1,445 research outputs found
Bericht zum Krebsgeschehen in Deutschland 2016
No full textDer „Bericht zum Krebsgeschehen in Deutschland“ stellt Informationen und Auswertungsergebnisse über Krebserkrankungen dar und beleuchtet Aspekte der Epidemiologie, der Versorgung, individueller und gesellschaftlicher Krankheitsfolgen sowie Möglichkeiten und Aktivitäten zur primären Prävention und Früherkennung von Krebs. Dabei führt er vielfältige und detaillierte Informationen aus verschiedenen Datenquellen zusammen. Eine wesentliche Entwicklung ist die zunehmende Zahl der Menschen, die in Deutschland mit Krebs oder nach einer überstandenen Krebserkrankung leben. Ein Anstieg der jährlichen Neuerkrankungen aufgrund des demographischen Wandels geht dabei einher mit kontinuierlichen Verbesserungen der Versorgung, die ein längeres Leben mit oder nach Krebs ermöglichen. Auf der anderen Seite bieten lebensstilbedingte Krebsrisikofaktoren wie Tabak- und Alkoholkonsum, Übergewicht, Bewegungsmangel oder exogene Einflussfaktoren wie UV-Strahlung ein erhebliches Potenzial zur Verringerung der Häufigkeit von Krebserkrankungen. Dies unterstreicht die Bedeutung von gut abgestimmten, langfristig angelegten Maßnahmen zur primären Prävention und Gesundheitsförderung. Der vorliegende Bericht ist die erste Ausgabe einer neuen Reihe des Zentrums für Krebsregisterdaten im Robert Koch-Institut und wird künftig alle fünf Jahre erscheinen
On functional module detection in metabolic networks
No full textFunctional modules of metabolic networks are essential for understanding the metabolism of an organism as a whole. With the vast amount of experimental data and the construction of complex and large-scale, often genome-wide, models, the computer-aided identification of functional modules becomes more and more important. Since steady states play a key role in biology, many methods have been developed in that context, for example, elementary flux modes, extreme pathways, transition invariants and place invariants. Metabolic networks can be studied also from the point of view of graph theory, and algorithms for graph decomposition have been applied for the identification of functional modules. A prominent and currently intensively discussed field of methods in graph theory addresses the Q-modularity. In this paper, we recall known concepts of module detection based on the steady-state assumption, focusing on transition-invariants (elementary modes) and their computation as minimal solutions of systems of Diophantine equations. We present the Fourier-Motzkin algorithm in detail. Afterwards, we introduce the Q-modularity as an example for a useful non-steady-state method and its application to metabolic networks. To illustrate and discuss the concepts of invariants and Q-modularity, we apply a part of the central carbon metabolism in potato tubers (Solanum tuberosum) as running example. The intention of the paper is to give a compact presentation of known steady-state concepts from a graph-theoretical viewpoint in the context of network decomposition and reduction and to introduce the application of Q-modularity to metabolic Petri net models
Computation and Visualization of Protein Topology Graphs Including Ligand Information
No full textpeer reviewe
The birth and early years of INA, the International Neurotoxicology Association
No full textAbstractThe International Neurotoxicology Association (INA) is a scientific society whose members have interest and expertise in the discipline of neurotoxicology. The idea of forming INA was born in 1984, as a follow-up to a NATO-sponsored meeting on Toxicology of the Nervous System. INA held its first meeting in the Netherlands in 1987 and has had continuous meetings every other year since then. INA is registered as a scientific society in the Netherlands, and is an affiliated society of IUTOX. This paper presents a personal account of the events that led to the birth of INA, and of the first fifteen years of this association
Katja Koch / Kinan Darwisch (Hrsg.): Dimensionen religiöser Erziehung muslimischer Kinder in Niedersachsen. Göttingen: Universitätsverlag Göttingen 2010 [Rezension]
No full textRezension von: Katja Koch / Kinan Darwisch (Hrsg.): Dimensionen religiöser Erziehung muslimischer Kinder in Niedersachsen. Göttingen: Universitätsverlag Göttingen 2010 (132 S.; ISBN 978-3-9418-7556-2
Koło się zamyka
No full textIna Söllner was one of Schulz’s young sitters. As an adult person, she discovered in her autograph book a portrait of her mother, Ina, made by Schulz. The drawing called The King of Frogs [Żabi król] and a dedication referring to her mother sitting provoke the author to analyze her family connections with Schulz. Even though she does not remember her meeting with the artist, she reconstructs Schulz’s place in her biography and the circumstances under which they might have met
Pioneering Doktormutter Remembering Ina-Maria Greverus
No full textThe author reconsiders German scholar Ina-Maria Greverus as a committed feminist supporter of female doctoral students and early career academics. Greverus acted as an innovator especially in the realms of anthropology and aesthetics, and initiated a new international dialogue forum with the Anthropological Journal or European Cultures, which she founded in 1990 together with Christian Giordano.</p
The Circle Closes
No full textIna Söllner was one of Schulz’s young sitters. As an adult person, she discovered in her autograph book a portrait of her mother, Ina, made by Schulz. The drawing called The King of Frogs [Żabi król] and a dedication referring to her mother sitting provoke the author to analyze her family connections with Schulz. Even though she does not remember her meeting with the artist, she reconstructs Schulz’s place in her biography and the circumstances under which they might have met
Chronicles of Oklahoma
No full textArticle discusses the life of the author and her family after homesteading in Logan County, Oklahoma Territory. Ina Robinson discusses the difficulties faced on the frontier, the people they encountered there, education available, and social life
From Petri Nets to differential equations: An integrative approach for biochemical network analysis
No full textWe report on the results of an investigation into the integration
of Petri nets and ordinary differential equations (ODEs) for the
modelling and analysis of biochemical networks, and the application of
our approach to the model of the influence of the Raf Kinase Inhibitor
Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK)
signalling pathway. We show that analysis based on a discrete Petri net
model of the system can be used to derive the sets of initial concentrations
required by the corresponding continuous ordinary differential
equation model, and no other initial concentrations produce meaningful
steady states. Altogether, this paper represents a tutorial in step-wise
modelling and analysis of larger models as well as in structured design
of ODEs
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