647 research outputs found
Ehrens et al., 2024, Viable and dead microfilariae of Litomosoides sigmodontis induce different eosinophil ETosis pathways
No full textRNA sequencing analysis of bone marrow-derived eosinophils stimulated with viable and dead Litomosoides sigmodontis microfilariae. The data contains the differentially expressed genes for eosinophils stimulated with microfilariae in comparison to unstimulated eosinophils. Differentially expressed genes with an adjusted p-value of 0.01 or lower was used for pathway analysis.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
The business case for investing in water in Oregon
No full textauthors: Davíd Pilz, JD (AMP Insights), Sarah Kruse, PhD (AMP Insights), Robert S. Raucher (Raucher LLC), Janet Clements (OneWater Econ), Tess Gardner (AMP Insights), Jeff Odefey (OneWater Econ), Trygve Madsen (Independent Contractor), Andrew Purkey (AMP Insights), Claire Sheridan (OneWater Econ), Amy McCoy (AMP Insights), Alex Ehrens (AMP Insights).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references (pages 202-2014).Completed under a contract awarded by the Oregon Water Resources Department to AMP Insights.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Theoretical formation of carbon nanomembranes under realistic conditions using classical molecular dynamics
No full textEhrens J, Gayk F, Vorndamme P, et al. Theoretical formation of carbon nanomembranes under realistic conditions using classical molecular dynamics. Physical Review B. 2021;103(11): 115416.Carbon nanomembranes made from aromatic precursor molecules are freestanding nanometer-thin materials of macroscopic lateral dimensions. Although produced in various versions for about two decades, not much is known about their internal structure. Here we present a systematic theoretical attempt to model the formation, structure, and mechanical properties of carbon nanomembranes using classical molecular dynamics simulations. We find theoretical production scenarios under which stable membranes form. They possess pores as experimentally observed. Their Young's modulus, however, is systematically larger than experimentally determined
LIKELIHOOD RATIO TESTS COMPARISON FOR THE U NIV ARIATE B EHRENS-FISHER PROB LEM
No full textABSTRACT: This paper presents a performance evaluation of the original likelihood ratio test, tw o proposed modifi cations and the t-test w ith degrees of freedom corrected b y W elch/ Satterthw aite's procedure for the univariate Behrens-F isher prob lem. Ty pe I error rate and pow er w ere evaluated b y M onte Carlo simulation. Convergence of the adjusted test statistic for the chi-sq uare distrib ution w as very fast. P ow er and ty pe I error rates w ere considered promising for recommending the use of such tests. Both modifi cations of the likelihood test could b e recommended for testing the null hy pothesis of eq ual normal means w ith heterogeneous variances for all sample siz es evaluated. They are considered as good as the t-test w ith degrees of freedom corrected b y W elch/ Satterthw aite's procedure, mainly for the test w ith adjusted degrees of freedom. Since the pow er of the original likelihood ratio test is greater in large samples, its use is advisab le for sample siz es larger than 30. K E Y W O RD S: Chi-sq uare; asy mptotic; likelihood function; Behrens-F isher prob lem
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Perceptual Similarity Affects Relational Judgements
No full textIn STEM instruction, the effectiveness of teaching by analogy is often limited by students’ focus on superficial features of the source and target exemplars; the strategy of progressive alignment (moving from perceptually similar to different targets) has been suggested to address this issue (Gentner & Hoyos, 2017). In contrast, computational models suggest maximizing surface feature variation to improve the relation learning, and human behavioral studies find a relational bias in learning (Austerweil & Ehrens, 2018). Here, participants were explicitly instructed to match stimuli based on relations while perceptual similarity of stimuli varied parametrically. We found that lower perceptual similarity reduced accurate relational matching (F = 9.53, p<.001), and observed a similar trend for reaction times. This finding demonstrates that perceptual similarity may interfere with relational judgements, but also hints at why progressive alignment may be effective. Implications for instructional sequence design will be discussed
Current perspective of new anti-Wolbachial and direct-acting macrofilaricidal drugs as treatment strategies for human filariasis
