3,035 research outputs found
The localization of proper nouns in J.K. Rowling's Harry Potter and the Philosopher’s Stone (1997) as presented in Harry Potter og de Vises Stein translated by Torstein Bugge Høverstad (2001)
No full textThis thesis conducts a comparative analysis of proper noun localization in the Norwegian translation of Harry Potter and the Philosopher’s Stone by Joanne K. Rowling (1997, translated 2001), focusing on the decisions made by translator Torstein Bugge Høverstad. It explores how English proper nouns are adapted for the Norwegian target audience, considering age group and nationality. While Harry Potter and the Philosopher’s Stone is one of the most translated works worldwide, the thesis specifically investigates the Norwegian translation's approach to proper nouns, including anthroponyms and toponyms. It examines translation strategies, notable patterns, and potential changes based on perceived importance.This thesis conducts a comparative analysis of proper noun localization in the Norwegian translation of Harry Potter and the Philosopher’s Stone by Joanne K. Rowling (1997, translated 2001), focusing on the decisions made by translator Torstein Bugge Høverstad. It explores how English proper nouns are adapted for the Norwegian target audience, considering age group and nationality. While Harry Potter and the Philosopher’s Stone is one of the most translated works worldwide, the thesis specifically investigates the Norwegian translation's approach to proper nouns, including anthroponyms and toponyms. It examines translation strategies, notable patterns, and potential changes based on perceived importance
Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial
No full textGlaxoSmithKlineThis study was designed, funded, and interpreted by GlaxoSmithKline in cooperation with an international steering committeeVansteenkiste, JF; Cho, BC; Vanakesa, T; De Pas, T; Zielinski, M; Kim, MS; Jassem, J; Yoshimura, M; Dahabreh, J; Nakayama, H; Havel, L; Kondo, H; Mitsudomi, T; Zarogoulidis, K; Gladkov, OA; Udud, K; Tada, H; Hoffman, H; Bugge, A; Taylor, P; Gonzalez, EE; Liao, ML; He, JX; Pujol, JL; Louahed, J; Debois, M; Brichard, V; Debruyne, C; Therasse, P; Altorki, N
The experience of SCN/M in relation to the implementation of 'Leading Better Care' and their views about the impacts upon patient care, themselves and colleagues: Final Report to NHS Forth Valley: August 2011
No full textThe non-fibrillating n-terminal of α-synuclein binds and co-fibrillates with heparin
No full textThe intrinsically disordered protein α-synuclein (aSN) is, in its fibrillated state, the main component of Lewy bodies-hallmarks of Parkinson's disease. Additional Lewy body components include glycosaminoglycans, including heparan sulfate proteoglycans. In humans, heparan sulfate has, in an age-dependent manner, shown increased levels of sulfation. Heparin, a highly sulfated glycosaminoglycan, is a relevant mimic for mature heparan sulfate and has been shown to influence aSN fibrillation. Here, we decompose the underlying properties of the interaction between heparin and aSN and the effect of heparin on fibrillation. Via the isolation of the first 61 residues of aSN, which lacked intrinsic fibrillation propensity, fibrillation could be induced by heparin, and access to the initial steps in fibrillation was possible. Here, structural changes with shifts from disorder via type I β-turns to β-sheets were revealed, correlating with an increase in the aSN1-61/heparin molar ratio. Fluorescence microscopy revealed that heparin and aSN1-61 co-exist in the final fibrils. We conclude that heparin can induce the fibrillation of aSN1-61, through binding to the N-terminal with an affinity that is higher in the truncated form of aSN. It does so by specifically modulating the structure of aSN via the formation of type I β-turn structures likely critical for triggering aSN fibrillation
Factors affecting continuation of clean intermittent catheterisation in people with multiple sclerosis: Results of the COSMOS mixed-methods study
No full textBackground: Clean intermittent catheterisation (CIC) is often recommended for people with multiple sclerosis (MS). Objective: To determine the variables that affect continuation or discontinuation of the use of CIC. Methods: A three-part mixed-method study (prospective longitudinal cohort (n = 56), longitudinal qualitative interviews (n = 20) and retrospective survey (n = 456)) was undertaken, which identified the variables that influenced CIC continuation/discontinuation. The potential explanatory variables investigated in each study were the individual’s age, gender, social circumstances, number of urinary tract infections, bladder symptoms, presence of co-morbidity, stage of multiple sclerosis and years since diagnosis, as well as CIC teaching