954 research outputs found
The birth and early years of INA, the International Neurotoxicology Association
No full textAbstractThe International Neurotoxicology Association (INA) is a scientific society whose members have interest and expertise in the discipline of neurotoxicology. The idea of forming INA was born in 1984, as a follow-up to a NATO-sponsored meeting on Toxicology of the Nervous System. INA held its first meeting in the Netherlands in 1987 and has had continuous meetings every other year since then. INA is registered as a scientific society in the Netherlands, and is an affiliated society of IUTOX. This paper presents a personal account of the events that led to the birth of INA, and of the first fifteen years of this association
Social epidemiology of cutaneous melanoma
Full text linkCutaneous melanoma is a disease presenting with a rising medico-social significance worldwide. Epidemiological research in the recent several years reveal unfavourable trends related to the increasing incidence and mortality rates . There exist considerable differences concerning the geographic distribution of the disease as well as between the representatives of different races. Age-standardized (world standard) incidence rate in Bulgaria among males increases from 1,7 per 100000 in 1980 up to 3,8 per 100000 in 2013 while that among females - from 1,7 per 100000 in 1980 up to 3,3 per 100000 in 2013. Age-standardized (world standard) mortality rate in Bulgaria among males increases from 0,5 per 100000 in 1980 up to 1,6 per 100000 in 2013 while that among females - fromCutaneous melanoma is a disease presenting with a rising medico-social significance worldwide. Epidemiological research in the recent several years reveal unfavourable trends related to the increasing incidence and mortality rates . There exist considerable differences concerning the geographic distribution of the disease as well as between the representatives of different races. Age-standardized (world standard) incidence rate in Bulgaria among males increases from 1,7 per 100000 in 1980 up to 3,8 per 100000 in 2013 while that among females - from 1,7 per 100000 in 1980 up to 3,3 per 100000 in 2013. Age-standardized (world standard) mortality rate in Bulgaria among males increases from 0,5 per 100000 in 1980 up to 1,6 per 100000 in 2013 while that among females - from 0,6 per 100000 in 1980 up to 1,0 per 100000 in 2013
Koło się zamyka
Full text linkIna Söllner was one of Schulz’s young sitters. As an adult person, she discovered in her autograph book a portrait of her mother, Ina, made by Schulz. The drawing called The King of Frogs [Żabi król] and a dedication referring to her mother sitting provoke the author to analyze her family connections with Schulz. Even though she does not remember her meeting with the artist, she reconstructs Schulz’s place in her biography and the circumstances under which they might have met
Pioneering Doktormutter Remembering Ina-Maria Greverus
No full textThe author reconsiders German scholar Ina-Maria Greverus as a committed feminist supporter of female doctoral students and early career academics. Greverus acted as an innovator especially in the realms of anthropology and aesthetics, and initiated a new international dialogue forum with the Anthropological Journal or European Cultures, which she founded in 1990 together with Christian Giordano.</p
The Circle Closes
No full textIna Söllner was one of Schulz’s young sitters. As an adult person, she discovered in her autograph book a portrait of her mother, Ina, made by Schulz. The drawing called The King of Frogs [Żabi król] and a dedication referring to her mother sitting provoke the author to analyze her family connections with Schulz. Even though she does not remember her meeting with the artist, she reconstructs Schulz’s place in her biography and the circumstances under which they might have met
Clinico-morphological Characteristics, Histological Typification and Their Correlation with Some Molecular Markers in Cutaneous Melanoma // Клинико-морфологични характеристики, хистотипизация и корелацията им с някои молекулярни маркери при кожен меланом
No full textМеланомът е злокачествен тумор с меланоцитен произход и изключително неблагоприятна прогноза. В областта на морфологичната диагностика на меланома навлиза практиката да се прилагат маркери, които по правило биват използвани за тумори с различна от тази на меланома хистогенеза. Те най-често се интерпретират като предиктори за прогресията на заболяването или служат като аналози на молекулярни изследвания при ниско туморно съдържание в тъканните проби. Целта на настоящата работа е да се проучат заболяемостта и смъртността от кожен меланом в България и за Варненска област, както и да се анализират и съпоставят клинични, хистологични, имунохистохимични и молекулярни характеристики на заболяването с оглед изясняване биологията на тумора и съставяне на примерен диагностичен алгоритъм. Динамиката на регистрираната стандартизирана заболяемост и смъртност в България в периода 1980-2013г. (световен стандарт) от кожен меланом показва неблагоприятна тенденция за нарастване през последните години, особено при мъжете Резултатите от сравнителния анализ (t-test) на броя на смъртни случаи с кожен меланом, регистрирани в СБАЛОЗ „Д-р М. Марков“-Варна през 2007-2016 г. показват статистически значима разлика (t=3,847; p=0,004), т.