135 research outputs found
Konstruksi Pemahaman Jamaah Majelis Zikir Al-Khidmah Terhadap Sakralitas Banyu Mana>qib
No full textAbstract: This article aims to describe how the construction of the congregation's understanding of the al-Khidmah zikir assembly about the sacredness of banyu mana> qib so that it influences and moves the congregation to put water around the assembly. To answer these questions, the author uses a qualitative research methodology with analysis using the theory of Peter L. Berger and Thomas Luckman about social construction. The construction of the understanding of the congregation of the Al-Khidmah zikir assembly when viewed with Berger and Luckman's theory will take place through dialegical interactions of subjective reality, symbolic reality, and objective reality. Subjective reality in this theory, each individual believes that the reading of mana>qib is a source of value. After that, it is symbolically represented - symbolic reality - by placing water around the qib. Then the combination of each individual raises an objective reality about banyu mana>qib. Simultaneously there is also a process of externalization, objectification, and iternalization. The externalization process occurs when the congregation adjusts to the values that have developed among the congregation. Then the objectification is marked by the congregation who has the same understanding and perception, namely, banyu mana> qib which is able to provide properties as a healing medium. Finally, the congregation identifies itself (internalization) about the needs they want to fulfill through / because of the water, so that an action appears.الملخص: يهد٠هذا المقال إلى دراسة كيÙية بناء Ùهم مجمع ذكر الخدمت على قدسية مياه المناقب وبالتالي التأثير على المصلين وتØريكهم لوضع الماء Øول التجمع. للإجابة على هذا السؤال ØŒ يستخدم المؤل٠منهجية بØØ« نوعي مع التØليل باستخدام نظرية بيتر Ù„.بيرجر وتوماس لاكمان ÙÙŠ البناء الاجتماعي. إن بناء Ùهم مجمع ذكرى الخدمتة ØŒ إذا ما نظر إليه بنظرية بيرغر ولوكمان ØŒ سيتم من خلال التÙاعل الديالكتيكي للواقع الذاتي والواقع الرمزي والواقع الموضوعي. الØقيقة الذاتية ÙÙŠ هذه النظرية ØŒ يعتقد كل Ùرد أن قراءة المناقب مصدر قيمة. بعد ذلك يتم تمثيلها رمزياً - الواقع الرمزي - بوضع الماء Øول مكان قراءة المناقب. ثم يؤدي الجمع بين كل Ùرد إلى Ø¥Øضار Øقيقة موضوعية Øول مناقب المياه. ÙÙŠ الوقت Ù†Ùسه ØŒ هناك أيضًا عملية المبالغة والتشكيل والإمالة. تØدث عملية التخارج عندما تتكي٠الجماعة مع القيم التي نشأت بين المصلين. ثم يتم تمييز التشيؤ من قبل المصلين الذين لديهم Ù†Ùس الÙهم والإدراك ØŒ أي مياه المناقب القادرة على توÙير الÙعالية كوسيلة للشÙاء. أخيرًا ØŒ يعرّ٠المصلين أنÙسهم (مستوطنين) Øول الاØتياجات التي يريدون تلبيتها من خلال / بسبب الماء ØŒ بØيث ينشأ Ùعل ما.Abstrak: Artikel ini bertujuan untuk mengungkapkan bagaimana konstruksi pemahaman jamaah majelis zikir Al-Khidmah tentang sakralitas banyu mana>qib sehingga mempengaruhi dan menggerakan jamaah untuk meletakkan air di sekitar majelis. Untuk menjawab pertanyaan tersebut, penulis menggunakan metodologi penelitian kualitatif dengan analisis menggunakan teori Peter L. Berger dan Thomas Luckman tentang konstruksi sosial. Konstruksi pemahaman jamaah majelis zikir Al-Khidmah jika dilihat dengan teori Berger dan Luckman maka akan berlangsung melalui interaksi dialegtis dari subjective reality, symbolic reality, dan objective reality. Subjective reality dalam teori ini, masing-masing individu meyakini bahwa bacaan manaqib adalah sumber nilai. Setelah itu direpresentasikan secara simbolis ”“symbolic reality- dengan meletakkan air di sekitar tempat pembacaan mana>qib. Kemudian gabungan masing-masing individu memunculkan satu objective reality tentang banyu mana>qib. Secara simultan juga terjadi proses eksteralisasi, objektifikasi, dan iternalisasi. Proses eksternalisasi terjadi ketika jamaah menyesuaikan diri dengan nilai yang sudah berkembang di kalangan jamaah. Kemudian objektifikasi ditandai dengan jamaah yang memiliki pemahaman dan presepsi yang sama, yakni, banyu mana>qib yang mampu memberikan khasiat sebagai media penyembuhan. Terakhir, jamaah mengidentifikasi dirinya (internalisasi) tentang kebutuhan yang hendak mereka penuhi melalui/lantaran air tersebut, sehingga muncul suatu tindakan
Production, Characterization, and Antioxidant Activity of Fucoxanthin from the Marine Diatom Odontella aurita
No full textThe production, characterization, and antioxidant capacity of the carotenoid fucoxanthin from the marine diatom Odontella aurita were investigated. The results showed that low light and nitrogen-replete culture medium enhanced the biosynthesis of fucoxanthin. The maximum biomass concentration of 6.36 g L−1 and maximum fucoxanthin concentration of 18.47 mg g−1 were obtained in cultures grown in a bubble column photobioreactor (Ø 3.0 cm inner diameter), resulting in a fucoxanthin volumetric productivity of 7.96 mg L−1 day−1. A slight reduction in biomass production was observed in the scaling up of O. aurita culture in a flat plate photobioreactor, yet yielded a comparable fucoxanthin volumetric productivity. A rapid method was developed for extraction and purification of fucoxanthin. The purified fucoxanthin was identified as all-trans-fucoxanthin, which exhibited strong antioxidant properties, with the effective concentration for 50% scavenging (EC50) of 1,1-dihpenyl-2-picrylhydrazyl (DPPH) radical and 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) radical being 0.14 and 0.03 mg mL−1, respectively. Our results suggested that O. aurita can be a natural source of fucoxanthin for human health and nutrition
