230 research outputs found
Análisis del contenido de taxol y otros taxanos y su relación con la expresión del gen ts en cultivos in vitro de Taxus globosa Schltdl
No full textCultivo de tejidos vegetales del árbol romerillo para obtener taxol
Get PDFLas plantas sintetizan compuestos importantes para la industria farmacéutica, agroquímica, cosmética y alimentaria. La mayoría de los compuestos con propiedades terapéuticas de interés farmacológico se encuentran en ciertos grupos taxonómicos de plantas con propiedades medicinales. En este sentido, las especies del género Taxus sintetizan alcaloides diterpénicos conocidos como taxanos, los cuales poseen propiedades anticancerígenas y actúan como agentes preventivos de enfermedades de las arterias coronarias. En este trabajo se revisó la importancia medicinal del taxol obtenido del romerillo, así como los avances en su cultivo de tejidos vegetales, dirigido hacia la mejora en la producción de taxanos para su aplicación terapéutica, con el fin de aportar información relevante para futuras investigaciones, enfocadas al aprovechamiento del romerillo en la biotecnología vegetal. En México, se distribuye la especie Taxus globosa Schltdl, árbol conocido de forma común como romerillo. Esta especie presenta alto contenido de taxanos, sin embargo, su aprovechamiento como fuente de estos compuestos se ve comprometida, debido a que es una especie en peligro de extinción
Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study.
Get PDFINTRODUCTION: Several common breast cancer genetic susceptibility variants have recently been identified. We aimed to determine how these variants combine with a subset of other known risk factors to influence breast cancer risk in white women of European ancestry using case-control studies participating in the Breast Cancer Association Consortium. METHODS: We evaluated two-way interactions between each of age at menarche, ever having had a live birth, number of live births, age at first birth and body mass index (BMI) and each of 12 single nucleotide polymorphisms (SNPs) (10q26-rs2981582 (FGFR2), 8q24-rs13281615, 11p15-rs3817198 (LSP1), 5q11-rs889312 (MAP3K1), 16q12-rs3803662 (TOX3), 2q35-rs13387042, 5p12-rs10941679 (MRPS30), 17q23-rs6504950 (COX11), 3p24-rs4973768 (SLC4A7), CASP8-rs17468277, TGFB1-rs1982073 and ESR1-rs3020314). Interactions were tested for by fitting logistic regression models including per-allele and linear trend main effects for SNPs and risk factors, respectively, and single-parameter interaction terms for linear departure from independent multiplicative effects. RESULTS: These analyses were applied to data for up to 26,349 invasive breast cancer cases and up to 32,208 controls from 21 case-control studies. No statistical evidence of interaction was observed beyond that expected by chance. Analyses were repeated using data from 11 population-based studies, and results were very similar. CONCLUSIONS: The relative risks for breast cancer associated with the common susceptibility variants identified to date do not appear to vary across women with different reproductive histories or body mass index (BMI). The assumption of multiplicative combined effects for these established genetic and other risk factors in risk prediction models appears justified
The influence of formulation and medicine delivery system on medication administration errors in care homes for older people.
Get PDFINTRODUCTION: Older people in care homes are at increased risk of medication errors and adverse drug events. The effect of formulation on administration errors is not known, that is whether the medicine is a tablet or capsule, liquid or device such as an inhaler. Also, the impact on administration errors of monitored dosage systems (MDS), commonly used in UK care homes to dispense tablets and capsules, is not known. This study investigated the influence of formulation and MDS on administration errors. METHODS: Administration errors were identified by pharmacists (using validated definitions) observing two drug rounds of residents randomly selected from a purposive sample of UK nursing and residential homes. Errors were classified and analysed by formulation and medicine delivery system. RESULTS: The odds of administration errors by formulation, when compared with tablets and capsules in MDS, were: liquids 4.31 (95% CI 2.02 to 9.21; p = 0.0002); topicals/transdermals/injections 19.61 (95% CI 6.90 to 55.73; p < 0.0001); inhalers 33.58 (95% CI 12.51 to 90.19; p < 0.0001). The odds of administration errors for tablets and capsules not in MDS were double those that were dispensed in MDS (adjusted OR 2.14, 95% CI 1.02 to 4.51; p = 0.04). CONCLUSIONS: Inhalers and liquid medicines were associated with significantly increased odds of administration errors. Training of staff in safe administration of these formulations needs implementing. Although there was some evidence that MDS reduced the odds of an administration error, the use of MDS impacts on other aspects of medicines management. Because of this, and as the primary topic of our study was not MDS, a prospective trial specifically designed to evaluate the overall impact of MDS on medicine management in care homes is needed
Tools for the implementation of a SCADA system in a desalination process
Get PDFIn this work a system is designed and implemented in SCADA MOVICON 11.5, in which the operation of five seawater desalination lines by reverse osmosis which work in parallel, with four coastal wells and two end-of-line pumps of the permeated water obtainedare integrated, synchronized and supervised as a single plant. Each desalination line has its own control system and can operate independently. As a product, synchronization algorithms were obtained that were added to the system through script codes, which guarantee continuous productivity in the desalination process, achieving synchronization between the mentioned sub-processes. Simultaneous operations of starting, washing and stopping that affected the performance of the osmosis lines are avoided. Alarmsare generated, reports are created, historical records and trends for the decision making on failures prediction, predictive maintenance and troubleshooting.Núñez Alvarez, José Ricardo-will be generated-orcid-0000-0002-6607-7305-600Benitez Pina, Israel Francisco-will be generated-orcid-0000-0003-2359-9768-600DIAZ PEREZ, SERGIO DAVID-will be generated-orcid-0000-0003-1105-9406-600Rodríguez Martínez, AlbertoOliveira, Djonathan-will be generated-orcid-0000-0002-5582-7959-60