No full textFilarial diseases like lymphatic filariasis and onchocerciasis belong to the Neglected Tropical Diseases and remain a public health problem in endemic countries. Lymphatic filariasis and onchocerciasis can lead to stigmatizing pathologies and present a socio-economic burden for affected people and their endemic countries. Current treatment recommendations by the WHO include mass drug administration with ivermectin for the treatment of onchocerciasis and a combination of ivermectin, albendazole and diethylcarbamazine (DEC) for the treatment of lymphatic filariasis in areas that are not co-endemic for onchocerciasis or loiasis. Limitations of these treatment strategies are due to potential severe adverse events in onchocerciasis and loiasis patients following DEC or ivermectin treatment, respectively, the lack of a macrofilaricidal efficacy of those drugs and the risk of drug resistance development. Thus, to achieve the elimination of transmission of onchocerciasis and the elimination of lymphatic filariasis as a public health problem by 2030, the WHO defined in its roadmap that new alternative treatment strategies with macrofilaricidal compounds are required. Within a collaboration of the non-profit organizations Drugs for Neglected Diseases initiative (DNDi ), the Bill & Melinda Gates Foundation, and partners from academia and industry, several new promising macrofilaricidal drug candidates were identified, which will be discussed in this review
Constraining the p-Mode–g-Mode tidal instability with GW170817
No full textWe analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron stars on GW170817. This nonresonant instability transfers energy from the orbit of the binary to internal modes of the stars, accelerating the gravitational-wave driven inspiral. We model the impact of this instability on the phasing of the gravitational wave signal using three parameters per star: an overall amplitude, a saturation frequency, and a spectral index. Incorporating these additional parameters, we compute the Bayes factor (ln B pg !pg) comparing our p-g model to a standard one. We find that the observed signal is consistent with waveform models that neglect p-g effects, with ln B pg !pg = 0.03 +0.70 -0.58 (maximum a posteriori and 90% credible region). By injecting simulated signals that do not include p-g effects and recovering them with the p-g model, we show that there is a ?50% probability of obtaining similar ln B pg !pg even when p-g effects are absent. We find that the p-g amplitude for 1.4 ?M? neutron stars is constrained to less than a few tenths of the theoretical maximum, with maxima a posteriori near one-tenth this maximum and p-g saturation frequency ~70 Hz. This suggests that there are less than a few hundred excited modes, assuming they all saturate by wave breaking. For comparison, theoretical upper bounds suggest ?103 modes saturate by wave breaking. Thus, the measured constraints only rule out extreme values of the p-g parameters. They also imply that the instability dissipates ?10^51 erg over the entire inspiral, i.e., less than a few percent of the energy radiated as gravitational waves
An interesting couple: the semantic development of dyad morphemes
No full textMost systematic discussion of dyad morphemes has focussed on Australian languages, owing to a combination of their relative prevalence there, and the development of a descriptive tradition that investigates them in some depth. In the course of researching this paper, however, I became aware of functionally and semantically similar morphemes in many other parts of the world, almost invariably described in isolation from any typological reference point. I have incorporated such data as far as I am aware of it, in the hope that a systematic study will encourage other investigators to identify, and investigate in detail, similar constructions in a range of languages. The current state of our research, however, as well as some interesting geographical skewings that I discuss below, such that outside Australia dyad constructions almost exclusively employ reciprocal morphology, means that most of this paper will focus on Australian languages
Erratum: All-sky search for gravitational-wave bursts in the first joint LIGO-GEO-Virgo run (Physical Review D - Particles, Fields, Gravitation and Cosmology (2010) 81 (102001))
No full textThis paper was published online on 5 May 2010 with an omission in the Collaboration author list. S. Dwyer has been
added as of 12 April 2012. The Collaboration author list is incorrect in the printed version of the journal
Just and sustainable? : examining the rhetoric and potential realities of UK food security
No full textThe dominant discourse in 20th century UK food and agricultural policies of a liberal, free trade agenda was modified at the turn of the 21st to embrace ecological sustainability and "food security." The latter term has a long international history; the relationship between issues of technical production and equality of distributional access are also much debated. The paper examines shifts in UK policy discourse in the context of international research, policy, and initiatives to promote food security, and highlights the implications for social justice in and through the food system
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