3,416 research outputs found
Níveis plasmáticos de neopterina e IL-10 como marcadores de depressão e alteração de personalidade associados ao traumatismo cranioencefálico grave
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2015.Justificativa: Traumatismo cranioencefálico é um grave problema de saúde pública, devido sua alta incidência, mortalidade e morbidade. No Brasil, cerca de 341 casos por 100.000 habitantes são registrados anualmente. Aproximadamente 50% dos sobreviventes de TCE grave apresentam sequelas de longo prazo e o aumento do risco da depressão é bem estabelecido, podendo estar relacionado com o processo inflamatório no sistema nervoso central (SNC). Objetivos: Identificar a associação dos níveis de marcadores inflamatórios (NPT e IL-10) com a incidência de depressão e alteração de personalidade após TCE grave. Resultados: Indivíduos do sexo masculino constituíam 78,4% da amostra e a idade média das vítimas de TCE grave foi de 31 anos. Dentre as variáveis sócio-demográficas, psiquiátricas e de hospitalização analisadas, apenas níveis séricos elevados de IL-10 (p=0,03) e a razão entre citocinas pró e anti-inflamatórias (TNF-a/IL-10, p=0,01) estiveram independentemente associados ao aparecimento da depressão pós TCE. A incidência de alteração de personalidade foi de 24,3%. Não houve associação dos níveis séricos de neopterina (TCE agudo) com a gravidade do TCE, tempo de coleta ou com a taxa de mortalidade (p=0,82). Conclusões e implicações: Nossos resultados sugerem que o aumento sérico dos níveis de IL-10 podem ser usados como um biomarcador de mau prognóstico em pacientes vítimas de TCE grave tanto na fase aguda (mortalidade hospitalar) como na fase crônica (depressão) do TCE. Os mecanismos envolvidos nas associações observadas continuam desconhecidos e precisam ser investigados em mais estudos.Abstract : Justification: traumatic brain injury (TBI) is a serious public health problem due to its high incidence, mortality and morbitidy. In Brazil, the annual incidence of traumatic brain injury (TBI) is approximately 341 cases per 100,000 inhabitants. Approximately 50% of severe TBI survivors have long-term sequelae that impair their functionality and social reintegration. The cause of the incresead risk of depression after TBI is unclear but may be inflammatory-related with incresead brain sensitivity to secondary inflammatory challenges. Objectives: Identify the association of levels of inflammatory markers (NPT and IL-10) with the incidence of depression and personality disorders after severe TBI. Results: The sample was comprised primarily for male gender (78,4%) and the mean age of the victims was 31 years old. Among all the socio demographics, psychiatric and hospitalization variables, only the serum levels of IL-10 (p = 0.03) and the ratio between pro- and antiinflammatory cytokines (TNF-a / IL-10, p = 0.01) were independently associated with depression after TBI. The incidence of personality change was 24.3%. There was no association of serum neopterin (acute TBI) with the severity of TBI, time of collection of blood samples or the mortality rate (p = 0.82). Conclusions: our results suggests that enhanced levels o IL-10 are a biomarker of worse prognosis of severe TBI patients evaluated in the acute (hospital mortality) and chronic (depression) phases of TBI. The mechanism involved in the observed associations remain to be investigated
Authority and Personality in M.M. Bakhtin\u27s Author and Hero in Aesthetic Activity
No full textM.M. Bakhtin\u27s fundamental claim in his seminal essay Author and Hero in Aesthetic Activity situates verbal action as the most essential constituent of human personality. A careful reading of this text reveals important truths about the relationship between free individual personhood and the nature of the speech utterance. Bakhtin connects the human experience of speech to the life and person of Jesus Christ emphasizing the incarnation and the Trinitarian view of God as essential principles for understanding the creative power of the word and consequent liabilities. Bakhtin develops these theological and philosophical coordinates around a discussion of the author-hero relationship in the novel asserting that the verbal utterance is creatively involved in building and sustaining the inner personhood of those it addresses. Bakhtin\u27s critical conclusion substantiates that from whom a word is received, and to whom the spoken word appeals has weighty influence on the type and character of human personality, and that personality\u27s relationship to authority
Documento Bancario, M.M. Mayence & Cie., Paris, 1908 Junio 14
No full textabstract: Handwritten letter from Rubén Darío to M.M. Mayence & Cie, informing about one meeting with the Spain's King and the location of Nicaraguan legation in Madrid.The original Rubén Darío Papers 1882-1945 (MSS-339) are located at ASU Libraries Archives & Special Collections. For more information about visiting the collection see http://hdl.handle.net/2286/L.A.0.The top margin has the hand written word "Particular" ("Private, Personal").In the left top margin apparently are written the words "Documento 267" ("Documento 267").Heading the letter there is a reference to a person called Santiago, whose last name hasn't been identified
M.M. Arkas: through the correlation between professional and patriotic
No full textУ статті розглянуто проблему співвідношення у творчому спадку М.М. Аркаса,
композитора, історика, громадського діяча, професійних і патріотичних засад. Проаналізовано
життєдіяльність М.М. Аркаса та виявлені основні чинники, що вплинули на формування його
світоглядних уявлень і врешті сприяли становленню у представника грецького роду українського
менталітету.В статье рассматривается проблема соотношения в творческом наследии Н.Н. Аркаса, композитора,
историка и общественного деятеля, профессионализма и патриотизма. Анализируется жизнедеятельность
Н.Н. Аркаса и выявляются основные компоненты, что способствовали формированию его духовного космоса
и становлению у представителя греческого рода украинского менталитета.The article examines the issues of rating the professional and patriotic constituents in the creative legacy of
M.M. Arkas, - the composer, historian and social activist. By researching into the life of M.M. Arkas, the author uncovers
