10 research outputs found
The interplay of modern myths about sexual aggression and moral foundations in the blaming of rape victims
No full textMilesi P, Süssenbach P, Bohner G, Megias JL. The interplay of modern myths about sexual aggression and moral foundations in the blaming of rape victims. European Journal of Social Psychology. 2020;50(1):111-123.Moral Foundations Theory proposes five intuition-based moral concerns: Care and Fairness ("individualizing foundations") as well as Loyalty, Authority, and Sanctity ("binding foundations"). In studies carried out in Italy, Spain, and Germany, the authors examined how these concerns are associated with the acceptance of modern myths about sexual aggression (AMMSA), and how both jointly predict rape victim blaming. Overall, victim blaming was positively predicted by Authority and Sanctity, and negatively predicted by Care and Fairness. Although victim blaming was best predicted by AMMSA, moral concerns also contributed to its prediction, partly independently, partly mediated through AMMSA, and in the case of Sanctity in interaction with AMMSA. Discussion highlights how integrating moral foundations in the investigation of victim blaming and AMMSA across different cultural contexts may deepen our understanding of why, in each cultural context, victim blaming and related beliefs are resistant to change
Monitoring vascular normalization induced by antiangiogenic treatment with (18)F-fluoromisonidazole-PET
Get PDFThis work was supported by the following sources: Fondo de Investigacion Sanitaria (Ministry of Health, Spain; numbers FIS PI10/0288, FIS PI13/00430, FIS PI 11/00616, CPII14/00005 and FIS PI14/00860; the first two awarded to MQF and the last three to MD), and "Fondo Europeo de Desarrollo Regional (FEDER) - Una manera de hacer Europa". MQF is a recipient of a 2010 Beca-Retorno from the AECC Scientific Foundation. Rosae Foundation and AVON Espana S.A.U. contributed to this work with unrestricted donations. Dovitinib was kindly provided by Novartis.BACKGROUND: Rationalization of antiangiogenics requires biomarkers. Vascular re-normalization is one widely accepted mechanism of action for this drug class. The interstitium of tumors with abnormal vasculature is hypoxic. We sought to track vascular normalization with (18)F-misonidazole ([18F]-FMISO, a probe that detects hypoxia) PET, in response to window-of-opportunity (WoO) treatment with the antiangiogenic dovitinib. METHODS: Two patient-derived pancreas xenografts (PDXs; Panc215 and Panc286) and the spontaneous breast cancer model MMTV-PyMT were used. Animals were treated during 1 week of WoO treatment with vehicle or dovitinib, preceded and followed by [18F]-FMISO-PET, [18F]-FDG-PET, and histologic assessment (dextran extravasation, hypoxia and microvessel staining, and necrosis, cleaved caspase-3 and Ki67 measurements). After WoO treatment, gemcitabine (pancreas)/adriamycin (breast) or vehicle was added and animals were treated until the humane endpoint. Tumor growth inhibition (TGI) and survival were the parameters studied. RESULTS: [18F]-FMISO SUV did not change after dovitinib-WoO treatment compared to vehicle-WoO (0.54 vs. 0.6) treatment in Panc215, but it decreased significantly in Panc286 (0.58 vs. 1.18; P < 0.05). In parallel, 10-KDa perivascular dextran extravasation was not reduced with dovitinib or vehicle-WoO treatment in Panc215, but it was reduced in Panc286. Whereas the addition of dovitinib to gemcitabine was indifferent in Panc215, it increased TGI in Panc286 (TGI switched from -59% to +49%). [18F]-FMISO SUV changes were accompanied by an almost 100% increase in interstitial gemcitabine delivery (665-1260 ng/mL). The results were validated in the PyMT model. CONCLUSIONS: [18F]-FMISO accurately monitored vascular re-normalization and improved interstitial chemotherapy delivery.This work was supported by the following sources: Fondo de Investigacion Sanitaria (Ministry of Health, Spain; numbers FIS PI10/0288, FIS PI13/00430, FIS PI 11/00616, CPII14/00005 and FIS PI14/00860; the first two awarded to MQF and the last three to MD), and "Fondo Europeo de Desarrollo Regional (FEDER) - Una manera de hacer Europa". MQF is a recipient of a 2010 Beca-Retorno from the AECC Scientific Foundation. Rosae Foundation and AVON Espana S.A.U. contributed to this work with unrestricted donations. Dovitinib was kindly provided by Novartis.S