method and intensity. Results: For some people with MS the prospect of undertaking CIC is difficult and may take a period of time to accept before beginning the process of using CIC. Ongoing support from clinicians, support at home and a perceived improvement in symptoms such as nocturia were positive predictors of continuation. In many cases, the development of a urinary tract infection during the early stages of CIC use had a significant detrimental impact on continuation. Conclusion: Procedures for reducing the incidence of urinary tract infection during the learning period (i.e. when being taught and becoming competent) should be considered, as well as the development of a tool to aid identification of a person’s readiness to try CIC
Anticoagulant treatment for venous thromboembolism: A pooled analysis and additional results of the XALIA and XALIA-LEA noninterventional studies
No full textBackground: The XALIA and XALIA-LEA prospective, noninterventional studies investigated the safety and effectiveness of rivaroxaban versus standard anticoagulation for venous thromboembolism (VTE) treatment in routine clinical practice across global regions. Objectives: This pooled analysis combined their data to determine the incidence of thromboembolic and bleeding events in both treatment groups and addressed specific bleeding patterns in a broad range of patients. Methods: Patients with objectively confirmed VTE and an indication for ≥3 months’ anticoagulation treatment received rivaroxaban or standard anticoagulation (eg, initial treatment with heparin/fondaparinux, followed by a vitamin K antagonist [VKA]). Treatment choice, dose, management, and duration were at the physician’s discretion. Primary outcomes (major bleeding, recurrent VTE, and all-cause mortality) were compared between the two treatment groups. Propensity score stratification, and matching were used to reduce bias due to confounding variables. Results: Overall, 7129 patients were enrolled from 36 countries; 6445 and 2714 patients were included in the propensity score–stratified and –matched analyses, respectively. Major bleeding and incidences of recurrent VTE were similar between treatment groups; all-cause mortality was lower with rivaroxaban than with standard anticoagulation. The incidences of genitourinary bleeding were higher with rivaroxaban than with standard anticoagulation therapy (46 and 23 events in the matched analysis, respectively). VKA management in real-world practice was suboptimal. Conclusion: XALIA and XALIA-LEA show similar safety and effectiveness profiles of rivaroxaban and standard anticoagulation for VTE treatment in routine practice in many parts of the world. The observations are consistent with results from the phase III EINSTEIN randomized controlled trials
Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice
No full textUdgivelsesdato: 2000-Jan-25The plasminogen activation (PA) system is involved in the degradation of fibrin and various extracellular matrix proteins, taking part in a number of physiological and pathological tissue remodeling processes including cancer invasion. This system is organized as a classical proteolytic cascade, and as for other cascade systems, understanding the physiological initiation mechanism is of central importance. The attempts to identify initiation routes for activation of the proform of the key enzyme urokinase-type plasminogen activator (pro-uPA) in vivo have been hampered by the strong activator potency of the plasmin, that is generated during the progress of the cascade. Using gene-targeted mice deficient in plasminogen (Plg -/- mice) [Bugge, T. H., Flick, M. J., Daugherty, C. C., and Degen, J. L. (1995) Genes Dev. 9, 794-807], we have now demonstrated and identified a component capable of initiating the cascade by activating pro-uPA. The urine from Plg -/- mice contained active two-chain uPA as well as a proteinase capable of activating exogenously added pro-uPA. The active component was purified and identified by mass spectrometry-based peptide mapping as mouse glandular kallikrein mGK-6 (true tissue kallikrein). The pro-uPA converting activity of the mGK-6 enzyme, as well as its ability to cleave a synthetic substrate for glandular kallikrein, was inhibited by the serine proteinase inhibitor leupeptin but not by other serine proteinase inhibitors such as aprotinin, antithrombin III, or alpha(1)-antitrypsin. We suggest that mouse glandular kallikrein mGK-6 is an activator of pro-uPA in the mouse urinary tract in vivo. Since this kallikrein is expressed in a number of tissues and also occurs in plasma, it can also be considered a candidate for a physiological pro-uPA activator in other locations
Festskrift til Hs. Maj. kong Oscar II. ved regjerings jubilæet den 18de september, 1897, fra det K Norske Frederiks universitet.
