1,195 research outputs found
Chirurgische Therapie des linksventrikulären Aneurysmas
No full textOBJECTIVE: Various surgical techniques have been introduced for patients with postinfarction LV aneurysm (LVA). Compared to conventional linear closure, endoventricular patch repair according to Dor is advocated to maintain LV geometry, allowing a more physiologic repair of LV aneurysm. However the impact of these different techniques on long-term results is discussed controversially. In this study we retrospectively analyzed patients with postinfarction LVA operated with different surgical techniques during the last 25 years. METHODS: The study included 305 pts. operated between 1974 and 2000. Mean age was 57 ± 9.6 years. 17 % were female and 83 % male. 200 pts (66 %) underwent linear resection of LVA (group L) and 105 (34 %) had aneurysmectomy with endoventricular patch according to the technique described by Dor and associates (group D). Repair of the LVA alone was performed in 98 patients (32 %). 207 patients (68 %) had associated coronary grafting with a mean number of 1.5 ± 1.4 grafts. 81.5 % of pts. were in NYHA class III or IV, and median preoperative ejection fraction was 34 ± 12 %. The vast majority of aneurysms were in the anterior region. Six patients underwent epicardial electrophysiological mapping and cryotherapy intraoperatively. The follow up period extends up to 25 years (mean 10 * 6.9 years) with a cumulative total of 2520 patient-years. RESULTS: Overall 30-day mortality was 6.2 % (19/305). Early mortality did not differ in group L (6.5 %) and D (5.7 %). Actuarial survival after 10 and 20 years was 55,6 ± 3,2 % and 16,7 ± 3,5 % respectively. There was also no significant difference in survival between patients of group L and D (55.4 % vs. 54.6 % at 10 years, p = 0.49). 13 patients (4.3 %) required a reoperation after in average 5.5 years. Freedom from reoperation after 10 years was 95.8 * 1.4 % and did not differ between both patient groups (group L 96.5 % vs. group D 95.1 % at 10 years, p = 0.06). As of December 2002, 130 patients (43 %) are alive. 83 % of the survivors are in New York Heart Association (NYHA) functional class I-II CONCLUSIONS LVA resection is a definite procedure with a low reoperation rate and can be performed with low operative mortality even in severely compromised patients. The clinical status of the patients improved significantly. In regard to the long-term survival and the reoperation rate we could not demonstrate a difference related to the surgical technique. With both surgical techniques comparable results regarding operative mortality, improvement in clinical status and survival can be achieved.ZIEL: Für Patienten mit Postinfarkt-LV-Aneurysma (LVA) gibt es verschiedene Operationstechniken. Im Vergleich zum konventionellen linearen Verschluss besteht der Vorteil der endoventrikulären Korrektur mit Patch nach Dor im Erhalt der LV-Geometrie, d. h. die Dor-Technik erlaubt eine bessere physiologische Korrektur von LV-Aneurysmen. Die Auswirkung dieser beiden Operationstechniken auf das Langzeitergebnis ist jedoch umstritten. In unserer Studie untersuchten wir rückwirkend Patienten mit Postinfarkt-LV-Aneurysma, die in den letzten 25 Jahren mit den beiden Operationstechiken operiert wurden. METHODEN: In unserer Studie begutachteten wir 305 Patienten, die zwischen 1974 und 2000 operiert wurden. Das Durchschnittsalter lag bei 57 ± 9,6 Jahren. 17 % der Patienten waren weiblich und 83 % männlich. 200 Patienten (66 %) unterzogen sich einer linearen LVA-Resektion (Gruppe L) und 105 (34 %) einer Aneurysmektomie mit einem endoventrikulären Patch, d. h. der von Dor et.al. beschriebenen Technik (Gruppe D). Bei 98 Patienten (32 %) wurde nur das LVA operiert, während bei 207 Patienten (68 %) gleichzeitig Bypässe angelegt wurden, und zwar im Durchschnitt 1,5 ± 1,4 Bypässe. 81,5 % der Patienten entsprachen der NYHA-Klassifikation III oder IV und die durchschnittliche präoperative Auswurffraktion (EF) betrug 34 ± 12 %. Die überwiegende Mehrheit der Aneurysmen befand sich in anteriorer Position. Sechs Patienten unterzogen sich intraoperativ einem epikardialen elektrophysiologischen Mapping und einer Kryotherapie. Der Follow-up-Zeitraum erstreckt sich auf bis zu 25 Jahre (im Durchschnitt 10 ± 6,9 Jahre), woraus sich eine Gesamtsumme von 2520 Patienten-Jahren ergibt. ERGEBNISSE: Die Gesamtmortalität innerhalb von 30 Tagen betrug 6,2 % (19/305). Die Frühmortalität unterschied sich in Gruppe L (6,5 %) und D (5,7 %) nicht. Die Überlebensrate nach 10 und 20 Jahren betrug 55,6 % ± 3,2 % bzw. 16,7 % ± 3,5%. Auch hier bestand kein wesentlicher Unterschied in der Überlebensrate der Patienten in Gruppe L und D (55,4 % bzw. 54,6 % nach 10 Jahren, p = 0,49). 13 Patienten (4,3 %) mussten nach durchschnittlich 5,5 Jahren reoperiert werden. Nach 10 Jahren benötigten 95,8 % ± 1,4 % der Patienten keine Reoperation, wobei hier kein Unterschied zwischen den beiden Patientengruppen bestand (Gruppe L 96,5 % bzw. Gruppe D 95,1 % nach 10 Jahren, p = 0,06). Bis Dezember 2002 hatten 130 Patienten (43 %) überlebt. 83 % der Überlebenden entsprachen der NYHA-Klassifikation I - II
3ΛH and 3Λ¯H‾ production in Pb–Pb collisions at √sNN = 2.76 TeV
No full textThe production of the hypertriton nuclei 3
H and 3
¯ H has been measured for the first time in Pb–Pb
collisions at √sNN = 2.76 TeV with the ALICE experiment at LHC. The pT-integrated 3
H yield in one
unity of rapidity, dN/dy × B.R.
