497 research outputs found
Dataset in support of Guenther, R.G. et al., 2022. "Effects of temperature and pH on the growth, calcification, and biomechanics of two species of articulated coralline algae"
No full textThis dataset supports the manuscript: Guenther, R.G. et al., 2022. "Effects of temperature and pH on the growth, calcification, and biomechanics of two species of articulated coralline algae" in Marine Ecology Progress Series.
DOI: https://doi.org/10.3354/meps14166.
Full author listing is Rebecca Guenther, Elliot M. A. Porcher, Emily Carrington, Patrick T. Martone
A funeral sermon, on the downfal of Buonaparte\u27s dynasty : a discourse preached on Thursday, July 7, 1814, the day appointed for the general thanksgiving.
No full textLabel of the Library of the Congregation of U.B. of the Borough of Bethlehem and its vicinity. No. 164
Framing the photographs: understanding digital photography as a computerization movement
No full textIn this chapter, the author examines a single computerization movement: digital photography. During the period 1991–2004, the technology in digital cameras was being refined by manufacturers and the advantages and limitations of digital cameras were discussed widely in the popular and trade-oriented media. The author explores this period of technological change using the concept of computerization movements, particularly drawing on how computerization movements use technological action frames, which reflect composite understandings of a technology’s function and use that are built up in the language about a technology. Content analysis data of major media sources shows a storyline developing alongside technology developments: The earliest digital cameras were widely hyped as potentially revolutionary but seriously limited in capability, and during the late 1990s concern was expressed regarding a perceived lack of sufficient technological progress toward acceptable quality technology. Once the technological limitations were overcome, widespread adoption was viewed as inevitable, even while concerns about such issues as digital manipulation remained. This simple story, however, does not reflect the more complex tensions experienced in many domains that rely heavily on photography. To explore this more complex story, the chapter also includes a more detailed look at a specialized domain, police and legal photography, where the adoption of 173 digital photography followed a rockier course than the popular media accounts would suggest
A new look at the pathogenesis of asthma
No full textAsthma is an inflammatory disorder of the conducting airways that has strong association with allergic sensitization. The disease is characterized by a polarized Th-2 (T-helper-2)-type T-cell response, but in general targeting this component of the disease with selective therapies has been disappointing and most therapy still relies on bronchodilators and corticosteroids rather than treating underlying disease mechanisms. With the disappointing outcomes of targeting individual Th-2 cytokines or manipulating T-cells, the time has come to re-evaluate the direction of research in this disease. A case is made that asthma has its origins in the airways themselves involving defective structural and functional behaviour of the epithelium in relation to environmental insults. Specifically, a defect in barrier function and an impaired innate immune response to viral infection may provide the substrate upon which allergic sensitization takes place. Once sensitized, the repeated allergen exposure will lead to disease persistence. These mechanisms could also be used to explain airway wall remodelling and the susceptibility of the asthmatic lung to exacerbations provoked by respiratory viruses, air pollution episodes and exposure to biologically active allergens. Variable activation of this epithelial-mesenchymal trophic unit could also lead to the emergence of different asthma phenotypes and a more targeted approach to the treatment of these. It also raises the possibility of developing treatments that increase the lung's resistance to the inhaled environment rather than concentrating all efforts on trying to suppress inflammation once it has become established.<br/
HTMS air quality monitoring