No full textI. bind. Odland, C. Om apostolatets begreb og oprindelse. Aschehoug, T.H. De norske communers retsforfatning før 1837. Leegaard, C. Undersøgelser over den kutane anæsthesi ved multipel nevrit og tabes dorsalis. Johannessen, A. Bidrag til studiet af rakit tilligemed en del oplysninger om almuens behandling af denne sygdom. Boeck, C. Om tuberkulosens exantemer. Guldberg, G.A. Études sur la dyssymétrie morphologique et fonctionnelle chez l'homme et les vertébrés supérieurs.--2. bind. Lieblein, J. Om Io-mythen. Monrad, M.J. Den menneskelige viljefrihed og det onde. Storm, G. Afgifter fra den norsek kirkeprovins til det apostoliske kammer og kardinalkollegiet 1311-1523 efter optegnelser i de pavelige arkiver. Torp, A. Bemerkungen zu den venetischen inschriften. Bugge, S. and Moe, M. Torsvisen i sin norske form udgivet med en afhandling om dens oprindelse og forhold til de andre nordiske former.Print version record
Measurement of inclusive K*0 (892), Phi (1020) and K(2)*0 (1430) production in hadronic Z decays
No full textThe inclusive production of the neutral vector mesons K*0(892) and φ(1020), and of the tensor meson K2*0(1430), in hadronic decays of the Z has been measured by the DELPHI detector at LEP. The average production rates per hadronic Z decay have been determined to be 0.77 ± 0.08 K*0(892), 0.104 ± 0.008 φ(1020) and 0.079 ± 0.040 K2*0(1430). The ratio of the tensor-to-vector meson production yields, 〈K2*0(1430)〉/〈K *0(892)〉 = 0.10± 0.05, is smaller than the 〈f2(1270)〉/〈ρ0(770)〉 and 〈f2′(1525)〉 /〈φ(1020)〉 ratios measured by DELPHI. The production rates and differential cross sections are compared with the predictions of JETSET 7.4 tuned to the DELPHI data and of HERWIG 5.8. The K*0(892) and φ(1020) data are compatible with model predictions, but a large disagreement is observed for the K2*0(1430)
Parsing with Regular Expressions & Extensions to Kleene Algebra
No full textIn the first part of this thesis, we investigate methods for regular expression parsing.We present an O(mn) two-pass algorithm for greedy regular expression parsing in a semi-streaming fashion for expressions of size m and input of size n.Pass one outputs a log of k bits per input symbol, where k is the number of alternatives and Kleene stars in the expression. This log is used in the second pass to produce a full parse tree.The two-pass algorithm is extended to an O(2^{m log m}+mn)-time optimally streaming parsing algorithm: parts of the parse tree are output as soon as it is semantically possible to do so.To be optimal, the algorithm performs a PSPACE-complete preprocessing step; for a fixed RE the running time is linear in the input size.Finally, we present and implement a determinization procedure, omitting the preprocessing step, and a surface language, Kleenex, for expressing general string transductions.We have implemented a compiler that translates Kleenex programs into efficient C code.The resulting programs are essentially optimally streaming, run in worst-case linear time in the input size, and show consistent high performance in the 1 Gbps range on various use cases.In the second part of this thesis, we study two extensions to Kleene algebra.Chomsky algebra is an algebra with a structure similar to Kleene algebra, but with a generalized mu-operator for recursion instead of the Kleene star.We show that the axioms of idempotent semirings along with continuity of the mu-operator completely axiomatize the equational theory of the context-free languages.KAT+B! is an extension to Kleene algebra with tests (KAT) that adds mutable state.We describe a test algebra B! for mutable tests and give a commutative coproduct between KATs.Combining the axioms of B! with those of KAT and some commutativity conditions completely axiomatize the equational theory of an arbitrary KAT enriched with mutable state.<br/
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