3
H→3He,π− = (3.86 ± 0.77(stat.) ± 0.68(syst.)) × 10−5 in the 0–10% most
central collisions, is consistent with the predictions from a statistical thermal model using the same
temperature as for the light hadrons. The coalescence parameter B3 shows a dependence on the
transverse momentum, similar to the B2 of deuterons and the B3 of 3He nuclei. The ratio of yields
S3 = 3
H/(3He×/p) was measured to be S3 = 0.60±0.13(stat.)±0.21(syst.) in 0–10% centrality events;
this value is compared to different theoretical models. The measured S3 is compatible with thermal
model predictions. The measured 3
H lifetime, τ = 181+54
−39(stat.) ± 33(syst.) ps is in agreement within 1σ
with the world average value.peerReviewe
Concerning the parameters choice of a speech recognition system of isolated arabic words
No full textProduction of (anti-)He-3 and (anti-)H-3 in p-Pb collisions at root s(NN)=5.02 TeV
No full textThe transverse momentum (p(T)) differential yields of (anti-)He-3 and (anti-)H-3 measured in p-Pb collisions at root s(NN) = 5.02 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The ratios of the p(T)-integrated yields of (anti-)He-3 and (anti-)H-3 to the proton yields are reported, as well as the pT dependence of the coalescence parameters B-3 for (anti-)He-3 and (anti-)H-3. For (anti-)He-3, the results obtained in four classes of the mean charged-particle multiplicity density are also discussed. These results are compared to predictions from a canonical statistical hadronization model and coalescence approaches. An upper limit on the total yield of (4)(He) over bar is determined
Investigating the antiviral therapeutic potentialities of marine polycyclic lamellarin pyrrole alkaloids as promising inhibitors for SARS-CoV-2 and Zika main proteases (Mpro)
No full textThe new coronavirus variant (SARS-CoV-2) and Zika virus are two world-wide health pandemics. Along history, natural products-based drugs have always crucially recognized as a main source of valuable medications. Considering the SARS-CoV-2 and Zika main proteases (Mpro) as the re-production key element of the viral cycle and its main target, herein we report an intensive computer-aided virtual screening for a focused list of 39 marine lamellarins pyrrole alkaloids, against SARS-CoV-2 and Zika main proteases (Mpro) using a set of combined modern computational methodologies including molecular docking (MDock), molecule dynamic simulations (MDS) and structure-activity relationships (SARs) as well. Indeed, the molecular docking studies had revealed four promising marine alkaloids including [lamellarin H (14)/K (17)] and [lamellarin S (26)/Z (39)], according to their notable ligand-protein energy scores and relevant binding affinities with the SARS-CoV-2 and Zika (Mpro) pocket residues, respectively. Consequentially, these four chemical hits were further examined thermodynamically though investigating their MD simulations at 100 ns, where they showed prominent stability within the accommodated (Mpro) pockets. Moreover, in-deep SARs studies suggested the crucial roles of the rigid fused polycyclic ring system, particularly aromatic A- and F- rings, position of the phenolic -OH and δ-lactone functionalities as essential structural and pharmacophoric features. Finally, these four promising lamellarins alkaloids were investigated for their in-silico ADME using the SWISS ADME platform, where they displayed appropriated drug-likeness properties. Such motivating outcomes are greatly recommending further in vitro/vivo examinations regarding those lamellarins pyrrole alkaloids (LPAs). Communicated by Ramaswamy H. Sarma
Radiation hardness and detector performance of new 180nm CMOS MAPS prototype test structures developed for the upgrade of the ALICE Inner Tracking System
No full textH-3(Lambda) and (3)((Lambda)over-bar)(H)over-bar lifetime measurement in Pb-Pb collisions at root s(NN)=5.02 TeV via two-body decay
No full textAn improved value for the lifetime of the (anti-)hypertriton has been obtained using the data sample of Pb-Pb collisions at root s(NN) = 5.02 TeV collected by the ALICE experiment at the LHC. The (anti-)hypertriton has been reconstructed via its charged two-body mesonic decay channel and the lifetime has been determined from an exponential fit to the dN/d(ct) spectrum. The measured value, tau = 242(-38)(+34) (stat.) +/- 17 (syst.) ps, is compatible with representative theoretical predictions, thus contributing to the solution of the longstanding hypertriton lifetime puzzle. (C) 2019 The Author. Published by Elsevier B.V
Myrmarachne dishani Benjamin 2015, sp. nov.
