62,963 research outputs found
First‐trimester trophoblasts obtained by chorionic villus sampling maintain tolerogenic and proteomic features in successful pregnancies despite a history of unexplained recurrent pregnancy loss
No full textProblem While there are several known causes for recurrent pregnancy loss (RPL), about 50% are unexplained (uRPL), and in these cases, an aberrant immune regulation seems to be involved. Although fetally derived trophoblast cells have a key role in immune regulation, it is difficult to study their immune function during pregnancy, and it is not known whether trophoblast function may be an inherent aberration in uRPL or whether it is associated with the outcome of the current pregnancy. Method of study Chorionic villus sampling (CVS) was performed for clinical indications at 12 weeks of gestation. Superfluous materials, divided in small explants, were cultured for 20-24 hours, and supernatants (conditioned medium) were collected from 36 women with singleton normal pregnancies, of whom 9 women had a history of RPL. The secreted immune protein profile was measured by proximity extension assay, and the conditioned medium was further used in functional ex vivo models to assess ability to polarize blood monocytes and CD4(+)T cells into immune regulatory phenotypes, as detected by flow cytometry. Results Conditioned medium from chorionic villi, human fetally derived placental tissue, was able to induce a decidual-type of M2-like macrophages, as well as an expansion of Treg cells ex vivo, both in women with uRPL and in control women. The preserved immunological properties were confirmed by a maintained immune protein profile in RPL compared with controls. Conclusion Trophoblasts in an ex vivo model maintain tolerogenic and proteomic profile features in successful pregnancies, despite a previous history of RPL.Funding Agencies|Swedish Research CouncilSwedish Research Council [2018-02776]; Linkoping University; Tor Vergata University; ALF Grants</p
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
Measurement of the ratio of prompt χ c to J / ψ production in pp collisions at √s = 7 TeV
No full textThe prompt production of charmonium χ c and J / ψ states is studied in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the Large Hadron Collider. The χ c and J / ψ mesons are identified through their decays χ c → J / ψ γ and J / ψ → μ + μ - using 36 pb - 1 of data collected by the LHCb detector in 2010. The ratio of the prompt production cross-sections for χ c and J / ψ, σ (χ c → J / ψ γ) / σ (J / ψ), is determined as a function of the J / ψ transverse momentum in the range 2 < p T J / ψ < 15 GeV / c. The results are in excellent agreement with next-to-leading order non-relativistic expectations and show a significant discrepancy compared with the colour singlet model prediction at leading order, especially in the low p T J / ψ region
Effects of low molecular weight heparin on the polarization and cytokine profile of macrophages and T helper cells in vitro
No full textLow molecular weight heparin (LMWH) is widely used in recurrent miscarriage treatment. The anticoagulant effects are established, while immunological effects are not fully known. Our aim was to assess LMWH effects on activation and polarization of central regulatory immune cells from healthy women, and on placenta tissues from women undergoing elective abortions. Isolated blood monocytes and T helper (Th) cells under different activation and polarizing conditions were cultured with or without LMWH. Flow cytometry showed that LMWH exposure induced increased expression of HLA-DR and CD206 in macrophages. This phenotype was associated with increased secretion of Th17-associated CCL20, and decreased secretion of CCL2 (M2-associated) and CCL22 (Th2), as measured by multiplex bead array. In accordance, LMWH exposure to Th cells reduced the proportion of CD25highFoxp3+ regulatory T-cells, intensified IFN-gamma secretion and showed a tendency to increase the lymphoblast proportions. Collectively, a mainly pro-inflammatory effect was noted on two essential tolerance-promoting cells. Although the biological significancies of these in vitro findings are uncertain and need to be confirmed in vivo, they suggest the possibility that immunological effects of LMWH may be beneficial mainly at an earlier gestational age to provide an appropriate implantation process in women with recurrent miscarriage
Faust : Romance Of The Secret Tribunals / By George W. M. Reynolds, Author Of "The Mysteries Of London", "Pickwick Abroad", &c. Illustrated In The First Style Of The Art
No full textFAUST : ROMANCE OF THE SECRET TRIBUNALS / BY GEORGE W. M. REYNOLDS, AUTHOR OF "THE MYSTERIES OF LONDON", "PICKWICK ABROAD", &C. ILLUSTRATED IN THE FIRST STYLE OF THE ART
Faust : Romance Of The Secret Tribunals / By George W. M. Reynolds, Author Of "The Mysteries Of London", "Pickwick Abroad", &c. Illustrated In The First Style Of The Art (1)
Cover (1)
Umschlagtitel (8)
Titelseite (9)
Contents (10)
Illustrations / Prologue (11)
Prologue (12)
Chapter I.-XCV. (14)
Epilogue (119
Erratum to: Effects of nutraceuticals on quality of life and sexual function of perimenopausal women (Journal of Endocrinological Investigation, (2017), 40, 1, (27-32), 10.1007/s40618-016-0500-2)