Relative quantification of the proteomic changes associated with the mycotoxin zearalenone in the H295R steroidogenesis model
No full textToxicon 58 (2011) pp. 533–542Zearalenone (ZEN) is a mycotoxin with endocrine disrupting effects having vast economic
implications in e.g. pig farming. Structurally, ZEN resembles 17 b -estradiol, and thus is able
to bind to estrogen receptors (ER) in target cells. Because of this, it is also classified as
a non-steroidal estrogen, a phytoestrogen, a mycoestrogen, and a growth promoter.
Quantitative proteomic analysis was undertaken using stable-isotope labeling by amino
acids in cell culture (SILAC) upon exposure of the steroidogenesis cell model H295R with
ZEN to elucidate its effect on protein regulation. ZEN significantly regulated 21 proteins,
including proteins with known endocrine disrupting effects and several oncogenes. In
addition, network analysis using Ingenuity Pathway Analysis showed that ZEN affected the
oxidative phosphorylation pathway and the mitochondrial dysfunction pathway, both
previously reported to be involved in endocrine dysfunction
Relative quantification of the proteomic changes associated with the mycotoxin zearalenone in the H295R steroidogenesis model
No full textToxicon 58 (2011) pp. 533–542Zearalenone (ZEN) is a mycotoxin with endocrine disrupting effects having vast economic
implications in e.g. pig farming. Structurally, ZEN resembles 17 b -estradiol, and thus is able
to bind to estrogen receptors (ER) in target cells. Because of this, it is also classified as
a non-steroidal estrogen, a phytoestrogen, a mycoestrogen, and a growth promoter.
Quantitative proteomic analysis was undertaken using stable-isotope labeling by amino
acids in cell culture (SILAC) upon exposure of the steroidogenesis cell model H295R with
ZEN to elucidate its effect on protein regulation. ZEN significantly regulated 21 proteins,
including proteins with known endocrine disrupting effects and several oncogenes. In
addition, network analysis using Ingenuity Pathway Analysis showed that ZEN affected the
oxidative phosphorylation pathway and the mitochondrial dysfunction pathway, both
previously reported to be involved in endocrine dysfunction
Relative quantification of the proteomic changes associated with the mycotoxin zearalenone in the H295R steroidogenesis model
No full textToxicon 58 (2011) pp. 533–542Zearalenone (ZEN) is a mycotoxin with endocrine disrupting effects having vast economic
implications in e.g. pig farming. Structurally, ZEN resembles 17 b -estradiol, and thus is able
to bind to estrogen receptors (ER) in target cells. Because of this, it is also classified as
a non-steroidal estrogen, a phytoestrogen, a mycoestrogen, and a growth promoter.
Quantitative proteomic analysis was undertaken using stable-isotope labeling by amino
acids in cell culture (SILAC) upon exposure of the steroidogenesis cell model H295R with
ZEN to elucidate its effect on protein regulation. ZEN significantly regulated 21 proteins,
including proteins with known endocrine disrupting effects and several oncogenes. In
addition, network analysis using Ingenuity Pathway Analysis showed that ZEN affected the
oxidative phosphorylation pathway and the mitochondrial dysfunction pathway, both
previously reported to be involved in endocrine dysfunction
Characterization of human ALKBH4 – an AlkB homolog with a possible function in gene regulation
No full textThe Fe(II)/2OG (2-oxoglutarate)-dependent dioxygenase superfamily comprises proteins that couple substrate oxidation to decarboxylation of 2OG to succinate. A member of this class of mononuclear non-haem Fe proteins is the Escherichia coli DNA/RNA repair enzyme AlkB. In the present work, we describe the magnetic and optical properties of the yet uncharacterized human ALKBH4 (AlkB homologue). Through EPR and UV–visible spectroscopy studies, we address the Fe-binding environment of the proposed catalytic centre of wild-type ALKBH4 and an Fe(II)-binding mutant. We could observe a novel unusual Fe(III) high-spin EPR-active species in the presence of sulfide with a gmax of 8.2. The Fe(II) site was probed with NO. An intact histidine-carboxylate site is necessary for productive Fe binding. We also report the presence of a unique cysteine-rich motif conserved in the N-terminus of ALKBH4 orthologues, and investigate its possible Fe-binding ability. Furthermore, we show that recombinant ALKBH4 mediates decarboxylation of 2OG in absence of primary substrate. This activity is dependent on Fe as well as on residues predicted to be involved in Fe(II) co-ordination. The present results demonstrate that ALKBH4 represents an active Fe(II)/2OG-dependent decarboxylase and suggest that the cysteine cluster is involved in processes other than Fe co-ordination.</jats:p
Management of acute mesenteric ischaemia: Results of a worldwide survey.