Intense pulsed light-based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops
Get PDFBackground: Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40% to 59% of these patients worldwide. The current study was aimed at evaluating the potential clinical benefit of an intense pulsed light (IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments. To our knowledge, this is the first series analyzing the therapeutic effect of this treatment option in this type of patients. Methods: This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye symptomatology. All patients received four sessions of IPL treatment using the Optima IPL system (Lumenis, Yokneam, Israel) adjusted to the official optimized Lumenis setting. Changes in symptomatology, corneal staining, conjunctival hyperemia, non-invasive break-up time (NIBUT), tear osmolarity, tear meniscus height (TMH), meiboscore and meibomian gland expressibility was analyzed after treatment. Results: Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires [ocular surface disease index (OSDI), standard patient evaluation of eye dryness (SPEED) and symptom assessment questionnaire in dry eye (SANDE)] as well as with the visual analogue scale (P < 0.001). Mean change in OSDI was − 15.0 ± 11.3. A significant reduction was found after treatment in the corneal staining score (P < 0.001). A significant reduction was found in tear film meniscus height (P = 0.012), as well as in tear film osmolarity (P = 0.001). A significant reduction was also found in meibomian gland expressibility (P = 0.003), changing the percentage of grade 3 eyes from 44.4% before IPL to 17.2% after treatment. Conclusions: IPL therapy combined with meibomian gland expression (MGX) seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments, with an additional improvement in clinical signs, such as tear osmolarity and corneal staining
High mass photon pairs in lepton+ lepton-gamma gamma events at LEP
Get PDFHigh mass photon pairs in lepton+ lepton-gamma gamma events at LEP Adriani, O.; Aguilar-Benitez, M.; Ahlen, S.P.; Alcaraz, J.; Aloisio, A.; Alverson, G.; Alviggi, M.G.; Ambrosi, G.; Linde, F.L. Published in: Physics Letters B DOI: 10.1016/0370-2693(92)91576-U Link to publication Citation for published version (APA): Adriani, O., Aguilar-Benitez, M., Ahlen, S. P., Alcaraz, J., Aloisio, A., Alverson, G., ... Linde, F. L. (1992). High mass photon pairs in lepton+ lepton-gamma gamma events at LEP. Physics Letters B, 295,[337][338][339][340][341][342][343][344][345][346] https://doi.org/10.1016/0370-2693(92)91576-U General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Download date: 28 Jun 2019 Physics Letters B 295 (1992) From the analysis of the reactions e + e-~ g + g-(n?) (g = e, #, ~) we observe four events, one e+e -~'7 and three #+ ~-??, with the invariant mass of the photon pairs close to 60 GeV. These events were selected from a data sample collected in the L3 detector corresponding to 950000 produced Z°'s. More data are necessary to ascertain the origin of these events
Measurement of WZ and ZZ production in pp collisions at √s = 8 TeV in final states with b-tagged jets
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Funded by SCOAP3 / License Version CC BY 4.0.Measurements are reported of the WZ and ZZ production cross sections in proton-proton collisions at s √ =8 TeV in final states where one Z boson decays to b-tagged jets. The other gauge boson, either W or Z, is detected through its leptonic decay (either W→eν , μν or Z→e + e − , μ + μ − , or νν ¯ ). The results are based on data corresponding to an integrated luminosity of 18.9 fb −1 collected with the CMS detector at the Large Hadron Collider. The measured cross sections, σ(pp→WZ)=30.7±9.3(stat.)±7.1(syst.)±4.1(th.)±1.0(lum.)pb and σ(pp→ZZ)=6.5±1.7(stat.)±1.0(syst.)±0.9(th.)±0.2(lum.)pb , are consistent with next-to-leading order quantum chromodynamics calculationsBMWF and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil);
MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES and CS (Croatia); RPF (Cyprus); MoER, SF0690030s09 and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF(Germany);GSRT(Greece);OTKAand NIH(Hungary);DAEand DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); NRF and WCU (Republic of Korea); LAS (Lithuania);MOE and UM(Malaysia); CINVESTAV, CONACYT, SEP, and UASLP-FAI (Mexico); MBIE (New Zealand); PAEC (Pakistan); MSHE and NSC (Poland); FCT (Portugal); JINR (Dubna); MON, RosAtom, RAS and RFBR (Russia); MESTD (Serbia); SEIDI and CPAN (Spain); Swiss Funding Agencies (Switzerland);
NSC (Taipei); ThEPCenter, IPST, STAR and NSTDA(Thailand); TUBITAK and TAEK (Turkey); NASU and SFFR (Ukraine); STFC (United Kingdom); DOE and NSF (USA)
PROTOTIPO DIDÁCTICO PARA LA ENSEÑANZA DE VIBRACIONES MECÁNICAS MEDIANTE EL DISEÑO DE UN BANCO DE PRUEBAS DE DESEQUILIBRIO Y VELOCIDAD CRÍTICA
No full textUvA-DARE (Digital Academic Repository) A test of QCD based on 3-jet events from Z ° decays L3 Collaboration
No full textA test of QCD based on three jet events from Z0 decays Adeva, B.; Adriani, O.; Aguilar-Benitez, M.; Ahlen, S.P.; Akbari, H.; Alcaraz, J.; Aloisio, A.; Alverson, G.; Linde, F.L. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. We present a study of 43 000 3-jet events from Z ° boson decays. Both the measured jet energy distributions and the event orientation are reproduced by second order QCD. An alternative model with scalar gluons fails to describe the data
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