No full textUnfortunately, one of the co-author first name was wrongly published in the original version. The complete correct name of the co-author is given below. A. M. C. Rapisarda. The original version of this article is also updated
Altered early infant gut microbiota in children developing allergy up to 5 years of age
No full textEarly colonization with bifidobacteria and lactobacilli is postulated to protect children from allergy, while Clostridium (C.) difficile colonization might be associated with allergic disease. Previous studies of infant gut microbiota in relation to subsequent allergy development have mostly employed culture-dependent techniques, studied genera of bacteria and the follow-up period was limited to 2 years. To relate gut microbiota in early infancy, notably bifidobacteria and lactobacilli at species level, to allergy development during the first 5 years of life and study if environmental factors influence the early infant gut microbiota. Fecal samples were collected at 1 week, 1 month and 2 months after birth from 47 Swedish infants, followed prospectively to 5 years of age. Bacterial DNA was analysed with real-time PCR and related to allergy development, family size as well as endotoxin and Fel d 1 levels in house dust samples. Primers binding to C. difficile, four species of bifidobacteria, two lactobacilli groups and Bacteroides fragilis were used. Children regarded as allergic manifested allergic symptoms and were skin prick test positive during their first 5 years while non-allergic children were neither. Children who developed allergy were significantly less often colonized with lactobacilli group I (Lactobacillus (L.) rhamnosus, L. casei, L. paracasei), Bifidobacterium adolescentis and C. difficile during their first 2 months. Infants colonized with several Bifidobacterium species had been exposed to higher amounts of endotoxin and grew up in larger families than infants harbouring few species. A more diverse gut microbiota early in life might prevent allergy development and may be related to the previously suggested inverse relationship between allergy, family size and endotoxin exposure.The definitive version is available at www.blackwell-synergy.com:Ylva Sjögren, Maria Jenmalm, Malin Böttcher, Bengt Björkstén and E Sverremar-Ekström, Altered early infant gut microbiota in children developing allergy up to 5 years of age, 2009, CLINICAL AND EXPERIMENTAL ALLERGY, (39), 4, 518-526.http://dx.doi.org/10.1111/j.1365-2222.2008.03156.xCopyright: Blackwell Publishing Ltdhttp://www.blackwellpublishing.com
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
C M Taylor Keylogging Data: 17 Oct 2014 – 07 Nov 2014
No full textThis dataset is comprised of keylogging data from the author C M Taylor captured October 2014; Keystroke files: 17/10/2014 – 07/11/2014. This data was created using keylogging software Spectre Pro (SpectreSoft) installed on a dedicated IBM Thinkpad laptop and then exported as TXT and RTF files. They can be used for image and text analysis, teaching, art projects, or anything else of inspiration
Malgrange's vanishing theorem for weakly pseudoconcave CR manifolds
No full textThe authors prove the following CR version of Malgrange's theorem: Assume M is a smooth, non-compact, weakly pseudoconcave CR manifold of type (n,k) of finite kind. Then the highest ∂−M cohomology Hp,n∂−M(M) vanishes for 0≤p≤n+k. This generalises a similar result for real analytic CR manifolds by the third author [in Hyperbolic problems and regularity questions, 137--150, Birkhäuser, Basel, 2007; MR2298789 (2008d:32034)].
Furthermore, they prove the following approximation theorem: If M is as above and U⊂⊂V⊂⊂M are two open sets such that V\sbs UV∖U has no compact connected component then for 0≤p≤n+k the restriction map Zp,n−1(V−)→Zp,n−1(U) has dense image, with respect to the \scr C^\inftyC∞ topology on U. The authors prove the following CR version of Malgrange's theorem: Assume M is a smooth, non-compact, weakly pseudoconcave CR manifold of type (n,k) of finite kind. Then the highest ∂−M cohomology Hp,n∂−M(M) vanishes for 0≤p≤n+k. This generalises a similar result for real analytic CR manifolds by the third author [in Hyperbolic problems and regularity questions, 137--150, Birkhäuser, Basel, 2007; MR2298789 (2008d:32034)].
Furthermore, they prove the following approximation theorem: If M is as above and U⊂⊂V⊂⊂M are two open sets such that V\sbs UV∖U has no compact connected component then for 0≤p≤n+k the restriction map Zp,n−1(V−)→Zp,n−1(U) has dense image, with respect to the \scr C^\inftyC∞ topology on U. The authors prove the following CR version of Malgrange's theorem: Assume M is a smooth, non-compact, weakly pseudoconcave CR manifold of type (n,k) of finite kind. Then the highest ∂−M cohomology Hp,n∂−M(M) vanishes for 0≤p≤n+k. This generalises a similar result for real analytic CR manifolds by the third author [in Hyperbolic problems and regularity questions, 137--150, Birkhäuser, Basel, 2007; MR2298789 (2008d:32034)].
Furthermore, they prove the following approximation theorem: If M is as above and U⊂⊂V⊂⊂M are two open sets such that V\sbs UV∖U has no compact connected component then for 0≤p≤n+k the restriction map Zp,n−1(V−)→Zp,n−1(U) has dense image, with respect to the \scr C^\inftyC∞ topology on U
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