55,143 research outputs found
Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial
Full text linkOral capecitabine (Xeloda<sup>®</sup>) is an effective drug with favourable safety in adjuvant and metastatic colorectal cancer. Oxaliplatin-based therapy is becoming standard for Dukes' C colon cancer in patients suitable for combination therapy, but is not yet approved by the UK National Institute for Health and Clinical Excellence (NICE) in the adjuvant setting. Adjuvant capecitabine is at least as effective as 5-fluorouracil/leucovorin (5-FU/LV), with significant superiority in relapse-free survival and a trend towards improved disease-free and overall survival. We assessed the cost-effectiveness of adjuvant capecitabine from payer (UK National Health Service (NHS)) and societal perspectives. We used clinical trial data and published sources to estimate incremental direct and societal costs and gains in quality-adjusted life months (QALMs). Acquisition costs were higher for capecitabine than 5-FU/LV, but higher 5-FU/LV administration costs resulted in 57% lower chemotherapy costs for capecitabine. Capecitabine vs 5-FU/LV-associated adverse events required fewer medications and hospitalisations (cost savings £3653). Societal costs, including patient travel/time costs, were reduced by >75% with capecitabine vs 5-FU/LV (cost savings £1318), with lifetime gain in QALMs of 9 months. Medical resource utilisation is significantly decreased with capecitabine vs 5-FU/LV, with cost savings to the NHS and society. Capecitabine is also projected to increase life expectancy vs 5-FU/LV. Cost savings and better outcomes make capecitabine a preferred adjuvant therapy for Dukes' C colon cancer. This pharmacoeconomic analysis strongly supports replacing 5-FU/LV with capecitabine in the adjuvant treatment of colon cancer in the UK
Effects of duct profile parameters on flow characteristics of pump-jet: A numerical analysis on accelerating and decelerating ducts distinguished by cambers and angles of attack
No full textThe aim of this study is to investigate the effects of duct profile parameters cambers and angles of attack that distinguish accelerating and decelerating ducts on the flow characteristics of pump-jet. A detailed numerical analysis is carried out to compare the properties of pump-jets with different cambers and attack angles, and to explore the mutual interaction between the duct and components of pump-jet. Beforehand, the numerical methodology is validated by comparing the experiment and simulation results of the pump-jet under mooring conditions and propeller VP1304. Five cambers (f = 0.5t, 0.25t, 0, -0.25t, -0.5t) and three attack angles (alpha = 4 degrees, 0 degrees, - 4 degrees) of duct profile are considered carefully to distinguish accelerating and decelerating ducts, focusing on the propulsion performance and flow field information. The results show that the flow velocity at the outlet of the accelerating ducts is significantly higher compared to the inlet velocity, as opposed to the phenomenon produced by decelerating ducts. The variation of camber makes the internal evolution of the flow field more intuitive compared with the change of angles of attack. Further results indicate that the maximum efficiency of pump-jet drops after the modest growth as the cambers decrease, whose location shifts towards the lower advance coefficient J. The alteration of alpha leads to making the trend more direct and apparent for the decelerating and accelerating ducts. The high f is advantageous for the cavitation resistance of inside components, like rotor blades and stator blades. The impacts of changing alpha on the distribution of pressure in pump-jets with accelerating and decelerating ducts are more prominent than changing f. Moreover, the effects of both variations of f and alpha on the circumferential distributions of the velocity components are prominent, while there are still significant differences between these changes. Additionally, the velocity distribution at the inlet of pump-jets with decelerating ducts is higher than that at the outlet, and the velocity distribution of pump-jets with accelerating ducts presents the opposite pattern
Simulation of gravel-sand bed response to flushing flows using a two-fraction entrainment approach: 2. Noninferior options for sediment maintenance flows
No full text
Measurement of fs /fu Variation with Proton-Proton Collision Energy and B -Meson Kinematics
No full textThe ratio of the Bs0 and B+ fragmentation fractions fs and fu is studied with Bs0→J/ψφ and B+→J/ψK+ decays using data collected by the LHCb experiment in proton-proton collisions at 7, 8, and 13 TeV center-of-mass energies. The analysis is performed in bins of B-meson momentum, longitudinal momentum, transverse momentum, pseudorapidity, and rapidity. The fragmentation-fraction ratio fs/fu is observed to depend on the B-meson transverse momentum with a significance of 6.0σ. This dependency is driven by the 13 TeV sample (8.7σ), while the results for the other collision energies are not significant when considered separately. Furthermore, the results show a 4.8σ evidence for an increase of fs/fu as a function of collision energy
