33,513 research outputs found
Early growth response gene-2 (Egr-2) regulates the development of B and T cells
No full textThe study was supported by Arthritis Research UK.
Copyright @ 2011 Li et al.BACKGROUND: Understanding of how transcription factors are involved in lymphocyte development still remains a challenge. It has been shown that Egr-2 deficiency results in impaired NKT cell development and defective positive selection of T cells. Here we investigated the development of T, B and NKT cells in Egr-2 transgenic mice and the roles in the regulation of distinct stages of B and T cell development. METHODS AND FINDINGS: The expression of Egr1, 2 and 3 were analysed at different stages of T and B cell development by RT-PCT and results showed that the expression was strictly regulated at different stages. Forced expression of Egr-2 in CD2+ lymphocytes resulted in a severe reduction of CD4+CD8+ (DP) cells in thymus and pro-B cells in bone marrow, which was associated with reduced expression of Notch1 in ISP thymocytes and Pax5 in pro-B cells, suggesting that retraction of Egr-2 at the ISP and pro-B cell stages is important for the activation of lineage differentiation programs. In contrast to reduction of DP and pro-B cells, Egr-2 enhanced the maturation of DP cells into single positive (SP) T and NKT cells in thymus, and immature B cells into mature B cells in bone marrow. CONCLUSIONS: Our results demonstrate that Egr-2 expressed in restricted stages of lymphocyte development plays a dynamic, but similar role for the development of T, NKT and B cells.This article is provided by the Brunel Open Access publishing fund
Saint Louis University Soccer Club, 1958
No full textThe SLU Soccer Club prepares to take on the Midwest Soccer All-Stars in the snow at the Public Schools Stadium. Identifications are (left to right), 1st row: D. Range, D. Puricelli, G. Block, M. Houlihan, J. Knobbe, B. O'Brien and G. Endler. 2nd row: D. Kelly, S. Murphy, B. Malone, J. Michalski, J. Monahan, B. Endler, B. Kauffman, B. Burns, T. Malone and B. Guelker. 3rd row: J. Klein, T. Quigley, L. Manna, J. Fuchs, T. Richmond and J. Dueker. (30 November 1958) [Photo by Father Luke, PHO 01.442.14
Saint Louis University Soccer Club prepares to take on the Midwest Soccer All-Stars
No full textThe SLU Soccer Club prepares to take on the Midwest Soccer All-Stars in the snow at the Public Schools Stadium. Identifications are (left to right), 1st row: D. Range, D. Puricelli, G. Block, M. Houlihan, J. Knobbe, B. O'Brien and G. Endler. 2nd row: D. Kelly, S. Murphy, B. Malone, J. Michalski, J. Monahan, B. Endler, B. Kauffman, B. Burns, T. Malone and B. Guelker. 3rd row: J. Klein, T. Quigley, L. Manna, J. Fuchs, T. Richmond and J. Dueker. (30 November 1958) [Photo by Father Luke, PHO 01.442.15
Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
No full textThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
Saint Louis University soccer co-captains George Endler and Bill O'Brien, 1958
No full textCo-captains George Endler (left) and Bill O'Brien led the SLU Soccer Club to an undefeated season, including a 3-1 victory over the Midwest All-Stars. With the team's elevation to varsity status, SLU was admitted into the Midwest College Soccer Conference. (30 November 1958) [Photo by Father Luke, PHO 01.442.31
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Saint Louis University soccer Co-Captains George Endler and Bill O'Brien, 1958
No full textClose-up of Co-captains George Endler (left) and Bill O'Brien, who led the SLU Soccer Club to an undefeated season, including a 3-1 victory over the Midwest All-Stars. With the team's elevation to varsity status, SLU was admitted into the Midwest College Soccer Conference. (30 November 1958) [Photo by Father Luke, PHO 01.442.30
Saint Louis University soccer co-captains George Endler and Bill O'Brien, 1958
No full textCo-captains George Endler (left) and Bill O'Brien led the SLU Soccer Club to an undefeated season, including a 3-1 victory over the Midwest All-Stars. With the team's elevation to varsity status, SLU was admitted into the Midwest College Soccer Conference. (30 November 1958) [Photo by Father Luke, PHO 01.442.30
Saint Louis University soccer co-captains George Endler and Bill O'Brien with athletic director Bob Stewart, 1958
No full textCo-captains George Endler (left) and Bill O'Brien (right), flank Athletic Director Bob Stewart, as they celebrate an undefeated season, including a 3-1 victory over the Midwest All-Stars. With the team's elevation to varsity status, SLU was admitted into the Midwest College Soccer Conference. (30 November 1958) [Photo by Father Luke, PHO 01.442.32
Measurement of the CKM angle gamma from a combination of B->Dh analyses
No full textA combination of three LHCb measurements of the CKM angle gamma is presented. The decays B->DK and B->Dpi are used, where D denotes an admixture of D0 and D0-bar mesons, decaying into K+K-, pi+pi-, K+-pi-+, K+-pi-+pi+-pi-+, KSpi+pi-, or KSK+K- final states. All measurements use a dataset corresponding to 1.0 fb-1 of integrated luminosity. Combining results from B->DK decays alone a best-fit value of gamma = 72.0 deg is found, and confidence intervals are set gamma in [56.4,86.7] deg at 68% CL, gamma in [42.6,99.6] deg at 95% CL. The best-fit value of gamma found from a combination of results from B->Dpi decays alone, is gamma = 18.9 deg, and the confidence intervals gamma in [7.4,99.2] deg or [167.9,176.4] deg at 68% CL, are set, without constraint at 95% CL. The combination of results from B->DK and B->Dpi decays gives a best-fit value of gamma = 72.6 deg and the confidence intervals gamma in [55.4,82.3] deg at 68% CL, gamma in [40.2,92.7] deg at 95% CL are set. All values are expressed modulo 180 deg, and are obtained taking into account the effect of D0-D0bar mixing
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