е. постепенното нарастване на смъртността през годините е прогресивна тенденция. При проведеното изследване ние установихме, че анти-HMB-45 антитяло дава умерено или силно позитивна реакция при 98% от пациентите, което верифицира меланоцитния произход на лезиите и потвърждава високата диагностична стойност на антитялото. При проведеното изследване съпоставихме експресията на маркерите анти-CD117 антитяло и анти-VEGF антитяло с дебелината на лезията в милиметри по скалата на Breslow с цел установяване на зависимост, която да обуслови прогресията на лезията. На базата на проведеното от нас изследване изработихме диагностичен алгоритъм за доуточняване поведението при кожен меланом. Предиктивността на анти-BRAF антитяло спрямо туморната биология на кожния меланом е съществена. Поради този факт вариантът за предшестващо молекулярната детекция имунохистохимично тестване е финансово изгодна и ефективна опция, особено при лезии с ниско туморно съдържание в тъканните проби, които не подлежат на молекулярно изследване. Въз основа на настоящото проучване бихме могли да заключим, че съществува статистически значимо покачване на смъртността от кожен меланом във Варненска област и България през периода от 2007 г. до 2016 г. и такава тенденция относно заболяемостта от тумора. Имунохистохимичните и молекулярни маркери, които тествахме, са есенциални за диагностиката и предиктивността поведението на кожен меланом, доказано чрез статистически значимите корелации помежду им, както и между тях и някои клинико-морфологични параметри. Тези резултати бяха достатъчни за изработването на двата мултифакторни регресионни модели, примерния диагностичен алгоритъм, както и за създаване възможност BRAF V600E мутация да се определя чрез имунохистохимична реакция. Посочените могат успешно да бъдат прилагани в клиничната практика.Melanoma is a malignant tumour of melanocytic origin characterized with an extremely poor prognosis. There is a rising interest in the application of specific molecular markers for the clarification of tumour biology and morphological diagnosis of skin melanoma. Our purpose was to study the incidence and mortality rates of skin melanoma in Bulgaria and in the region of Varna as well as to analyse and juxtapose the clinical, histological, immunohistochemical and molecular characteristics of the disease with a view to clarification of tumour biology and compilation of a template diagnostic algorithm. The analysis of the incidence and the mortality rate in Bulgaria during the period from year 1980 to year 2013 showed an unfavourable progressive tendency of gradual increase of the incidence and the mortality rate in the recent decades, especially in men. The analysis of a total of 452 skin melanoma patients, 234 males and 218 females, demonstrated a statistically significant difference concerning the number of deceased patients (t=3,847; p=0,004), i.e. a progressive trend of gradual increase of the mortality rate. The immunohistochemical verification of the malignant melanocytic lesions by means of the differentiation marker anti-HMB45 antibody demonstrated a moderately or strongly expressed positive reaction in 98% of the patients. The expression of the markers for progression such as anti-CD117 antibody and anti-VEGF antibody was juxtaposed to lesion thickness in mm after Breslow. Anti-CD117 antibody showed the tendency to be expressed in tumor nests near the basement membrane of the epidermis, and loosed the ability of expression in the tumor nests of the deeper dermal layers and in the metastatic lesions, thus marking the progression of the lesion. A diagnostic algorithm including the necessary parameters for skin melanoma patients was elaborated. The anti-BRAF antibody predictive value towards the tumour biology of skin melanoma was of essential importance. Its preliminary molecular immunohistochemical detection was a cost-saving and effective option, especially in lesions with a low tumour content in tissue samples, thus not liable to molecular examination. We could conclude that there is a statistically significant increase of skin melanoma mortality rate in the region of Varna, as well as in Bulgaria. That is why the further investigations in this field are vital for the patients. The immunohistochemical and molecular markers tested presented with important diagnostic and predictive value as proved by the significant correlations between them and the clinico-morphological parameters in skin melanoma patients. These results were sufficient for elaborating the two multifactorial regression models properly tested, the template algorithm for the diagnosis of skin melanoma and also was created an opportunity for immunohistochemical detection of BRAF V600E mutation. All of these could efficiently be applied in the clinical practice
Chronicles of Oklahoma
Full text linkArticle discusses the life of the author and her family after homesteading in Logan County, Oklahoma Territory. Ina Robinson discusses the difficulties faced on the frontier, the people they encountered there, education available, and social life
La Cañada Drive, River Road to Ina Road
No full texttableOfContents: The Pima County Department of Transportation proposes to widen approximately 2.7 miles of La Cañada Drive from a two-lane arterial road into a four-lane arterial road between River Road and Ina Road. The project also includes the installation of a closed stormwater collection and conveyance system, installation of culverts to create an all-weather roadway, and addition of curbs, sidewalks, bike lanes, and a public use trail
Ina M. McCausland Correspondence
Full text linkEntry is a letter from the Maine State Library in receipt of a book for the Maine Author Collection
PRIVATIZACIJA INA-e; UZROCI, MODEL, POSLJEDICE : Diplomski rad
Full text linkU Republici Hrvatskoj 90-ih godina prošlog stoljeća provođeni su procesi pretvorbe i privatizacije. Hrvatski privatizacijski model bio je osmišljen na način da se sastojao od dvije etape; pretvorbene i privatizacijske. Postupak pretvorbe društvenog vlasništva započeo je 23. travnja 1991. donošenjem Zakona o pretvorbi društvenih poduzeća. Pretvorbenu etapu obilježavaju dva paralelna tijeka; formalnopravni tijek i financijski tijek pretvorbe. Druga etapa privatizacijskog procesa je privatizacijska etapa koja se dijeli na: privatizaciju portfelja u posjedu Hrvatskog fonda za privatizaciju (HFP), unutar koje imamo kuponsku privatizaciju i na privatizaciju koja se odvija izvan HFP (privatizacija javnih poduzeća i privatizacija bankarske industrije). Proces privatizacije započeo je zapravo već donošenjem Zakona o Hrvatskom fondu za privatizaciju (HFP), a sam HFP je osnovan 1.svibnja 1993.g. Privatizaciju javnih poduzeća provodi Ministarstvo gospodarstva javnom dražbom ili izravnim pregovorima s potencijalnim kupcima. U procesu privatizacije javnih poduzeća krenulo se na privatizaciju INA-e.
