was Arthur Stevens, the famous Belgian art critic and art dealer. Although she is now mostly forgotten, she was one of the most highly regarded women in Paris of the 1880s. She inspired Guy de Maupassant when he created Madame Forestier in Bel-Ami. Talking about her life is to discover who shaped her ideas about painting. Her taste for Romantic landscapes comes from her husband's love for the Barbizon School. Charles Baudelaire and his Salon de 1846 also inspired her: she took up his comparison between Painting and Musical harmony as well as the importance of memory. In spite of these men's influences, Les Impressions d'une femme au salon de 1859 is definitely a female text. Often, the author reminds the reader of her sexual identity, her thoughts are typically feminine: shallow and lightweight. In fact, Mathilde Stevens seems to caricature stereotypical female behaviour. Is it a strategy? In fact, she doesn't compete with male critics: she can write and think more freely.Cette femme de lettres, aujourd'hui tombée dans l'oubli, fut une des figures des plus en vue de la société parisienne des années 1880. Elle inspira à Guy de Maupassant le personnage de Mme Forestier dans Bel-Ami. Si cette figure atypique mérite que l'on s'attarde sur son existence, c'est pour découvrir qui a influencé sa conception de la Peinture. Elle a ainsi emprunté à son mari, marchand des artistes de l'école de Barbizon, son goût pour les paysages romantiques. On retrouve également certaines idées développées par Charles Baudelaire dans son Salon de 1846. Mathilde Stevens reprend son analogie entre peinture et harmonie musicale ainsi que le rôle important joué par la mémoire dans l'appréciation d'une œuvre. À bien y regarder, Mathilde Stevens semble avoir caricaturé le comportement féminin. Est-ce une stratégie de sa part ? Si son appartenance au " beau sexe " la marginalise et la discrédite quelque peu auprès de ses confrères masculins, elle lui offre paradoxalement un vaste champ de liberté. Étant une critique " hors norme ", elle n'a, de ce fait, aucun modèle, aucun discours à reproduire pour être entendue du grand public
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