No full textMyrmarachne dishani sp. nov. (Figures 5A–C, 6A–D, 7A–F, 8G–H) Type material Holotype, male from Sri Lanka, Sabaragamuuwa Province, Ratnapura District, Eastern Sinharaja, Morningside section, 23 February 2007, leg. S.P. Benjamin and Z. Jaleel (MHNG). Paratypes, 2 males 2 females. Label data as above, NMSL. Etymology The species is named for my wife Dishani P. Benjamin. Used as a noun in apposition. Diagnosis Separated from all other Sri Lankan species of the genus except for M. imbellis, by the presence of a cylindrical opisthosoma, which lacks any visible constriction. Similar to M. imbellis, but separated by the presence of white bands on the prosoma and centre of the distal half of the chelicerae (Figures 5A–C, 8G, H). The white bands are clearly visible in live as well as alcohol preserved specimens. Further, males are separated by the stout RTA with a tapering tip (Figures 6A, B, 7C–E). Females are separated by the oval CO and relatively shorter S (Figure 6D, C). Description Male: total length: 7.2–9.2; prosoma length: 4.8–6.0, width: 1.2–1.6. Leg I: femur 2.3, patella 0.8, tibia 2.0, metatarsus 1.2, tarsus 0.8. Prosoma almost 2× longer than wide. The cephalic half is somewhat elevated from the thoracic half, lateral sides parallel, with conspicuous white bands fringed with white hairs as in Figures 5A–C, 8G, H. Opisthosoma cylindrical, almost as much as 2× longer than wide, uniformly dark brown (Figure 5A–C). Preserved specimens are yellowish with darker lateral sides (Figure 8G, H). The white bands are faintly visible in preserved specimens (Figure 8G, H). All legs are brownish with dark rings, yellowish in preserved specimens (Figures 5A–C, 8G, H). All eyes surrounded by dark rings. Chelicerae elongated, shorter than carapace, with slightly convex inner and outer sides, dorsal surface is broader than the ventral surface. They are black in colour with a prominent white band fringed with white hairs in the centre of the distal half (Figure 5A–C). Leg formula 4132. Leg spination not examined. Palps as in Figure 6A, B. Female paratype: total length: 4.0; prosoma length: 1.8, width: 0.8. Leg 1: femur 0.8, patella 0.3, tibia 0.6, metatarsus 0.4 tarsus 0.3 Morphology as above, however, females lack the white fringes present in the chelicerae and prosoma of males. Leg formula 4132. Leg spination not examined. Epigynum and vulva as in Figure 6C, D. Distribution Known only from Sri Lanka. Other material examined Sri Lanka, Southern province: 2 males, Galle District, Sinharaja jungle, Kanneliya section, 13–16 July 1978, Coll. K.V. Krombein, P.B. Karunaratne, T. Wijesinhe, V. Kulasekara, L. Jayawickrema. USNM. Sabaragamuuwa Province, 3 males 2 females, Ratnapura District, Eastern Sinharaja, Morningside section, 23 February 2007, SP. Benjamin and Z. Jaleel. Central Province, 3 males 1 female, Kandy District, Deltoa, Loolcondera Estate, c. 1480 m, 07°08 ʹ 45 ″ N, 80°41 ʹ 53 ʹ E, 11 May 2010, Hand collecting, leg. S. Batuwita and N. Atukorala, NMSL. Western Province, 1 male, l Kalutara District, Gurulu Bedda, Kalugala Forest Reserve, 06°26 ʹ 35 ″ N, 80°14 ʹ 52 ″ E, 40 m, 10 January 2014, leg. SP. Benjamin and N. Athukorala, NMSL.Published as part of Benjamin, Suresh P., 2015, Model mimics: antlike jumping spiders of the genus Myrmarachne from Sri Lanka, pp. 2609-2666 in Journal of Natural History 49 (43) on pages 2618-2623, DOI: 10.1080/00222933.2015.1034209, http://zenodo.org/record/400086
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