No full textOn January 8th, 2018, Portland Public Schools selected Portland State University to conduct monitoring and modeling to assess indoor and outdoor air quality and air flow conditions at Harriet Tubman Middle School (HTMS) in Portland, OR. Portland State University completed Phase I (from February 1, 2018 to April 19, 2018), of the proposed project and released a report to Portland Public Schools on April 18, 2018. Portland State University has now completed Phase II (from August 20, 2018 to October 19, 2018) and Phase III (from April 18, 2019 to June 18, 2019) monitoring. This report serves to summarize the findings of the Phase II and III efforts, including: measurements of indoor and outdoor levels of air pollution, quantification of the efficiency of the HVAC system and building renovation to reduce indoor levels of traffic-related air pollution, and recommendations for maintaining installed air treatment systems.submitted to Portland Public Schools c/o John Burnham ; prepared by Elliott T. Gall, Assistant Professor, Mechanical and Materials Engineering, Portland State University, Linda A. George, Professor, Environmental Science and Management, Portland State University, Raul B. Cal, Associate Professor, Mechanical and Materials Engineering, Portland State University, Aurélie Laguerre Research Analyst, Portland State University.Title from PDF caption (viewed on January 27, 2022).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English.Phase I report, February 1, 2018-April 19, 2018Phase II report, August 20, 2018-October 19, 2018Phase III report, April 18, 2019-June 18, 201
Disease Exacerbation in Multiple Sclerosis Patients is Characterized by Loss of Terminally Differentiated CD8+ T Regulatory Cells
No full textThe 52nd Annual Medical Student Research Forum at UT Southwestern Medical Center (Tuesday, February 4, 2014, 3-6 p.m., D1.502)Each year the Medical Student Research Program awards students for the best oral presentation and the best poster presentation as judged by faculty across campus. This author received an award as one of the best oral presentations at this forum.Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) that afflicts more than 400,000 people in the US. Although the etiology of the disease is unknown, pathogenic T cells are thought to underlie MS immune pathology. In contrast to the
current paradigm, we recently showed that MS patients harbor CNS-specific CD8+ T regulatory cells (CD8 Tregs) that are deficient during disease relapse. In the current study, we demonstrate that the neuroantigen-specific CD8 Tregs were cytolytic and eliminated pathogenic CD4+ T cells. Sorting of CD8+ T cells using an array of surface cellular markers revealed that the CD8 Tregs were terminally differentiated (CD27-, CD45RO-). The CD8 Treg-mediated suppression was perforin, granzyme B, and interferon-γ-dependent. Interestingly, we found that MS patients with acute disease exacerbation displayed a significant loss (averaging 25%) in the terminally differentiated CD8+ T cells, with a concurrent loss in perforin and granzyme B expression. In order to restore the regulatory potential of impaired CD8 Tregs during exacerbation, we pre-treated exacerbation-derived bulk CD8+ T cells with the cytokine IL-12 and significantly increased the suppressive capability of the cells by ~48% through upregulation of granzyme B and perforin. Our studies uncover the immune suppressive mechanism of neuroantigen-specific CD8 Tregs, and may contribute to the design of clinically relevant immune therapies for MS patients.Southwestern Medical Foundatio
Measurement of the and production cross sections in multilepton final states using 3.2 fb of collisions at = 13 TeV with the ATLAS detector
No full textSee paper for full list of authors - 22 pages plus author list + cover page (40 pages total), 8 figures, 5 tables. Submitted to Eur. Phys. J. C. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/TOPQ-2015-22/International audienceA measurement of the and production cross sections in final states with either two same-charge muons, or three or four leptons (electrons or muons) is presented. The analysis uses a data sample of proton-proton collisions at TeV recorded with the ATLAS detector at the Large Hadron Collider in 2015, corresponding to a total integrated luminosity of 3.2 fb. The inclusive cross sections are extracted using likelihood fits to signal and control regions, resulting in pb and pb, in agreement with the Standard Model predictions
