677 research outputs found
WA97 results on strangeness production in lead-lead collisions at 158
No full texte , J.C. Lassalle e , V. Lenti b , Ph. Leruste l , J.A. Lien j , R. Lietava g , R.A. Loconsole b , L. Lopez e , G. Løvhøiden j , M. Luptak g , I. Macha n , V. Mack i , V. Manzari b , P. Martinengo e , M.A. Mazzoni o , F. Meddi o , A. Michalon r , M.E. Michalon-Mentzer r , P. Middelkamp e , M. Morando k , M.T. Muciaccia b , E. Nappi b , J.L. Narjoux l , F. Navach b , K. Norman d , B. Osculati f , B. Pastircak g , F. Pellegrini k , K. Pska m , F. Posa b , E. Querci
Obstacles and facilitators to preventing fetal alcohol spectrum disorder: a qualitative study with general practitioners
No full textInternational audienceCopyright © 2024 Leruste, Baelen, Doray, Maillard, Marimoutou and Spodenkiewicz.Background: Fetal Alcohol Spectrum Disorders are the leading cause of non-genetic intellectual disability. The damage caused, although completely preventable, is irreversible and requires lifelong support. General Practitioners have an important role in the prevention of Fetal Alcohol Spectrum Disorders. However, evidence suggests that General Practitioners do not monitor systematically alcohol consumption among pregnant women. Objectives: The aim of this study was to understand the barriers and motivations of General Practitioners in the prevention of Fetal Alcohol Spectrum Disorders on Reunion Island. Methods: A qualitative research study was conducted by conducting semi-structured individual interviews with general practitioners. Participants were selected by random or snowball sampling. General practitioners who worked only in unscheduled care services were excluded from this study. After the interviews were transcribed, a verbatim analysis was performed according to the principles of grounded theory. Results: Twenty interviews were conducted by two researchers between November and December 2020. General practitioners expressed discomfort in addressing alcohol consumption and excessive drinking in women. They had inaccurate theoretical knowledge and a lack of practical experience with Fetal Alcohol Spectrum Disorders. They also showed little knowledge of the Fetal Alcohol Spectrum Disorders care pathway available on Reunion Island. Both patients and general practitioners expressed discomfort when discussing womenu2019s alcohol consumption. Conflicting government policies were highlighted as alcohol promotion campaigns overshadowed Fetal Alcohol Spectrum Disorders prevention initiatives. Conclusion: General practitioners should be open and non-judgmental in their interactions with women and couples, with a focus on early detection and short-term intervention. General practitioners should be better educated about Fetal Alcohol Spectrum Disorders and have a clearer understanding of the Fetal Alcohol Spectrum Disorders care pathway
Evidence for prompt high-p⊥η′-mesons at the ISR
No full textISR data on the ratios η/π0, η′/π and ω/π at medium to high transverse momentum are examined in the context of prompt meson production through the higher twist mechanism in addition to the standard process of parton scattering and fragmentation. The η′/π ratio in particular, can only be well understood by a sizeable prompt contribution in good agreement with the large η′ cross section expected from higher twist calculations. Furthermore, by neglecting any glue component in the η′, a pseudoscalar mixing angle of ≈ −15° is preferred, slightly lower than some recent measurements
Measurement of Collins asymmetries in inclusive production of charged pion pairs in e+e− annihilation at BABAR
No full textWe present measurements of Collins asymmetries in the inclusive process e+e−→ππX, where π stands for charged pions, at a center-of-mass energy of 10.6 GeV. We use a data sample of 468 fb−1 collected by the BABAR experiment at the PEP-II B factory at SLAC, and consider pairs of charged pions produced in opposite hemispheres of hadronic events. We observe clear asymmetries in the distributions of the azimuthal angles in two distinct reference frames. We study the dependence of the asymmetry on several kinematic variables, finding that it increases with increasing pion momentum and momentum transverse to the analysis axis, and with increasing angle between the thrust and beam axis
Dalitz plot analyses of B-0 -> (D-DK+)-K-0 and B+-> (D)over-bar(-)D(0)K(+) decays
No full text© 2015, APS Journal
First results from the 1994 lead beam run of WA97
No full textWA97 is designed to study strange and multi-strange baryon and anti-baryon production in 160 A GeV/c Ph-Ph collisions at the SPS with a telescope of silicon microdetectors. Four planes of silicon pixel detectors were successfully employed during the 1994 Pb run. A total of 60M central Pb-Pb events were collected. We describe the experimental setup and report on some preliminary results from the off-line analysis
Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors
No full text\ua9 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.Atypical teratoid/rhabdoid tumors (ATRTs) typically arise in the central nervous system (CNS) of children under 3 years of age. Despite intensive multimodal therapy (surgery, chemotherapy and, if age permits, radiotherapy), median survival is 17 months1,2. We show that ATRTs robustly express B7-H3/CD276 that does not result from the inactivating mutations in SMARCB1 (refs. 3,4), which drive oncogenesis in ATRT, but requires residual SWItch/Sucrose Non-Fermentable (SWI/SNF) activity mediated by BRG1/SMARCA4. Consistent with the embryonic origin of ATRT5,6, B7-H3 is highly expressed on the prenatal, but not postnatal, brain. B7-H3.BB.z-chimeric antigen receptor (CAR) T cells administered intracerebroventricularly or intratumorally mediate potent antitumor effects against cerebral ATRT xenografts in mice, with faster kinetics, greater potency and reduced systemic levels of inflammatory cytokines compared to CAR T cells administered intravenously. CAR T cells administered ICV also traffic from the CNS into the periphery; following clearance of ATRT xenografts, B7-H3.BB.z-CAR T cells administered intracerebroventricularly or intravenously mediate antigen-specific protection from tumor rechallenge, both in the brain and periphery. These results identify B7-H3 as a compelling therapeutic target for this largely incurable pediatric tumor and demonstrate important advantages of locoregional compared to systemic delivery of CAR T cells for the treatment of CNS malignancies
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