the key factors and events that influenced the formation of his spiritual cosmos and thus eventually conduced
to moulding the Ukrainian mentality in a member of the Greek kinship
M.M. Arkas: through the correlation between professional and patriotic
No full textУ статті розглянуто проблему співвідношення у творчому спадку М.М. Аркаса,
композитора, історика, громадського діяча, професійних і патріотичних засад. Проаналізовано
життєдіяльність М.М. Аркаса та виявлені основні чинники, що вплинули на формування його
світоглядних уявлень і врешті сприяли становленню у представника грецького роду українського
менталітету.В статье рассматривается проблема соотношения в творческом наследии Н.Н. Аркаса, композитора,
историка и общественного деятеля, профессионализма и патриотизма. Анализируется жизнедеятельность
Н.Н. Аркаса и выявляются основные компоненты, что способствовали формированию его духовного космоса
и становлению у представителя греческого рода украинского менталитета.The article examines the issues of rating the professional and patriotic constituents in the creative legacy of
M.M. Arkas, - the composer, historian and social activist. By researching into the life of M.M. Arkas, the author uncovers
the key factors and events that influenced the formation of his spiritual cosmos and thus eventually conduced
to moulding the Ukrainian mentality in a member of the Greek kinship
M.M. Arkas: through the correlation between professional and patriotic
No full textУ статті розглянуто проблему співвідношення у творчому спадку М.М. Аркаса,
композитора, історика, громадського діяча, професійних і патріотичних засад. Проаналізовано
життєдіяльність М.М. Аркаса та виявлені основні чинники, що вплинули на формування його
світоглядних уявлень і врешті сприяли становленню у представника грецького роду українського
менталітету.В статье рассматривается проблема соотношения в творческом наследии Н.Н. Аркаса, композитора,
историка и общественного деятеля, профессионализма и патриотизма. Анализируется жизнедеятельность
Н.Н. Аркаса и выявляются основные компоненты, что способствовали формированию его духовного космоса
и становлению у представителя греческого рода украинского менталитета.The article examines the issues of rating the professional and patriotic constituents in the creative legacy of
M.M. Arkas, - the composer, historian and social activist. By researching into the life of M.M. Arkas, the author uncovers
the key factors and events that influenced the formation of his spiritual cosmos and thus eventually conduced
to moulding the Ukrainian mentality in a member of the Greek kinship
Plant introduction, conservation and enrichment of biodiversity in M.M. Gryshko National Botanical Garden of the NAS of Ukraine
No full textThe paper deals with the main achievements of scientists of M.M. Gryshko National Botanical Garden of the NAS of Ukraine (NBG) in scientific, conservation, cultural and educational activities. The results of researches on biodiversity, conservation, plants protection, introduction, acclimatization and selection, allelopathy, medical botany, landscape design, bioindication and hemosystematycs are given. It is noted that over 14 thousands species, forms and varieties of plants, are collected in NBG, and the most unique collections attributed to the objects of national heritage. Breeders have obtained more than 300 certificates or author ship on plant varieties. NBG carries out extensive international cooperation, several new exposition of plant collection appeared in Botanical Garden. In recent years the achievements of NBG scientists were awarded by two State Awards in the field of science and technology of Ukraine
Perception of M.M. Bakhtin in the West: some general remarks
No full textIn the present work is a translation of the short introductory work of Turin’s Professor Roberto Salizzoni dedicated to the analysis of art of M.M. Bakhtin and some reflections of the author of the translation, which led him to assess creativity Russian thinker, present in this book of the Italian scientist. First of all, the author of the translation does not agree with the disparaging assessment of creativity of Bakhtin how unoriginal and more abounding plagiarism. The author of the translation argues injustice exaggerated influence on the concept of Bakhtin from literary trends and ideas, including by the media those of the so-called “circle of Bakhtin”. The necessity of considering of creativity of Russian thinker as philosophical, creativity independent and original. Such a conclusion can fail and approval of Neokantian origin of “philosophical roots” of Bakhtin’s concept of philosophy of culture
Author Correction: the Influence of Nano Filter Elements on Pressure Drop and Pollutant Elimination Efficiency in Town Border Stations
No full textThe original version of this Article contained an error in the order of the author names, which was incorrectly given as Hamed Ebadiyan, Saeed Zeinali Heris, Seyed Borhan Mousavi, Shamin Hosseini Nami ; Mousa Mohammadpourfard. Consequently, in the Author Contributions section, “H.E. Investigation. S.Z.H. Supervision, Conceptualization, Methodology, Validation. S.B.M. Formal analysis, Writing original draft. S.H.N. Formal analysis, Writing original draft. M.M. Validation.” now reads: “S.Z.H. Supervision, Conceptualization, Methodology, Validation. H.E. Investigation. S.B.M. Formal analysis, Writing original draft. S.H.N. Formal analysis, Writing original draft. M.M. Validation.” The original Article has been corrected. © 2023, The Author(s)
Mapping the structure and development of Science using co-citation analysis
No full textCo-citation analysis is a unique method used for studying the cognitive structure of science andassessing the research productivity. It is a research tool for examining the intellectual development and structure of the scientific discipline. This paper illustrates principles, techniques and applications of co-citation analysis. It also introduces the newly emerging co-citation analysis softwares,especially SciVal Spotlight and CiteSpace. Co-citation analysis is based on grouping together the papers that are frequently cited in pairs. Combined with single-link clustering and multidimensional scaling techniques, co-citation analysis can literally map the structure of specialized research areas as well as science as a whole
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