2,777 research outputs found
H. Lee Moffitt Cancer Center and Research Institute, c.1986
No full textThe H. Lee Moffitt Cancer Center and Research Institute opened on the Tampa campus in 1986 and has become a leader in treatment and research of cancer. The Center is named for the USF alumnus who led the drive in the Florida Legislature to create it. The exact date that this photograph was taken is unknown.https://digitalcommons.usf.edu/usf_photos/1194/thumbnail.jp
shawlab-moffitt/CSEminer-manuscript: Manuscript Supplementary Code Release v1
No full text<p>Supplementary github package for the manuscript titled "Discovery of immunotherapy targets for pediatric solid and brain tumors by exon-level expression."</p>
H. Lee Moffitt, USF alumnus and Florida legislator, c.1974
No full textH. Lee Moffitt is a USF alumnus who became Speaker of the House of Representatives in Florida. Moffitt pushed in the Legislature for a cancer treatment and research center in Florida. The H. Lee Moffitt Cancer Center and Research Institute on the Tampa campus is named in his honor. The exact date that this photograph was taken is unknown.https://digitalcommons.usf.edu/usf_photos/1195/thumbnail.jp
DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
No full textSingle Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be
associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose
polymerase), and both BRCA1 and BRCA2. In the present study, we have performed a comprehensive analysis of 18 genes involved in BER using a tagging SNP approach in a large series of BRCA1 and BRCA2 mutation carriers. 144 SNPs were analyzed in a two stage study involving 23,463 carriers from the CIMBA consortium (the Consortium of Investigators of Modifiers of BRCA1 and BRCA2). Eleven SNPs showed evidence of association with breast and/or ovarian cancer at p,0.05 in the combined analysis. Four of the five genes for which strongest evidence of association was observed were DNA glycosylases. The strongest evidence was for rs1466785 in the NEIL2 (endonuclease VIII-like 2) gene (HR: 1.09, 95% CI (1.03– 1.16), p = 2.761023) for association with breast cancer risk in BRCA2 mutation carriers, and rs2304277 in the OGG1 (8-guanine DNA glycosylase) gene, with ovarian cancer risk in BRCA1 mutation carriers (HR: 1.12 95%CI: 1.03–1.21,
p = 4.861023). DNA glycosylases involved in the first steps of the BER pathway may be associated with cancer risk in BRCA1/ 2 mutation carriers and should be more comprehensively studied
Advancing Cancer Control through Research and Cancer Registry Collaborations in the Caribbean
No full textInternational audienceBackground - Few national registries exist in the Caribbean, resulting in limited cancer statistics being available for the region. Therefore, estimates are frequently based on the extrapolation of mortality data submitted to the World Health Organization. Thus, regional cancer surveillance and research need promoting, and their synergy must be strengthened. However, differences between countries outweigh similarities, hampering registration and availability of data. Methods - The African-Caribbean Cancer Consortium (AC3) is a broad-based resource for education, training, and research on all aspects of cancer in populations of African descent. The AC3 focuses on capacity building in cancer registration in the Caribbean through special topics, training sessions, and biannual meetings. We review the results from selected AC3 workshops, including an inventory of established cancer registries in the Caribbean region, current cancer surveillance statistics, and a review of data quality. We then describe the potential for cancer research surveillance activities and the role of policymakers. Results - Twelve of 30 Caribbean nations have cancer registries. Four of these nations provide high-quality incidence data, thus covering 14.4% of the population; therefore, regional estimates are challenging. Existing research and registry collaborations must pave the way and are facilitated by organizations like the AC3. Conclusions - Improved coverage for cancer registrations could help advance health policy through targeted research. Capacity building, resource optimization, collaboration, and communication between cancer surveillance and research teams are key to obtaining robust and complete data in the Caribbean
Abstract A17: Outreach efforts to reduce cancer disparities via a partnership between the Ponce Health Sciences University and the Moffitt Cancer Center
No full textAbstract
Introduction: The disproportionate burden of cancer among U.S. Hispanics is well documented. The Ponce School of Medicine and Moffitt Cancer Center Partnership, is a collaborative academic institutional partnership between a minority-serving institution and an NCI-designated cancer center focused on reducing cancer health disparities among Hispanics in Tampa, Florida and Ponce, Puerto Rico. Within the Partnership's structure, the Outreach Core combines community-based participatory research and social marketing approaches to deliver planned, community-focused, educational activities designed to increase awareness of cancer prevention, early detection, treatment programs, and cancer research for Hispanics in Tampa, FL, and Ponce, PR. This abstract describes the community engagement strategies used to improve recognition and trust in minority and underserved communities.
Methods: The strategies for impacting health disparities and achieving the goals of the Outreach Core included forming a community advisory panel, building relationships with existing community-academic partnerships, engaging new partners, appearances at health-oriented events, presentations to local community leaders, community forums and “branding” our educational events. These activities take place in Tampa, FL and Ponce, PR.
Results: During the past four years we have made significant progress toward achieving our goals by: 1) establishing quarterly meetings with a community advisory panel at each site; 2) maintaining 32 community partners; 3) successful “branding” of our educational events (e.g. ¡Salud! Serie de charlas, Latinos y el cancer, Hablemos de cáncer); 4) conducting cancer education events in Tampa n=9 and PR n=8; 6) increasing access to cancer screening opportunities by providing free health screenings at events and linkages to community resources; 5) recruited over 300 participants for biobanking studies.
Conclusion: Community outreach and engagement strategies, in particular “branding” and building trust within the community, may be used effectively for participant recruitment and for delivery of important population-focused messages. This collaborative approach has worked well as we continue to experience an increase in attendance at our events. The two Hispanic communities value language-appropriate and culturally relevant cancer education, and their participation and feedback guides the organization of future events and creates trust for participation in future research studies.