Versión colombiana de la escala “Acceptance of Modern Myths about Sexual Aggression”: primeros análisis psicométricos
No full textResumen En este estudio se presentan los primeros datos psicométricos en muestras colombianas de la “Acceptance of Modern Myths about Sexual Aggression Scale” (AMMSA) (Gerger, Kley, Bohner y Siebler, 2007), instrumento que permite evaluar mitos modernos sobre las agresiones sexuales. Dos estudios fueron llevados a cabo con muestras universitarias. En el primero, trescientos doce estudiantes completaron la versión colombiana de esta escala así como otros dos instrumentos que miden constructos relacionados (Sexism Ambivalent Inventory, ASI, y Rape Myth Acceptance Scale, RMAS). En el estudio 2, ciento noventa y seis universitarios respondieron tanto a la versión colombiana de esta escala como a una serie de preguntas sobre un escenario ficticio de agresión sexual. Los resultados obtenidos a partir de ambos estudios permiten concluir que la versión colombiana de la escala AMMSA posee una adecuada fiabilidad y validez. Comparada con la escala RMAS, las puntuaciones medias en el AMMSA fueron mayores y sus distribuciones normales. Dichos hallazgos sugieren que la versión colombiana de la escala AMMSA es un instrumento de medida adecuado para estudiar la percepción social de las agresiones sexuales en muestras colombianas
First measurement of muon neutrino charged-current interactions on hydrocarbon without pions in the final state using multiple detectors with correlated energy spectra at T2K
Get PDFThis paper reports the first measurement of muon neutrino charged-current interactions without pions in the final state using multiple detectors with correlated energy spectra at T2K. The data was collected on hydrocarbon targets using the off-axis T2K near detector (ND280) and the on-axis T2K near detector (INGRID) with neutrino energy spectra peaked at 0.6 GeV and 1.1 GeV, respectively. The correlated neutrino flux presents an opportunity to reduce the impact of the flux uncertainty and to study the energy dependence of neutrino interactions. The extracted double-differential cross sections are compared to several Monte Carlo neutrino-nucleus interaction event generators showing the agreement between both detectors individually and with the correlated result
Measurements of neutrino oscillation parameters from the T2K experiment using 3.6 x 1021 protons on target
Get PDFThe T2K experiment presents new measurements of neutrino oscillation parameters using 19.7 (16.3) × 10 20 protons on target (POT) in (anti-)neutrino mode at the far detector (FD). Compared to the previous analysis, an additional 4.7 × 10 20 POT neutrino data was collected at the FD. Significant improvements were made to the analysis methodology, with the near-detector analysis introducing new selections and using more than double the data. Additionally, this is the first T2K oscillation analysis to use NA61/SHINE data on a replica of the T2K target to tune the neutrino flux model, and the neutrino interaction model was improved to include new nuclear effects and calculations. Frequentist and Bayesian analyses are presented, including results on sin 2θ13 and the impact of priors on the δCP measurement. Both analyses prefer the normal mass ordering and upper octant of sin 2θ23 with a nearly maximally CP-violating phase. Assuming the normal ordering and using the constraint on sin 2θ13 from reactors, sin2θ23=0.561-0.032+0.021 using Feldman–Cousins corrected intervals, and Δm322=2.494-0.058+0.041×10-3eV2 using constant Δχ2 intervals. The CP-violating phase is constrained to δCP=-1.97-0.70+0.97 using Feldman–Cousins corrected intervals, and δCP= 0 , π is excluded at more than 90% confidence level. A Jarlskog invariant of zero is excluded at more than 2 σ credible level using a flat prior in δCP, and just below 2 σ using a flat prior in sin δCP. When the external constraint on sin 2θ13 is removed, sin2θ13=28.0-6.5+2.8×10-3, in agreement with measurements from reactor experiments. These results are consistent with previous T2K analyses
Corrigendum : Role of NAFLD on the health related QoL response to lifestyle in patients with metabolic syndrome: The PREDIMED plus cohort
Get PDF20.500.12530/87907[This corrects the article DOI: 10.3389/fendo.2022.868795.]
