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Sagebrush Saga
No full textMSS B 540 Civilian Conservation Corps Newsletters, 1935-1941Newsletters of Company 4429, 193
Southern Pacific (SP) 4429 on "Morning Daylight"
No full textA 6 x 9 photograph print showing the Southern Pacific (SP) 4429, 4-8-4, streamlined steam locomotive on passenger train No. 99, "Morning Daylight", passing through mountains going from Los Angeles to San Francisco, CA
Block Card 4429 Overland Parkway
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling (Toledo, Ohio) | Colonial Revival Style | Homeville Subdivision (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 4429 Overland Parkway (Toledo, Ohio
Southern Pacific (SP) 4429 on "Morning Daylight"
No full textA 7 x 10 photograph print showing the Southern Pacific (SP) 4429, 4-8-4, streamlined steam locomotive on passenger train No. 99, "Morning Daylight", passing through mountains going from Los Angeles to San Francisco, CA
Block Card 4429 Seagert Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Split-Level Style | 4429 Seagert Drive (Toledo, Ohio) | Dwelling | Estero Place (Toledo, Ohio) | Trilby Area (Toledo, Ohio)
Southern Pacific (SP) 4429 on "Morning Daylight"
No full textA 7 x 10 photograph print showing the Southern Pacific (SP) 4429, 4-8-4, streamlined steam locomotive on passenger train No. 99, "Morning Daylight", from Los Angeles to San Francisco, CA
Platter bowl S/8269/4429+4430 adorned with red slip.
No full textPlatter bowl S/8269/4429+4430 adorned with red slip.</p
Limited value of acyclovir in the treatment of uncomplicated herpes zoster
No full textContains fulltext :
4429.pdf (Publisher’s version ) (Open Access
Four-dimensional distribution of the 2010 Eyjafjallajökull volcanic cloud over Europe observed by EARLINET
No full textThe eruption of the Icelandic volcano Eyjafjallajökull in April–May 2010 represents a "natural experiment" to study the impact of volcanic emissions on a continental scale. For the first time, quantitative data about the presence, altitude, and layering of the volcanic cloud, in conjunction with optical information, are available for most parts of Europe derived from the observations by the European Aerosol Research Lidar NETwork (EARLINET). Based on multi-wavelength Raman lidar systems, EARLINET is the only instrument worldwide that is able to provide dense time series of high-quality optical data to be used for aerosol typing and for the retrieval of particle microphysical properties as a function of altitude. In this work we show the four-dimensional (4-D) distribution of the Eyjafjallajökull volcanic cloud in the troposphere over Europe as observed by EARLINET during the entire volcanic event (15 April–26 May 2010). All optical properties directly measured (backscatter, extinction, and particle linear depolarization ratio) are stored in the EARLINET database available at http://www.earlinet.org. A specific relational database providing the volcanic mask over Europe, realized ad hoc for this specific event, has been developed and is available on request at http://www.earlinet.org. During the first days after the eruption, volcanic particles were detected over Central Europe within a wide range of altitudes, from the upper troposphere down to the local planetary boundary layer (PBL). After 19 April 2010, volcanic particles were detected over southern and south-eastern Europe. During the first half of May (5–15 May), material emitted by the Eyjafjallajökull volcano was detected over Spain and Portugal and then over the Mediterranean and the Balkans. The last observations of the event were recorded until 25 May in Central Europe and in the Eastern Mediterranean area. The 4-D distribution of volcanic aerosol layering and optical properties on European scale reported here provides an unprecedented data set for evaluating satellite data and aerosol dispersion models for this kind of volcanic events
Effects of miR-4429/NQO1 on high glucose-induced renal tubular epithelial injury and inflammatory factor secretion
No full textObjective To investigate the effect of miR-4429/NQO1 and dependent reduced coenzyme/NADH quinone dehydrogenase 1(NQO1) on the proliferation,apoptosis and inflammatory factor secretion of renal tubular epithelial cells induced by high glucose,and its mechanism.Methods Human renal tubular epithelial HK-2 cells were cultured in vitro and treated with 30 mmol/L glucose for 24 h to prepare a renal tubular epithelial cell injury model of diabetic nephropathy.The model rats were recorded as the high-glucose group.HK-2 cells were cultured for 24 h with the medium containing 5.5 mmol/L glucose and recorded as the normal control group.HK-2 cells were cultured with the medium containing 50 mmol/L mannitol for 24 h and recorded as the high-osmosis control group.The miR-4429 inhibitor(anti-miR-4429),negative control sequence(anti-miR-NC),small interfering RNA of anti-miR-4429 and NQO1(si-NOQ1),and negative control sequence of anti-miR-4429 and si-NQO1(si-NC) were transfected into HK-2 cells and treated with 30 mmol/L glucose for 24 h.The rats treated as described above were recorded as HG + anti-miR-4429 group,HG + anti-miR-NC group,HG + anti-miR-4429 + si-NQO1 group and HG + anti-miR-4429 + si-NC group,respectively.qRT-PCR was used to detect the expression levels of miR-4429 and NQO1 mRNAs.Cell survival rate,apoptosis rate,Caspase-3 protein level,NQO 1 protein level,malondialedhyde(MDA) content,superoxide dismutase(SOD) activity,interleukin-1β(IL-1β) content,tumor necrosis factor-α(TNF-α) content were detected.The double luciferase reporting experiment validated the effect of miR-4429 overexpression on wild and mutant NQO1 luciferase activity.Western blot was used to detect the expression of Caspase-3 and NQO1.Results After high glucose treatment,the expression levels of miR-4429 and Caspase-3 were significantly increased(P<0.05),and the apoptosis rate was significantly increased(P<0.05).The content of MDA and the levels of IL-1β and TNF-α were significantly increased(P<0.05).but the expression level of NQO1 mRNA was significantly reduced(P<0.05),and the cell survival rate and SOD activity were significantly reduced(P<0.05).After inhibiting the expression of miR-4429,the apoptosis rate and the expression of Caspase-3 were significantly reduced(P<0.05),the content of MDA and the levels of IL-1β and TNF-α were significantly reduced(P<0.05),and the cell survival rate was significant It increased(P<0.05),and the activity of SOD increased significantly(P<0.05).Double luciferase reporting experiments confirmed that miR-4429 could inhibit luciferase activity in the 3’-UTR region of NQO1(P<0.05).Inhibition of NQO1 expression could significantly reduce the protective effect of inhibition of miR-4429 expression on high glucose-induced renal tubular epithelial cell injury.Conclusions MiR-4429 can promote high glucose-induced apoptosis of renal tubular epithelial cells,reduce cell survival,and aggravate oxidative and inflammatory damage of cells through targeted regulation of expression of NQO1
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