Suppression of non-prompt J/ψ, prompt J/ψ, and Y(1S) in PbPb collisions at √s NN = 2.76 TeV
Full text linkThis is the Pre-print verison of the Article. The official published version can be accessed from the link below - Copyright @ 2012 Springer VerlagYields of prompt and non-prompt J/ψ, as well as U (1S) mesons, are measured by the CMS experiment via their μ + μ − decays in PbPb and pp collisions at Ö{s\textNN} = 2.76 sNN=276 TeV for quarkonium rapidity |y| < 2.4. Differential cross sections and nuclear modification factors are reported as functions of y and transverse momentum p T, as well as collision centrality. For prompt J/ψ with relatively high p T (6.5 < p T < 30 GeV/c), a strong, centrality-dependent suppression is observed in PbPb collisions, compared to the yield in pp collisions scaled by the number of inelastic nucleon-nucleon collisions. In the same kinematic range, a suppression of non-prompt J/ψ, which is sensitive to the in-medium b-quark energy loss, is measured for the first time. Also the low-p T U (1S) mesons are suppressed in PbPb collisions.This work was supported by the Austrian Federal Ministry of Science and Research; the Belgium Fonds de la Recherche Scientifique, and Fonds voor Wetenschappelijk
Onderzoek; the Brazilian Funding Agencies (CNPq, CAPES, FAPERJ, and FAPESP); the Bulgarian Ministry of Education and Science; CERN; the Chinese Academy of Sciences, Ministry of Science and Technology, and National Natural Science Foundation of China; the Colombian Funding Agency (COLCIENCIAS); the Croatian Ministry of Science, Education and Sport; the Research Promotion Foundation, Cyprus; the Estonian Academy of Sciences and NICPB; the Academy of Finland, Finnish Ministry of Education and Culture, and Helsinki Institute of
Physics; the Institut National de Physique Nucl´eaire et de Physique des Particules / CNRS, and Commissariat a l’Energie Atomique et aux Energies Alternatives / CEA, France; the Bundesministerium fur Bildung und Forschung, Deutsche Forschungsgemeinschaft, and Helmholtz-Gemeinschaft Deutscher Forschungszentren, Germany; the General Secretariat for Research and Technology, Greece; the National Scientific Research Foundation, and National Office for
Research and Technology, Hungary; the Department of Atomic Energy and the Department of Science and Technology, India; the Institute for Studies in Theoretical Physics and Mathematics, Iran; the Science Foundation, Ireland; the Istituto Nazionale di Fisica Nucleare, Italy; the Korean
Ministry of Education, Science and Technology and the World Class University program of NRF, Korea; the Lithuanian Academy of Sciences; the Mexican Funding Agencies (CINVESTAV, CONACYT, SEP, and UASLP-FAI); the Ministry of Science and Innovation, New Zealand; the Pakistan Atomic Energy Commission; the Ministry of Science and Higher Education and the National Science Centre, Poland; the Fundac¸ ao para a Ciencia e a Tecnologia, Portugal; JINR (Armenia, Belarus, Georgia, Ukraine, Uzbekistan); the Ministry of Education and Science of the Russian Federation, the Federal Agency of Atomic Energy of the Russian Federation, Russian Academy of Sciences, and the Russian Foundation for Basic Research; the Ministry of Science and Technological Development of Serbia; the Ministerio de Ciencia e Innovacion, and Programa Consolider-Ingenio 2010, Spain; the Swiss Funding Agencies (ETH Board, ETH Zurich, PSI, SNF, UniZH, Canton Zurich, and SER); the National Science Council, Taipei; the Scientific and Technical Research Council of Turkey, and Turkish Atomic Energy Authority; the Science and Technology Facilities Council, UK; the US Department of Energy, and the US National Science Foundation
Characterization of three chitosanase isozymes isolated from a commercial crude porcine pepsin preparation
No full textEvidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
Full text linkFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
“Mirror Image Effect” Space Charge Distribution in XLPE Power Cable under Opposite Stressing Voltage Polarity
No full textThe paper presents space charge distributions under opposite voltage polarities in full size cross-linked polyethylene power cables using the pulsed electro-acoustic technique. Under both positive and negative polarities, space charge distributions possess similar profiles but opposite polarities. A similar phenomenon had been reported previously in plaque samples and was termed the “mirror image effect”. By comparing the results between cables treated by degassing under different conditions, the paper concludes that the “mirror image” charge distribution is mainly attributed to a bulk effect within the volume of the insulation, whilst electron transfer by tunneling through an electrode/insulator interface contributes to the generation of homo “mirror image” close to the electrodes
- …