Measurements of the νμ and (ν)over-barμ-induced coherent charged pion production cross sections on 12C by the T2K experiment
No full textWe report an updated measurement of the νμ-induced, and the first measurement of the ν ̄μ-induced coherent charged pion production cross section on C12 nuclei in the Tokai-to-Kamioka experiment. This is measured in a restricted region of the final-state phase space for which pμ,π>0.2 GeV, cos(θμ)>0.8 and cos(θπ)>0.6, and at a mean (anti)neutrino energy of 0.85 GeV using the T2K near detector. The measured νμ charged current coherent pion production flux-averaged cross section on C12 is (2.98±0.37(stat)±0.31(syst)-0.00+0.49(Q2 model))×10-40 cm2. The new measurement of the ν ̄μ-induced cross section on C12 is (3.05±0.71(stat)±0.39(syst)-0.00+0.74(Q2 model))×10-40 cm2. The results are compatible with both the NEUT 5.4.0 Berger-Sehgal (2009) and GENIE 2.8.0 Rein-Sehgal (2007) model predictions
Longitudinal association of dietary acid load with kidney function decline in an older adult population with metabolic syndrome
Get PDFBackground: Diets high in acid load may contribute to kidney function impairment. This study aimed to investigate the association between dietary acid load and 1-year changes in glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR).
Methods: Older adults with overweight/obesity and metabolic syndrome (mean age 65 ± 5 years, 48% women) from the PREDIMED-Plus study who had available data on eGFR (n = 5,874) or UACR (n = 3,639) at baseline and after 1 year of follow-up were included in this prospective analysis. Dietary acid load was estimated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) at baseline from a food frequency questionnaire. Linear and logistic regression models were fitted to evaluate the associations between baseline tertiles of dietary acid load and kidney function outcomes. One year-changes in eGFR and UACR were set as the primary outcomes. We secondarily assessed ≥ 10% eGFR decline or ≥10% UACR increase.
Results: After multiple adjustments, individuals in the highest tertile of PRAL or NEAP showed higher one-year changes in eGFR (PRAL, β: –0.64 ml/min/1.73 m2; 95% CI: –1.21 to –0.08 and NEAP, β: –0.56 ml/min/1.73 m2; 95% CI: –1.13 to 0.01) compared to those in the lowest category. No associations with changes in UACR were found. Participants with higher levels of PRAL and NEAP had significantly higher odds of developing ≥10% eGFR decline (PRAL, OR: 1.28; 95% CI: 1.07–1.54 and NEAP, OR: 1.24; 95% CI: 1.03–1.50) and ≥10 % UACR increase (PRAL, OR: 1.23; 95% CI: 1.04–1.46) compared to individuals with lower dietary acid load.
Conclusions: Higher PRAL and NEAP were associated with worse kidney function after 1 year of follow-up as measured by eGFR and UACR markers in an older Spanish population with overweight/obesity and metabolic syndrome
Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort
Get PDFOBJECTIVE: To evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic syndrome (MetS). METHODS: Baseline and 1 year follow up data from the PREDIMED-plus cohort (men and women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as affected by lifestyle during 1 year of follow up. RESULTS: Data from 5205 patients with mean age of 65 years and a 48% of female participants. Adjusted linear multivariate mixed regression models showed that patients with lower probability of NAFLD (HSI < 36 points) were more responsive to er-MeDiet (β 0.64 vs β 0.05 per er-MeDiet adherence point, p< 0.01) and PA (β 0.05 vs β 0.01 per MET-h/week, p = 0.001) than those with high probability for NAFLD in terms Physical SF-36 summary in the 1 year follow up. 10 points of er-MeDiet adherence and 50 MET-h/week were thresholds for a beneficial effect of lifestyle on HRQoL physical domain in patients with lower probability of NAFLD. CONCLUSION: The evaluation of NAFLD by the HSI index in patients with MetS might identify subjects with different prospective sensitivity to lifestyle changes in terms of physical HRQoL (http://www.isrctn.com/ISRCTN89898870)
Updated T2K measurements of muon neutrino and antineutrino disappearance using <math display="inline"><mrow><mn>3.6</mn><mo>×</mo><mrow><msup><mrow><mn>10</mn></mrow><mrow><mn>21</mn></mrow></msup></mrow></mrow></math> protons on target
No full textMuon neutrino and antineutrino disappearance probabilities are identical in the standard three-flavor neutrino oscillation framework, but CPT violation and nonstandard interactions can violate this symmetry. In this work we report the measurements of sin2θ23 and Δm322 independently for neutrinos and antineutrinos. The aforementioned symmetry violation would manifest as an inconsistency in the neutrino and antineutrino oscillation parameters. The analysis discussed here uses a total of 1.97×1021 and 1.63×1021 protons on target taken with a neutrino and antineutrino beam respectively, and benefits from improved flux and cross section models, new near-detector samples and more than double the data reducing the overall uncertainty of the result. No significant deviation is observed, consistent with the standard neutrino oscillation picture