The Road Less Traveled
No full textWHAT HAPPENS TO SERVANT-LEADERS WHEN THEY GET TIRED? Not long ago I was reminded of a quote-two quotes actually-which the noted author M. Scott Peck had shared with us as part of his 1993 Greenleaf conference keynote address. Peck, who passed away in 2005, and who is best known as the author of The Road Less Traveled, had admitted at the time that he was feeling tired, and he quoted T. S. Elliot, who had written: Middle age is when they keep asking you to do more and more, and you\u27re not yet decrepit enough to turn them down
El Imperio estremecido. Historias. Revista de la Dirección de Estudios Históricos. Num. 25 (1991) octubre-marzo
No full text1 Sir Francisc Bacon, "Of Vicissitudes of Things", The Essays, Penguir/Harmondsworth, 1985, p. 231.2 Véase J.R. Hale, "1588 and All That", The New York Review, Febrero 16, 1989.3 Philip II of Spain, Londres, Thames and Houston, 1975.4 Norton, 1988.6 James Anthony Froude, The Spanish Story of the Armada and Other Essays, Longmans, Green and Co., Londres, 1901, p. 102.6 En cuanto a esta edición y su presentación hay ciertas rarezas que no se explican. Según los adelantos publicitarios, esta es la primera vez que las memorias de Contreras aparecen en inglés en forma de libro. La verdad es que la traducción bastante tiesa de Catherine Alison Phillips apareció en 1926, bajo la firma de Jonathan Cape en Londres y Alfred A. Knopf en Nueva York. Se dice que el texto de la nueva traducción proviene de una versión decimonónica impresa en el Boletino d'lstoria de Madrid, "del cual hay una copia en el Museo-Británico". Boletino d'lstoria no es ni siquiera un título español, y las memorias originales las publicó por primera vez Manuel Serrano Sanz en el Boletín de la Real Academia de la Historia en 1900. Se las ha vuelto a reeditar en edición rústica en la Colección Austral (Madrid, Espasa Calpe, 1988) como Alonso Contreras, Discurso de mi vida, editara por Henry Ettinghausen.7 La exhibición fue acompañada por un catálogo en dos lujosos volúmenes que contienen algunos ensayos excelentes, Carlos III y la Ilustración, Ministerio de Cultura, Madrid, 1988. Tomado del New York Review of Books.Reseña de Jerald T. Milanchi y Susan Milbrath, editores, First Encounters: Spanish Explorations in the Caribbean and the United States, 1492-1570, University of Florida, Press, 1990, 222 pp. Peter Pierson, Commander of the Armada: The Seventh Duke of Medina Sidonia, Yale University Press, 1990, 304 pp. Alonso de Contreras, The Adventures of Captain Alonso de Contreras: A 17th Century Journey, traducción y notas de Philip Dallas, Paragon, 1990, 193 pp. Jonathan I. Israel, Dutch Primacy in World Trade, 1585-1740, Oxford University Press, Clarendon Press, 1990, 462 pp. Steven N. Orso, Art and Death at the Spanish Habsburg Court: The Royal Exequies for Philip IV, University of Missouri Press, 1990, 214 pp. John Lynch, Bourbon Spain, 1700-1808, Basil Blackwell, 1990, 450 pp. A la vez que contemplamos los grandes cambios históricos a nuestro alrededor, tiene cierto encanto volver la vista a épocas pretéritas, cuando los viejos imperios parecían amenazados por el derrumbe, mientras que otros imperios nuevos tomaban su lugar. Esto mismo sucedía, también, en el siglo XVII, cuando los contemporáneos especulaban sobre el futuro remoto para un imperio español cada vez más petrificado y sobre lo que sucedería en el caso de que llegara a derrumbarse. Uno de ellos, Sir Francis Bacon, al reflexionar sobre el ascenso y caída de los estados, de sus lecturas sacó una conclusión no muy confortable: “Se puede contar con que habrá guerra del desgajamiento y estremecimiento de un gran estado e imperio. Puesto que los grandes imperios, mientras duran, enervan y destruyen las fuerzas de los nativos a los que han sometido, respaldándose en sus propias fuerzas protectoras; y al fallar, todo se va a la ruina y se vuelven la presa. Tal cosa sucedió en la decadencia del imperio romano; y lo mismo en el imperio de Alemania, después de Carlos el Grande, en el que cada pájaro se llevó una pluma; y no habría de suceder otra cosa con España, de llegar a destrozarse”
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