43 research outputs found
[Continuous sinusoid systemic Fudr infusion in advanced colorectal carcinoma. Preliminary experience].
No full textSinusoidal circadian continuous infusion with a maximal flow rate in the afternoon (3-9 pm) reduces Fudr toxicity. In order to estimate if the reported lower toxicity is merely due to the quasi-intermittence of the daily dose or to the circadian rhythm of infusion. Ten patients with widespread cancer (9 colorectal and 1 renal) underwent sinusoidal continuous iv Fudr infusion with the peak level in antiphase (ie 68% of the dose from 3 to 9 am) as compared with the Römeling shape. An initial dose of 0.15 mg/kg/d for 14 days monthly has been given, escalating it every cycle by 0.025 mg/kg/d increments until toxicity. Mean (+/- SD) number of cycles has been 4.1 +/- 2.1 (range 2-8), maximal dose given has been 0.2 mg/kg/die in 5 patient and mean dose intensity of 0.570 +/- 0.04. Gastrointestinal toxicity consisted of nausea/vomiting WHO grade 1 in one patient and diarrhoea grade 1 in two, grade 2 and 3 in one and one case. Toxicity and dose intensity of both sinusoidal infusion seem to be similar and allow higher dose of Fudr than continuous constant infusion. Some other studies have to be done to include pharmacokinetics evaluation in order to estimate chronobiologic implication in continuous Fudr infusion
[Clinical use of a totally implantable and programmable pump for the infusion of drugs].
No full textTotally implantable programmable systems allow preordained complex continuous infusion of drugs. Sixteen totally programmable implantable pumps (Medtronic DAD) have been implanted in fifteen advanced colorectal and renal cancer patients for continuous ia and iv sinusoidal Fudr infusion. Median duration of pump function was 125 days (range 46-468), there was observed only one case of malfunction device which required the implant of a new device, and three complications of pump pocket (seroma, hematoma and infection) without interrumption of chemotherapy for clinical causes. The use of totally implantable programmable systems provides and important clinical improvement in controlled long-term drugs administration improving quality of life and duration of chemotherapy
Surgical resection of gastrointestinal stromal tumor after treatment with imatinib: clinical case
No full textSerum, urine and peritoneal fluid levels of 5-FU following intraperitoneal administration.
No full textStarch microsphere-induced arterial flow redistribution after occlusion of replaced hepatic arteries in patients with liver metastases
No full textGlobal population aging and heat exposure in the 21st century: implications for late-life well-being and policy
No full textClimate change has profound consequences for older adults’ well-being. Global increases in the frequency, intensity and duration of extreme heat spells pose the most direct threats, given older adults’ underlying health conditions and reduced capacity to thermoregulate. Individual-level consequences of heat exposure are well-documented, yet gerontological research has paid less attention to older adults’ heat exposure at the population level. World regions with both increasing concentrations of older adults and high temperature extremes are potential hotspots where growing aged populations are at risk of heat-related health threats. We estimate older adults’ current and future heat exposure in six global regions (Africa, Asia, Europe, North America, Oceania, South America). Analyses use NASA NEX Global Daily Downscaled Product climate data and country-level projections for the size and distribution of the age 65+ population. We focus on measures of cumulative heat exposure (cooling degree days) and acute exposure to heat extremes (95th percentile of daily maximum temperatures). We project that by 2050, populations aged 65+ globally exposed to >1200 cooling degree days will double. We also project that one-quarter of the aged population worldwide (roughly 340 million) will be living in climates with 95th percentile TMax95 > 99.5 F◦, a critical exposure threshold for health. The drivers of this population-level exposure vary by region. Population aging will drive exposure in historically hot regions in Africa and Asia, whereas climate change will drive heat exposure in historically older regions in Europe and North America. These results can inform public policy and local decision-making.S002333-USDOE - Pennsylvania State Universityhttps://doi.org/10.1093/geroni/igad104.0499Published versio
First observation of the decay Bs0→K*0K*0
No full textThe first observation of the decay B0s→K∗0K∗0 is reported using 35 pb−1 of data collected by LHCb in proton–proton collisions at a centre-of-mass energy of 7 TeV. A total of 49.8±7.5 B0s→(K+π−)(K−π+) events are observed within ±50 MeV/c2 of the B0s mass and 746 MeV/c2 < mKπ < 1046 MeV/c2, mostly coming from a resonant B0s→K∗0K∗0 signal. The branching fraction and the CP-averaged K∗0 longitudinal polarization fraction are measured to be B(B0s→K∗0K∗0)=(2.81±0.46(stat.)±0.45(syst.)±0.34(fs/ fd))×10−5 and fL =0.31±0.12(stat.)±0.04(syst.)
Measurement of the CP-violating phase phi(s) from B-s(0) -> J/psi pi(+)pi(-) decays in 13 TeV pp collisions
No full textDecays of B-s(0) and (B) over bar (0)(s) mesons into J/psi pi(+)pi(-) final states are studied in a data sample corresponding to 1.9 fb(-1) of integrated luminosity collected with the LHCb detector in 13 TeV pp collisions. A time-dependent amplitude analysis is used to determine the final-state resonance contributions, the CP-violating phase phi(s) = -0.057 +/- 0.060 +/- 0.011 rad, the decay-width difference between the heavier mass B-s(0) eigenstate and the B-0 meson of -0.050 +/- 0.004 +/- 0.004 ps(-1), and the CP-violating parameter vertical bar lambda vertical bar = 1.01(-0.06)(+0.08) +/- 0.03, where the first uncertainty is statistical and the second systematic. These results are combined with previous LHCb measurements in the same decay channel using 7 TeV and 8 TeV pp collisions obtaining phi(s) = 0.002 +/- 0.044 +/- 0.012 rad, and vertical bar lambda vertical bar = 0.949 +/- 0.036 +/- 0.019. (C) 2019 The Author. Published by Elsevier B.V
Screening for abdominal aortic aneurysms and associated risk factors in a general population
No full textObjectives:To evaluate the prevalence of abdominal aortic aneurysms (AAA) in a general population and to compare the results with those of similar studies in other countries.Design:Ultrasound screening study and collection of clinical and biochemical data.Setting:An urban Health Service District in Genoa, Italy.Materials:A general population, aged 65–75 years, invited by personal letter between 1991–1994.Results:1601 subjects (741 males and 860 females) out of 2734 invited (58.5%) were evaluated. According to the ultrasound findings, 27 patients (1.7%) had an aortic dilatation of 26–29 mm; an AAA of 30–39 mm was found in 37 (2.3%) and an AAA ≥ 40 mm in 33 (2.1%). The overall prevalence for AAA was 4.4% (8.8% in males and 0.6% in females respectively). The prevalence of smoking, alcohol consumption, coronary heart disease, chronic obstructive pulmonary disease and arterial disease were significantly higher in patients with AAA (p < 0.01).Conclusions:Ultrasound screening for AAA is a reliable and useful method and should be focused on men, regardless of concurrent disease