Od 1990. INA je poduzeće u državnom vlasništvu, a od 1993. dioničko društvo. Prva faza privatizacije, u kojoj kupnjom 25 posto plus jedne dionice Inin strateški partner postaje MOL, završena je 2003. godine. U 2006. godini INA je ušla u sljedeću fazu privatizacije kada je Vlada RH pustila u prodaju 1.700.000 njenih redovnih dionica. U siječnju 2009. godine MOL i Vlada Republike Hrvatske potpisali su Dodatak dioničarskom ugovoru. Sukladno tim ugovorima INA, d.d. izlazi iz zakonski uređenog dijela plinskog poslovanja. Činjenice da je osnovano Istražno povjerenstvo za privatizaciju Ina-e, da je bivši premijer Sanader uhićen i suđen za primanje mita od MOL-a, da je RH podnijela arbitražnu tužbu protiv MOL-a, a i podatak studije američke konzultantske tvrtke AT&Karney te Oil & Gas Consultinga koja je pokazala da je MOL nakon preuzimanja Ine hrvatsku stranu nepridržavanjem dogovora oštetio za 6,2 milijarde dolara upućuju na nedostatak strategije o hrvatskoj energetskoj budućnosti, već upravo suprotno pokazuju kako se u privatizaciju Ina-e ušlo bez strategije i sa samo jednim ciljem, a to je zadovoljiti vlastite i političke interese. Želja autorice je da se iz pogreške koja je nastala u privatizaciji INA-e, nauči nešto za privatizacije koje tek dolaze, kako se takve greške ne bi ponovile. INA je jedna od tvrtki koji su nositelji hrvatskog gospodarstva, nažalost mi se prema njoj nismo tako odnosili. Pitanje je što je RH mogla dobiti da je INA ostala u njenom većinskom vlasništvu. To su sad samo nagađanja. Financijski rezultati INA-e zadnjih godina su pozitivni, pokazatelji za 2015. i prvi kvartal 2016. pokazuju da posluje s gubitkom, što i kako će biti dalje pokazati će vrijeme koje je pred nama.In Croatia, the 90’s of last century were implemented processes of transformation and privatization. Croatian privatization model was designed in such a way that it consisted of two stages; transformation and privatization. The process of transformation of social ownership began on April 23, 1991. Transformation stage is marked by two parallel flow; formal legal flows and financial flows transformation. The second stage of the privatization process of was privatization stage, which is divided into the privatization portfolio held by the Croatian Privatization Fund (HFP), within which we have the coupon privatization and the privatization that takes place outside of the HFP (privatization of public enterprises and privatization of the banking industry). The privatization process started in May 1, 1993. In the process of privatization of public enterprises moved on to the privatization of INA.
Since 1990, INA is a company owned by the state and since 1993 a joint stock company. The first stage of privatization, in which the purchase of 25 percent plus one share of INA's strategic partner MOL station, completed in 2003. In 2006 INA went into the next stage of privatization when the Government has launched the sale of 1,700,000 of its common shares. In January 2009 MOL and the Croatian government signed the Amendment to the Shareholders Agreement. Pursuant to these agreements, INA, d.d exits from the regulated part of the gas business. The fact that the established inquiry commission for the privatization of INA that former Prime Minister Ivo Sanader was arrested and tried for accepting bribes from MOL that the Republic of Croatia filed an arbitration claim against MOL, and information studies of US consulting firm AT & Karney and Oil & gas Consulting which showed that MOL following the takeover of INA Croatian side of non-compliance with the agreement damaged for $ 6.2 billion refer to the lack of strategy on Croatia's energy future, but on the contrary show that the privatization of INA is entered without a strategy and with only one goal and that is to meet their own and political interests. The desire of the author is that of errors that occurred in the privatization of INA, learn something privatization yet to come, that such mistakes would not happen again. INA is one of the companies which are the carriers of the Croatian economy, unfortunately we didn´t treated her on that way. The question is what is the Republic of Croatia could get to the INA remained in its majority property. They are now just speculation. Financial results of INA´s last year are positive. Indicators for 2015 and the first quarter of 2016 indicate that operates at a loss, and the time will show what happens next
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