Citation Format: Jessica McIntyre, Cynthia Cortes, Jomar Lopez, Eida Castro, Clement Gwede, Susan Vadaparampil, Vani Simmons, Thomas Brandon, Julio Jimenez, Gwendolyn Quinn. Outreach efforts to reduce cancer disparities via a partnership between the Ponce Health Sciences University and the Moffitt Cancer Center. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr A17.</jats:p
Developing the Florida Academic Cancer Center Alliance Health Disparities Common Measure: The Florida Health and Ancestry Survey
No full textPURPOSE: Our specific aim was to develop and assess the consensus-based validity of common measures for understanding health behaviors and ancestry in Florida’s population subgroups and establish the feasibility of wide-scale implementation of the measures and biospecimen collection within three cancer centers’ catchment areas. METHODS: Using the National Cancer Institute’s Grid-Enabled Measures web-based platform and an iterative process, we developed the Florida Health and Ancestry Survey (FHAS). We then used three sampling approaches to implement the FHAS: community-engaged, panel respondent, and random digit dialing (RDD). We asked a subset of participants to provide a saliva sample for future validation of subjective ancestry report with DNA-derived ancestry markers. RESULTS: This process supported the FHAS content validity. As an indicator of feasibility, the goals for completed surveys by sampling approach were met for two of the three cancer centers, yielding a total of 1438 completed surveys. The RDD approach produced the most representative sample. The panel sampling approach produced inadequate representation of older individuals and males. The community-engaged approach along with social media recruitment produced extreme underrepresentation only for males. Two of the cancer centers mailed biospecimen kits, whereas one did not due to resource constraints. On average, the community engaged approach was more productive in obtaining returned biospecimen samples (80%) than the panel approach (48%). CONCLUSIONS: We successfully developed and implemented the FHAS as a common measure to show its feasibility for understanding cancer health disparities in Florida. We identified sampling approach successes and challenges to obtaining biospecimens for ancestry research
Developing a comprehensive Cardio-Oncology Program at a Cancer Institute: the Moffitt Cancer Center experience
No full textCardio-oncology is a multidisciplinary field focusing on the management and prevention of cardiovascular complications in cancer patients and survivors. While the initial focus of this specialty was on heart failure associated with anthracycline use, novel anticancer agents are increasingly utilized and are associated with many other cardiotoxicities including hypertension, arrhythmias and vascular disease. Since its inception, the field has developed at a rapid pace with the establishment of programs at many major academic institutions and community practices. Given the complexities of this patient population, it is important for providers to possess knowledge of not only cardiovascular disease but also cancer subtypes and their specific therapeutics. Developing a cardio- oncology program at a stand-alone cancer center can present unique opportunities and challenges when compared to those affiliated with other institutions including resource allocation, cardiovascular testing availability and provider education. In this review, we present our experiences establishing the cardio-oncology program at Moffitt Cancer Center and provide guidance to those individuals interested in developing a program at a similar independent cancer institution
Developing a comprehensive Cardio-Oncology Program at a Cancer Institute: the Moffitt Cancer Center experience
No full textCardio-oncology is a multidisciplinary field focusing on the management and prevention of cardiovascular complications in cancer patients and survivors. While the initial focus of this specialty was on heart failure associated with anthracycline use, novel anticancer agents are increasingly utilized and are associated with many other cardiotoxicities including hypertension, arrhythmias and vascular disease. Since its inception, the field has developed at a rapid pace with the establishment of programs at many major academic institutions and community practices. Given the complexities of this patient population, it is important for providers to possess knowledge of not only cardiovascular disease but also cancer subtypes and their specific therapeutics. Developing a cardio- oncology program at a stand-alone cancer center can present unique opportunities and challenges when compared to those affiliated with other institutions including resource allocation, cardiovascular testing availability and provider education. In this review, we present our experiences establishing the cardio-oncology program at Moffitt Cancer Center and provide guidance to those individuals interested in developing a program at a similar independent cancer institution.</jats:p
Abstract A31: Patient navigation for culturally diverse populations: The experience of the Moffitt Cancer Center's Patient Navigator Research Program (PNRP)
No full textAbstract
The purpose of the PNRP patient navigation is to provide individualized assistance to persons with abnormal cancer screening tests or cancer diagnosis by trained, culturally sensitive navigators familiar with the patient's community. The Moffitt Cancer Center is one of nine NCI-funded sites nationally to study the impact that patient navigation has on four main outcomes: 1) time from screening to definitive diagnosis; 2) time from definitive diagnosis to treatment; 3) patient satisfaction; and 4) cost effectiveness. Moffitt's patient navigators navigated over 640 patients referred from seven community clinics in four counties. The majority of the patients were female (93%), Hispanics (54%), with annual household income under $20,000 (80%), mostly unemployed (47.5%), and with an average of 8.8 years of education. Lay patient navigators familiar with the patients’ culture and language were trained to navigate patients with breast or colorectal cancer screening abnormalities. The navigators were asked to record in a log the barriers that they identified, along with the actions they took to assist the patients address such barriers. Navigators addressed 20 different types of barriers in an average of 10 encounters per patient. This presentation will 1) describe the processes of patient navigation utilized by Moffitt PNRP, including training requirements, and caseloads for patient navigators, and 2) discuss the most relevant barriers that navigators found among medically underserved patients to access cancer health services, and actions taken to address such barriers. Moffitt patient navigators engage in a number of actions to help address unique barriers faced by this population when trying to access cancer care services.
Citation Information: Cancer Epidemiol Biomarkers Prev 2010;19(10 Suppl):A31.</jats:p
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