90,292 research outputs found

    Reply to comments on 'EPR study of He-implanted Si' by P. Pivac, B. Rakvin, R. Tonini, F. Corni, G. Ottaizani, Published in Mater. Sci. Eng. B73 (2000) 60-63 - Written by M. Kakazey, M. Vlasova, and J.G. Gonzalez-Rodriguez - Reply to discussion

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    Reply to comments on 'EPR study of He-implanted Si' by P. Pivac, B. Rakvin, R. Tonini, F. Corni, G. Ottaizani, Published in Mater. Sci. Eng. B73 (2000) 60-63 - Written by M. Kakazey, M. Vlasova, and J.G. Gonzalez-Rodriguez - Reply to discussio

    SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders

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    The sialic-acid-binding immunoglobulin-like lectin SIGLEC-G is a negative regulator of B-cell receptor-mediated calcium signaling. Its deficiency leads to reduced turnover and increased proliferation and survival of murine B-1a cells. Siglecg-/- mice show a premature expansion of polyclonal CD5+ B cells in the spleen and the peritoneal cavity. Here we studied the fate of B lymphocytes in Siglecg-/- mice over time. We demonstrate that in aging animals SIGLEC-G deficiency promotes progressive accumulation of monoclonal B lymphocytes and increases the susceptibility to develop B-cell lymphoproliferative disorders. Lymphoid tumors arising in aged Siglecg-/- mice are monoclonal and histologically heterogeneous as they include diffuse large B-cell lymphoma, follicular lymphoma, and medium-to-large B-cell monomorphic lymphoma but surprisingly not chronic lymphocytic leukemia. The tumors express high levels of BCL-2 and are transplantable. In keeping with these findings we have also observed a remarkable down-regulation of the human ortholog SIGLEC10 in human B-cell lymphoma and leukemia cell lines. Taken together, these observations indicate that the down-regulation of negative B-cell receptor regulators such as SIGLEC-G/SIGLEC10 may represent another mechanism relevant to the pathogenesis of B-cell lymphomas. © 2014 Ferrata Storti Foundation

    Observations of Bºs→ψ(2S)η and Bº(s)→ψ(2S)π+π- decays

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    First observations of the B0s →ψ(2S)η, B0 →ψ(2S)π + π − and B0s →ψ(2S)π + π − decays are made using a dataset corresponding to an integrated luminosity of 1.0 fb−1 collected by the LHCb experiment in proton–proton collisions at a centre-of-mass energy of √ s = 7 TeV. The ratios of the branching fractions of each of the ψ(2S) modes with respect to the corresponding J/ψ decays are B(B0s →ψ(2S)η) ÷ B(B0s →J/ψη) = 0.83± 0.14 (stat)±0.12 (syst) ±0.02 (B), ; B(B0→ψ(2S)π + π − ) ÷ B(B0→J/ψπ + π − ) = 0.56± 0.07 (stat)±0.05 (syst)± 0.01 (B), ; B(B0s →ψ(2S)π + π − ) ÷ B(B0s →J/ψπ + π − ) = 0.34± 0.04 (stat)±0.03 (syst)± 0.01 (B), where the third uncertainty corresponds to the uncertainties of the dilepton branching fractions of the J/ψ and ψ(2S) meson decays

    Father Reyes Rodriguez, Hispanic Oral Histories, Accn 1369

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    Father Rodriguez (b. 1934) talks about his family roots in Mexico, the marriage of his parents and their life in Layton, Utah, and his childhood. Other topics include home remedies, cooking, traditional hispanic family life, religion, his church service, entering the seminary at the age of 25, the psychological impact of his training, Catholicism, a memorable sermon, and life as a Catholic priest. Interviewed by Leslie Kelen, 117 pages

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ

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    The ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd), where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5. The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%. Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations

    SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders

    No full text
    The sialic-acid-binding immunoglobulin-like lectin SIGLEC-G is a negative regulator of B-cell receptor-mediated calcium signaling. Its deficiency leads to reduced turnover and increased proliferation and survival of murine B-1a cells. Siglecg-/- mice show a premature expansion of polyclonal CD5+ B cells in the spleen and the peritoneal cavity. Here we studied the fate of B lymphocytes in Siglecg-/- mice over time. We demonstrate that in aging animals SIGLEC-G deficiency promotes progressive accumulation of monoclonal B lymphocytes and increases the susceptibility to develop B-cell lymphoproliferative disorders. Lymphoid tumors arising in aged Siglecg-/- mice are monoclonal and histologically heterogeneous as they include diffuse large B-cell lymphoma, follicular lymphoma, and medium-to-large B-cell monomorphic lymphoma but surprisingly not chronic lymphocytic leukemia. The tumors express high levels of BCL-2 and are transplantable. In keeping with these findings we have also observed a remarkable down-regulation of the human ortholog SIGLEC10 in human B-cell lymphoma and leukemia cell lines. Taken together, these observations indicate that the down-regulation of negative B-cell receptor regulators such as SIGLEC-G/SIGLEC10 may represent another mechanism relevant to the pathogenesis of B-cell lymphomas

    The clock diet: a practical nutritional guide to manage obesity through chrononutrition

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    Chronobiology studies the biological rhythms or circadian cycles of living organisms and their adaptation to external changes. Biological rhythms can affect hormone production cycles such as sleep/wake, and nutrition/fasting, but these factors can also alter the circadian rhythm (CR). In recent years, numerous studies have highlighted how feeding times and frequency can influence biological rhythms. Additionally, individuals’ chronotype, working shifts, and food intake can make a deep impact on people’s tendency to develop obesity and metabolic diseases. In this context, a single food and a specific combination of these, can also affect the CR and fasting cycle and consequently body weight and viceversa. The purpose of the review is to propose practical nutritional recommendations to help in resynchronizing the circadian rhythm as a tool in weight control. (Cite this article as: Barrea L, Frias-Toral E, Aprano S, Castellucci B, Pugliese G, Rodriguez-Veintimilla D, et al. The clock diet: a practical nutritional guide to manage obesity through chrononutrition. Minerva Med 2022;113:172-88. DOI: 10.23736/ S0026-4806.21.07207-4

    [Women and violence: an everyday fact]

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    In comparison with other countries, Mexico lacks information on the issue of violence against women, especially regarding the incidence and prevalence of battering and emotional abuse. The aim of this study was to determine the frequency and distribution of violence against women among both rural and urban populations in the state of Jalisco, Mexico. A cross-sectional study was conducted among two groups randomly selected; 1,163 rural women (RW) and 427 urban women (UW). Variables included: frequency of violence of family members against women and vice versa, socioeconomic variables and reason for violence. The results were: a) 44.2 per cent and 56.7 per cent rural and urban female population, respectively, suffered some form of violence; b) the principal aggressor was the husband in more than 60 per cent of the cases in both rural and urban areas. Significant statistical difference (p < 0.05) were found between rural and urban groups in relation to low education, middle-age and family size over 7 members

    [Women and violence: an everyday fact]

    No full text
    In comparison with other countries, Mexico lacks information on the issue of violence against women, especially regarding the incidence and prevalence of battering and emotional abuse. The aim of this study was to determine the frequency and distribution of violence against women among both rural and urban populations in the state of Jalisco, Mexico. A cross-sectional study was conducted among two groups randomly selected; 1,163 rural women (RW) and 427 urban women (UW). Variables included: frequency of violence of family members against women and vice versa, socioeconomic variables and reason for violence. The results were: a) 44.2 per cent and 56.7 per cent rural and urban female population, respectively, suffered some form of violence; b) the principal aggressor was the husband in more than 60 per cent of the cases in both rural and urban areas. Significant statistical difference (p < 0.05) were found between rural and urban groups in relation to low education, middle-age and family size over 7 members
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