No full textBackground: Acute mesenteric ischaemia (AMI) is a condition with high mortality. This survey assesses current attitudes and practices to manage AMI worldwide. Methods: A questionnaire survey about the practices of diagnosing and managing AMI, endorsed by several specialist societies, was sent to different medical specialists and hospitals worldwide. Data from individual health care professionals and from medical teams were collected. Results: We collected 493 individual forms from 71 countries and 94 team forms from 34 countries. Almost half of respondents were surgeons, and most of the responding teams (70%) were led by surgeons. Most of the respondents indicated that diagnosis of AMI is often delayed but rarely missed. Emergency revascularisation is often considered for patients with AMI but rarely in cases of transmural ischaemia (intestinal infarction). Responses from team hospitals with a dedicated special unit (14 team forms) indicated more aggressive revascularisation. Abdominopelvic CT-scan with intravenous contrast was suggested as the most useful diagnostic test, indicated by approximately 90% of respondents. Medical history and risk factors were thought to be more important in diagnosis of AMI without transmural ischaemia, whereas for intestinal infarction, plasma lactate concentrations and surgical exploration were considered more useful. In elderly patients, a palliative approach is often chosen over extensive bowel resection. There was a large variability in anticoagulant treatment, as well as in timing of surgery to restore bowel continuity. Conclusions: Delayed diagnosis of AMI is common despite wide availability of an adequate imaging modality, i.e. CT-scan. Large variability in treatment approaches exists, indicating the need for updated guidelines. Increased awareness and knowledge of AMI may improve current practice until more robust evidence becomes available. Adherence to the existing guidelines may help in improving differences in treatment and outcomes. © 2023 The Author
Evidence for the decay B0→J/ψω and measurement of the relative branching fractions of meson decays to J/ψη and J/ψη′
No full textFirst evidence of the B 0 → J / ψ ω decay is found and the B s 0 → J / ψ η and B s 0 → J / ψ η ′ decays are studied using a dataset corresponding to an integrated luminosity of 1.0 fb -1 collected by the LHCb experiment in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV. The branching fractions of these decays are measured relative to that of the B 0 → J / ψ ρ 0 decay:frac(B (B 0 → J / ψ ω), B (B 0 → J / ψ ρ 0)) = 0.89 ± 0.19 (stat) - 0.13 + 0.07 (syst),frac(B (B s 0 → J / ψ η), B (B 0 → J / ψ ρ 0)) = 14.0 ± 1.2 (stat) - 1.5 + 1.1 (syst) - 1.0 + 1.1 (frac(f d, f s)),frac(B (B s 0 → J / ψ η ′), B (B 0 → J / ψ ρ 0)) = 12.7 ± 1.1 (stat) - 1.3 + 0.5 (syst) - 0.9 + 1.0 (frac(f d, f s)), where the last uncertainty is due to the knowledge of f d / f s, the ratio of b-quark hadronization factors that accounts for the different production rate of B 0 and B s 0 mesons. The ratio of the branching fractions of B s 0 → J / ψ η ′ and B s 0 → J / ψ η decays is measured to befrac(B (B s 0 → J / ψ η ′), B (B s 0 → J / ψ η)) = 0.90 ± 0.09 (stat) - 0.02 + 0.06 (syst)
Measurement of the ratio of branching fractions B(B0→K∗0γ )/B(B0s→φγ ) and the directCP asymmetry inB 0→K∗0γ
No full textThe ratio of branching fractions of the radiative B decays B0→K⁎0γ and B0s→ϕγ has been measured using an integrated luminosity of 1.0 fb−1 of pp collision data collected by the LHCb experiment at a centre-of-mass energy of s√=7TeV. The value obtained is
B(B0→K⁎0γ)B(B0s→ϕγ)=1.23±0.06(stat.)±0.04(syst.)±0.10(fs/fd),
where the first uncertainty is statistical, the second is the experimental systematic uncertainty and the third is associated with the ratio of fragmentation fractions fs/fd. Using the world average value for B(B0→K⁎0γ), the branching fraction B(B0s→ϕγ) is measured to be (3.5±0.4)×10−5.
The direct CP asymmetry in B0→K⁎0γ decays has also been measured with the same data and found to be
ACP(B0→K⁎0γ)=(0.8±1.7(stat.)±0.9(syst.))%.
Both measurements are the most precise to date and are in agreement with the previous experimental results and theoretical expectations
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